CN101019655B - Preparation of milk coated heme polypeptide - Google Patents
Preparation of milk coated heme polypeptide Download PDFInfo
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- CN101019655B CN101019655B CN200710055385A CN200710055385A CN101019655B CN 101019655 B CN101019655 B CN 101019655B CN 200710055385 A CN200710055385 A CN 200710055385A CN 200710055385 A CN200710055385 A CN 200710055385A CN 101019655 B CN101019655 B CN 101019655B
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- ferroheme
- polypeptide
- dairy products
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Abstract
The process of preparing milk coated heme polypeptide includes the following steps: adding heme polypeptide paste into milk in 0.1-1.0 time, and mechanical grinding to make milk protein coat heme polypeptide, form superfine structure of heme polypeptide and solubilizing compound, and form one kind of heme polypeptide coordination compound. The said milk may cow milk, goat milk, whole milk powder and/or instant milk powder. The milk coated heme polypeptide has raised stability in water, and may be used in preparing beverage or medicine.
Description
Technical field
The invention provides a kind of preparation of milk coated heme polypeptide, be used for keeping the stability of ferroheme polypeptide water solution, belong to technical field of bioengineering.
Background technology
Ferroheme is the porphyrin compound of iron content, is the important composition composition of the contained hemoglobin of blood rbc.Ferroheme can be directly by little intestinal absorption, is not subjected to the influence of the material that the contained obstruction iron ion of plant food absorbs, and its absorption rate iron more contained than inorganic molysite and plant food is much higher.Ferroheme is that the good food of generally acknowledging is mended the iron source.
Animal blood is the abundant source of ferroheme, but the animal blood meal has the smell of blood, in the hemoglobin combination of the protein (globin) of ferroheme and it very tight, just can absorb after ferroheme disengages with protein digestibility in intestines and stomach.But the absorption optimal site of ferroheme is in the small intestine upper end, and proteopeptic optimal site also is in the small intestine upper end, treats to have entered the small intestine lower end when the digestion of food hemoglobin matter disengages ferroheme, reduces the absorption rate of its heme iron greatly.Therefore, must manage ferroheme is extracted from hemoglobin, or manage to weaken closely linking of ferroheme and protein, to improve the absorption rate of ferroheme as good benefit chalybeate.
Find use the protease hydrolytic hemoglobin through scientific research, can obtain the peptide class be combined into of ferroheme and proteolysis generation ferroheme-polypeptide complex (hereinafter to be referred as: the ferroheme polypeptide).But, because the ferroheme polypeptide has lost the macromolecular parcel of intact globin matter, water-soluble reduction greatly, the suspension instability that forms in water is easy to coalescent precipitation.Being made into the efficient benefit chalybeate beverage for instant, at first is the coalescent precipitation that will prevent the ferroheme polypeptide do not precipitate so that can place for a long time, this just the present invention to deal with problems.
Summary of the invention
The invention provides a kind of preparation of milk coated heme polypeptide, purpose is intended to avoid the ferroheme polypeptide to form deposit seed in water, make can place for a long time and do not precipitate contain the ferroheme drink, become the efficient benefit chalybeate of instant.
The technology of the present invention solution is as follows: after the ferroheme polypeptide is gone out the ferroheme polypeptide concentrate of its pulpous state through centrifugation, add 0～2.0 times of granulated sugar and 0.1～1.0 times of dairy products proteinoid, adopt the method for mechanical lapping, make ferroheme polypeptide and solubilize compound (as: granulated sugar and dairy products proteinoid) reach the submicron-sized particulate structure, form a kind of new ferroheme polypeptide complex, preparation has the preparation of better dissolution rate thus, is convenient to make stable heme drink, oral liquid or the electuary of containing.
The dairy products proteinoid that the present invention relates to is meant milk or goat milk and whole milk powder thereof or contains sugared instant milk powder.
The mechanical lapping that the present invention relates to comprises polishing, shearing method, crush method.
The inventive method is wrapped up the ferroheme polypeptide by protein, be dispersed into small particle, can float on a liquid long-term and stably, even water modulation again after the drying can prevent that also its ferroheme polypeptide from coalescent precipitation taking place.So just can make the beverage that heme iron is strengthened easily, also can be dried to the extract of malt and milk or milk powder sample of blood red pigment iron and strengthen solid beverage, and can guarantee that the heme iron that makes like this has the very high rate that digests and absorbs in enteron aisle.
Characteristics of the present invention are: contain the solubilising coordination thing of ferroheme polypeptide composition, promptly be convenient to the preparation of water-soluble drink, the medicament production of being more convenient for.Can select for use various pharmaceutic adjuvants to prepare preparation.These pharmaceutic adjuvants are that the medicine of the interpolation material that uses for ease of oral, parenteral or other medicament purposes is formed.The product that is to say the method for the invention is as the drug therapy effective amount of actives, and contains one or more pharmaceutically acceptable carriers.
Clinical treatment of the present invention is worth and not only has been to solve the ferroheme polypeptide directly as the effectively drug use of single component, improves ferroheme polypeptide bioavilability in human body; The coordination thing that ferroheme polypeptide and dairy products proteinoid form is through using ultraviolet spectra, mass spectral analysis; after the affirmation; its ferroheme chemiluminescent polypeptide structure does not change. because the protection of milk protein is arranged; the ferroheme polypeptide can not form insoluble polymer, mends the iron drink but temper to be easy to restore for the finely dispersed ferroheme that contains.
Good effect of the present invention is: adopt mechanical lapping can realize that ferroheme polypeptide and dairy products proteinoid form mixed ligand thing structure, form complete ligand, improved the stability of solution in the red pigment polypeptide water, the drink or the medicine that make the ferroheme polypeptide to become to be prepared into good water solubility.
