CN109393458A - A kind of preparation method of Lycium chinense glycopeptide particle electuary - Google Patents
A kind of preparation method of Lycium chinense glycopeptide particle electuary Download PDFInfo
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Abstract
The embodiment of the present application shows a kind of preparation method of Lycium chinense glycopeptide particle electuary, it include: by dried fruit of lycium barbarum pulverization process, obtain dried fruit of lycium barbarum powder, dried fruit of lycium barbarum powder extracts, after filtering and concentration, obtain Lycium chinense glycopeptide extracting solution, beta-cyclodextrin is configured to wall material solution, Lycium chinense glycopeptide extracting solution and wall material solution are uniformly mixed, obtain core wall mixed liquor, monoglyceride is added in wall core mixed liquor, obtain premix, premix colloid mill homogenization is obtained into emulsion, emulsion spray drying and granulating is obtained into glycopeptide pellet product, semi-finished product obtain Lycium chinense glycopeptide particle electuary by whole grain；The preparation method of Lycium chinense glycopeptide shown in the embodiment of the present application, by adding this auxiliary material of beta-cyclodextrin, adjust grain made parameter of the core wall than forming microcapsules with spray drying technology embedding glycopeptide, improve Lycium chinense glycopeptide situation easy to moisture absorption, Lycium chinense glycopeptide particle electuary obtained is easier to save, and guarantees glycopeptide activity without significant changes during saving.
Description
Technical field
The present invention relates to wolfberry fruit extract preparation method, in particular to a kind of preparation method of Lycium chinense glycopeptide particle electuary.
Background technique
Fructus lycii is China's traditional Chinese medicine and invigorant, has various health care functions, the Food Hygiene Surveillance of the Ministry of Public Health, China
Inspection institute's identification fructus lycii " being both drug and food " in 1988.It is rich in a variety of biological nutrition functional components in fructus lycii, such as plants
The liposoluble constituents such as the water soluble ingredients such as object glycopeptide, glycine betaine, amino acid and carotenoid.Lycium chinense glycopeptide is one kind by six kinds
The polysaccharide side chain and 18 kinds of amino acid groups of own carbon sugared (rhamnose, arabinose, xylose, mannose, galactolipin, glucose) composition
At the connected water-soluble sugar albumen of protein backbone, be main active constituent in fructus lycii.Body immunity can be improved, have anti-
The effect of cancer, for cancer, enhancing hematopoiesis function, free radical is removed in liver protection decompression, antifatigue, anti-radiation, enhances cell activity.?
The fields such as medicine, health food are widely used.Granule refers to the dry particle shape dosage form that extract and proper auxiliary materials are mixed,
It had not only maintained decoction and has absorbed the features such as fast, effective rapid, but also overcame the shortcomings that decoction is long placed in easy mildew.In addition, granule
By Hydrolysis kinetics, volume-diminished, concentration are improved, and transport, is easy to carry.Lycium chinense glycopeptide has the characteristics that the easy moisture absorption, temperature-sensitive, system
Not easily molded at granule, when commercialization, is not easy to store.
Summary of the invention
The embodiment of the present invention provides a kind of preparation method of Lycium chinense glycopeptide particle electuary, solves Lycium chinense glycopeptide and particle is made
Agent is not easily molded, and when commercialization is not easy the problem of storing.
