CN110384237A - A kind of single granule and preparation method thereof - Google Patents
A kind of single granule and preparation method thereof Download PDFInfo
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- CN110384237A CN110384237A CN201910691003.7A CN201910691003A CN110384237A CN 110384237 A CN110384237 A CN 110384237A CN 201910691003 A CN201910691003 A CN 201910691003A CN 110384237 A CN110384237 A CN 110384237A
- Authority
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- China
- Prior art keywords
- single particle
- wolfberry fruit
- fructus lycii
- fruit extract
- particle
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- 239000008187 granular material Substances 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 239000000284 extract Substances 0.000 claims abstract description 59
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 37
- 244000241838 Lycium barbarum Species 0.000 claims abstract description 34
- 235000015459 Lycium barbarum Nutrition 0.000 claims abstract description 34
- 235000015468 Lycium chinense Nutrition 0.000 claims abstract description 34
- 238000000034 method Methods 0.000 claims abstract description 28
- 238000001694 spray drying Methods 0.000 claims abstract description 14
- 230000008569 process Effects 0.000 claims abstract description 10
- 239000002245 particle Substances 0.000 claims description 54
- 238000000605 extraction Methods 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 8
- 238000007710 freezing Methods 0.000 claims description 4
- 230000008014 freezing Effects 0.000 claims description 4
- 230000005855 radiation Effects 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 5
- 229940079593 drug Drugs 0.000 abstract description 5
- 150000004676 glycans Chemical class 0.000 description 25
- 229920001282 polysaccharide Polymers 0.000 description 23
- 239000005017 polysaccharide Substances 0.000 description 23
- 239000000243 solution Substances 0.000 description 22
- 239000000843 powder Substances 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 10
- 238000001035 drying Methods 0.000 description 10
- 238000001914 filtration Methods 0.000 description 10
- 239000000203 mixture Substances 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 8
- 239000000706 filtrate Substances 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 238000010992 reflux Methods 0.000 description 8
- 238000005469 granulation Methods 0.000 description 7
- 230000003179 granulation Effects 0.000 description 7
- 229920001353 Dextrin Polymers 0.000 description 6
- 239000004375 Dextrin Substances 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 235000019425 dextrin Nutrition 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 6
- 239000007921 spray Substances 0.000 description 6
- 235000013339 cereals Nutrition 0.000 description 5
- 238000009826 distribution Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 235000019441 ethanol Nutrition 0.000 description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 235000017784 Mespilus germanica Nutrition 0.000 description 4
- 244000182216 Mimusops elengi Species 0.000 description 4
- 235000000560 Mimusops elengi Nutrition 0.000 description 4
- 235000007837 Vangueria infausta Nutrition 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- 229940088598 enzyme Drugs 0.000 description 4
- 235000021022 fresh fruits Nutrition 0.000 description 4
- 230000033001 locomotion Effects 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- -1 small molecule compound Chemical class 0.000 description 4
- 229920000858 Cyclodextrin Polymers 0.000 description 3
- 239000001116 FEMA 4028 Substances 0.000 description 3
- 229920002774 Maltodextrin Polymers 0.000 description 3
- 239000005913 Maltodextrin Substances 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 3
- 235000011175 beta-cyclodextrine Nutrition 0.000 description 3
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- 239000000470 constituent Substances 0.000 description 3
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- 235000013305 food Nutrition 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
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- 238000004519 manufacturing process Methods 0.000 description 3
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- 235000019698 starch Nutrition 0.000 description 3
- 238000000108 ultra-filtration Methods 0.000 description 3
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- 208000035240 Disease Resistance Diseases 0.000 description 2
- 240000008397 Ganoderma lucidum Species 0.000 description 2
- 235000001637 Ganoderma lucidum Nutrition 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 2
- 239000001569 carbon dioxide Substances 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 235000013312 flour Nutrition 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000008518 lycium barbarum polysaccharide Substances 0.000 description 2
