CN109476591A - 6-芳基氨基吡啶酮甲酰胺mek抑制剂化合物的中间体的制备方法 - Google Patents

6-芳基氨基吡啶酮甲酰胺mek抑制剂化合物的中间体的制备方法 Download PDF

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Publication number
CN109476591A
CN109476591A CN201780044044.6A CN201780044044A CN109476591A CN 109476591 A CN109476591 A CN 109476591A CN 201780044044 A CN201780044044 A CN 201780044044A CN 109476591 A CN109476591 A CN 109476591A
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China
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compound
formula
independently selected
alkali
alkyl
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CN201780044044.6A
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CN109476591B (zh
Inventor
王路路
刘飞
朱益忠
张洪英
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Capital Pharmaceutical Holdings Beijing Co ltd
Chia Tai Tianqing Pharmaceutical Group Co Ltd
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
Shouyao Holdings Beijing Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms

Abstract

本申请提供了作为MEK抑制剂的6‑芳基氨基吡啶酮甲酰胺化合物的中间体的制备方法，包括采用式V化合物为原料制备作为6‑芳基氨基吡啶酮甲酰胺化合物的中间体的式（III）化合物。

Description

PCT国内申请，说明书已公开。

Claims (12)

  1. PCT国内申请，权利要求书已公开。
CN201780044044.6A 2016-08-12 2017-08-11 6-芳基氨基吡啶酮甲酰胺mek抑制剂化合物的中间体的制备方法 Active CN109476591B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610666408.1A CN107721894A (zh) 2016-08-12 2016-08-12 一种6‑芳基氨基吡啶酮甲酰胺mek抑制剂化合物的中间体的制备方法
CN2016106664081 2016-08-12
PCT/CN2017/097045 WO2018028665A1 (zh) 2016-08-12 2017-08-11 6-芳基氨基吡啶酮甲酰胺mek抑制剂化合物的中间体的制备方法

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CN109476591A true CN109476591A (zh) 2019-03-15
CN109476591B CN109476591B (zh) 2020-05-05

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CN201780044044.6A Active CN109476591B (zh) 2016-08-12 2017-08-11 6-芳基氨基吡啶酮甲酰胺mek抑制剂化合物的中间体的制备方法

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US (1) US10501468B2 (zh)
EP (1) EP3498690A4 (zh)
CN (2) CN107721894A (zh)
WO (1) WO2018028665A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115484955A (zh) * 2020-04-30 2022-12-16 正大天晴药业集团股份有限公司 用于治疗met基因异常疾病的氨基吡啶衍生物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4011342A (en) * 1971-06-02 1977-03-08 Seperic Method and composition for the treatment of hypertension with ortho-disubstituted arylguanidines
EP0075205A2 (de) * 1981-09-17 1983-03-30 BASF Aktiengesellschaft Isothioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Bekämpfung unerwünschten Pflanzenwuchses
CN1033624A (zh) * 1987-07-17 1989-07-05 纽特拉斯威特公司 高效甜味剂
CN102020651A (zh) * 2010-11-02 2011-04-20 北京赛林泰医药技术有限公司 6-芳基氨基吡啶酮甲酰胺mek抑制剂

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108358939A (zh) 2014-07-29 2018-08-03 上海科州药物研发有限公司 作为蛋白激酶抑制剂的杂环化合物及其制备方法和用途

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4011342A (en) * 1971-06-02 1977-03-08 Seperic Method and composition for the treatment of hypertension with ortho-disubstituted arylguanidines
EP0075205A2 (de) * 1981-09-17 1983-03-30 BASF Aktiengesellschaft Isothioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Bekämpfung unerwünschten Pflanzenwuchses
CN1033624A (zh) * 1987-07-17 1989-07-05 纽特拉斯威特公司 高效甜味剂
CN102020651A (zh) * 2010-11-02 2011-04-20 北京赛林泰医药技术有限公司 6-芳基氨基吡啶酮甲酰胺mek抑制剂

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Publication number Publication date
CN107721894A (zh) 2018-02-23
EP3498690A1 (en) 2019-06-19
US20190177335A1 (en) 2019-06-13
US10501468B2 (en) 2019-12-10
CN109476591B (zh) 2020-05-05
WO2018028665A1 (zh) 2018-02-15
EP3498690A4 (en) 2020-04-08

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Effective date of registration: 20190524

Address after: No. 369, Yuzhou South Road, Lianyungang, Jiangsu Province

Applicant after: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Applicant after: Capital Pharmaceutical Holdings (Beijing) Co., Ltd.

Address before: No. 369, Yuzhou South Road, Lianyungang, Jiangsu Province

Applicant before: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Applicant before: Beijing Centaurus Biopharma Technology Co., Ltd.

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Address after: No. 369, Yuzhou South Road, Lianyungang, Jiangsu Province

Patentee after: CHIA TAI TIANQING PHARMACEUTICAL GROUP Co.,Ltd.

Patentee after: Capital Pharmaceutical Holdings (Beijing) Co.,Ltd.

Address before: No. 369, Yuzhou South Road, Lianyungang, Jiangsu Province

Patentee before: CHIA TAI TIANQING PHARMACEUTICAL GROUP Co.,Ltd.

Patentee before: Shouyao holding (Beijing) Co.,Ltd.