CN109563082A - 核磁共振显像化合物、其中间体、核磁共振显像剂及应用、以及核磁共振成像方法 - Google Patents

核磁共振显像化合物、其中间体、核磁共振显像剂及应用、以及核磁共振成像方法 Download PDF

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CN109563082A
CN109563082A CN201780048213.3A CN201780048213A CN109563082A CN 109563082 A CN109563082 A CN 109563082A CN 201780048213 A CN201780048213 A CN 201780048213A CN 109563082 A CN109563082 A CN 109563082A
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compound
formula
acid
optionally
magnetic resonance
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CN109563082B (zh
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刘潜
张亚卓
杨潇骁
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Beijing Neurosurgical Institute
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Beijing Neurosurgical Institute
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G01N24/088—Assessment or manipulation of a chemical or biochemical reaction, e.g. verification whether a chemical reaction occurred or whether a ligand binds to a receptor in drug screening or assessing reaction kinetics

Abstract

一种苯甲酰胺甲基吡咯烷类化合物或其药学上可接受的盐、其中间体、核磁共振显像剂及应用、以及核磁共振成像方法。所述苯甲酰胺甲基吡咯烷类化合物具有式(I)所示的通式结构，其中，R1、R2、R3、X1、X2、X3、X4、Ln如说明书所定义。

Description

PCT国内申请，说明书已公开。

Claims (12)

  1. PCT国内申请，权利要求书已公开。
CN201780048213.3A 2016-08-19 2017-08-18 核磁共振显像化合物、其中间体、核磁共振显像剂及应用、以及核磁共振成像方法 Active CN109563082B (zh)

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CN2016106954455 2016-08-19
CN201610695445.5A CN106366075B (zh) 2016-08-19 2016-08-19 吡咯烷类化合物、盐、核磁探针和药物应用、试剂、药物
PCT/CN2017/098003 WO2018033132A1 (zh) 2016-08-19 2017-08-18 核磁共振显像化合物、其中间体、核磁共振显像剂及应用、以及核磁共振成像方法

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CN201780048213.3A Active CN109563082B (zh) 2016-08-19 2017-08-18 核磁共振显像化合物、其中间体、核磁共振显像剂及应用、以及核磁共振成像方法

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Cited By (1)

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CN114276308A (zh) * 2021-12-24 2022-04-05 南京科技职业学院 一类磁共振造影剂及其制备方法与应用

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CN106366075B (zh) * 2016-08-19 2018-06-12 北京市神经外科研究所 吡咯烷类化合物、盐、核磁探针和药物应用、试剂、药物
CN107663228B (zh) * 2017-10-13 2021-01-19 北京市神经外科研究所 核磁共振显像化合物、核磁共振显像剂及应用、以及核磁共振成像方法
US11177693B1 (en) 2018-09-07 2021-11-16 Apple Inc. Wearable loops with embedded circuitry
CN110105408B (zh) * 2019-05-09 2022-11-08 上海药明康德新药开发有限公司 DNA编码化合物库构建中的On-DNA芳基叠氮化合物的合成方法

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Publication number Priority date Publication date Assignee Title
CN114276308A (zh) * 2021-12-24 2022-04-05 南京科技职业学院 一类磁共振造影剂及其制备方法与应用
CN114276308B (zh) * 2021-12-24 2023-08-11 南京科技职业学院 一类磁共振造影剂及其制备方法与应用

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