JP4726497B2 - Cosmetics - Google Patents

Description

  The present invention relates to a cosmetic, and more particularly to a cosmetic in which collagen is stably blended.

    Conventionally, collagen has been blended in cosmetics and other external compositions because it has an excellent moisturizing effect, and is also said to have anti-wrinkle and tarmi effects. Applied. Until now, collagen originated mainly from cows, pigs and chickens. However, in recent years, there have been problems such as mad cow disease, and due to advances in technology for extracting collagen from a large amount of fish skin generated in the fishery processing process, the incorporation of marine collagen derived from fish has attracted attention. On the other hand, many of the compositions for external use represented by cosmetics are blended with glycerin or the like in order to impart moisture retention. However, when a large amount of glycerin or the like is blended, the solubility of collagen is lowered, and white turbidity / precipitation occurs, so that a large amount of glycerin or the like cannot be blended. Therefore, an external composition capable of containing a large amount of glycerin or the like in a protein-containing preparation such as collagen has been demanded. There is a report that 1,2-pentanediol and 1,2-hexylene glycol are effective for stable blending of collagen (see, for example, Patent Document 1). Fucoidan, on the other hand, focuses on its viscosity and moisturizing properties, and its application for the purpose of improving the feeling of use, such as providing a smooth feeling when used on the skin, giving a moist feeling, and removing excess sebum, is being investigated ( For example, see Patent Documents 2, 3, and 4.) However, it has not been known that fucoidan has an action of improving the solubility of collagen or the like in a preparation containing glycerin or diglycerin at a high concentration.

JP 2003-183150 A JP-A-1-31707 Japanese Examined Patent Publication No. 7-14850 JP-A-1-305011

  The present invention has been made under such circumstances, and in a skin external preparation containing collagen, even in a state where glycerin or diglycerin is contained at a high concentration, it is uniformly dissolved and stored. It is an object of the present invention to provide means capable of suppressing changes with time such as starch even at times.

In view of such a situation, the present inventors maintain a uniform dissolved state even in the case of containing a high concentration of glycerin or diglycerin in cosmetics containing collagen, and are stable even over time. As a result of earnest research efforts in search of means for obtaining cosmetics, it was found that the coexistence of 0.0005 to 0.1% by mass of fucoidan improves the uniformity of the formulation system and the stability over time, The present invention has been completed. That is, the present invention is as follows.
(1) 1) and fucoidan, 2) and collagen, 3) and glycerine or Jiguriseri down, 4) contains a 1-hydroxy-1,1-diphosphonic acid,
The content of the fucoidan is 0.0005 to 0.1% by mass with respect to the total amount of the cosmetic,
Cosmetics characterized in that the content of glycerin or diglycerin is 30 to 90% by mass in total with respect to the total amount of cosmetics.
(2) The cosmetic according to (1), wherein the collagen is marine collagen.
(3) The cosmetic according to ( 1) or (2), wherein the ratio of fucoidan to collagen is fucoidan / collagen = 10/1 to 1/10.
(4) The cosmetic according to any one of (1) to (3) , which is a pack fee.

  According to the present invention, in cosmetics containing collagen and a high concentration of glycerin or diglycerin, coexistence of fucoidan makes the formulation system uniform, and further changes over time such as the formation of starch during storage. Means for suppressing can be provided.

