CN103536670A - Composition for improving alimentary anemia as well as preparation method thereof - Google Patents
Composition for improving alimentary anemia as well as preparation method thereof Download PDFInfo
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- CN103536670A CN103536670A CN201310485725.XA CN201310485725A CN103536670A CN 103536670 A CN103536670 A CN 103536670A CN 201310485725 A CN201310485725 A CN 201310485725A CN 103536670 A CN103536670 A CN 103536670A
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Abstract
The invention relates to compositions from plants, and provides a composition for improving alimentary anemia. The composition comprises the following components in parts by weight: 100-200 parts of a Chinese-date extract, 30-50 parts of chlorinated ferriheme and 200-300 parts of an auxiliary material. The composition provided by the invention selects and uses Chinese dates in south Xinjiang, is abundant in nutrition and has an extremely good qi and blood tonifying effect. The composition combined with the chlorinated ferriheme not only improves conditions of spleen and stomach of a patient and enhances alimentation, but also further supplements heme directly. The composition is non-irritant to intestines and stomach of the patient.
Description
Technical field
The present invention relates to a kind of compositions from plant, be specifically related to a kind of for improving the composition and method of making the same of nutritional anemia.
Background technology
Fructus Jujubae is traditional nutriment of enriching blood, and in Traditional Chinese Medical Concepts, insufficiency of vital energy and blood is improved to effect.Nutritional anemia refers to because of the necessary nutrient substance of body hemopoietic, as the materials such as ferrum, folic acid, dimension biogen D reduce relatively or utterly, makes the formation of hemoglobin or erythrocytic generation not enough, so that the low a kind of disease of hemopoietic function.But it is high that the iron content of fresh Chinese dates is also not so good as the lean meat such as animal livers and pig, cattle, sheep, therefore do not have (actual is the to improve anemia) effect of enriching blood; And bright Fructus Jujubae dries into after Fructus Jujubae, contained vitamin C can be with water loss, and nourishing blood function is lower.
The Fructus Jujubae that produce Xinjiang region has nutritious feature, the nutriment of enriching blood of recommending for the traditional Chinese medical science.Aksu Prefecture, South Sinkiang, Xinjiang is positioned at 40 ° of north latitude, height above sea level 800 meters upper and lower, be the area that global optimum is produced high-quality Fructus Jujubae.Local institute produces " TIANZAO " and compares with logical kind Fructus Jujubaes of other area plantations, has greatly, skin is thin, meat is thick, the speciality of sweet in the mouth.Li Shizhen (1518-1593 A.D.) < < Compendium of Materia Medica > > carries, and the elite of Fructus Jujubae depends on its sunlight.Southern Xinjiang light application time is long, and annual 4-10 month to date sunshine time reaches 2027.1 hours, and the sunshine time of average every day can reach more than 10 hours, and illuminance is strong, is extremely conducive to the fruit growth of Fructus Jujubae; The basic reason that South Sinkiang Fructus Jujubae is better than interior ground Fructus Jujubae with regard to be the period of maturation of Fructus Jujubae obtain more sunlight, rain and dew moisten.The nutritional labeling of fresh Chinese dates is high, but the shelf-life is short, transportation difficulty.In order intactly to preserve the nutritional labeling of fresh Chinese dates, researcher has proposed the methods such as alcohol extracting method (as patent CN101983587A), fermentation method (as patent CN102813020A) and has preserved Fructus Jujubae effective ingredient.
For nutritional anemia, choose reasonable extracting method and with the compatibility of medicine, the current suitable compositions that still can not meet user demand, the QI and blood that can meet in Traditional Chinese Medical Concepts is supplemented, and can, for nutritional anemia, effectively improve hemopoietic function again.
Summary of the invention
In order to overcome above-mentioned defect, the object of this invention is to provide a kind of compositions of improving nutritional anemia.
Another object of the present invention is to provide the preparation method of described compositions.
The concrete technical scheme that realizes above-mentioned purpose of the present invention is:
For improving a compositions for nutritional anemia, comprise the component of following weight parts:
Fructus Jujubae extract 100-200 part
Protohemin 30-50 part
Adjuvant 200-300 part.
