CN109350627A - A kind of freeze-dried sheep placenta extract powder and preparation method thereof - Google Patents
A kind of freeze-dried sheep placenta extract powder and preparation method thereof Download PDFInfo
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- CN109350627A CN109350627A CN201811433439.8A CN201811433439A CN109350627A CN 109350627 A CN109350627 A CN 109350627A CN 201811433439 A CN201811433439 A CN 201811433439A CN 109350627 A CN109350627 A CN 109350627A
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- 241001494479 Pecora Species 0.000 title claims abstract description 57
- 210000002826 placenta Anatomy 0.000 title claims abstract description 36
- 239000000843 powder Substances 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title abstract description 6
- 210000001161 mammalian embryo Anatomy 0.000 claims abstract description 28
- 238000000034 method Methods 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000012528 membrane Substances 0.000 claims abstract description 16
- 238000000605 extraction Methods 0.000 claims abstract description 8
- 239000000706 filtrate Substances 0.000 claims abstract description 8
- 239000002002 slurry Substances 0.000 claims abstract description 8
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 239000008280 blood Substances 0.000 claims abstract description 6
- 239000012153 distilled water Substances 0.000 claims abstract description 6
- 238000001728 nano-filtration Methods 0.000 claims abstract description 6
- 210000004369 blood Anatomy 0.000 claims abstract description 5
- 239000012141 concentrate Substances 0.000 claims abstract description 4
- 239000012530 fluid Substances 0.000 claims abstract description 4
- 239000012535 impurity Substances 0.000 claims abstract description 4
- 238000002203 pretreatment Methods 0.000 claims abstract description 4
- 238000010257 thawing Methods 0.000 claims abstract description 4
- 238000004140 cleaning Methods 0.000 claims abstract description 3
- 238000001914 filtration Methods 0.000 claims description 4
- 235000013372 meat Nutrition 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 241000894006 Bacteria Species 0.000 claims 1
- 230000008569 process Effects 0.000 abstract description 4
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 description 3
- 241000283707 Capra Species 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000007071 enzymatic hydrolysis Effects 0.000 description 2
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 2
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Developmental Biology & Embryology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Reproductive Health (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Cosmetics (AREA)
- Gynecology & Obstetrics (AREA)
Abstract
The present invention provides a kind of freeze-dried sheep placenta extract powders and preparation method thereof, described method includes following steps: (1) sheep embryo raw material pre-treatment: choosing fresh sheep embryo, after cleaning the impurity such as removal blood with pure water, blends under low temperature, freeze thawing and homogenate under low temperature obtain sheep embryo's slurries；(2) extraction of sheep placenta: being added distilled water in sheep embryo's slurries, low temperature filters to get filtrate after extracting；(3) filtrate is crossed into 6000 molecular weight ultrafiltration membranes and 3000 molecular weight ultrafiltration membranes respectively, collects the component of molecular weight 3000-6000；(4) nanofiltration membrane concentration water removal is carried out to the component of collection, concentrate is then crossed into micropore degerming；(5) filtered fluid is lyophilized up to freeze-dried sheep placenta extract powder.The method of the invention technique is advanced, reasonable, easy to operate, quality controllable, whole process all carries out at a lower temperature, remains the natural active matter in sheep embryo to greatest extent, the component of the effective component being sufficiently extracted in sheep embryo, 3000-6000 molecular weight is convenient for absorption of human body again.
Description
Technical field
The present invention relates to a kind of freeze-dried sheep placenta extract powders and preparation method thereof.
Background technique
Chinese medicine thinks " though embryo grasps the shape of the day after tomorrow, holding congenital gas ", has and recovers one's youthful vigour, benefit lean sun, benefiting essence-blood,
Help kidney yang, nourishing blood and invigorating qi, moisturizing, tranquilizing the mind, with painstaking effort beauty treatment and other effects.Modern medicine study shows: placenta contains
The bioactive substances such as panimmunity globulin, active peptide and amino acid, mineral matter and other components are a kind of body's immunities
Regulator and nutrition, cosmetic health product.Scientist compares the cell tissue the study found that Goat Placenta to many animals placenta
Mechanism is the most similar to Human plactnta, is that human body is easiest to the placenta absorbed, while Goat Placenta will not infect hepatitis virus, Bu Huiyu
The mankind generate cross-infection, relatively safe, are ideal human placenta's substitutes.
