CN109475567A - 基于硅烷醇的治疗有效载荷 - Google Patents

基于硅烷醇的治疗有效载荷 Download PDF

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Publication number
CN109475567A
CN109475567A CN201780045309.4A CN201780045309A CN109475567A CN 109475567 A CN109475567 A CN 109475567A CN 201780045309 A CN201780045309 A CN 201780045309A CN 109475567 A CN109475567 A CN 109475567A
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China
Prior art keywords
alkyl
base
methyl
group
silanol
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Pending
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CN201780045309.4A
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English (en)
Chinese (zh)
Inventor
J·万纳尔
H·N·阮
D·S·沃纳
L·O·奥弗里
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Blinkbio Inc
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Blinkbio Inc
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
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    • A61K47/545—Heterocyclic compounds
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • A61K9/0097—Medicinal compositions released by microdevices, e.g. microelectromechanical systems [MEMS], microdevices comprising chips or microdevices on silicon
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    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
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CN201780045309.4A 2016-06-09 2017-06-09 基于硅烷醇的治疗有效载荷 Pending CN109475567A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662347700P 2016-06-09 2016-06-09
US62/347,700 2016-06-09
US201662349274P 2016-06-13 2016-06-13
US62/349,274 2016-06-13
US201762477695P 2017-03-28 2017-03-28
US62/477,695 2017-03-28
PCT/US2017/036728 WO2017214491A1 (en) 2016-06-09 2017-06-09 Silanol based therapeutic payloads

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CN109475567A true CN109475567A (zh) 2019-03-15

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US (5) US10064880B2 (enExample)
EP (1) EP3468500A4 (enExample)
JP (2) JP2019517564A (enExample)
CN (1) CN109475567A (enExample)
AU (1) AU2017277949B2 (enExample)
CA (1) CA3026651A1 (enExample)
WO (1) WO2017214491A1 (enExample)

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