- 239000004005 microsphere Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- 230000001376 precipitating effect Effects 0.000 description 2
- 238000001223 reverse osmosis Methods 0.000 description 2
- 210000000697 sensory organ Anatomy 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 239000011122 softwood Substances 0.000 description 2
- 238000005563 spheronization Methods 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 108010059892 Cellulase Proteins 0.000 description 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- DKKCQDROTDCQOR-UHFFFAOYSA-L Ferrous lactate Chemical compound [Fe+2].CC(O)C([O-])=O.CC(O)C([O-])=O DKKCQDROTDCQOR-UHFFFAOYSA-L 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 235000002710 Ilex cornuta Nutrition 0.000 description 1
- 241001310146 Ilex cornuta Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 244000241872 Lycium chinense Species 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 235000010326 Osmanthus heterophyllus Nutrition 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 244000197580 Poria cocos Species 0.000 description 1
- 235000008599 Poria cocos Nutrition 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 241000208292 Solanaceae Species 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 229940106157 cellulase Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229960000935 dehydrated alcohol Drugs 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000004225 ferrous lactate Substances 0.000 description 1
- 229940037907 ferrous lactate Drugs 0.000 description 1
- 235000013925 ferrous lactate Nutrition 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 235000020710 ginseng extract Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000011132 hemopoiesis Effects 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000005070 ripening Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000002893 slag Substances 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000000194 supercritical-fluid extraction Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000008542 thermal sensitivity Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/10—General methods of cooking foods, e.g. by roasting or frying
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention provides a kind of single granule and preparation method thereof, the single granule includes wolfberry fruit extract, and wherein the single granule is made by spray drying process.The single granule has the advantages that grain shape degree is good, drug carrying capacity is uniform.
Description
Technical field
The invention belongs to granule manufacturing technology fields, more particularly to a kind of single granule and preparation method thereof, more
More particularly to a kind of single granule comprising wolfberry fruit extract.
Background technique
Fructus lycii generally refers to fructus lycii, that is, the ripening fruits of matrimony vine of solanaceae plant, picks in summer and autumn maturation.
Fructus lycii is the dual-purpose of drug and food food of the Ministry of Public Health, China approval, and health-care efficacy is brilliant, and fructus lycii has important meaning to human health
Justice.Polysaccharides rich in fructus lycii, polysaccharides is a kind of water-soluble polysaccharide, by arabinose, glucose, gala
This 6 kinds of monosaccharide components compositions of sugar, mannose, xylose, rhamnose, polysaccharides can protect leucocyte, leucocyte helped to increase
Value, enhances the hematopoiesis function of human body, improves the immunity of the human body, and improves disease resistance.The vitamin A contained in fructus lycii has dimension
Epithelial tissue normal growth is held in the ability of differentiation, facilitates preventing respiratory tract infection, improves the disease resistance of respiratory tract.
In the past few decades, the glycoconjugate of Chinese wolfberry fruit (fructus lycii) is come from because it is potential sanatory
It acts on and is concerned.In addition, being ground according to the external, internal and clinical of the hypoglycemic and effect for reducing blood fat of isolated LBP fraction
Study carefully, shows that these purified fractions of fructus lycii may be available the adjuvant for making treatment diabetes and its related disease.
CN108815300A discloses a kind of preparation method of wolfberry fruit extract, includes the following steps: to stock up, by fresh Chinese holly
Qi 900-1100g is cleaned up with circulating water, spare；It is broken: fresh fructus lycii to be smashed, crust is broken, and pulp is fragment,
Pericarp, pulp and juice are spare；It extracts；It receives pure and strong；Precipitating filtering；Packaging.