(1) Fucoidan as an essential component of the external preparation for skin of the present invention Fucoidan is a sulfated polysaccharide containing fucose as a main constituent sugar, and has anti-ulcer action and gastric ulcer and other causative bacteria such as Helicobacter pylori to the stomach wall. It has been reported that since it has an action of inhibiting adhesion, it is useful for the prevention and treatment of gastric diseases by adding it to foods and beverages and taking it on a daily basis (JP-A-7-138166). This fucoidan is contained in large quantities as a constituent of algal bodies of algae such as the marine brown alga Okinawa mozuku (Cladosiphonokamuranus TOKIDA), which is particularly warm water. Fucoidan contained in this Okinawa mozuku is a polysaccharide with a structure in which a uronic acid residue is bonded to a part of a sugar chain composed of α1-3 linked fucose and sulfated fucose and partially contains an acetyl group. is there. Fucoidan can be easily extracted by removing water-insoluble matter by an operation such as extraction from hot water with hot water or homogenization with water and centrifugation. It is preferable to adjust the total amount of the extract so that the fucoidan content is 0.0005 to 0.1% by mass, more preferably 0.001 to 0.01% by mass. This is because if the amount of fucoidan is too small, the effect of inhibiting the formation of starch and the like of the present invention cannot be obtained, and if too much, fucoidan's own slimy feeling is too effective and it is difficult to use it in the touch. It is in such a fucoidan, than Corp. north bank, a molecular weight distribution 10,000 to 300,000 are commercially available, can be used to buy this product, preferred.

(2) Collagen which is an essential component of the cosmetic of the present invention The collagen of the present invention uses, for example, fish such as carp, goldfish carp, flat eyed carp, carp, carp, coral, and the bone, skin, Examples include marine collagen obtained after extracting water-soluble collagen components from means such as tendons, duckweeds, etc. through means such as washing, degreasing, acid filtration, enzyme treatment, salting out, dialysis, and heat treatment. In the skin external preparation of the present invention, the ratio of such marine collagen to fucoidan is preferably fucoidan / collagen = 10/1 to 1/10, more preferably 5/1 to 1/5. . When the amount of marine collagen is too small, the collagen is uniformly dissolved in the preparation system and there is no meaning of the present invention, and when it is too large, the production inhibitory effect such as starch of the present invention may not be sufficiently exhibited. Because there is. As such collagen, there is a commercially available product, and an aqueous solution of about 0.5% by mass in the name of “Pangkogen Marine” is commercially available from GATTEFOSSE, and this can be used and is preferable.

(3) Glycerin or diglycerin which is an essential component of the cosmetic of the present invention The glycerin or diglycerin used in the cosmetic of the present invention may be used alone or in combination. However, the total amount may be 30 to 90% by mass of the whole preparation system. In such a range where the content ratio of glycerin or diglycerin in the preparation system is low, the problem of poor solubility of collagen does not occur. Therefore, the ratio in the formulation system of glycerin or diglycerin of the present invention is 30% or more, preferably 35% or more, more preferably 40% or more. This is because when the glycerin or diglycerin concentration is 30% or more, the problem of non-uniformity occurs, and when it is 35% or more, it becomes more prominent. The upper limit is 90% or less, preferably 80% or less, more preferably 70% or less. This is because the effect of the present invention cannot be obtained if the glycerin or diglycerin concentration is too high.

(4) 1-hydroxyethane-1,1-diphosphonic acid, which is a constituent of the cosmetic of the present invention.
The present invention relates to the fact that fucoidan has an inhibitory action on the precipitation of collagen in a high-concentration polyhydric alcohol-containing preparation, but 1-hydroxyethane-1,1-diphosphonic acid is such a fucoidan. The effect is enhanced. It is preferable to contain 0.01-0.5% of 1-hydroxyethane-1,1-diphosphonic acid having such an action. 1-Hydroxyethane-1,1-diphosphonic acid having such action is commercially available as “Turpinal SL” from Koginis Japan as a 60% aqueous solution, which can be purchased and used. preferable.