Preferably, the component that comprises following weight parts:
Fructus Jujubae extract 130-160 part
Protohemin 30-40 part
Adjuvant 250-280 part.
The dosage form of described compositions is capsule.
Preferably, described Fructus Jujubae extract is that the extract ，Zao planting site district of Southern Xinjiang product Fructus Jujubae is positioned at 40 ° of north latitude, and height above sea level is 800 ± 50 meters, for example Aksu, Xinjiang.The kind of Fructus Jujubae is grey Fructus Jujubae, fine horse Fructus Jujubae or Zhanhua winter jujube (trade name is TIANZAO).The regional 8-10 monthly average temperature difference per day of plantation Fructus Jujubae, at 17.0-18.5 ℃, is conducive to Fructus Jujubae fruit soluble solids and sucrose accumulation; Autumn, rainfall was few, also made the TIANZAO of cultivating out have more nutrition.
Wherein, described Fructus Jujubae extract is that the extraction of water extract-alcohol precipitation method obtains, and described water extract-alcohol precipitation method comprises step:
1) get the broken enucleation of Fructus Jujubae, after extracting in water, filter, get filtrate;
2) be evaporated to relative density 1.17-1.20(60 ℃ survey), then adding ethanol to make containing amount of alcohol is 70-80wt%, standing 20-30 hour;
3) drying under reduced pressure, gets dry extract, and dried cream powder is broken to sieve, and obtains Fructus Jujubae extract.
Wherein, in described step 1), extracting in water twice, for the first time reinforcing body quality 7-9 water doubly, for the second time reinforcing body quality 5-7 water doubly.The time of each water extraction is 1-3 hour.
Step 2) in, concentrating under reduced pressure adopts the pressure of conventional concentrating under reduced pressure, and temperature is controlled at room temperature to 60 ℃.
Wherein, in described step 3), at vacuum-0.03kPa to drying under reduced pressure, preferably drying under reduced pressure under vacuum-0.07kPa, temperature 70 C condition under-0.10kPa, temperature 60-80 ℃ condition.During grinding and sieving, adopt the parameter of sieving of this area routine, for example, cross 80 mesh sieves or 140 mesh sieves or 200 mesh sieves.
Described adjuvant is the acceptable adjuvant of pharmacy, comprises one or more in binding agent, lubricant, disintegrating agent, stabilizing agent, excipient.
Wherein, described binding agent is selected from one or more in water, sucrose, hydroxypropyl emthylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, dextrin; Described lubricant is selected from one or more in sodium lauryl sulphate, magnesium stearate, dodecylbenzene sodium sulfonate; Described disintegrating agent is selected from a kind of in carboxymethyl starch sodium, polyvinylpolypyrrolidone, cross-linking sodium carboxymethyl cellulose; Described stabilizing agent is selected from one or more in magnesium stearate, calcium stearate, zinc stearate; Described excipient is selected from one or more in dextrin, maltose, gelatin, mannitol, lactose, polyacrylic resin.
For improving a preparation method for nutritional anemia compositions, it is to get Fructus Jujubae extract 100-200 part and the mixing of protohemin 30-50 part, adds adjuvant 200-300 part, dry rear granulation.
Beneficial effect of the present invention is:
Adopt water extract-alcohol precipitation method to prepare Fructus Jujubae extract, effectively preserved the nutritional labeling in Fructus Jujubae, effective ingredient long shelf-life, is convenient to transportation and preserves;
Select Southern Xinjiang to produce TIANZAO, nutritious, there is the fabulous effect that fills blood, the preparation method of Fructus Jujubae extract has guaranteed in product, there is no harmful metal pollution thing; In conjunction with protohemin, both improved user's taste situation, augment nutritional absorption, directly supplement again haemachrome.And can user's the intestines and stomach not produced and be stimulated.
Accompanying drawing explanation
Fig. 1 is Fructus Jujubae extract preparation technology flow chart
Fig. 2 is study subject hemoglobin mean change curve from baseline
The specific embodiment
Following examples are used for illustrating the present invention, but are not used for limiting the scope of the invention.