The embodiment of the present application shows a kind of preparation method of Lycium chinense glycopeptide particle electuary, and the method includes following steps
It is rapid:
After dried fruit of lycium barbarum pulverization process, obtained dried fruit of lycium barbarum powder；
The dried fruit of lycium barbarum powder is proposed into processing through ultrasonic-microwave auxiliary water, obtains Lycium chinense glycopeptide first extract；
By the Lycium chinense glycopeptide first extract through level Four ultrafiltration and nanofiltration concentration, Lycium chinense glycopeptide extracting solution is obtained；
It is 30-50%, wall material solution that beta-cyclodextrin, which is configured to mass fraction,；
The Lycium chinense glycopeptide extracting solution and the wall material solution are uniformly mixed according to the ratio of 1:3~1:5, obtain core wall
Mixed liquor；
Monoglyceride is added in the wall core mixed liquor, after mixing evenly, obtains premix；
The premix colloid mill homogenization is obtained into the emulsion that solid concentration is 20%~40%；
By the emulsion spray pelletization treatment, the condition of the emulsion spray pelletization treatment are as follows: the sucking of emulsion
Speed is 250ml/h~350ml/h, and atomizing pressure is 0.1Mpa~0.3Mpa, and intake air temperature is 150 DEG C~170 DEG C, spraying
After the completion of granulation, continuing logical hot wind makes grain fluidized drying；Cooling is shut down discharging when temperature of charge is down to 45 DEG C or less, is obtained
To glycopeptide pellet product；
Semi-finished product obtain the Lycium chinense glycopeptide particle electuary through whole grain.
Further, after the dried fruit of lycium barbarum pulverization process, dried fruit of lycium barbarum powder particle size is 40 mesh~60 mesh.
Further, the extraction conditions that the ultrasonic-microwave auxiliary water mentions are as follows: the ratio of fructus lycii and water is 1:20~1:30,
Extracting temperature is 40 DEG C~60 DEG C, and extraction time is 20min~40min, and ultrasonic power is 160W~200W, and microwave power is
300W~400W.
Further, the level Four ultrafiltration and nanofiltration concentration include: and will propose processing through ultrasonic-microwave auxiliary water to obtain
Extracting solution through 200,000 molecular weight ultrafiltration membrance filter handle, obtain a filtered fluid, a filtered fluid is sub very much through 1
The ultrafiltration membrance filter of amount is handled, and obtains ultrafiltrate, and the ultrafiltrate is carried out nanofiltration concentration.
Further, it is 0.2%~0.3% that the additive amount of the monoglyceride, which accounts for the ratio of the wall core mixed liquor,.
Further, glycopeptide content is 35%~55% in the Lycium chinense glycopeptide extracting solution.
Further, the Lycium chinense glycopeptide extracting solution and wall material solution are uniformly mixed according to the ratio of 1:4, obtain wall core
Mixed liquor, the solid concentration of the emulsion are 20%, the condition of the emulsion spray pelletization treatment are as follows: the suction of emulsion
Entering speed is 300ml/h, and intake air temperature is 170 DEG C.
By above technical scheme as it can be seen that the embodiment of the present application shows a kind of preparation method of Lycium chinense glycopeptide particle electuary,
It the described method comprises the following steps: after dried fruit of lycium barbarum pulverization process, obtained dried fruit of lycium barbarum powder, by the Chinese wolfberry fruit dry fruit powder
End proposes processing through ultrasonic-microwave auxiliary water, obtains the preliminary extracting solution of Lycium chinense glycopeptide, by the preliminary extracting solution of the Lycium chinense glycopeptide through four
Grade ultrafiltration and nanofiltration concentration, obtain Lycium chinense glycopeptide extracting solution, beta-cyclodextrin are configured to wall material solution, by the fructus lycii sugar
Peptide extracting solution and the wall material solution are uniformly mixed according to the ratio of 1:3~1:5, obtain core wall mixed liquor, mixed in the wall core
It closes in liquid and monoglyceride is added, after mixing evenly, obtain premix, the premix colloid mill homogenization is obtained into solid
The emulsion that object concentration is 20%~40%, by the emulsion spray pelletization treatment, the emulsion spray pelletization treatment
Condition are as follows: the suction velocity of emulsion is 250ml/h~350ml/h, and atomizing pressure is 0.1Mpa~0.3Mpa, intake air temperature
It is 150 DEG C~170 DEG C, after the completion of spraying granulation, continuing logical hot wind makes grain fluidized drying；Cooling, is down to 45 to temperature of charge
DEG C or less when shut down discharging, obtain glycopeptide pellet product, semi-finished product obtain the Lycium chinense glycopeptide particle electuary through whole grain；This
The preparation method of the Lycium chinense glycopeptide exemplified is implemented in application, by adding this auxiliary material of beta-cyclodextrin, adjusts core wall ratio and mist
Change grain made parameter, by adjusting the technology of preparing of microcapsules, improves Lycium chinense glycopeptide situation easy to moisture absorption, Lycium chinense glycopeptide obtained
Grain electuary is easier to save.