CN109601998A discloses a kind of extracting method of black fruit fructus lycii, which is characterized in that the extracting method include with
Lower operation: A. prepares black fruit fructus lycii juice；B. pectase 0.02-0.10wt%, cellulase are added into the black fruit fructus lycii juice
0.005wt%-0.025wt% is digested, enzymolysis time 60-180min, and hydrolysis temperature is 20-60 DEG C, and filtering must filter
Liquid one；C. the filtrate one is subjected to ultrafiltration, the process conditions of the ultrafiltration are as follows: 20-45 DEG C of temperature, pressure 0.05-
0.15MPa obtains filtrate two after ultrafiltration；D. the filtrate two is carried out reverse osmosis；The reverse osmosis process conditions are as follows: temperature
20-40 DEG C, pressure 3.0-4.0MPa.
CN103798759A discloses a kind of for alleviating the preparation containing wolfberry fruit extract of physical fatigue, and composition should
The active constituent and its weight content of preparation are: American ginseng extract 30-40%, wolfberry fruit extract 30-45%, Poria cocos extract
Object 15-28%, ferrous lactate 2-10%, remaining is auxiliary material.
CN106721836B discloses a kind of side using squeezing method using the medlar fresh fruit preparation fresh particle electuary of fructus lycii
Method, this method are that color protection is beaten after first cleaning the medlar fresh fruit of fresh picking, obtain first of Normal juice；By first of gained
Normal juice sequentially enters colloid mill and super-pressure nanoscale high pressure homogenizer, after gained fructus lycii slag is carried out plate and frame filter press squeezing
Obtain first-time filtrate；By first-time filtrate with it is high-pressure homogeneous after Normal juice mix, it is fine to be filtered to remove a small amount of pulp through fruit juice filter
Dimension, obtains secondary filtrate；Maltodextrin and beta-cyclodextrin will be added in secondary filtrate, additive amount is feed liquid soluble solid
55-80%, adding proportion are after 1:1 (W/W) is deployed, to be spray-dried, and spray drying parameters are 140 DEG C of inlet air temperature-
160 DEG C, air inflow 80%-95%, pump speed 26mL/min-34mL/min, leaving air temp is controlled at 70 DEG C -85 DEG C；It will be made
Medlar fresh fruit spray powder and binder mixing granulation, medlar fresh fruit powder, 95% ethyl alcohol, water adding proportion be 9.5:0.3:
0.2 (W/V/V) is packed after dry.
CN102988603A discloses a kind of polysaccharides particle, and following bulk pharmaceutical chemicals are made, fructus lycii 20-30g, mushroom
10-20g, ganoderma lucidum 5-10g.The preparation method comprises the following steps: weighing each component, difference pulverization, by fructus lycii by the weight proportion of bulk pharmaceutical chemicals
It is decocted in 90-95 DEG C of water-bath, clear cream shape is concentrated in 100 mesh filtering, filtrate, and flavoring mushroom, ganoderma lucidum fine powder mix, particle are made, and does
It is dry to get.
CN107028895A discloses a kind of polysaccharides particle and preparation method thereof, which includes following weight
Part raw material: 20-40 parts of polysaccharides powder, 20-40 parts of lactose, 5-20 parts of dextrin, 5-20 parts of microcrystalline cellulose, silica 1-
10 parts.
CN107581343A discloses a kind of preparation method of polysaccharides particle, carries out in accordance with the following steps: step 1)
Fructus lycii is impregnated into 30-35min, is then beaten with beater, obtains fructus lycii slurries with filtered through gauze；Step 2) adds enzyme
Enter in distilled water, 30-35min is activated between 30-35 DEG C, obtains enzyme mixation；Step 3) is by fructus lycii obtained in step 1
Slurries are added in enzyme mixation obtained in step 2, adjust pH value, are gradually warming up to 90 DEG C, enzyme deactivation 30-35min, cooling
It to room temperature, filters, stands, take supernatant to get polysaccharide solution.Step 4) is then concentrated under reduced pressure, and dehydrated alcohol precipitating is added,
Distilled water washs repeatedly, dry Lycium barbarum polysaccharide extract.Wheat is added in the Lycium barbarum polysaccharide extract that step 5) obtains step
Bud dextrin, Icing Sugar, addition ethyl alcohol is wetting agent softwood, then particle is made, and crosses 12-16 mesh, drying to obtain product.
