CN110237153A - A kind of mixture pellets and preparation method thereof - Google Patents
A kind of mixture pellets and preparation method thereof Download PDFInfo
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- CN110237153A CN110237153A CN201910690972.0A CN201910690972A CN110237153A CN 110237153 A CN110237153 A CN 110237153A CN 201910690972 A CN201910690972 A CN 201910690972A CN 110237153 A CN110237153 A CN 110237153A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
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Abstract
The present invention provides a kind of mixture pellets and preparation method thereof, the mixture pellets include that ginseng extract and wolfberry fruit extract, the wherein ginseng extract in the mixture pellets and wolfberry fruit extract are that non-medicinal extract form is mixed into.The mixture pellets have the advantages that side reaction is small.
Description
Technical field
The invention belongs to granule manufacturing technology field, relate more specifically to a kind of mixture pellets and preparation method thereof.
Background technique
Compound ginseng granules agent is made of fructus schisandrae, ginseng, fructus lycii etc..Ginseng, fructus schisandrae and fructus lycii from ancient times just by
It is applied in Dietotherapy health.Ginseng is the traditional precious medicinal herbs most in use in China, is mainly grown in East Asia, especially cold district.
Ginseng mainly contains the effective components such as ginsenoside, panaxan, ginseng polypeptide, volatile oil, amino acid and microelement.Have
The adaptability of raising body, strengthen immunity, improvement microcirculation, a variety of biologies of raising tissue anti-anoxia ability and anti-aging etc. are living
Property, ginseng is usually used in restoring more afterwards, adjusting hormone, reduce blood glucose, enhancing physical strength, control liver index and liver function health care etc..
Ginsenoside has enhancing study, antifatigue, raising immunity, memory, anti-aging, adjunct antineoplastic, reparation sexual function etc.
Effect.Fructus schisandrae has the effects that liver protection, tranquilizing the mind, is depressured, lessens fatigue and strengthen immunity.Fructus lycii is nourishing liver and kidney yin
Good merchantable brand, modern research shows that it has effects that hypoglycemic and cholesterol, beauty.Ginseng be compound ginseng granules agent mainly at
/ mono-.In the past few decades, the glycoconjugate from Chinese wolfberry fruit (fructus lycii) is because of its potential sanatory work
With and be concerned.In addition, according to external, the internal and clinical research of the hypoglycemic and effect for reducing blood fat of isolated LBP fraction,
Show that these purified fractions of fructus lycii may be available the adjuvant for making treatment diabetes and its related disease.
CN102132816B discloses a kind of compound nourishing granules electuary of fructus lycii ginseng and preparation method thereof, with parts by weight
Meter consisting of: 55-60 parts of composite powder, 15-20 parts of milk powder, 7-12 parts of vegetable fat powder, 2-5 parts of oligofructose, 1-3 parts of xylitol,
With 10-15 parts of powdered glucose, wherein composite powder group become fructus lycii 28-33 parts, 18-23 parts of ginseng, 5-10 parts of Radix Glycyrrhizae, Radix Astragali 16-
21 parts, 10-15 parts of jujube, 6-11 parts of Chinese yam.
CN102716263A discloses composition and its application of a kind of maca, ginseng and fructus lycii, and the composition is by weight
Percentage: maca 30-85%, ginseng 10-40%, fructus lycii 5-30% mixed preparing form, and the composition are added edible auxiliary
Tablet, hard capsule, granule, soft capsule, vina, oral solution and beverage is made in material.