In embodiment, Fructus Jujubae used is TIANZAO.Originate in the national Green Food Bases of Aksu, Xinjiang.
Embodiment 1: the preparation of Fructus Jujubae extract
The process chart of preparation is as Fig. 1.
1) get Fructus Jujubae, broken enucleation, extracting in water 2 times, each 1 hour, add for the first time 8 times of water gagings, add for the second time 6 times of water gagings, cross elimination filtrate.
2) under temperature 60 C decompression (vacuum 0.05kPa) be concentrated into relative density 1.18(60 ℃ survey), add ethanol make containing alcohol amount be 75%, standing 24 hours, taking precipitate.
3) precipitate dried under reduced pressure (vacuum is-0.07kPa that temperature is 70 ℃), to moisture≤4.0%, gets dry extract.Dried cream powder is broken, crosses 80 mesh sieves, obtains Fructus Jujubae extract.Paste-forming rate is 10%.
Embodiment 2: the preparation of Fructus Jujubae extract
1) get Fructus Jujubae, broken enucleation, extracting in water 2 times, each 1 hour, add for the first time 7 times of water gagings, add for the second time 6 times of water gagings, cross elimination filtrate.
2) under temperature 60 C decompression (vacuum 0.05Kpa) be concentrated into relative density 1.17(60 ℃ survey), add ethanol make containing alcohol amount be 75wt%, standing 28 hours, taking precipitate.
3) precipitate dried under reduced pressure (vacuum-0.07Kpa, temperature is 60 ℃), to moisture≤4.0%, gets dry extract.Dried cream powder is broken, crosses 80 mesh sieves, obtains Fructus Jujubae extract.Paste-forming rate is 8%.
Embodiment 3: the preparation of capsule
Raw material: embodiment 1 Fructus Jujubae extract 150g, protohemin 39g
Adjuvant: microcrystalline Cellulose 256.5g, magnesium stearate 4.5g
450g, makes 1000 capsules altogether.
Getting Fructus Jujubae extract and protohemin (purchased from Ke Min bio tech ltd, Shanghai) mixes, add adjuvant, dry at 45 ℃, the compound particles after oven dry, by 40 mesh sieves, incapsulates granule in shell (gelatin glue softgel shell) with full-automatic capsule filling machine after granulate.
Embodiment 4: the preparation of capsule
Raw material: embodiment 1 Fructus Jujubae extract 180g, protohemin 40g
Adjuvant: microcrystalline Cellulose 255g, magnesium stearate 5.0g
Preparation method, with embodiment 3, is made 1000 capsules.
Embodiment 5: the preparation of capsule
Raw material: embodiment 1 Fructus Jujubae extract 150g, protohemin 36g
Adjuvant: microcrystalline Cellulose 250g, magnesium stearate 5.0g
Preparation method, with embodiment 3, is made 1000 capsules.
Experimental example 1:
The made compositions of embodiment 3 is produced to three batches altogether, and room temperature is placed Shi Ba Ge Yue， Hebei province health inspection center and is registered detection, comprises stability test, hygiene inspection.The results are shown in Table 1,2.
Table 1: microorganism detection result
Hygiene inspection the results are shown in Table 2.
Table 2: embodiment 3 formulas are produced three batch sample arsenic, lead, hydrargyrum testing result
Experimental result shows: in 3 three crowdes of embodiment, arsenic, lead, the hydrargyrum of test agent all meet GB16740 health care (function) food universal standard regulation.
Owing to having detected arsenic, lead, hydrargyrum in hygiene inspection, and all meet GB16740 health care (function) food universal standard regulation, show that formula for a product, raw material, technology process, quality standard formulation meet the requirements; The physicochemical property of arsenic, lead, mercury element is stable, is not subject to the impact of the conditions such as storage time, condition of storage, packaging material and changes.