(5) External preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing 1) fucoidan, 2) collagen, and 3) glycerin or diglycerin. In the external preparation for skin of the present invention, in addition to such essential components, optional components that are usually used in external preparations for skin can be contained within a range that does not interfere with the present invention. Examples of such optional ingredients include macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, and hardened coconut oil. Oil, wax, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum, oil, wax, liquid wax, liquid paraffin, squalane, bean wax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin , Hydrocarbons such as microcrystalline wax, higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, cetyl alcohol, stearyl alcohol, isostearyl Alcohol, behenyl alcohol, octyldodecanol, higher alcohol such as myristyl alcohol, cetostearyl alcohol, etc., cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate, dimethylpolysiloxane, methylphenylpoly Loxane, linear polysiloxane such as diphenylpolysiloxane, cyclic polysiloxane such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexanesiloxane, amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, Oil agents such as silicone oil such as modified polysiloxane such as fluorine-modified polysiloxane, anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, triethanolamine ether of alkyl sulfate, chloride Cationic surfactants such as stearyltrimethylammonium, benzalkonium chloride, laurylamine oxide, imidazoline-based amphoteric surfactants (2-cocoyl-2-imida Zolinium hydroxide-1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), amphoteric surfactants such as acylmethyltaurine, sorbitan fatty acid esters (sorbitan) Monostearate, sorbitan sesquioleate, etc.), glycerin fatty acids (eg, glyceryl monostearate), propylene glycol fatty acid esters (eg, propylene glycol monostearate), hardened castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbitol monolaurate, etc.), POE glycerin fatty acid ester Tells (POE-glycerol monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkylphenyl ethers (POE nonylphenyl) Ethers, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), Nonionic surfactants such as sucrose fatty acid esters and alkyl glucosides, polyethylene glycol not classified as essential components, erythritol, sorbitol, xylitol, maltitol, propylene glycol, dipro Polyhydric alcohols such as lenglycol, isoprene glycol, 1,3-butanediol, 1,2-pentanediol, 2,4-hexylene glycol, 1,2-hexanediol, 1,2-octanediol, pyrrolidone carvone Moisturizing ingredients such as sodium acid, lactic acid, sodium lactate, guar gum, quince seed, carrageenan, galactan, gum arabic, pectin, mannan, starch, xanthan gum, curdlan, methylcellulose, hydroxyethylcellulose, carboxymethylcellulose, methylhydroxypropylcellulose, chondroitin Sulfuric acid, dermatan sulfate, glycogen, heparan sulfate, hyaluronic acid, sodium hyaluronate, tragacanth gum, keratan sulfate, chondroitin, mucoitin sulfate, hydroxy Ethyl guar gum, carboxymethyl guar gum, dextran, keratosulfuric acid, locust bean gum, succinoglucan, caronic acid, chitin, chitosan, carboxymethyl chitin, agar, polyvinyl alcohol, polyvinyl pyrrolidone, carboxyvinyl polymer, sodium polyacrylate, bentonite, etc. Thickener, surface treated, mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, silica, silica, aluminum oxide, barium sulfate, etc. Bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide inorganic pigments, surface may be treated, mica titanium, fish phosphorus foil, oxy Pearls such as bismuth chloride, raked Red 202, Red 228, Red 226, Yellow 4, Blue 404, Yellow 5, Red 505, Red 230, Red 223, Orange 201, Red 213, Yellow 204, Organic dyes such as yellow No. 203, blue No. 1, green No. 201, purple No. 201, red No. 204, organic powders such as polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer, paraaminobenzoic acid UV absorbers, anthranilic acid UV absorbers, salicylic acid UV absorbers, cinnamic acid UV absorbers, benzophenone UV absorbers, sugar UV absorbers, 2- (2'-hydroxy-5'-t- UV absorbers such as octylphenyl) benzotriazole, 4-methoxy-4′-t-butyldibenzoylmethane, ethanol, isopropyl Lower alcohols such as diols, vitamin A or its derivatives, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 or its derivatives, vitamin B such as vitamin B12, vitamin B15 or its derivatives, α- Preferred examples include vitamin E such as tocopherol, β-tocopherol, γ-tocopherol, vitamin E acetate, vitamin D, vitamin H, pantothenic acid, panthetin, pyrroloquinoline quinone and the like. Among these, the carboxyvinyl polymer can impart viscosity to the formulation system by coexisting it, and has the effect of suppressing the heterogeneity of the formulation system and the formation of starch. It is also one of the preferred forms that it is contained in an amount of 0.01 to 2% by mass, more specifically 0.1 to 1% by mass.

