CN109476610A - 一种苯基嘧啶酮化合物的盐、多晶型物及其药物组合物和用途 - Google Patents

一种苯基嘧啶酮化合物的盐、多晶型物及其药物组合物和用途 Download PDF

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Publication number
CN109476610A
CN109476610A CN201880002904.4A CN201880002904A CN109476610A CN 109476610 A CN109476610 A CN 109476610A CN 201880002904 A CN201880002904 A CN 201880002904A CN 109476610 A CN109476610 A CN 109476610A
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solution
added
formula
solvent
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CN201880002904.4A
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CN109476610B (zh
Inventor
沈敬山
何洋
陈伟铭
李剑峰
田广辉
公绪栋
王震
张容霞
柳永建
蒋华良
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Suzhou Wangshan Wangshui Biopharmaceutical Co ltd
Shanghai Institute of Materia Medica of CAS
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Suzhou Vigonvita Life Sciences Co ltd
Shanghai Institute of Materia Medica of CAS
Topharman Shanghai Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

一种苯基嘧啶酮化合物的盐、多晶型物及其药物组合物和用途，具体公开一种如下式(I‑A)所示的苯基并嘧啶酮化合物的盐酸盐，及其药学上可接受的多晶型物、溶剂化物、水合物、共结晶、无水物或无定形形式，包含它们的药物组合物和药物单元剂型，制备上述物质的方法和它们的用途。

Description

PCT国内申请，说明书已公开。

Claims (13)

  1. PCT国内申请，权利要求书已公开。
CN201880002904.4A 2017-07-07 2018-07-02 一种苯基嘧啶酮化合物的盐、多晶型物及其药物组合物和用途 Active CN109476610B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201710551480 2017-07-07
CN2017105514804 2017-07-07
PCT/CN2018/093965 WO2019007299A1 (zh) 2017-07-07 2018-07-02 一种苯基嘧啶酮化合物的盐、多晶型物及其药物组合物和用途

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CN109476610A true CN109476610A (zh) 2019-03-15
CN109476610B CN109476610B (zh) 2022-05-24

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US (1) US11434226B2 (zh)
EP (1) EP3650444B8 (zh)
JP (1) JP7450842B2 (zh)
KR (1) KR102323090B1 (zh)
CN (1) CN109476610B (zh)
AU (1) AU2018298154B2 (zh)
RU (1) RU2761213C2 (zh)
WO (1) WO2019007299A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113402424A (zh) * 2021-06-22 2021-09-17 上海泰初化工技术有限公司 一种氰基丙烯酸酯类化合物的合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0636626A1 (en) * 1993-07-20 1995-02-01 Laboratoires Glaxo Sa Pyrazolopyrimidine Derivatives
CN1746171A (zh) * 2004-09-10 2006-03-15 上海特化医药科技有限公司 杂环并嘧啶酮衍生物、制备方法和用途
WO2010066111A1 (zh) * 2008-12-10 2010-06-17 上海特化医药科技有限公司 一类含有嘧啶酮苯基的化合物、其药物组合物及其制备方法和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9301192D0 (en) * 1993-06-09 1993-06-09 Trott Francis W Flower shaped mechanised table
AR070454A1 (es) * 2008-02-27 2010-04-07 Nycomed Gmbh Pirrolopirimidincarboxamidas y composiciones farmaceuticas que las comprenden

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0636626A1 (en) * 1993-07-20 1995-02-01 Laboratoires Glaxo Sa Pyrazolopyrimidine Derivatives
CN1746171A (zh) * 2004-09-10 2006-03-15 上海特化医药科技有限公司 杂环并嘧啶酮衍生物、制备方法和用途
WO2010066111A1 (zh) * 2008-12-10 2010-06-17 上海特化医药科技有限公司 一类含有嘧啶酮苯基的化合物、其药物组合物及其制备方法和用途

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113402424A (zh) * 2021-06-22 2021-09-17 上海泰初化工技术有限公司 一种氰基丙烯酸酯类化合物的合成方法

Also Published As

Publication number Publication date
AU2018298154B2 (en) 2020-09-24
US20200140415A1 (en) 2020-05-07
RU2020105706A3 (zh) 2021-08-06
RU2020105706A (ru) 2021-08-06
RU2761213C2 (ru) 2021-12-06
JP7450842B2 (ja) 2024-03-18
WO2019007299A1 (zh) 2019-01-10
CN109476610B (zh) 2022-05-24
AU2018298154A1 (en) 2020-02-27
EP3650444B1 (en) 2022-09-07
EP3650444A4 (en) 2020-05-20
KR20200024302A (ko) 2020-03-06
US11434226B2 (en) 2022-09-06
JP2020529972A (ja) 2020-10-15
KR102323090B1 (ko) 2021-11-05
EP3650444B8 (en) 2023-10-18
EP3650444A1 (en) 2020-05-13

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Patentee after: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Patentee after: SUZHOU VIGONVITA LIFE SCIENCES Co.,Ltd.

Address before: 201203 555 Zhangjiang Road, Zhangjiang, Pudong New Area, Shanghai

Patentee before: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Patentee before: SUZHOU VIGONVITA LIFE SCIENCES Co.,Ltd.

Patentee before: TOPHARMAN SHANGHAI Co.,Ltd.

TR01 Transfer of patent right
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Address after: 201203 555 Zhangjiang Road, Zhangjiang, Pudong New Area, Shanghai

Patentee after: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Country or region after: China

Patentee after: Suzhou Wangshan Wangshui Biopharmaceutical Co.,Ltd.

Address before: 201203 555 Zhangjiang Road, Zhangjiang, Pudong New Area, Shanghai

Patentee before: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Country or region before: China

Patentee before: SUZHOU VIGONVITA LIFE SCIENCES Co.,Ltd.

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