Also carry out functional component check, in the dose of capsules every days 4, the content of 4 capsules is equivalent to Fructus Jujubae 6.0g simultaneously; Protohemin 0.156g(iron content 13mg); Microcrystalline Cellulose 1.026g; Magnesium stearate 0.018g.
Experimental example 2.
Get 60 of healthy mices (body weight 18-22g), sex equilibrium is divided into 5 groups at random, by isometric(al) (0.2ml volume/10g body weight) gastric infusion every day 1 time: administration group is 0.18g/10g (dose/body weight) dosage, matched group gavages equal-volume 0.5%GMC (Carboxymethyl cellulose sodium) liquid, totally ten days.Laboratory animal is got blood after administration anterior orbit, measures white mice red blood cell count(RBC) (RBC), hemoglobin (Hb) (control value before experiment).
Experimental result shows, the RBC after administration treated animal is lost blood and after recovering, Hb value are higher than matched group, and statistical test has significance or utmost point significant difference, and data are as table 3.
Table 3: mouse experiment
| Medicine | Consumption | RBC(10 12/L) | Hb(10 9L) |
| Embodiment 2 | 0.18g/10g | 7.88±0.65 | 2.02±0.30 |
| Embodiment 3 | 0.18g/10g | 7.60±0.55 | 2.35±0.38 |
| |
0.18g/10g | 7.59±0.85 | 2.40±0.29 |
Experimental example 3:
Study subject is that the intestines and stomach, esophagus disease are led anemogenic patient, totally 40, is adult.The effect of the compositions of the embodiment of the present invention 3 in hemoglobin is as Fig. 2.Study subject is taken placebo or embodiment 3 compositionss (amount to 1.8g 4 of every days), continues 4 weeks.Every day, the content of four was equivalent to Fructus Jujubae 6.0g; Protohemin 0.156g(iron content 13mg); Microcrystalline Cellulose 1.026g; Magnesium stearate 0.018g.
Survey weekly Hemoglobin Value.As shown in Figure 2, study subject hemoglobin mean change amount from baseline of using embodiment 3 was greater than 3fL in the time of 22 days, and study subject hemoglobin mean change amount from baseline of using placebo is the nearly 1fL that declines.Experimental result shows that method of the present invention and compound are effective to increasing the experimenter's who suffers from nutritional anemia hemoglobin.During experimenter takes, there is no gastrointestinal upset reaction, the experimenters more than half represent that appetite increases.
Below be only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (9)
1. for improving a compositions for nutritional anemia, it is characterized in that, comprise the component of following weight parts:
Fructus Jujubae extract 100-200 part
Protohemin 30-50 part
Adjuvant 200-300 part.
2. compositions according to claim 1, is characterized in that, comprises the component of following weight parts:
Fructus Jujubae extract 130-160 part
Protohemin 30-40 part
Adjuvant 250-280 part.
3. compositions according to claim 1, is characterized in that, the dosage form of described compositions is capsule.
4. compositions according to claim 1, is characterized in that, described Fructus Jujubae extract is that the extraction of water extract-alcohol precipitation method obtains, and described water extract-alcohol precipitation method comprises step:
1) get the broken enucleation of Fructus Jujubae, after extracting in water, filter, get filtrate;
2) be evaporated to relative density 1.17-1.20, then adding ethanol to make containing amount of alcohol is 70-80%, standing 20-30 hour;
3) drying under reduced pressure, gets dry extract, and dried cream powder is broken to sieve, and obtains Fructus Jujubae extract.
5. compositions according to claim 4, is characterized in that, in described step 1), and extracting in water twice, for the first time reinforcing body quality 7-9 water doubly, for the second time reinforcing body quality 5-7 water doubly.
6. compositions according to claim 4, is characterized in that, in described step 3), at vacuum-0.03kPa to drying under reduced pressure under-0.10kPa, temperature 60-80 ℃ condition.
7. according to the arbitrary described compositions of claim 1-6, it is characterized in that, described adjuvant is the acceptable adjuvant of pharmacy, comprises one or more in binding agent, lubricant, disintegrating agent, stabilizing agent, excipient.
