CN109464376A - It is a kind of to swallow children's toothpaste and preparation method thereof using pears lithocyte as abrasive - Google Patents

It is a kind of to swallow children's toothpaste and preparation method thereof using pears lithocyte as abrasive Download PDF

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Publication number
CN109464376A
CN109464376A CN201811535935.4A CN201811535935A CN109464376A CN 109464376 A CN109464376 A CN 109464376A CN 201811535935 A CN201811535935 A CN 201811535935A CN 109464376 A CN109464376 A CN 109464376A
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China
Prior art keywords
lithocyte
toothpaste
pears
children
abrasive
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Pending
Application number
CN201811535935.4A
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Chinese (zh)
Inventor
杨勇
崔超
施晓琪
王绒
田韦琴
范超群
钱运华
蒋金龙
杜卫刚
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Huaiyin Institute of Technology
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Huaiyin Institute of Technology
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Priority to CN201811535935.4A priority Critical patent/CN109464376A/en
Publication of CN109464376A publication Critical patent/CN109464376A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63Steroids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30Characterized by the absence of a particular group of ingredients

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Emergency Medicine (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

The present invention provides a kind of using pears lithocyte as the children's toothpaste of swallowing of abrasive, is mainly configured to by following raw material: lithocyte, moisturizer, thickener, foaming agent, essence, sweetener, preservative, bacteriostatic agent, deionized water.Preparation method includes: that (A) extracts lithocyte (B) from pear flesh mentioned lithocyte added deionized water, moisturizer, foaming agent are added after ultrasound, after stirring 20min, addition thickener, essence, sweetener, preservative, bacteriostatic agent are stirred under vacuum 20min or more, form lotion.The present invention makees abrasive using natural extract pears lithocyte, and the toothpaste irritation of production is low, securely and reliably, can swallow, meet the requirement of children's toothpaste.