Detailed description of the invention
In order to illustrate more clearly of the technical solution of the application, letter will be made to attached drawing needed in the embodiment below
Singly introduce, it should be apparent that, for those of ordinary skills, without creative efforts, also
Other drawings may be obtained according to these drawings without any creative labor.
Fig. 1 is the flow chart for the preparation method that a kind of Lycium chinense glycopeptide particle electuary exemplified is preferably implemented in the application one.
Specific embodiment
Technical solution in order to enable those skilled in the art to better understand the present invention, below in conjunction with of the invention real
The attached drawing in example is applied, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described implementation
Example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common
Technical staff's every other embodiment obtained without making creative work, all should belong to protection of the present invention
Range.
Referring to Fig. 1, for a kind of preparation method of Lycium chinense glycopeptide particle electuary shown in the embodiment of the present application, the method
The following steps are included:
Step S1 is crushed: after dried fruit of lycium barbarum pulverization process, obtained dried fruit of lycium barbarum powder.
Step S2 is extracted: the dried fruit of lycium barbarum powder is proposed processing through ultrasonic-microwave auxiliary water, is obtained Lycium chinense glycopeptide and is just mentioned
Liquid.
Step S3, filtering and concentration: it by the preliminary extracting solution of the Lycium chinense glycopeptide through level Four ultrafiltration and nanofiltration concentration, obtains
To Lycium chinense glycopeptide extracting solution.
Wall material solution configuration: beta-cyclodextrin is configured to wall material solution by step S4.
Step S5 prepares core wall mixed liquor: by the Lycium chinense glycopeptide extracting solution and the wall material solution according to 1:3~1:5
Ratio be uniformly mixed, obtain core wall mixed liquor.
Step S6 adds monoglyceride: monoglyceride is added in the wall core mixed liquor, after mixing evenly, is pre-mixed
Liquid.
Step S7, colloid mill homogenization: the premix colloid mill homogenization, which is obtained solid concentration, is
20%~40% emulsion；
Step S8, spraying granulation processing: by the emulsion spray pelletization treatment, the emulsion spray pelletization treatment
Condition are as follows: the suction velocity of emulsion is 250ml/h~350ml/h, and atomizing pressure is 0.1Mpa~0.3Mpa, intake air temperature
It is 150 DEG C~170 DEG C, after the completion of spraying granulation, continuing logical hot wind makes grain fluidized drying；Cooling, is down to 45 to temperature of charge
DEG C or less when shut down discharging, obtain glycopeptide pellet product；
Step S9, semi-finished product obtain the Lycium chinense glycopeptide particle electuary through whole grain.
Wherein, step S1, dried fruit of lycium barbarum are packed into pulverizer and are crushed, and used pulverizer is Lowtemperaturepulverizer, low
Temperature, which crushes, refers to the mistake that the substance for being cooled to brittle point temperature is broken into the lesser particle of partial size or powder under external force
Journey.Freeze grinding technology can guarantee pulverized substance, such as natural products, in crushing process, structural constituent is not damaged.
The fructus lycii material used in the present embodiment requires to break the material of cell wall in crushing process, using crushing not under low temperature environment
Active mass's ingredient of fructus lycii can be damaged.
Step S2 extracts the preliminary extracting solution of Lycium chinense glycopeptide using the method that ultrasonic-microwave auxiliary water mentions, and water extraction is by fructus lycii
The method for adding boiling to take juice, the leaching content of Lycium chinense glycopeptide can effectively be improved and improve Chinese holly by being mentioned using ultrasonic-microwave auxiliary water
The leaching velocity and leaching rate of Qi glycopeptide.In step S3 in such a way that level Four ultrafiltration and nanofiltration concentration combine, Chinese holly is filtered out
Impurity in Qi glycopeptide and the concentration for further increasing Lycium chinense glycopeptide.