CN106668321A discloses a kind of preparation method of ginseng-wolfberry fruit composition, with fresh fructus lycii and fresh ginseng
It for raw material, the described method comprises the following steps: (1) cleaning: fresh ginseng being cleaned and is shredded after draining, fresh fructus lycii is cleaned
It is shredded after draining；(2) color stabilizer and bioactivity stabilizer is added: be added into the fresh ginseng of chopping, the sub- particle of fresh fructus lycii by
Vc, Vc sodium, Vc phosphate, composite color fixative and bioactivity stabilizer composed by tea polyphenols；(3) coarse crushing: by step (2)
The obtained particle primary mill containing color stabilizer and bioactivity stabilizer makees coarse crushing processing, spare；(4) it digests: pressing
Pure water is added in the mixing coarse granule that the ratio for the treatment of liquor ratio 1:8-12 is obtained to step (3), thick of the mixing is then added
The complex enzyme of grain weight 0.1-5% is digested, and the complex enzyme is made of hemicellulase, amylase and pectase；(5) surpass
Micro- cryogenic pulverization: the slurry agent after step (4) enzymatic hydrolysis, which is placed in progress ultra micro cryogenic pulverization, obtained granularity in micronized pulverization instrument, is
The slurry of 100-300 mesh to get.
CN109464474A discloses a kind of using oligopeptide as the ginseng and lucid ganoderma compound powder of carrier comprising: ginseng pulverate,
Glossy ganoderma powder and oligomeric Gly-His-Lys, each component are by weight percentage, composed of the following components: ginseng pulverate 10-20%, glossy ganoderma powder
10-20%, oligomeric Gly-His-Lys 60-80%.
CN104957605A discloses a kind of ginseng, fructus lycii compound health lozenge, is made of the raw material of following weight:
(1) raw material is prepared: ginseng freeze-dried powder 10-15 parts of kg, 18-21 parts of fructus lycii freeze-dried powder；(2) additive is prepared: 18-22 parts of sucrose,
18-22 parts of dextrin, 18-22 parts of mannitol, 1-3 parts of Mint Essence mixings, it is spare to cross 80-100 mesh.
CN103768024A discloses a kind of nano particle of ginseng saponin Rh 2, and the nano particle is by ginsenoside
Rh2 is made with albumin；The albumin is selected from bovine serum albumin(BSA), human serum albumins, sheep blood serum albumin, preferably
Human serum albumins and/or bovine serum albumin(BSA)；Preferably, the average grain diameter of the nano particle of the ginseng saponin Rh 2 is situated between
Between 150-200nm.
CN107496375A discloses a kind of preparation method of compound Chinese medicine granule, it is characterised in that: the preparation method
The following steps are included:, using auxiliary material as solid absorbent, extract is carried out low-temperature boiling using the extract of Chinese medicine as adhesive
Granulation, obtains molding particle；Under the premise of not changing extract and auxiliary material proportion in granule, using made of auxiliary material
Slurries embed molding particle, then carry out high temperature fluidized drying, obtain Chinese medicinal granule；The low-temperature boiling granulation
Temperature >=40 DEG C, temperature≤100 DEG C of the high temperature fluidized drying.
CN106420631A discloses a kind of preparation method of micropore sodium alginate-starch composite particles, successively includes
Following steps: a sprays hydrogen peroxide into food-grade sodium alginate, and the fountain height of the hydrogen peroxide is the 1%- of sodium alginate quality
2.5%, 6-18h is kept the temperature at 35-50 DEG C, and the deionized water of 9-15 times of sodium alginate quality, stirring to alginic acid is then added
Sodium is completely dissolved, and obtains sodium alginate soln, by acquired solution by standing after centrifugation, removal of impurities；It is 30%- that b, which configures starch concentration,
Amylase is added by 400-600u/g starch in 50% starch emulsion, and after insulation reaction 1-2 hours, step a is added thereto
Gained sodium alginate soln, obtains mixed solution；Carbonate and glucolactone are added into mixed liquor obtained by step b by c, stir
It mixes uniformly, is spray-dried, obtains micropore sodium alginate-starch composite particles.
CN102451159A discloses a kind of ultra-fine vinpocetine drug composite particles, is one kind with vinpocetine nanometer
Particle is active constituent, using water-soluble pharmaceutic adjuvant as the composite granule of carrier, and the vinpocetine mass percentage is 5-
50%, the mass percentage of water-soluble pharmaceutic adjuvant is 50-95%, and vinpocetine average grain diameter is 500-2000nm.