Description of drawings
Fig. 1 is the ferroheme polypeptide forms suspension in water microscopically (400 *) deposit seed photo;
Fig. 2 forms the particulate that is wrapped up by milk proem, the microscopically that suspends (400 *) photo for the ferroheme polypeptide in water.
The specific embodiment:
Embodiment 1
Get ferroheme polypeptide slurry 10kg and add 20kg granulated sugar and 10kg milk, with the abundant ground and mixed of colloid mill, promptly make be rich in ferroheme contain the milk syrup, can directly wash by water and take or add drink such as milk soya-bean milk to make iron fortified food product edible.
Embodiment 2
In 10kg ferroheme polypeptide slurry, add the 1kg whole milk powder, put into colloid mill mechanical lapping and fully mixed in 30～60 minutes, promptly make the milk slurry that is rich in ferroheme, can directly wash by water and take or add drink such as milk soya-bean milk to make iron fortified food product edible.
Embodiment 3
In 10kg ferroheme polypeptide slurry, add 8kg granulated sugar and 8kg goat milk, fully mix with colloid mill, promptly make be rich in ferroheme contain the milk syrup, can directly wash by water and take or add drink such as milk soya-bean milk to make iron fortified food product edible.
Embodiment 4
In 10kg ferroheme polypeptide slurry, add 2kg goat milk, 5kg whole milk powder, fully mix with colloid mill, promptly make be rich in ferroheme contain the milk syrup, can directly wash by water and take or add drink such as milk soya-bean milk to make iron fortified food product edible.
Embodiment 5
Get that embodiment 1 or embodiment 2,3,4 make be rich in ferroheme contain 15 kilograms in milk syrup, add in 5 kilograms of granulated sugar and 300 kilograms of fresh milks and dissolve spray-drying again, or put into 50 kilograms of instant whole milk powders and mix back oven dry pulverizing, can obtain milk powder sample or extract of malt and milk sample of blood red pigment solid Drink material.
Claims (2)
1. the ferroheme polypeptide that coats of dairy products, it is characterized in that by following method preparation: ferroheme polypeptide slurry is added 0.1～1.0 times of dairy products proteinoid, adopt the method for mechanical lapping, make ferroheme polypeptide and dairy products proteinoid reach the submicron-sized particulate structure;
Described dairy products proteinoid is meant milk or goat milk and whole milk powder thereof or contains sugared instant milk powder.
2. the described dairy products of claim 1 coat the preparation method of ferroheme polypeptide, may further comprise the steps: ferroheme polypeptide slurry is added 0.1～1.0 times of dairy products proteinoid, adopt the method for mechanical lapping, by the dairy products proteinoid ferroheme-polypeptide complex parcel is protected, make ferroheme polypeptide and dairy products proteinoid reach the submicron-sized particulate structure;
Described dairy products proteinoid is meant milk or goat milk and whole milk powder thereof or contains sugared instant milk powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710055385A CN101019655B (en) | 2007-03-07 | 2007-03-07 | Preparation of milk coated heme polypeptide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710055385A CN101019655B (en) | 2007-03-07 | 2007-03-07 | Preparation of milk coated heme polypeptide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101019655A CN101019655A (en) | 2007-08-22 |
| CN101019655B true CN101019655B (en) | 2010-05-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN200710055385A Expired - Fee Related CN101019655B (en) | 2007-03-07 | 2007-03-07 | Preparation of milk coated heme polypeptide |
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| CN (1) | CN101019655B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101748181B (en) * | 2010-01-15 | 2012-12-26 | 白求恩医科大学制药厂 | Method for preparing high-ferric content ferroheme polypeptide composite with pepsin hydrolysis method |
-
2007
- 2007-03-07 CN CN200710055385A patent/CN101019655B/en not_active Expired - Fee Related
Non-Patent Citations (8)
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| 常致成.微胶囊技术开发应用进展.精细与专用化学品 17.1999,(17),19-22. |
| 常致成.微胶囊技术开发应用进展.精细与专用化学品 17.1999,(17),19-22. * |
| 袁俊杰等.微胶囊技术及在食品添加剂中的应用.中国食品添加剂 2.1997,(2),44-50. |
| 袁俊杰等.微胶囊技术及在食品添加剂中的应用.中国食品添加剂 2.1997,(2),44-50. * |
| 袁曦等.氯化血红素-β环糊精包合物的研制.中国药学杂志36 6.2001,36(6),389-391. |
| 袁曦等.氯化血红素-β环糊精包合物的研制.中国药学杂志36 6.2001,36(6),389-391. * |
| 谢跃勤等.B- 环糊精与氯化血红素包合作用的研究.安徽教育学院学报22 3.2004,22(3),65-66. |
| 谢跃勤等.B- 环糊精与氯化血红素包合作用的研究.安徽教育学院学报22 3.2004,22(3),65-66. * |
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| CN101019655A (en) | 2007-08-22 |
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Owner name: LI XUEZHU Free format text: FORMER OWNER: SUN JIUDING Effective date: 20140912 |
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Free format text: CORRECT: ADDRESS; FROM: 130012 CHANGCHUN, JILIN PROVINCE TO: 518107 SHENZHEN, GUANGDONG PROVINCE |
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Effective date of registration: 20140912 Address after: 518107, Guangdong, Shenzhen Guangming District new bright street Southern District Chenguang lotion Co., Ltd. Product Technology Development Department Patentee after: Li Xuezhu Address before: 130012 B105 room, century home, No. 56 nanhu road, Jilin, Changchun Patentee before: Sun Jiuding |
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| CF01 | Termination of patent right due to non-payment of annual fee |
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| CF01 | Termination of patent right due to non-payment of annual fee |