It is beta-cyclodextrin that the raw material that wall material solution uses is configured in step S4, and beta-cyclodextrin is easier to crystallize in water,
The solubility of beta-cyclodextrin in water is relatively low under room temperature, so should raising configuration temperature appropriate when configuring wall material solution
Degree, beta-cyclodextrin is capable of forming stable hydrate, and beta-cyclodextrin does not have hygroscopicity, as Lycium chinense glycopeptide microcapsules
Wall material solution have very big advantage.The inclusion compound of microcapsule type is made in beta-cyclodextrin and this molecule of Lycium chinense glycopeptide, no
Lycium chinense glycopeptide inside capable of only protecting as the outer wall of microcapsules solves the problems, such as that its is hygroscopic, and beta-cyclodextrin does not have
The state in drying that this characteristic of hygroscopicity enables to Lycium chinense glycopeptide lasting, the further suction for solving Lycium chinense glycopeptide
Moist problem.
In step S5, the ratio of Lycium chinense glycopeptide extracting solution and wall material solution is mixed according to the ratio of 1:3~1:5, core wall ratio
It is more obvious to the drugloading rate and grain diameter influence of prepared microcapsules, as the content of usual wall material is greater than containing for core material
Amount, the value of core wall ratio is too small, the Microcapsules Size of formation is bigger than normal and each microcapsules contained by Lycium chinense glycopeptide amount
Also on the low side, and the value of core wall ratio is excessive, the wall thickness of the microcapsules of formation is too small, is unfavorable for subtract hygroscopic to Lycium chinense glycopeptide
Weak, by test of many times, optimal microcapsules effect can be reached by setting 1:3~1:5 for core wall ratio.
Be added to monoglyceride in step S6, in order to enable microcapsules obtained have good plasticity, be not adhered and
This plasticizer of monoglyceride is added in good dispersion, it is possible to reduce microcapsule aggregation reduces the thickness of effect microcapsule wall, and single
Sweet rouge can reduce intermolecular frictional force, so that microcapsule granule obtained is uniform.Homogeneous is ground to premix in step S7
Processing can further refine material excessively.
Spray drying is the method for the microencapsulation most generally used, due to not needing to reach drying in drying process core material
The inlet air temperature of air-flow, therefore be conducive to embed heat-sensitive substance, and particle is uniform, solid, readily soluble, and step is opposite because it is made
Simply, drying time is short, meets the advantages such as GMP specification has obtained more and more applications in medicine, field of health care food.The skill
Art is relatively high for processing parameters requirements such as feed concentration, wall core proportions, if there is problem, not only results in granulation
Quality is greatly affected, and production efficiency can also can be greatly reduced.The embodiment of the present application is by previous process and reconfigures
Spraying granulation technique: the fixture concentration 20%~40% of emulsion, the suction velocity of emulsion are 250ml/h~350ml/
H, atomizing pressure is 0.1Mpa~0.3Mpa, intake air temperature is 150 DEG C~170 DEG C, and production microcapsules are not only high-efficient, and
Lycium chinense glycopeptide grain products embedding rate reaches 70% or more.
In step S9, glycopeptide pellet product, which continues logical hot wind, makes grain fluidized drying, material is cooled to 45 DEG C, sampling
After the water content for measuring glycopeptide pellet product, whole grain obtains final Lycium chinense glycopeptide particle electuary.