CN102240035B discloses a kind of preparation method of wolfberry extract health-care granules, processing step are as follows:
Supercritical carbon dioxide extracting is carried out after fructus lycii is pulverized, obtains liquid extract and solid-state extract remainder, then by solid-state
The water-soluble extraction of extract remainder obtains water-soluble extracting solution, and the water-soluble extracting solution after above-mentioned gained liquid extract and concentration is mixed
It closes, sucrose, dextrin is added, dry, pulverize, using as wolfberry fruit extract health care after dry method granulation processes granulation after sieving
Grain electuary；The extraction conditions of above-mentioned supercritical carbon dioxide extracting are as follows: extraction temperature is 32 DEG C -35 DEG C, extracting pressure 18-
25Mpa, 42 DEG C -45 DEG C of separation temperature, separating pressure 6Mpa-12Mpa.
" research of spray drying wolfberry fruit powder drying aid ", Chen Zhiyin etc., food industry science and technology, the 2nd phase in 2010, with fresh
Fructus lycii is raw material, produces wolfberry fruit powder through juicing, filtering, allotment, colloid mill, homogeneous and drying process with atomizing, using single factor test and
Orthogonal experiment combines, and has studied the influence of three kinds of drying aids and its additive amount to wolfberry fruit powder flour extraction and sense organ.Experimental result
Show that spray drying effect is best, out when maltodextrin is added 60%, and 8%, CMC addition 1.0% is added in beta-cyclodextrin
Powder rate reaches 30.5%, and sensory evaluation scores 9.78 are divided；By variance analysis, influence of the maltodextrin to flour extraction and sense organ is obtained
Maximum, beta-cyclodextrin take second place, and CMC influences fructus lycii spray drying not significant.
However, existing current fructus lycii single granule is usually to pass through medicinal extract form to prepare, existing medicinal extract method,
Due to the stickiness of polysaccharide, leads to grain forming difference in granulation process and drug carrying capacity is uneven, and work as and use routine
When spray drying device, Particle Behavior distribution is undesirable, causes Particle attrition occur and drug carrying capacity is low and uneven.In addition,
Many ingredients are all mixed in together, have the defects that impurity is more, and some impurity can even cause side reaction, such as fructus lycii is to can
Cause to get angry and eyes are uncomfortable, and is not suitable for thering is inflammation and diarrhea personnel to take.This field need a kind of granulation outcome good and
The uniform single particle of drug carrying capacity especially includes the granule of wolfberry fruit extract.
Summary of the invention
The present inventor, by cooperative development, mentions on the basis of system research for fructus lycii in current single particle preparation
It takes object substantially all using medicinal extract as raw material, there is a problem of that raw material stickiness is high, impurity content is high, by furtheing investigate and closing
It develops, takes suitable spray dried form, propose following technical scheme, so as to solve above-mentioned technical problem simultaneously.
In one aspect of the invention, a kind of single granule is provided, which includes wolfberry fruit extract,
In wolfberry fruit extract in the single granule be that non-medicinal extract form is added, and the single granule passes through spray drying process
It is made.
For single particle of the invention, it includes wolfberry fruit extract in single particle preparation in the form of a solution
It is added.
Preferably, the single particle also includes auxiliary material.It is highly preferred that the auxiliary material is starch and/or dextrin.
Preferably, the angle of repose of the single particle is 25-32 °.
Preferably, the angle of repose of the single particle is 26-30 °.
Preferably, the bulk density of the single particle is 60-90g/100cm3。
In another aspect of this invention, a kind of method for preparing aforementioned single particle is provided, this method includes following step
It is rapid: (1) fructus lycii to be extracted, obtain wolfberry fruit extract solution；(2) it is granulated in spray drying device.
Preferably, the extraction of the wolfberry fruit extract uses microwave radiation exaraction or supercritical fluid extraction.
Preferably, the wolfberry fruit extract extracts from the new fresh fructus lycii of freezing.