  The cosmetic of the present invention contains a high concentration of glycerin or diglycerin, and is preferably applied to the moisturizing cosmetic taking advantage of its moisture retention. In particular, since collagen is uniformly dissolved, application to a uniform and transparent gel cosmetic is suitable. Examples of such materials include lotions, essences, gel massage materials, and gel pack materials. In addition, using a uniform and transparent appearance, it can also be applied to transparent massage fees, transparent pack fees, etc. that are accented with particles such as scrubs.

  Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to the examples.

  According to the prescription shown below, the gel-like pack material which is the cosmetics of this invention was created. That is, after the components a), b), c) and d) are mixed well, they are gradually added to b), c) and d) in the order of b), c) and d) in the order of the cosmetic of the present invention. A gel-like pack 1 was obtained. Comparative Example 1 was obtained by replacing fucoidan with pure water in the gel pack 1 of Example 1.

I)
Glycerin 25.000% by mass
Diglycerin 12.000% by mass
Ethanol 5.000 mass%
Ethylparaben 0.100% by mass
Phenoxyethanol 0.300% by mass
Carboxyvinyl polymer 0.900 mass%
Pure water 25.000% by mass
B)
Potassium hydroxide 0.760 mass%
Pure water 6.500% by mass
C)
Turpinal SL (1-hydroxyethyl-1,1-diphosphonic acid) 0.050% by mass
Pure water 1.000 mass%
D)
Pankogen Marine 1.000% by mass
(About 0.005 mass% as the amount of collagen)
Fucoidan 0.001% by mass
Pure water 22.389% by mass

A gel-like pack, which is a cosmetic of the present invention, was prepared according to the formulation shown below. That is, after the components a), b), c) and d) are mixed well, they are gradually added to b), c) and d) in the order of b), c) and d) in the order of the cosmetic of the present invention. A gel-like pack 2 was obtained. In gel pack 2 of Example 2 was Comparative Example 2 obtained by substituting the fucoidan in pure water.

I)
Glycerin 42.000% by mass
Ethylparaben 0.100% by mass
Phenoxyethanol 0.300% by mass
Carboxyvinyl polymer 0.900 mass%
Pure water 25.000% by mass
B)
Potassium hydroxide 0.760 mass%
Pure water 6.500% by mass
C)
Turpinal SL (1-hydroxyethyl-1,1-diphosphonic acid) 0.050% by mass
Pure water 1.000 mass%
D)
Pankogen Marine 2.000% by mass
(About 0.010 mass% as the amount of collagen)
Fucoidan 0.100% by mass
Pure water 21.290 mass%

(Comparative Example 3)
According to the formulation shown below, a cosmetic material of Comparative Example 3 having a low polyhydric alcohol content was prepared. That is, after the components a), b), c) and d) were mixed well, they were gradually added to b) in the order of b), c) and d) to obtain Comparative Example 3.
I)
Glycerin 15.000% by mass
Ethylparaben 0.100% by mass
Phenoxyethanol 0.300% by mass
Carboxyvinyl polymer 0.900 mass%
Pure water 25.000% by mass
B)
Potassium hydroxide 0.760 mass%
Pure water 6.500% by mass
C)
Turpinal SL (1-hydroxyethyl-1,1-diphosphonic acid) 0.050% by mass
Pure water 1.000 mass%
D)
Pankogen Marine 2.000% by mass
(About 0.010 mass% as the amount of collagen)
Pure water 48.390% by mass

(Comparative Example 4)
A cosmetic of Comparative Example 4 having a high polyhydric alcohol content was prepared according to the formulation shown below. That is, after the components a), b), c) and d) were mixed well, they were gradually added in the order of b), c) and d) to a) under stirring to obtain Comparative Example 4.
I)
Glycerin 70.000% by mass
Diglycerin 20.000 mass%
Carboxyvinyl polymer 0.500 mass%
Pure water 2,000% by mass
B)
Potassium hydroxide 0.550 mass%
Pure water 3.500% by mass
C)
Turpinal SL (1-hydroxyethyl-1,1-diphosphonic acid) 0.020% by mass
Pure water 0.500% by mass
D)
Pankogen Marine 1.000% by mass
(About 0.005 mass% as the amount of collagen)
Pure water 1.930% by mass