By above technical scheme as it can be seen that the embodiment of the present application shows a kind of preparation method of Lycium chinense glycopeptide particle electuary,
It the described method comprises the following steps: after dried fruit of lycium barbarum pulverization process, obtained dried fruit of lycium barbarum powder, by the Chinese wolfberry fruit dry fruit powder
End proposes processing through ultrasonic-microwave auxiliary water, obtains the preliminary extracting solution of Lycium chinense glycopeptide, by the preliminary extracting solution of the Lycium chinense glycopeptide through four
Grade ultrafiltration and nanofiltration concentration, obtain Lycium chinense glycopeptide extracting solution, beta-cyclodextrin are configured to wall material solution, by the fructus lycii sugar
Peptide extracting solution and the wall material solution are uniformly mixed according to the ratio of 1:3~1:5, obtain core wall mixed liquor, mixed in the wall core
It closes in liquid and monoglyceride is added, after mixing evenly, obtain premix, the premix colloid mill homogenization is obtained into solid
The emulsion that object concentration is 20%~40%, by the emulsion spray pelletization treatment, the emulsion spray pelletization treatment
Condition are as follows: the suction velocity of emulsion is 250ml/h~350ml/h, and atomizing pressure is 0.1Mpa~0.3Mpa, intake air temperature
It is 150 DEG C~170 DEG C, after the completion of spraying granulation, continuing logical hot wind makes grain fluidized drying；Cooling, is down to 45 to temperature of charge
DEG C or less when shut down discharging, obtain glycopeptide pellet product；The preparation method of Lycium chinense glycopeptide shown in the embodiment of the present application, passes through
This auxiliary material of beta-cyclodextrin is added, adjust core wall ratio and atomization grain made parameter improves by adjusting the technology of preparing of microcapsules
Lycium chinense glycopeptide situation easy to moisture absorption, Lycium chinense glycopeptide particle electuary obtained are easier to save.
As the application preferred embodiment, after the dried fruit of lycium barbarum pulverization process, dried fruit of lycium barbarum powder particle size is
40 mesh~60 mesh.The size of dried fruit of lycium barbarum powder particle directly affects the extraction effect of Lycium chinense glycopeptide, tests prove that, Chinese wolfberry fruit dry
Fruit powder particle size is that 40 mesh~60 mesh are best.
As the application preferred embodiment, extraction conditions that the ultrasonic-microwave auxiliary water mentions are as follows: the ratio of fructus lycii and water
Example be 1:20~1:30, Extracting temperature be 40 DEG C~60 DEG C, extraction time be 20min~40min, ultrasonic power be 160W~
200W, microwave power is 300W~400W, and under the extraction conditions which mentions, the extraction efficiency of Lycium chinense glycopeptide is most
Height, activity are best.
As the application preferred embodiment, the level Four ultrafiltration and nanofiltration concentration include: will be auxiliary through ultrasonic-microwave
It helps water to mention the extracting solution that processing obtains to handle through the ultrafiltration membrance filter of 200,000 molecular weight, obtains a filtered fluid, it will be described primary
Filtered fluid is handled through the ultrafiltration membrance filter of 10,000 molecular weight, obtains ultrafiltrate, and the ultrafiltrate is carried out nanofiltration concentration.Through
The ultrafiltration membrane of 200,000 and 10,000 molecular weight is crossed, then the ultrafiltrate of gained 200,000 or less, 10,000 or more is subjected to nanofiltration concentration, is obtained
It is because of 10000-200000 molecule that the purifying concentration of Lycium chinense glycopeptide extracting solution, which takes the Lycium chinense glycopeptide extracting solution of 10,000-20 ten thousand molecular weight,
The Lycium chinense glycopeptide activity highest of amount, up to 200umoles TE/g or more.
As the application preferred embodiment, the ratio that the additive amount of the monoglyceride accounts for the wall core mixed liquor is
0.2%~0.3%.The effect of monoglyceride is in order to enable microcapsules obtained have good plasticity, are not adhered and divide
It is good to dissipate property, and the additive amount of monoglyceride is 0.2%~0.3% to be enough to increase plasticity and dispersibility for microcapsules.
As the application preferred embodiment, glycopeptide content is 35%~55% in the Lycium chinense glycopeptide extracting solution, by institute
State in Lycium chinense glycopeptide extracting solution the control of glycopeptide content 35%~55% be on the one hand to control extract fluid viscosity guarantee it is subsequent
On the other hand the yield rate of spraying granulation is to guarantee Lycium chinense glycopeptide granule granule commerieal sugar peptide content 50% or more.
As the application preferred embodiment, the Lycium chinense glycopeptide extracting solution and wall material solution are mixed according to the ratio of 1:4
It closes uniformly, obtains wall core mixed liquor, the solid concentration of the emulsion is 20%, the item of the emulsion spray pelletization treatment
Part are as follows: the suction velocity of emulsion is 300ml/h, and intake air temperature is 170 DEG C.