In existing sheep placenta extracting method, the process means of enzymatic hydrolysis and high-temperature sterilization are used in technical process mostly,
Enzymatic hydrolysis and high temperature can destroy the natural active matter in placenta, and the type and content of natural active matter in sheep placenta is caused to be difficult to
Guarantee, is unfavorable for guaranteeing the quality of sheep placenta product, meanwhile, the extraction efficiency of sheep placenta is not also high.
Summary of the invention
It is an object of the present invention to provide a kind of method for preparing freeze-dried sheep placenta extract powder from sheep embryo, this method is maximum
The natural active matter of limit remained in sheep embryo.It is another object of the present invention to provide the sheep of the method preparation
Tire element freeze-dried powder.
In order to realize first above-mentioned purpose, present invention employs technical solutions below:
A method of from sheep, embryo prepares freeze-dried sheep placenta extract powder, includes the following steps:
(1) sheep embryo raw material pre-treatment: choosing fresh sheep embryo, after cleaning the impurity such as removal blood with pure water, temperature control 0
~5 DEG C are blended with meat grinder, -15 DEG C~5 DEG C freeze thawing and homogenate, obtain sheep embryo's slurries that granularity is 30~50 μm；
(2) extraction of sheep placenta: being added distilled water in sheep embryo's slurries, controls 1~5 DEG C of temperature, 50~80 revs/min of revolving speed
Clock is stirred extraction, then filters to get filtrate；
(3) filtrate is crossed into 6000 molecular weight ultrafiltration membranes and 3000 molecular weight ultrafiltration membranes respectively, collects molecular weight 3000-6000
Component；
(4) nanofiltration membrane concentration water removal is carried out to the component of collection, concentrate is then crossed into micropore and is filtered degerming；
(5) filtered fluid is lyophilized at -55 DEG C, obtains freeze-dried sheep placenta extract powder.
Preferably, in the step (1), using the sheep embryo at 3 monthly ages as raw material.
Preferably, the additional amount of distilled water is 5~10 times in the step (2).
Preferably, stirring extraction time is 1~1.5 hour in the step (2).
Preferably, filtering filter sizes are 300 mesh in the step (2).
Preferably, nanofiltration membrane concentration removes water to Baume degrees 1.03 in the step (4).
Preferably, micro- in the step (4), the filter sizes of micro porous filtration degerming are 0.22 μm.
In order to realize second above-mentioned purpose, the present invention also provides above-mentioned any one technical solutions to be prepared
Freeze-dried sheep placenta extract powder.
Compared with prior art, the invention has the benefit that the method for the invention technique is advanced, reasonable, operation letter
Single, quality controllable, whole process all carries out at a lower temperature, remains the natural active products in sheep embryo to greatest extent
The component of matter, the effective component being sufficiently extracted in sheep embryo, 3000-6000 molecular weight is convenient for absorption of human body again.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction with specific embodiment, it is clear that described
Embodiment be only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiment of the present invention, this field
Those of ordinary skill's every other embodiment obtained, belongs to protection scope of the present invention.
Embodiment 1
A method of from sheep, embryo prepares freeze-dried sheep placenta extract powder, includes the following steps:
(1) sheep embryo raw material pre-treatment: the sheep embryo for choosing 3 monthly ages is raw material, is cleaned 3-5 times with pure water, is removed
The impurity such as blood, 0~5 DEG C of temperature control is blended with meat grinder, -15 DEG C~5 DEG C freeze thawing and homogenate, obtains the sheep that granularity is 30~50 μm
Embryo's slurries；
(2) extraction of sheep placenta: 5~10 times of distilled water of addition in sheep embryo's slurries, 1~5 DEG C of temperature of control, revolving speed 50~
80 revs/min are stirred extraction 1~1.5 hour, then cross 300 mesh filter membranes and obtain filtrate；
(3) filtrate is crossed into 6000 molecular weight ultrafiltration membranes and 3000 molecular weight ultrafiltration membranes respectively, collects molecular weight 3000-6000
Component；
(4) nanofiltration membrane concentration is carried out to the component of collection and removes water to Baume degrees 1.03, then by concentrate cross 0.22 μm it is micro-
Hole is filtered degerming；
(5) filtered fluid is lyophilized at -55 DEG C, obtains freeze-dried sheep placenta extract powder.
Through detecting, the sheep placenta of above method preparation is white, slightly sweet, free from extraneous odour, soluble easily in water, without preservative.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, all any modification, equivalent substitution, improvement and etc. be should all be included in the protection scope of the present invention.