Preferably, the wolfberry fruit extract extracts from the new fresh fructus lycii of freezing.
For the present invention, it is preferable that the fructus lycii extracts solution and is preferably prepared by the following: (1) will newly pick
Or the fructus lycii of freezing crushes, then with chloroform: carbinol mixture solution is flowed back (preferably 20-60min), filtering；
(2) alcohol reflux is added into filtration residue, is heated to reflux (preferably 10-30min)；(3) petroleum ether is used in extraction element
Flowed back (preferably 10-30min), and filtering obtains residue, residue is dried；(4) with water to filtering and drying
Residue carry out water-soluble polysaccharide mixture extraction.
Preferably, the volume ratio of chloroform and methanol is 3-8:1, more preferable 5:1 in step (1).
Preferably, it in step (3), is carried out preferably in Soxhlet extractor.Preferably, the Extracting temperature in the step
It is 90 DEG C.
In step (4), the water-soluble polysaccharide mixture preferably directly uses as an aqueous solution.
The inventors discovered that step (1) chloroform: carbinol mixture solution flows back, and can remove the rouge in fructus lycii
Fat class compound, carrying out reflux with ethyl alcohol in step (2) can remove oligosaccharide and small molecule compound, and step uses stone in (3)
Oily ether, which carries out reflux, can remove lipid and coloring compound, and can further remove oligosaccharide.With it is existing without
The simple medicinal extract of purifying is compared, and is handled by above-mentioned multiple consecutive steps, can remove fat compound, oligosaccharide and small
Molecular compound can cause extract to be adhered and some of small molecule compound and low if these compounds do not remove
Glycan and compound have adverse effect instead to when taking the single particle.
In addition, in the present invention, by above-mentioned mutually matched step step by step, can remove to the maximum extent undesirable
Inert matter or sensitizer, obtain higher polysaccharides (LBP).Preferably, include water solubility in step (4)
In the fructus lycii extracted solution of polysaccharide (i.e. polysaccharides) mixture, in terms of extract component all in water (only calculated with extract,
Do not include water), content of the polysaccharides in extract be 80wt.% or more, more preferable 90wt.% or more, most preferably
95wt.% or more.
Sharp contrast is formed with this, only for polysaccharides content, polysaccharides is entire in conventional medicinal extract
Content in extract is even lower usually in 40wt.%.
For the present invention, the preparation of single particle is particularly preferably carried out using following method, this method includes following step
It is rapid: (1) softwood to be made in auxiliary material, microballoon is made, microsphere average grain diameter is preferably 0.1-2.0mm；(2) microballoon is added
Auxiliary particle is used as in tower, being blown into hot-air from tower bottom makes the auxiliary particle in fluidized state；(3) wolfberry fruit extract is molten
Liquid sprays to downwards the auxiliary particle in ebullated bed by atomizer from tower top, stops spray after reaching corresponding medical fluid carrying capacity
Liquid can continue dry to required degree.
In step (3), preferably wolfberry fruit extract solution is sprayed to from tower top by atomizer upwards by cocurrent process
Auxiliary particle in ebullated bed.
It is known to those skilled in the art that the medical fluid refers to Qi extract solution.
One skilled in the art will recognize that in the step (4), if selection continues to dry and continue drying
Time can easily be determined by liquor strength and spray time.
Preferably, the microballoon in the step (1) is prepared by extrusion spheronization method.
Preferably, the auxiliary material is starch and/or dextrin.
In existing many single particle preparations, need that extract solution is concentrated, due to most active constituents
With thermal sensitivity, it will lead to the decomposition of effective component in concentration process and generate by-product.Drying mode of the invention can
To use the extract solution without concentration, so as to avoid the generation of this unfavorable situation.
Therefore, for the present invention, wolfberry fruit extract solution does not need to be concentrated.Preferably, wolfberry fruit extract solution
The content of middle polysaccharides is 1.0-8.0wt%, preferably 2.0-6.0wt%.