In order to enable those skilled in the art to better understand the solution of the present invention, below with reference to embodiment to the present invention make into
The detailed description of one step.
Embodiment 1:
Step S1: after dried fruit of lycium barbarum pulverization process, obtained dried fruit of lycium barbarum powder；
Step S2: the dried fruit of lycium barbarum powder is proposed into processing through ultrasonic-microwave auxiliary water, Lycium chinense glycopeptide is obtained and tentatively extracts
Liquid；
Step S3: by the preliminary extracting solution of the Lycium chinense glycopeptide through level Four ultrafiltration and nanofiltration concentration, Lycium chinense glycopeptide is obtained
Extracting solution；
Step S4: beta-cyclodextrin is configured to wall material solution；
Step S5: the Lycium chinense glycopeptide extracting solution and the wall material solution are uniformly mixed according to the ratio of 1:3, obtain core
Wall mixed liquor；
Step S6: monoglyceride is added in the wall core mixed liquor, after mixing evenly, obtains premix；
Step S7: the premix colloid mill homogenization is obtained into the emulsion that solid concentration is 40%；
Step S8: by the emulsion spray pelletization treatment, the condition of the emulsion spray pelletization treatment are as follows: emulsion
Suction velocity be 300ml/h, atomizing pressure be 0.1Mpa~0.3Mpa, intake air temperature be 160 DEG C, spraying granulation complete
Afterwards, continuing logical hot wind makes grain fluidized drying；Cooling shuts down discharging when temperature of charge is down to 45 DEG C or less, obtains glycopeptide
Grain semi-finished product；
Step S9: semi-finished product obtain the Lycium chinense glycopeptide particle electuary through whole grain.
Embedding rate is 85.4% under 1 experiment condition of embodiment, the preparation process phase with conventional Lycium chinense glycopeptide granular preparation
It is significantly improved than embedding rate.
Embodiment 2:
Step S1: after dried fruit of lycium barbarum pulverization process, obtained dried fruit of lycium barbarum powder；
Step S2: the dried fruit of lycium barbarum powder is proposed into processing through ultrasonic-microwave auxiliary water, Lycium chinense glycopeptide is obtained and tentatively extracts
Liquid；
Step S3: by the preliminary extracting solution of the Lycium chinense glycopeptide through level Four ultrafiltration and nanofiltration concentration, Lycium chinense glycopeptide is obtained
Extracting solution；
Step S4: beta-cyclodextrin is configured to wall material solution；
Step S5: the Lycium chinense glycopeptide extracting solution and the wall material solution are uniformly mixed according to the ratio of 1:3, obtain core
Wall mixed liquor；
Step S6: monoglyceride is added in the wall core mixed liquor, after mixing evenly, obtains premix；
Step S7: the premix colloid mill homogenization is obtained into the emulsion that solid concentration is 20%；
Step S8: by the emulsion spray pelletization treatment, the condition of the emulsion spray pelletization treatment are as follows: emulsion
Suction velocity be 350ml/h, atomizing pressure be 0.1Mpa~0.3Mpa, intake air temperature be 160 DEG C, spraying granulation complete
Afterwards, continuing logical hot wind makes grain fluidized drying；Cooling shuts down discharging when temperature of charge is down to 45 DEG C or less, obtains glycopeptide
Grain semi-finished product；
Step S9: semi-finished product obtain the Lycium chinense glycopeptide particle electuary through whole grain.
Embedding rate is 84.7% under 2 experiment condition of embodiment, the preparation process phase with conventional Lycium chinense glycopeptide granular preparation
It is significantly improved than embedding rate.
