CN101028286A - Sheep placenta extracts and preparation thereof - Google Patents
Sheep placenta extracts and preparation thereof Download PDFInfo
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- CN101028286A CN101028286A CNA2006100203779A CN200610020377A CN101028286A CN 101028286 A CN101028286 A CN 101028286A CN A2006100203779 A CNA2006100203779 A CN A2006100203779A CN 200610020377 A CN200610020377 A CN 200610020377A CN 101028286 A CN101028286 A CN 101028286A
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- caprae seu
- seu ovis
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- placenta
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Abstract
A sheep placenta extract in the form of oral liquid is prepared from sheep placenta through freeze-drying at -40-0 deg.C, pulverizing, extracting, sieving, and sterilizing.
Description
Technical field
The present invention relates to a kind of preparation method of Placenta caprae seu ovis extract.
Background technology
Placenta caprae seu ovis is to grow the plate-like soft tissue that the back forms by the embryo on the uterus, and relies on Placenta Hominis and umbilical cord and parent to link always.Parent has been concentrated nutrition, flows to fetus by Placenta Hominis, and the Placenta Hominis major function acts on the nutrition supply effect, the effect of defence protective effect and endocrine hormone.Active antibodies in the Placenta Hominis claims Placenta extract, derives from the sheep placental extract that is called of Placenta caprae seu ovis preparation, wherein mainly contains growth hormone, antepituitary element, follicle autacoid etc.At present, existing report is injected into sheep placental extract in person in middle and old age's human body, takes effect obviously, can regain one's strength rapidly, delays the function of the aging of each organ dysfunction.
Normal animal Placenta Hominis is rounded or oval, the pan that periphery is thin, central authorities are thick.Size as people and Placenta caprae seu ovis is mutually specious, and diameter is about 15～20cm, and thickness is 1.5～3cm, the about 500g of weight.If be used to produce sheep placental extract, can take out fetus in Placenta Hominis body or March, should place 0 ℃ of preservation to be no more than 2h at 20 minutes, running immediately goes in-20 ℃ of freezers to preserve, because the very fast decomposition failure of placenta component in the room temperature, and the yield of Placenta caprae seu ovis extract is low.But because except temperature, the factor that influences placenta component, quality is complicated, still unmatchful Placenta caprae seu ovis extract effectively extracts the purpose that reaches control of quality at present.
Summary of the invention
Technical scheme of the present invention has provided a kind of preparation method of Placenta caprae seu ovis extract, and another technical scheme of the present invention has provided the Placenta caprae seu ovis extract of this method preparation.
The invention provides a kind of preparation method of Placenta caprae seu ovis extract, it is in-40 ℃～0 ℃ environment, freezes cool-drying, pulverizing, extracts, sieves, sterilizes, is prepared into Placenta caprae seu ovis extract.
Further, described ambient temperature is-20 ℃～0 ℃.
Particularly, preparation method of extract of the present invention comprises the steps:
A, get fresh Placenta caprae seu ovis, under 0 ℃～-4 ℃, remove garbage, scavenging period: 20～40min;
B, the Placenta caprae seu ovis after will cleaning are pulverized under-15 ℃～-20 ℃ conditions, cross 200 orders～500 mesh sieves, and acetone extraction use in sterilization, must Placenta caprae seu ovis extract I; Or
Placenta caprae seu ovis after cleaning is pulverized under-15 ℃～-20 ℃ conditions, and lyophilisation, pulverizing under-15 ℃～-20 ℃ conditions again gets Placenta caprae seu ovis extract II;
Extract I, II or its mixing are Placenta caprae seu ovis extract of the present invention.
Wherein, be 4～22 weeks Foetus Caprae seu Ovis age of the described Placenta caprae seu ovis of step a.Further, be 12～14 weeks Foetus Caprae seu Ovis age of the described Placenta caprae seu ovis of step a.
Wherein, the described pulverizing temperature of step b is-20 ℃.
Wherein, the described temperature of step b is-20 ℃ for the lyophilisation temperature.
The Placenta caprae seu ovis extract that the present invention also provides this method to be prepared from.
The invention provides a kind of medicine or health food, it is to be active component by described Placenta caprae seu ovis extract, adds the medicament that acceptable accessories or complementary composition are prepared from.
Wherein, described medicament is oral liquid, tablet, injection, granule, capsule.
The inventive method is simple to operate, and cost is low, and be convenient to big production and use, the yield height, and the Placenta caprae seu ovis oral liquid quality controllability of preparation is strong, for consumer provides a kind of new selection.
Obviously, according to foregoing of the present invention,,, can also make modification, replacement or the change of other various ways not breaking away under the above-mentioned basic fundamental thought of the present invention prerequisite according to the ordinary skill knowledge and the customary means of this area.
The specific embodiment of form is described in further detail foregoing of the present invention again by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
Specific implementation method
The preparation of embodiment 1 capsule of the present invention
A, get the Placenta caprae seu ovis 50kg of fresh 4～22 all different gestational age, under 0 ℃, remove garbage;
B, the Placenta caprae seu ovis after will cleaning are crossed 200 mesh sieves-20 ℃ of pulverizing, sterilization, and lixiviate, extract is Placenta caprae seu ovis extract I;
C, with extract I, add starch, granulation, encapsulated, capsule.