" preparation process and activity research of compound ginseng granules agent ", shadow etc., Exploitation of Agriculture in Heilongjiang science 2015 the 1st
Phase is stable preparation process, effectively controllable compound ginseng granules agent, using ginseng, fructus schisandrae, fructus lycii as raw material, with just
Test method is handed over, using wet granulation, with the content of ginsenoside Re, the qualification rate of granule is index, preferably compound ginseng
Preparation Technology of Granules, and be measured to the antifatigue and oxygen deficit tolerance for preparing granule is active.
However, existing mixture pellets are usually to pass through medicinal extract form to prepare, have the defects that impurity is more, purity is low,
Some of impurity even can cause side reaction.This field needs a kind of composite particles that side reaction is small, especially includes fructus lycii
With the side reaction of the mixture pellets of ginseng.
Summary of the invention
The present inventor on the basis of system research, by cooperative development, for current composite particles preparation in fructus lycii and
Ginseng extract is added all in the form of medicinal extract substantially, there is a problem of that impurity is more, especially introduces very in medicinal extract preparation process
Mostly unknown impurity (such as degradation ingredient) and sensitization impurity, some impurity can lead to the risk for side reaction occur, in particular for
Certain allergic constitution personnel, it is possible that allergic reaction, the present inventor by further investigation and cooperative development, propose with
Lower technical solution, so as to solve above-mentioned technical problem.
In one aspect of the invention, a kind of mixture pellets are provided, which includes ginseng extract and Chinese holly
Qi extract, wherein the ginseng extract in the mixture pellets and wolfberry fruit extract are that non-medicinal extract form is mixed into.
Preferably, which is pellet form, and the pellet average grain diameter is 0.2-2.0mm, and heap density is 72-
90g/100cm3It is 26-30 ° with angle of repose.
It is highly preferred that the wolfberry fruit extract that the composite particles include is mixed into the form of a solution in composite particles preparation
Preferably, the composite particles include also comprising auxiliary material.
Preferably, the composite particles also include Radix Schisandrae Bicolori extract.
In a preferred embodiment of the present invention, the composite particles also include Radix Schisandrae Bicolori extract, the north
Schisandra chinens P.E is mixed into the form of medicinal extract in composite particles preparation.
Preferably, the medicinal extract of the wolfberry fruit extract and/or Radix Schisandrae Bicolori extract is that water-ethanol mixed solution extracts system
The medicinal extract obtained.
In another aspect of this invention, a kind of method for preparing aforementioned composite particles is provided, this method includes following step
It is rapid: (1) by the medicinal extract of wolfberry fruit extract solution and ginseng extract solution and optional Radix Schisandrae Bicolori extract, optional auxiliary
Material is uniformly mixed, and mixture is made；(2) mixture is granulated.
Preferably, the extraction of the wolfberry fruit extract, ginseng extract and Radix Schisandrae Bicolori extract uses Microwave-assisted Extraction
It takes or supercritical fluid extraction.
Preferably, the wolfberry fruit extract extracts from the new fresh fructus lycii of freezing.
Preferably, described be granulated uses mist projection granulating or extruding pelletization.
For the present invention, it is preferable that the fructus lycii extracts solution and is preferably prepared by the following: (1) will newly pick
Or the fructus lycii of freezing crushes, then with chloroform: carbinol mixture solution is flowed back (preferably 20-60min), filtering；(2)
Alcohol reflux is added into filtration residue, is heated to reflux (preferably 10-30min)；(3) it is carried out in extraction element with petroleum ether
It flows back (preferably 10-30min), filtering obtains residue, residue is dried；(4) with water to filtering and dry remnants
The extraction of object progress water-soluble polysaccharide mixture.
Preferably, the volume ratio of chloroform and methanol is 3-8:1, more preferable 5:1 in step (1).
Preferably, it in step (3), is carried out preferably in Soxhlet extractor.Preferably, the Extracting temperature in the step is
90℃。
In step (4), the water-soluble polysaccharide mixture preferably directly uses as an aqueous solution.