Embodiment 3:
Step S1: after dried fruit of lycium barbarum pulverization process, obtained dried fruit of lycium barbarum powder；
Step S2: the dried fruit of lycium barbarum powder is proposed into processing through ultrasonic-microwave auxiliary water, Lycium chinense glycopeptide is obtained and tentatively extracts
Liquid；
Step S3: by the preliminary extracting solution of the Lycium chinense glycopeptide through level Four ultrafiltration and nanofiltration concentration, Lycium chinense glycopeptide is obtained
Extracting solution；
Step S4: beta-cyclodextrin is configured to wall material solution；
Step S5: the Lycium chinense glycopeptide extracting solution and the wall material solution are uniformly mixed according to the ratio of 1:4, obtain core
Wall mixed liquor；
Step S6: monoglyceride is added in the wall core mixed liquor, after mixing evenly, obtains premix；
Step S7: the premix colloid mill homogenization is obtained into the emulsion that solid concentration is 20%；
Step S8: by the emulsion spray pelletization treatment, the condition of the emulsion spray pelletization treatment are as follows: emulsion
Suction velocity be 300ml/h, atomizing pressure be 0.1Mpa~0.3Mpa, intake air temperature be 170 DEG C, spraying granulation complete
Afterwards, continuing logical hot wind makes grain fluidized drying；Cooling shuts down discharging when temperature of charge is down to 45 DEG C or less, obtains glycopeptide
Grain semi-finished product；
Step S9: semi-finished product obtain the Lycium chinense glycopeptide particle electuary through whole grain.
Embedding rate is 91.4% under 3 experiment condition of embodiment, the preparation process phase with conventional Lycium chinense glycopeptide granular preparation
It is significantly improved than embedding rate.
In addition, feed rate A (ml/h), solid concentration B (%), core wall ratio C (glycopeptide extract β-that the present invention selectes
Cyclodextrin), intake air temperature D (DEG C) four factor and three horizontal (being shown in Table 1) determined carry out four factors, three horizontal quadrature test sides
Case design, is shown in Table 1:
1 Lycium chinense glycopeptide spray-drying process experimental factor water-glass of table
Table 2L9(34) orthogonal experiments table
Show that optimum combination is A2B1C2D3 by the interpretation of result of table 1, i.e. feed rate 300mL/h, solid concentration
20%, 170 DEG C of core wall ratio 1:4, intake air temperature, Lycium chinense glycopeptide particle embedding rate reaches 61.4% with this condition.Influence Chinese holly
The principal element order of Qi glycopeptide spray-drying process are as follows: feed rate > solid concentration > wall core ratio > intake air temperature.
Embedding rate reaches 71.3% or more under the selected conditional parameter of the present invention, 3.25% or less semi-finished product water content.
Inspection is sampled to 9 batch products in table 1, measures its hydroscopicity, angle of repose and solubility, as the result is shown product
Average hydroscopicity illustrates that glycopeptide granule granule stability is good for 14.2%；Average angle of repose is 32.7 ° 35 ° of < and illustrates its mobility
Well, and 9 batches of sample solubility are 90% or more；Sensory evaluation is carried out to particle electuary product, product color of sampling
Uniformly, and without moisture absorption caking phenomenon；Dissolubility is good, dissolves in 50-80 DEG C of water rapidly, without precipitating；Measure Lycium chinense glycopeptide electuary
Finished granule glycopeptide content is 50% or more；It is good that measurement Lycium chinense glycopeptide antioxidant activity in 90 days is stored under room temperature, without significant
Variation；According to the result process, stabilization, reproducible, the process conditions for showing that the moulding process is tested are cut
It is real feasible.
Those skilled in the art will readily occur to its of the application after considering specification and practicing application disclosed herein
Its embodiment.This application is intended to cover any variations, uses, or adaptations of the application, these modifications, purposes or
Person's adaptive change follows the general principle of the application and including the undocumented common knowledge in the art of the application
Or conventional techniques.The description and examples are only to be considered as illustrative, and the true scope and spirit of the application are by above
Claim is pointed out.
It should be understood that the application is not limited to the accurate process for being described above and being shown in the accompanying drawings, and
And various modifications and changes may be made without departing from the scope thereof.Scope of the present application is only limited by the accompanying claims.