Description

It is a kind of to swallow children's toothpaste and preparation method thereof using pears lithocyte as abrasive
Technical field
The invention belongs to field of toothpaste, and in particular to it is a kind of using natural green extract pears lithocyte as abrasive can Swallow children's toothpaste and preparation method thereof.
Background technique
Lithocyte is from extracting in pear flesh, and it is harmless natural materials that main component, which is lignin, Manufactured toothpaste can be swallowed.Lithocyte has certain friction value, can clean tooth, and will not damage enamel.Lithocyte For ball-type crystal form, surface is smooth, it is possible to reduce the abrasion to tooth.
Child is the important period of tooth development, ensures that the oral health of child is the key that it is allowed to grow up strong and sturdy.Children Children's enamel can should not be damaged, and its irritation is strong because adult toothpaste friction is big using adult toothpaste when brushing teeth, held Easily cause the aversion of children, in addition, adult toothpaste fluorinated volume is obvious higher for children, exists to children's health Hidden danger.
Many children's toothpastes now are lack of pertinence on the basis of adult toothpaste, certain constituents therein Pediatric Oral Emergency environment may be destroyed, is threatened to Pediatric Oral Emergency health.This kind of toothpaste is only the reduction of in formula to children The dosage of the harmful substance of health, such as fluorinated volume, but such way and unreliable, children as a specific group, There are problems that swallowing toothpaste, if such toothpaste is used for a long time, necessarily children's torso is caused to seriously endanger.Therefore one kind is developed Children's toothpaste can naturally be swallowed as the market demand.
Summary of the invention
There is a problem of that friction is big, irritation is strong and fluorinated volume is higher for current toothpaste, the present invention provides one kind Using pears lithocyte as the children's toothpaste of swallowing of abrasive, making primary raw material used in toothpaste is all natural materials, floride-free Compound, it is safe and harmless.
The present invention is achieved by the following technical solutions:
It is a kind of to swallow children's toothpaste using pears lithocyte as abrasive, it is mixed with by the raw material of following parts by weight: 2 parts ~ 10 parts of abrasives;35 parts ~ 65 parts moisturizer;0.2 part ~ 1 part thickener;1.0 parts ~ 2.5 parts surfactants;0.1 part ~ 0.5 part Sweetener;0.1 part ~ 5 portions bacteriostatic agents;0.8 part ~ 1.5 parts essence;0.1 part ~ 0.5 portion preservative;Water surplus, total amount are 100 parts;
The abrasive is pears lithocyte;The water is deionized water.
Further improvement of the present invention scheme are as follows:
The moisturizer is the composition of sorbierite and glycerol, and the weight ratio of the glycerol and sorbierite is 1:2 ~ 3.
The thickener is the composition of cellulose gum and xanthan gum, and the weight ratio of the cellulose gum and xanthan gum is 1: 2~7。
The surfactant is one or both of laruyl alcohol sodium sulfovinate, lauroyl propylhomoserin sodium.
The sweetener is one or more of xylitol, sorbierite, saccharin sodium.
The bacteriostatic agent is one or more of dipotassium glycyrrhizinate, triclosan, Chlorhexidine.
The essence is one or both of flavoring apple essence, lemon extract, strawberry essence, grape essence, Mint Essence More than.
The preservative is one or more of sodium benzoate, methyl hydroxybenzoate, sorbic acid.
Further improvement project of the invention are as follows:
The pears lithocyte extracts according to the following steps: weighing pear flesh, adds deionized water, blends;Concentrated hydrochloric acid is added, so that processing Concentration of hydrochloric acid is 0.8mol/L ~ 1.2mol/L in liquid;80 DEG C of 20 ~ 40min of heat preservation, soaking time are had a rest stirring;Heat preservation terminates plus goes Ionized water stirs, and stands, pours out upper layer suspension, rinses 5 ~ 6 times repeatedly;It filters, gained lithocyte is spread out;60~65 4 ~ 6h is dried at DEG C, is cooled to room temperature, and lithocyte is collected.
Further improvement project of the invention are as follows:
It prepares a kind of using pears lithocyte as the scheme for swallowing children's toothpaste of abrasive, comprising the following steps: lithocyte is added Ultrasound to lithocyte is uniformly dispersed after to deionized water, addition thickener and moisturizer stir 10 ~ 30min, add thickener, Essence, sweetener, preservative, bacteriostatic agent are stirred under vacuum, and form lotion, obtain the swallowing using pears lithocyte as abrasive Children's toothpaste.
The invention has the benefit that
The present invention used primary raw material during making toothpaste is all natural materials, and floride-free compound is safe and harmless, One, abrasive is pears lithocyte, and lithocyte is natural extract, is made of lignin, harmless, even if accidentally gulping down, Can be absorbed by enteron aisle rapid digestion, crystal form be ball shape structure, using its make children's toothpaste can preferably clean tooth and Tooth is not caused to damage.Secondly, sweetener traditional saccharin sodium is substituted with xylitol, reduce the stimulation to Pediatric Oral Emergency Property;The nontoxic grade substance in the true border of xylitol in blood will not be converted to glucose after people's food, and can be metabolized completely;Xylitol Also have the function of preventing decayed tooth, is natural harmless caries preventive agent.Thirdly, select the extract dipotassium glycyrrhizinate in natural Radix Glycyrrhizae to be children The bacteriostatic agent of toothpaste can preferably inhibit bacterial growth, protection Pediatric Oral Emergency safety.
Specific implementation method
Embodiment 1 ~ 5 a kind of swallows children's toothpaste and its preparation using pears lithocyte as abrasive
Embodiment 1 ~ 5 is using pears lithocyte as the formula for swallowing children's toothpaste of abrasive such as table 1
In above-described embodiment, lithocyte is to be put into pear flesh and appropriate amount of deionized water after pulper sufficiently blends, will be to be processed Liquid is placed in conical flask, and concentrated hydrochloric acid is added, so that the final concentration of 0.8mol/L ~ 1.2mol/L of hydrochloric acid in treatment fluid, in 80 DEG C of water In bath heat 20 ~ 40min, intermittent stirring, after homogenate is transferred in beaker, add deionized water, with glass bar stir 1min, it is quiet 30s is set, upper layer suspension is poured out, is rinsed repeatedly according to this lithocyte 5 ~ 6 times, until cleaning, then filters, lithocyte is spread out, It is placed in 60 ~ 65 DEG C of 4 ~ 6h of baking in baking oven, is cooled to room temperature in drier, collect lithocyte to obtain the final product.
It is prepared according to the formula in table 1 a kind of using pears lithocyte as the children's toothpaste of swallowing of abrasive, including following step Rapid: ultrasound to lithocyte is uniformly dispersed after the deionized water of lithocyte and formula ratio is added into reactor, addition thickener with Moisturizer stirs 10 ~ 30min, then thickener, essence, sweetener, preservative, bacteriostatic agent vacuum is added into above-mentioned reactor and stirs 20min or more is mixed, lotion is formed, obtains the children's toothpaste containing lithocyte.
Embodiment 1 ~ 5 is investigated according to GB8372 toothpaste standard, concrete outcome see the table below 2.
From upper table 2:
Embodiment 1 ~ 5 meets toothpaste GB8372 toothpaste standard basic demand, and lotion is uniform, pure white, can bring to children good Sense organ and use feeling.
It is not fluorine-containing by above method production using pears lithocyte as the toothpaste of swallowing of abrasive, it is without any side effects, It solves the problems, such as that children swallow toothpaste, meets the requirement of children's safety.