The inventors discovered that step (1) chloroform: carbinol mixture solution flows back, and can remove the rouge in fructus lycii
Fat class compound, carrying out reflux with ethyl alcohol in step (2) can remove oligosaccharide and small molecule compound, and step uses stone in (3)
Oily ether, which carries out reflux, can remove lipid and coloring compound, and can further remove oligosaccharide.With it is existing without
The simple medicinal extract of purifying is compared, and is handled by above-mentioned multiple consecutive steps, and fat compound, oligomeric can be most effectively removed
Sugar and small molecule compound can cause extract high viscosity and some of small molecules if these compounds do not remove
It closes object and oligosaccharide and compound has adverse effect instead to when taking the composite particles.
In addition, in the present invention, by above-mentioned mutually matched step step by step, can remove to the maximum extent undesirable
Inert matter obtains the polysaccharides (LBP) of higher yields.Preferably, include water-soluble polysaccharide (i.e. Chinese holly in step (4)
Qi polysaccharide) mixture fructus lycii extracted solution in, in terms of extract component all in water (only calculated with extract, do not include water),
Content of the polysaccharides in extract is 80wt.% or more, more preferable 90wt.% or more, most preferably 95wt.% or more.
Sharp contrast is formed with this, only for polysaccharides content, polysaccharides is being extracted in conventional medicinal extract
Content in object is even lower usually in 40wt.%.
Further, it is preferable to ground, in the ginseng extract of the invention, 3 kinds of glycosides shown in lower formula (I)-(III)
More than 50% (weight) of the total glycosides compound of class compound Zhan, more than preferably 70% (weight):
Wherein: glc indicates that glucopyranosyl, rha indicate rhamnopyranosyl.
Preferably, the weight ratio of saponin(e shown in formula (I)-(III) is (1-10): (1-10): (10-30).
In ginsenoside, it is currently known at least more than 30 kinds of saponin(es.The present inventor it has been investigated that, 3 kinds of saponin(es
With preferable antifatigue, raising immunity effect, therefore these three saponin(es of high level can effectively improve composite particles
The effect of agent.
Correspondingly, the ginseng extract rich in 3 kinds of glycosides compounds of the invention, which preferably passes through, includes the following steps
Method be made: by ginseng extract medicinal extract carry out column chromatography for separation, which includes: the chromatographic column filler matrix used
For silica gel, the matrix is bonded with the reverse phase stationary phase material of octadecyl carbochain, and elution is mutually the mixed of ethyl alcohol and deionized water
Object is closed, eluent needed for merging.Combined eluent is used directly for the preparation of mixture pellets.
Preferably, the content of saponin(e shown in formula (I)-(III) is 2.0-10.0wt% in the combined eluent, preferably
3.0-8.0wt%.
In column chromatography, it is preferred to use linear elution.
It is highly preferred that eluting ethanol content in phase in linear elution and gradually mentioning 60v% from 5v% in 120 minutes.
Eluent is monitored using HPLC-MASS.
The commercially available acquisition of ginseng extract medicinal extract.
For the present invention, the preparation of composite particles is particularly preferably carried out using following method, this method includes following step
Rapid: (1) the fructus schisandrae medicinal extract that will be concentrated into 0.5-1.0g/mL is uniformly mixed with auxiliary material, and softwood is made, and extrusion spheronization is made micro-
Ball, microsphere average grain diameter are preferably 0.2-2.0mm；(2) microballoon is added in tower and is used as auxiliary particle, be blown into heat from tower bottom
Air makes the auxiliary particle in fluidized state；(3) ginseng extract solution or wolfberry fruit extract solution will be stored respectively
Basin pressurized with compressed air out, and heated；(4) by described in ginseng extract solution or wolfberry fruit extract solution from tower
Top sprays to downwards the auxiliary particle in ebullated bed by atomizer, stops spraying liquid after reaching corresponding medical fluid carrying capacity, can be after
It is continuous dry to required degree；(5) wind speed is improved, particle is blown out out of tower and enters cyclone separator to get composite particles.