Claims (8)
1. a kind of method for preparing freeze-dried sheep placenta extract powder from sheep embryo, which comprises the following steps:
(1) sheep embryo raw material pre-treatment: choosing fresh sheep embryo, after cleaning the impurity such as removal blood with pure water, temperature control 0~5
It DEG C is blended with meat grinder, -15 DEG C~5 DEG C freeze thawing and homogenate, obtains sheep embryo's slurries that granularity is 30~50 μm；
(2) extraction of sheep placenta: being added distilled water in sheep embryo's slurries, controls 1~5 DEG C of temperature, 50~80 revs/min of revolving speed into
Row stirring is extracted, and is then filtered to get filtrate；
(3) filtrate is crossed into 6000 molecular weight ultrafiltration membranes and 3000 molecular weight ultrafiltration membranes respectively, collects the group of molecular weight 3000-6000
Point；
(4) nanofiltration membrane concentration water removal is carried out to the component of collection, concentrate is then crossed into micropore and is filtered degerming；
(5) filtered fluid is lyophilized at -55 DEG C, obtains freeze-dried sheep placenta extract powder.
2. the method for preparing freeze-dried sheep placenta extract powder as described in claim 1, which is characterized in that in the step (1), with 3
The sheep embryo at monthly age is raw material.
3. the method for preparing freeze-dried sheep placenta extract powder as described in claim 1, which is characterized in that in the step (2), distilled water
Additional amount be 5~10 times.
4. the method for preparing freeze-dried sheep placenta extract powder as described in claim 1, which is characterized in that in the step (2), stirring is mentioned
Taking the time is 1~1.5 hour.
5. the method for preparing freeze-dried sheep placenta extract powder as described in claim 1, which is characterized in that in the step (2), filtering filter
Membrane aperture is 300 mesh.
6. the method for preparing freeze-dried sheep placenta extract powder as described in claim 1, which is characterized in that in the step (4), nanofiltration membrane
Concentration removes water to Baume degrees 1.03.
7. the method for preparing freeze-dried sheep placenta extract powder as described in claim 1, which is characterized in that in the step (4), micropore mistake
The filter sizes for filtering out bacterium are 0.22 μm.
8. the freeze-dried sheep placenta extract powder that any one of claim 1 to 7 is prepared.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811433439.8A CN109350627A (en) | 2018-11-28 | 2018-11-28 | A kind of freeze-dried sheep placenta extract powder and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811433439.8A CN109350627A (en) | 2018-11-28 | 2018-11-28 | A kind of freeze-dried sheep placenta extract powder and preparation method thereof |
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| Publication Number | Publication Date |
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| CN109350627A true CN109350627A (en) | 2019-02-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811433439.8A Pending CN109350627A (en) | 2018-11-28 | 2018-11-28 | A kind of freeze-dried sheep placenta extract powder and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109908181A (en) * | 2019-04-23 | 2019-06-21 | 独角兽生命科学股份公司 | The preparation method of anti-aging Porcine HGF |
| CN110540575A (en) * | 2019-06-06 | 2019-12-06 | 殷洪波 | preparation method of probiotic fermented and de-energized placenta composite polypeptide |
| CN113577005A (en) * | 2021-08-02 | 2021-11-02 | 京美瑞禾健康科技(辽宁)有限公司 | Sheep placenta ultramicro factor mask liquid and preparation method thereof |
| CN114028836A (en) * | 2021-09-26 | 2022-02-11 | 承创(常熟)医药科技有限公司 | Method for removing pigment and odor from plant extract |
| CN114350733A (en) * | 2021-12-29 | 2022-04-15 | 广东冠龙生物科技有限公司 | Oyster active protein peptide composite precise enzymolysis process |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN110540575A (en) * | 2019-06-06 | 2019-12-06 | 殷洪波 | preparation method of probiotic fermented and de-energized placenta composite polypeptide |
| CN113577005A (en) * | 2021-08-02 | 2021-11-02 | 京美瑞禾健康科技(辽宁)有限公司 | Sheep placenta ultramicro factor mask liquid and preparation method thereof |
| CN114028836A (en) * | 2021-09-26 | 2022-02-11 | 承创(常熟)医药科技有限公司 | Method for removing pigment and odor from plant extract |
| CN114350733A (en) * | 2021-12-29 | 2022-04-15 | 广东冠龙生物科技有限公司 | Oyster active protein peptide composite precise enzymolysis process |
| CN114350733B (en) * | 2021-12-29 | 2024-01-26 | 广东冠龙生物科技有限公司 | Oyster active protein peptide composite accurate enzymolysis technology |
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Application publication date: 20190219 |