CN109453123B - 一种康普瑞汀类衍生物冻干粉针及其制备方法 - Google Patents

一种康普瑞汀类衍生物冻干粉针及其制备方法 Download PDF

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Publication number
CN109453123B
CN109453123B CN201811372794.9A CN201811372794A CN109453123B CN 109453123 B CN109453123 B CN 109453123B CN 201811372794 A CN201811372794 A CN 201811372794A CN 109453123 B CN109453123 B CN 109453123B
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combretastatin
freeze
derivative
phospholipid
injection
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Chinese (zh)
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CN109453123A (zh
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周建平
丁杨
袁洲
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China Pharmaceutical University
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China Pharmaceutical University
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Priority to PCT/CN2018/118108 priority patent/WO2020103175A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201811372794.9A 2018-11-19 2018-11-19 一种康普瑞汀类衍生物冻干粉针及其制备方法 Active CN109453123B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201811372794.9A CN109453123B (zh) 2018-11-19 2018-11-19 一种康普瑞汀类衍生物冻干粉针及其制备方法
PCT/CN2018/118108 WO2020103175A1 (fr) 2018-11-19 2018-11-29 Injection de poudre lyophilisée dérivée de combrétastatine et procédé de préparation associé

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201811372794.9A CN109453123B (zh) 2018-11-19 2018-11-19 一种康普瑞汀类衍生物冻干粉针及其制备方法

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CN109453123A CN109453123A (zh) 2019-03-12
CN109453123B true CN109453123B (zh) 2021-05-11

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CN (1) CN109453123B (fr)
WO (1) WO2020103175A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110237050A (zh) * 2019-07-11 2019-09-17 苏州大学 一种康普瑞汀纳米粒及其制备方法
CN114460179A (zh) * 2020-11-09 2022-05-10 深圳市健翔生物制药有限公司 一种注射用醋酸地加瑞克体外释放度的测定方法
CN113024400A (zh) * 2021-03-08 2021-06-25 沈阳药科大学 一种秋水仙碱衍生物及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006119121A2 (fr) * 2005-04-29 2006-11-09 University Of Louisville Research Foundation, Inc. Decoration de surfaces de cellules avec des agents actifs
CN102190625B (zh) * 2010-03-18 2013-08-28 南京圣和药业有限公司 二苯乙烯类肿瘤靶向药物Combretastatin A4类似物
US20140010886A1 (en) * 2011-04-07 2014-01-09 Georgia Tech Research Corporation Compositions comprising saccharide binding moieties and methods for targeted therapy
CN102863388B (zh) * 2011-07-05 2015-04-29 南京圣和药业股份有限公司 肿瘤靶向药物Combretastatin A4衍生物
CN105288648B (zh) * 2015-10-14 2018-11-06 东南大学 一种亲水性药物的磷脂化合物、其药物组合物及应用
CN106580945B (zh) * 2015-10-14 2019-11-08 上海天氏利医药科技有限公司 一种考布他汀a4衍生物及其制剂
CN105476966A (zh) * 2016-01-29 2016-04-13 中国药科大学 一种水飞蓟宾磷脂复合物纳米冻干粉及其制备方法

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WO2020103175A1 (fr) 2020-05-28
CN109453123A (zh) 2019-03-12

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