In addition, for the single granule of the application, due to containing a large amount of carbohydrates in wolfberry fruit extract, have compared with
Big viscosity, therefore certain difficulty is caused to granulation.Glutinous ingredient is caused by the spray drying and removing described previously, because
This granulation efficiency is higher.
The present inventor's research also found that the relative density of fructus lycii extracted solution will affect the effect of spray drying, when fructus lycii mentions
When the relative density of liquid being taken to be higher than 1.08 (60 DEG C measurement), when spray drying, can generate many thin filiforms, be unfavorable for generating equal
The particle at even ideal angle of repose, then medical fluid active constituent content is low when too low.Therefore, wolfberry fruit extract solution of the invention
Relative density be preferably 1.02-1.05, more preferably 1.02-1.04.
Preferably, the temperature in the step (3) is lower than 90 DEG C, more preferably less than 80 DEG C.
Preferably, the drying temperature in the step (4) is lower than 90 DEG C, more preferably less than 80 DEG C.
With reference to Fig. 1 and 2, it is described from tower bottom be blown into hot-air pass through nozzle ring carry out.Preferably, in nozzle ring
Centre is provided with taper protrusion (the protrusion part i.e. for the flat base part of taper protrusion).It is highly preferred that
The length of part of the taper protrusion more than the planar annular of nozzle ring accounts for the about 1/2- of entire taper protrusion length about
Between 3/5.
Compared with prior art, nozzle design through the invention, two-phase (granule solid and dry gas gas phase)
VELOCITY DISTRIBUTION it is particularly advantageous to dispersing solid drying system, can generate higher intensity particle dispersion.For example, working as medical fluid
When entering fluidized particles by spraying, impact strength and particle speed be particularly conducive to medical fluid even into and Particle Breakage rate
It is reduced to minimum.In addition, this nozzle allows higher gas spray rate, to substantially increase drying efficiency.In addition,
Compared with the design of the nozzle of the prior art, more stable particle circulation can be obtained, the random distribution of particle movement is less, from
And it help to obtain especially uniform drugloading rate.
By a large amount of simulated experiments and actual test, when portion of the taper protrusion more than the planar annular of nozzle ring
When the length divided is accounted between the 3/5-4/5 of entire taper protrusion length, optimal particle motion cycle can be obtained, from
And it is particularly conducive to obtain uniform drugloading rate.With reference to Fig. 3, which refers to that L1/L2 is 3/5-4/5.That is, (entire taper is convex
The length in portion-nozzle ring slit horizontal component height out)/entire taper protrusion length=3/5-4/5.
Preferably, the cross section of the taper protrusion is circle.
Most preferably, the length of the cross-sectional diameter transition of the taper protrusion accounts for entire taper protrusion minister
1/2 or more of degree.In such a case it is possible to obtain better particle distribution of movement.
Figure of description
Fig. 1 is the schematic cross-section of the gas nozzle design of the prior art；
Fig. 2 is the schematic cross-section of gas nozzle design according to the present invention；
Fig. 3 is gas-nozzles cross-section schematic diagram according to the present invention.
Specific embodiment
Below with reference to following embodiment and corresponding comparative example, the present invention is described in further detail, but the present invention
Embodiment it is without being limited thereto.
Embodiment 1
The fructus lycii (place of production Zhongweiof Ningxia, northwest China) for taking fresh material, is crushed, and chloroform: the 5:1v/v mixing of methanol is then used
Object solution carries out reflux 30min, and alcohol reflux is added into filtration residue, is heated to reflux 10min, in Soxhlet for filtering
With petroleum ether reflux 10min in extractor, filters, residue is dried, then residue is carried out with 80 DEG C of hot water
The extraction of water-soluble polysaccharide mixture obtains wolfberry fruit extract solution.Starch/dextrin (1:1) is taken, is uniformly mixed, is made soft
Microballoon is made in material, extrusion spheronization, and microsphere average grain diameter is preferably from about 0.50mm；The microballoon is added in tower as auxiliary
Grain, being blown into hot-air from tower bottom with 1.60m/s makes the auxiliary particle be in that (taper protrusion is in nozzle ring for fluidized state
The length of part more than planar annular account for entire taper protrusion length about 3/5)；Wolfberry fruit extract solution will be stored
Go out basin pressurized with compressed air, and carry out being heated to about 80 DEG C；By ginseng extract solution or wolfberry fruit extract solution
It is described that the auxiliary particle in ebullated bed is sprayed to downwards by atomizer from tower top, stop spraying liquid after 20 min, can continue
It is dry to required degree at 90 DEG C；Wind speed and deflection nozzle angle are improved, particle is blown out out of tower and enters cyclone separator,
Up to single particle.