Claims (10)

1. a kind of swallow children's toothpaste using pears lithocyte as abrasive, which is characterized in that mixed by the raw material of following parts by weight Conjunction is prepared: 2 parts ~ 10 parts abrasives;35 parts ~ 65 parts moisturizer;0.2 part ~ 1 part thickener;1.0 parts ~ 2.5 parts surface-actives Agent;0.1 part ~ 0.5 part sweetener;0.1 part ~ 5 portions bacteriostatic agents;0.8 part ~ 1.5 parts essence;0.1 part ~ 0.5 portion preservative;More than water Amount, total amount are 100 parts;
The abrasive is pears lithocyte;The water is deionized water.
2. a kind of children's toothpaste is swallowed using pears lithocyte as abrasive according to claim 1, it is characterised in that: institute It states pears lithocyte to extract according to the following steps: weighing pear flesh, add deionized water, blend;Concentrated hydrochloric acid is added, so that salt in treatment fluid Acid concentration is 0.8mol/L ~ 1.2mol/L;80 DEG C of 20 ~ 40min of heat preservation, soaking time are had a rest stirring;Heat preservation terminates plus deionized water, Stirring stands, pours out upper layer suspension, rinses 5 ~ 6 times repeatedly;It filters, gained lithocyte is spread out;It is dried at 60 ~ 65 DEG C Dry 4 ~ 6h, is cooled to room temperature, and collects lithocyte.
3. a kind of children's toothpaste is swallowed using pears lithocyte as abrasive according to claim 1, it is characterised in that: institute Moisturizer is stated as the composition of sorbierite and glycerol, the weight ratio of the glycerol and sorbierite is 1:2 ~ 3.
4. a kind of children's toothpaste is swallowed using pears lithocyte as abrasive according to claim 1, it is characterised in that: institute Thickener is stated as the composition of cellulose gum and xanthan gum, the weight ratio of the cellulose gum and xanthan gum is 1:2 ~ 7.
5. a kind of children's toothpaste is swallowed using pears lithocyte as abrasive according to claim 1, it is characterised in that: institute Stating surfactant is one or both of laruyl alcohol sodium sulfovinate, lauroyl propylhomoserin sodium.
6. a kind of children's toothpaste is swallowed using pears lithocyte as abrasive according to claim 1, it is characterised in that: institute Stating sweetener is one or more of xylitol, sorbierite, saccharin sodium.
7. a kind of children's toothpaste is swallowed using pears lithocyte as abrasive according to claim 1, it is characterised in that: institute Stating bacteriostatic agent is one or more of dipotassium glycyrrhizinate, triclosan, Chlorhexidine.
8. a kind of children's toothpaste is swallowed using pears lithocyte as abrasive according to claim 1, it is characterised in that: institute Stating essence is one or more of flavoring apple essence, lemon extract, strawberry essence, grape essence, Mint Essence.
9. a kind of children's toothpaste is swallowed using pears lithocyte as abrasive according to claim 1, it is characterised in that: institute Stating preservative is one or more of sodium benzoate, methyl hydroxybenzoate, sorbic acid.
10. preparing a kind of using pears lithocyte as the method for swallowing children's toothpaste of abrasive, which is characterized in that including following step Rapid: ultrasound to lithocyte is uniformly dispersed after lithocyte is added to deionized water, and addition thickener and moisturizer stir 10 ~ 30min, Add thickener, essence, sweetener, preservative, bacteriostatic agent, be stirred under vacuum, form lotion, obtain it is described with pears lithocyte for mill Liniment swallows children's toothpaste.
CN201811535935.4A 2018-12-14 2018-12-14 It is a kind of to swallow children's toothpaste and preparation method thereof using pears lithocyte as abrasive Pending CN109464376A (en)

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CN201811535935.4A CN109464376A (en) 2018-12-14 2018-12-14 It is a kind of to swallow children's toothpaste and preparation method thereof using pears lithocyte as abrasive

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7175863B1 (en) * 2005-09-15 2007-02-13 Den-Mat Corporation Method of isolating stone cells
CN103439159A (en) * 2013-08-22 2013-12-11 安徽农业大学 Method for detecting distribution of lignin tissue of stone cells of pear fruit
CN105853318A (en) * 2016-06-23 2016-08-17 桂林亦元生现代生物技术有限公司 Toothpaste and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7175863B1 (en) * 2005-09-15 2007-02-13 Den-Mat Corporation Method of isolating stone cells
CN103439159A (en) * 2013-08-22 2013-12-11 安徽农业大学 Method for detecting distribution of lignin tissue of stone cells of pear fruit
CN105853318A (en) * 2016-06-23 2016-08-17 桂林亦元生现代生物技术有限公司 Toothpaste and preparation method thereof

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Application publication date: 20190315

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