Claims (7)
1. a kind of preparation method of Lycium chinense glycopeptide particle electuary, which is characterized in that the described method comprises the following steps:
After dried fruit of lycium barbarum pulverization process, obtained dried fruit of lycium barbarum powder；
The dried fruit of lycium barbarum powder is proposed into processing through ultrasonic-microwave auxiliary water, obtains Lycium chinense glycopeptide first extract；
By the Lycium chinense glycopeptide first extract through level Four ultrafiltration and nanofiltration concentration, Lycium chinense glycopeptide extracting solution is obtained；
It is 30-50%, wall material solution that beta-cyclodextrin, which is configured to mass fraction,；
The Lycium chinense glycopeptide extracting solution and the wall material solution are uniformly mixed according to the ratio of 1:3~1:5, obtain the mixing of core wall
Liquid；
Monoglyceride is added in the wall core mixed liquor, after mixing evenly, obtains premix；
The premix colloid mill homogenization is obtained into the emulsion that solid concentration is 20%~40%；
By the emulsion spray pelletization treatment, the condition of the emulsion spray pelletization treatment are as follows: the suction velocity of emulsion
For 250ml/h~350ml/h, atomizing pressure is 0.1Mpa~0.3Mpa, and intake air temperature is 150 DEG C~170 DEG C, spraying granulation
After the completion, continuing logical hot wind makes grain fluidized drying；Cooling shuts down discharging when temperature of charge is down to 45 DEG C or less, obtains sugar
Peptide particles semi-finished product；
Semi-finished product obtain the Lycium chinense glycopeptide particle electuary through whole grain.
2. a kind of preparation method of Lycium chinense glycopeptide particle electuary according to claim 1, which is characterized in that the Chinese wolfberry fruit dry
After fruit pulverization process, dried fruit of lycium barbarum powder particle size is 40 mesh~60 mesh.
3. a kind of preparation method of Lycium chinense glycopeptide particle electuary according to claim 1, which is characterized in that the ultrasound is micro-
The extraction conditions that wave auxiliary water mentions are as follows: the ratio of fructus lycii and water is 1:20~1:30, and Extracting temperature is 40 DEG C~60 DEG C, when extraction
Between be 20min~40min, ultrasonic power be 160W~200W, microwave power be 300W~400W.
4. a kind of preparation method of Lycium chinense glycopeptide particle electuary according to claim 1, which is characterized in that the level Four is super
Filter and nanofiltration concentration include: that will mention ultrafiltration membrane of the extracting solution through 200,000 molecular weight that processing obtains through ultrasonic-microwave auxiliary water
Filtration treatment obtains a filtered fluid, and a filtered fluid is handled through the ultrafiltration membrance filter of 10,000 molecular weight, obtains ultrafiltration
The ultrafiltrate is carried out nanofiltration concentration by liquid.
5. a kind of preparation method of Lycium chinense glycopeptide particle electuary according to claim 1, which is characterized in that the monoglyceride
Additive amount account for the wall core mixed liquor ratio be 0.2%~0.3%.
6. a kind of preparation method of Lycium chinense glycopeptide particle electuary according to claim 1, which is characterized in that the fructus lycii sugar
Glycopeptide content is 35%~55% in peptide extracting solution.
7. a kind of preparation method of Lycium chinense glycopeptide particle electuary according to claim 1, which is characterized in that by the fructus lycii
Glycopeptide extracting solution and wall material solution are uniformly mixed according to the ratio of 1:4, obtain wall core mixed liquor, the solid content of the emulsion is dense
Degree is 20%, the condition of the emulsion spray pelletization treatment are as follows: the suction velocity of emulsion is 300ml/h, intake air temperature
It is 170 DEG C.
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Cited By (3)
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| CN110384237A (en) * | 2019-07-29 | 2019-10-29 | 北京本草方源药业集团有限公司 | A kind of single granule and preparation method thereof |
| CN110801019A (en) * | 2019-12-02 | 2020-02-18 | 宁夏天仁枸杞生物科技股份有限公司 | Preparation method of lycium barbarum glycopeptide granules |
| CN113951515A (en) * | 2020-12-15 | 2022-01-21 | 王彦海 | Preparation method of blood vessel endothelial cell bioactive lycium barbarum amino acid and lycium barbarum amino acid |
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