Through detecting, in single particle obtained, the content of polysaccharides is 0.82%.
Comparative example 1
Embodiment 1 is repeated, difference is only that gas nozzle uses the nozzle arrangements of the prior art shown in FIG. 1.Through examining
It surveys, in single particle obtained, the content of polysaccharides is 0.74%.
Particle qualification and drugloading rate rate inspection
According to granule Index for examination, the granule of preparation is carried out.Powder is more in comparative example 1, and after being dissolved in water
There is muddiness, and the obvious powder of embodiment 1 is less, and does not occur turbid phenomenon after being dissolved in water.
In addition, checking Particle Breakage situation, 100 particles are taken at random, the breakage rate of embodiment 1 is 2%, and
Comparative example 1 is 5%.
In addition, embodiment 1 have considerably higher drugloading rate, show particle motion state and distribution be particularly conducive to
Medical fluid contact.
It can be clearly seen by above-described embodiment and comparative example, spray drying process of the invention has more preferably effect, In
The prior art is better than in many index.
Comparative example 2
Embodiment 1 is repeated, difference is only in that the length of part of the taper protrusion more than the planar annular of nozzle ring
Degree accounts for about the 1/2 of entire taper protrusion length.Through detecting, in single particle obtained, the content of polysaccharides is
0.77%.And compared with Example 1, slightly there is powder.
Above-mentioned comparison it is found that the proportional numerical value on the preparation of the single granule have significantly affect, small variation
Just produce apparent influence.
This written description discloses the present invention, including optimal mode using example, and also enables those skilled in the art
The manufacture and use present invention.It is of the invention can patentable scope be defined by the claims, and may include this field skill
Other examples that art personnel expect.If this other examples have not different from the structural elements of the literal language of claims
Element, or if this other examples include the equivalent structure member with the literal language of claims without substantial differences
Element, then this other examples are intended within the scope of claims.In the case where not will cause inconsistent degree, pass through
It is incorporated herein with reference to by all references referred to herein place.
Claims (10)
1. a kind of single granule, which includes wolfberry fruit extract, and wherein the fructus lycii in the single granule is extracted
Object is the addition of non-medicinal extract form, and the single granule is made by spray drying process.
2. single particle according to claim 1, it includes wolfberry fruit extract in single particle preparation with solution shape
Formula is added.
3. single particle according to claim 1 or 2, also includes auxiliary material.
4. single particle according to claim 1 or 2, wherein the angle of repose of the single particle is 25-32 °.
5. single particle according to claim 4, wherein the angle of repose of the single particle is 26-30 °.
6. single particle according to any one of the preceding claims, wherein the bulk density of the single particle is 60-
90g/100cm3。
7. a kind of method prepared according to any one of preceding claims single particle, method includes the following steps: (1)
Fructus lycii is extracted, wolfberry fruit extract solution is obtained；(2) it is granulated in spray drying device.
8. method according to claim 7, wherein the extraction of the wolfberry fruit extract uses microwave radiation exaraction or shooting flow
Body extracts.
9. according to the method for claim 7 or 8, wherein the wolfberry fruit extract extracts from the new fresh fructus lycii of freezing.
10. according to the described in any item methods of claim 7-9, wherein the relative density of the wolfberry fruit extract solution is
1.02-1.05。
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