8. compositions according to claim 7, is characterized in that, described binding agent is selected from one or more in water, sucrose, hydroxypropyl emthylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, dextrin; Described lubricant is selected from one or more in sodium lauryl sulphate, magnesium stearate, dodecylbenzene sodium sulfonate; Described disintegrating agent is selected from a kind of in carboxymethyl starch sodium, polyvinylpolypyrrolidone, cross-linking sodium carboxymethyl cellulose; Described stabilizing agent is selected from one or more in magnesium stearate, calcium stearate, zinc stearate; Described excipient is selected from one or more in dextrin, maltose, gelatin, mannitol, lactose, polyacrylic resin.
9. for improving a preparation method for the compositions of nutritional anemia, it is characterized in that, get the mixing of Fructus Jujubae extract 100-200 part and protohemin 30-50 part, add adjuvant 200-300 part, dry rear granulation.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105831756A (en) * | 2016-03-10 | 2016-08-10 | 青海省畜牧兽医科学院 | Yak hemoglobin functional food and preparation method thereof |
| CN109480096A (en) * | 2018-12-21 | 2019-03-19 | 广东驱动力生物科技股份有限公司 | A kind of pet tablet and preparation method thereof of enriching blood |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1981002834A1 (en) * | 1980-04-03 | 1981-10-15 | P Lindroos | Heme concentrate and method for the preparation thereof |
| WO1990012801A1 (en) * | 1989-04-26 | 1990-11-01 | Huhtamäki Oy | Process for the purification of hemin, a novel hemin derivative and a process for its preparation |
| CN1092310A (en) * | 1993-07-23 | 1994-09-21 | 谭世平 | Blood nutritious instant granule and manufacture method thereof |
| WO1997015591A1 (en) * | 1995-10-23 | 1997-05-01 | Rice University | Hemoglobin mutants that reduce heme loss |
| CN1067558C (en) * | 1996-01-16 | 2001-06-27 | 庄庆彬 | Blood-enriching agent-Yixuejing and preparation method thereof |
-
2013
- 2013-10-17 CN CN201310485725.XA patent/CN103536670A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1981002834A1 (en) * | 1980-04-03 | 1981-10-15 | P Lindroos | Heme concentrate and method for the preparation thereof |
| WO1990012801A1 (en) * | 1989-04-26 | 1990-11-01 | Huhtamäki Oy | Process for the purification of hemin, a novel hemin derivative and a process for its preparation |
| CN1092310A (en) * | 1993-07-23 | 1994-09-21 | 谭世平 | Blood nutritious instant granule and manufacture method thereof |
| WO1997015591A1 (en) * | 1995-10-23 | 1997-05-01 | Rice University | Hemoglobin mutants that reduce heme loss |
| CN1067558C (en) * | 1996-01-16 | 2001-06-27 | 庄庆彬 | Blood-enriching agent-Yixuejing and preparation method thereof |
Non-Patent Citations (5)
| Title |
|---|
| 余元勋等: "《中国医学分子微量元素学》", 30 November 2009, article "（3）新型铁剂的开发", pages: 97 * |
| 农业部农民科技教育培训中心组: "《枣栽培技术》", 30 September 2001, article "（3）西北干旱地带河谷枣区", pages: 2 * |
| 吴斌等: "血红素铁防治缺特性贫血研究", 《海峡药学》, vol. 9, no. 1, 31 December 1997 (1997-12-31) * |
| 詹益兴: "《绿色精细化工——天然产品制造法•第三集》", 31 January 2008, article "01 大枣渣多糖" * |
| 韩璐: "大枣中主要活性成分分析及改善营养性贫血的实验研究", 《甘肃中医学院 硕士学位论文》, 2 March 2012 (2012-03-02) * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105831756A (en) * | 2016-03-10 | 2016-08-10 | 青海省畜牧兽医科学院 | Yak hemoglobin functional food and preparation method thereof |
| CN109480096A (en) * | 2018-12-21 | 2019-03-19 | 广东驱动力生物科技股份有限公司 | A kind of pet tablet and preparation method thereof of enriching blood |
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Application publication date: 20140129 |