<Test Example 1>
Regarding the gel cosmetics of Example 1, Comparative Example 1, Example 2, Comparative Example 2, Comparative Example 3, and Comparative Example 4, observations were made on the appearance immediately after the preparation and when stored at 5 ° C. for 3 months. Regarding the appearance immediately after the preparation, the absorbance at 550 nm was measured using distilled water as a control. Uniform and transparent ones were marked with ◯, and non-uniform ones with x. Furthermore, starch formation by long-term storage was examined. The storage condition was 3 months at 5 ° C. The degree of starch formation was evaluated by a four-level evaluation by visual observation (score 1: no starch, score 2: very slightly starch, score 3: slightly starch, score 4: clearly starch) Asked.

The gel cosmetics of Example 1 and Example 2 were transparent immediately after production, and no subsequent starch formation was observed. Comparative Example 1 from which fucoidan was removed from Example 1 was transparent immediately after preparation, but formation of starch was observed during long-term storage. Comparative Example 2 with a large amount of collagen was opaque and non-uniform immediately after production. Comparative Example 3 having a small amount of glycerin or diglycerin was transparent and uniform, but Comparative Example 4 having a very large amount of glycerin or diglycerin was an opaque and non-uniform system immediately after preparation.

The essence which is the cosmetics of this invention was created according to the prescription shown below. That is, after the components a), b), c) and d) were mixed well, they were gradually added to b) in the order of b), c) and d) to obtain an essence.
I)
Glycerin 20.000 mass%
Diglycerin 45.000% by mass
Ethylparaben 0.100% by mass
Phenoxyethanol 0.300% by mass
Pure water 15.000% by mass
B)
Carboxyvinyl polymer 0.100% by mass
Pure water)
Turpinal SL (1-hydroxyethyl-1,1-diphosphonic acid) 0.050% by mass
Pure water 1.000 mass%
D)
Pankogen Marine 1.000% by mass
(About 0.005 mass% as the amount of collagen)
Fucoidan 0.0005% by mass
Pure water 17.4495 mass%

According to the prescription shown below, the gel-like massage material which is the cosmetics of the present invention was prepared. That is, after mixing the ingredients of a), b), c) and d) well, gradually add b), c), d) and e) to the mixture under agitation, and add the gel massage material. Obtained.
I)
Glycerin 25.000% by mass
Diglycerin 12.000% by mass
Ethanol 5.000 mass%
Ethylparaben 0.100% by mass
Phenoxyethanol 0.300% by mass
Carboxyvinyl polymer 1.900 mass%
Pure water 25.000% by mass
B)
Potassium hydroxide 1.760% by mass
Pure water 6.500% by mass
C)
Turpinal SL (1-hydroxyethyl-1,1-diphosphonic acid) 0.200% by mass
Pure water 1.000 mass%
D)
Milonecton 0.001% by mass
Seaweed extract 0.100% by mass
Pankogen Marine 0.100% by mass
(The amount of collagen is about 0.0005 mass%)
Fucoidan 0.001% by mass
Pure water 20.338% by mass
E)
Avicel 0.700% by mass

  The present invention can be applied to cosmetics such as gel cosmetics and essences.

Claims (4)

1) and fucoidan, 2) and collagen, 3) and glycerine or Jiguriseri down, 4) contains a 1-hydroxy-1,1-diphosphonic acid,
The content of the fucoidan is 0.0005 to 0.1% by mass with respect to the total amount of the cosmetic,
Cosmetics characterized by content of the said glycerin or diglycerin being 30-90 mass% in total with respect to cosmetics whole quantity .   The cosmetic according to claim 1, wherein the collagen is marine collagen. The cosmetic according to claim 1 or 2, wherein the ratio of fucoidan to collagen is fucoidan / collagen = 10/1 to 1/10. The cosmetic according to any one of claims 1 to 3 , wherein the cosmetic is a pack fee.