One skilled in the art will recognize that the medical fluid refers to ginseng extract solution or wolfberry fruit extract solution.
One skilled in the art will recognize that in the step (4), if when selection continues to dry and continue dry
Between can easily be determined by liquor strength and spray time.
One skilled in the art will recognize that the ratio of fructus schisandrae medicinal extract and auxiliary material in step (1) can be according to load
Dose is determined.
Preferably, the auxiliary material is starch and/or dextrin.
In existing many composite particles preparations, need that extract solution is concentrated, due to most active constituents
With thermal sensitivity, it will lead to the decomposition of effective component in concentration process and generate by-product.Drying mode of the invention can
To use the extract solution without concentration, so as to avoid the generation of this unfavorable situation.
In addition, due to containing carbohydrate in medical fluid extract, having larger viscous for the mixture pellets of the application
Property, therefore certain difficulty is caused to granulation.By the spray drying and removing high viscosity ingredient described previously, therefore
Granulation efficiency is higher.
The present invention goes back the activity the study found that compared with ginseng extract and wolfberry fruit extract, in Radix Schisandrae Bicolori extract
Ingredient thermal stability with higher, therefore auxiliary particle first can be made with auxiliary material.In addition, due to fructus schisandrae medicinal extract stickiness
It is smaller, compare and is suitable as auxiliary particle use.
Preferably, the temperature in the step (3) is lower than 90 DEG C, more preferably less than 80 DEG C.
Preferably, the drying temperature in the step (4) is lower than 90 DEG C, more preferably less than 80 DEG C.Figure of description
Fig. 1 is the example photo figure chosen according to the guinea pig skin surface allergic reaction of comparative example 1.
Specific embodiment
Below with reference to following embodiment and corresponding comparative example, the present invention is described in further detail, but of the invention
Embodiment is without being limited thereto.
Embodiment 1
The fructus lycii (place of production Zhongweiof Ningxia, northwest China) for taking fresh material, is crushed, and chloroform: the 5:1v/v mixture of methanol is then used
Solution carries out reflux 30min, and alcohol reflux is added into filtration residue, is heated to reflux 10min for filtering, extracts in Soxhlet
With petroleum ether reflux 10min in device, filters, residue is dried, then residue is carried out with 80 DEG C of hot water water-soluble
The extraction of property polysaccharide mixture, obtains wolfberry fruit extract solution.Ginseng extract medicinal extract (self-control) progress column chromatography for separation is made
Chromatographic column is the reverse phase stationary phase material (purchased from Qingdao Haiyang chemical company) of silica matrix bonding octadecyl carbochain, is washed
Out-of-phase is the mixture of ethyl alcohol and deionized water, takes linear elution, ethanol content is gradually mentioned in 120 minutes from 5v%
60v% monitors eluent using HPLC-MASS, merges eluent, wherein saponin(e shown in formula described above (I)-(III) contains
Amount is 2.6wt%.The fructus schisandrae medicinal extract for being concentrated into 0.7g/mL is uniformly mixed with starch/dextrin (1:1) according to 1:6w/w,
Softwood is made, microballoon is made in extrusion spheronization, and microsphere average grain diameter is preferably 0.51mm；The microballoon is added in tower as auxiliary
Particle, being blown into hot-air from tower bottom makes the auxiliary particle in fluidized state；Ginseng extract solution or Chinese holly will be stored respectively
Qi extract solution goes out basin pressurized with compressed air, and carries out being heated to about 80 DEG C；By ginseng extract solution or Chinese holly
The auxiliary particle in ebullated bed is sprayed to downwards from tower top by atomizer described in Qi extract solution, is carried reaching corresponding medical fluid
Stop spraying liquid after amount, can continue dry to required degree at 90 DEG C；Wind speed is improved, blows out particle out of tower into whirlwind point
From device to get composite particles.
Through detecting, in composite particles obtained, the content of polysaccharides is 0.52%, saponin(e shown in formula (I)-(III)
Content is 0.18wt%；Mean particle size is 0.51mm, and heap density is 77g/100cm3It is 27 ° with angle of repose.
Comparative example 1
By fructus schisandrae, ginseng, fructus lycii is dry and crushes, and respectively plus 40 times of water, soaks at a temperature of 60 DEG C under ultrasonic wave added
2h is mentioned, repeats to extract once, combined extract is concentrated into about 1.0g/mL, obtains medicinal extract, according to medicine substantially the same manner as Example 1
Object carrying capacity calculates the dosage of medicinal extract, mixes with the starch/dextrin mixed accessories of 1:1, is made compound by extrusion spheronization method
Grain, mean particle size 0.50mm.
Hypersensitive test test
Healthy albino guinea-pig 40 is taken, female, weight 250-300g is (by the attached Nanjing hospital animal reality of Nanjing Medical University
Center offer is provided), it is divided into two groups, every group 20, takes respectively
The mixture pellets (second group) (crushing) of embodiment 1 (first group) and comparative example 1, dosage 3.1mg/g, specifically
It is to feed 2 kinds of granule levigations with feed.First 24 hours of test, is taken off tested guinea pig back hair with scissors and razor
Only, it is ensured that skin is complete, records 1,2,4 and 8 hour tested area's erythema, the situation of change of oedema.It has been observed that first group
Have very slight erythema occur within 1 cavy 2 hours after taking mixture pellets, no oedema, erythema disappears after 4 hours；And
Second group has and erythema occurs within 5 cavys 2 hours after taking mixture pellets, no oedema, wherein 2 there is Severe erythema, 3
There is slight erythema, erythema does not disappear after 4 hours.
By above-described embodiment and comparative example it can be clearly seen that when using conventional medicinal extract method preparation, due to mentioning
The presence for taking impurity and decomposition by-products in object can lead to the slight allergy of guinea pig skin.With this formed sharp contrast when, when adopting
When with granule of the invention, allergic reaction incidence is low and slight, to substantially increase the safety of mixture pellets.
This written description discloses the present invention, including optimal mode using example, and also enables those skilled in the art
The manufacture and use present invention.It is of the invention can patentable scope be defined by the claims, and may include this field skill
Other examples that art personnel expect.If this other examples have not different from the structural elements of the literal language of claims
Element, or if this other examples include the equivalent structure element with the literal language of claims without substantial differences,
Then this other examples are intended within the scope of claims.In the case where not will cause inconsistent degree, by reference to
It will be incorporated herein in place of all references referred to herein.
Claims (10)
1. a kind of mixture pellets, which includes ginseng extract and wolfberry fruit extract, wherein the mixture pellets
In ginseng extract and wolfberry fruit extract be non-medicinal extract form be mixed into.
2. composite particles according to claim 1, it includes wolfberry fruit extract in composite particles preparation with solution shape
Formula is mixed into.
3. composite particles according to claim 1 or 2 also include auxiliary material.
4. composite particles according to claim 2, wherein the composite particles also include Radix Schisandrae Bicolori extract.
5. composite particles according to any one of the preceding claims, wherein the Radix Schisandrae Bicolori extract is in composite particles
It is mixed into the form of medicinal extract in preparation.
6. composite particles according to any one of the preceding claims, the medicinal extract of the Radix Schisandrae Bicolori extract is water-second
Mixed alkoxide solution extracts medicinal extract obtained.
7. a kind of method prepared according to any one of preceding claims composite particles, method includes the following steps: (1)
The medicinal extract of wolfberry fruit extract solution and ginseng extract solution and optional Radix Schisandrae Bicolori extract, optional auxiliary material are mixed
Uniformly, mixture is made；(2) mixture is granulated.
8. method according to claim 7, wherein the extraction of the wolfberry fruit extract, ginseng extract and Radix Schisandrae Bicolori extract
Using microwave radiation exaraction or supercritical fluid extraction.
9. according to the method for claim 7 or 8, wherein the wolfberry fruit extract extracts from the new fresh fructus lycii of freezing.
10. according to the described in any item methods of claim 7-9, wherein described be granulated uses mist projection granulating or extruding pelletization.
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