The preparation of embodiment 2 tablets of the present invention
A, get the Placenta caprae seu ovis 50kg of fresh 22 all gestational ages, under 0 ℃, remove garbage;
B, with a step Placenta caprae seu ovis-20 ℃ of pulverizing, cross 500 mesh sieves, again in-20 ℃ of following lyophilizations, pulverizing, extract II;
C, with extract II, add starch, granulation, add magnesium stearate, tabletting is prepared into tablet.
The preparation of embodiment 3 oral liquids of the present invention
A, get the Placenta caprae seu ovis 50kg of fresh 4 all different gestational age, under 0 ℃, remove garbage;
B, the Placenta caprae seu ovis after will cleaning are crossed 300 mesh sieves-15 ℃ of pulverizing, and acetone extraction is used in sterilization, volatilizes acetone, and extract is Placenta caprae seu ovis extract I;
C, with extract I, add oral agents with solvent, correctives, be prepared into oral liquid.
Embodiment 4 preparation tablets of the present invention
A, get the Placenta caprae seu ovis 50kg of fresh 22 all gestational ages, under-4 ℃, remove garbage;
B, with a step Placenta caprae seu ovis-15 ℃ of pulverizing, cross 200 mesh sieves, again in-15 ℃ of following lyophilizations, pulverizing, extract II;
C, with extract II, add starch, granulation, add magnesium stearate, tabletting is prepared into tablet.
Embodiment 5 preparation tablets of the present invention
A, get the Placenta caprae seu ovis 50kg of fresh 22 all gestational ages, under-4 ℃, remove garbage;
B, with a step Placenta caprae seu ovis-40 ℃ of pulverizing, cross 200 mesh sieves, again in-40 ℃ of following lyophilizations, pulverizing, extract II;
C, with extract II, add starch, granulation, add magnesium stearate, tabletting is prepared into tablet.
The yield of embodiment 6 Foetus Caprae seu Ovis extracts of the present invention
By embodiment 1 described method the calculating of the yield of the Placenta caprae seu ovis of different gestational age, different parts is seen Table 1:
The analytical unit of materials such as table 1 different gestational age Foetus Caprae seu Ovis weight and availability: g/ only
| Gestational age (week) | Female Placenta Hominis | Young Placenta Hominis | The tire lamb | Garbage | Availability | Dry | Yield |
| 4 | 10 | 2 | 8 | 46 | 1∶2∶3 | 8 | 9 |
| 8 | 45 | 36 | 34 | 65 | 1∶8∶1 | 8 | 7 |
| 10 | 218 | 66 | 136 | 86 | 4∶8∶1 | 50 | 11.1 |
| 12 | 420 | 104 | 385 | 118 | 7∶7∶1 | 115 | 12.65 |
| 14 | 400 | 148 | 480 | 120 | 8∶6∶1 | 124 | 12.01 |
| 16 | 350 | 180 | 540 | 140 | 7∶6∶1 | 117 | 9.15 |
| 22 | 250 | 11.2 | 4.48 |
By table 1 as can be known, gestational age 12～14 whens week female Placenta Hominis weight bigger, amount of dry matter is many, and the yield height, the intacellin the best for preparing during wherein with 14 all gestational ages.
The content situation of each composition in the Placenta caprae seu ovis extract of different gestational age sees Table 2:
The analytical unit of the active component of table 2 lyophilizing Foetus Caprae seu Ovis extract: %
| Gestational age (week) | Protein | Crude fat | Composition | E 2(ul/ml) | Bioactive peptide (mg/ml) |
| 4 | 75 | 9.2 | 2.37 | 33.5 | 201±117 |
| 8 | 58 | 6.4 | 2.4 | 66.5 | 637±67 |
| 10 | 59 | 4.8 | 2.17 | 250.5 | 763±92 |
| 12 | 84 | 4.6 | 2.3 | 265.5 | 897±165 |
| 14 | 85 | 4.6 | 2.48 | 268.5 | 994±122 |
| 16 | 74 | 5.4 | 7.3 | 87.8 | 238±158 |
| 22 | 72 | 9.34 | 2.06 | 39.5 | 83±55 |
Above-mentioned test explanation adopts in the Foetus Caprae seu Ovis extract of the inventive method preparation bioactive peptide all higher, and is preferable with the Placenta caprae seu ovis of 12～14 all gestational ages, especially in gestational age best results during 14 weeks.Therefore, in industrialization aborning, the selection of raw material plays decision, and the Foetus Caprae seu Ovis extract controllability that the present invention is prepared is strong, steady quality.
Claims (10)
1, a kind of preparation method of Placenta caprae seu ovis extract is characterized in that: in-40 ℃～0 ℃ environment, freeze cool-drying, pulverizing, extract, sieve, sterilize, be prepared into Placenta caprae seu ovis extract.
2, the preparation method of Placenta caprae seu ovis extract according to claim 1 is characterized in that: described ambient temperature is-20 ℃～0 ℃.
3, the preparation method of Placenta caprae seu ovis extract according to claim 1 and 2, it is characterized in that: it comprises the steps:
A, get fresh Placenta caprae seu ovis, under 0 ℃～-4 ℃, remove garbage, scavenging period: 20～40min;
B, the Placenta caprae seu ovis after will cleaning are pulverized under-15 ℃～-20 ℃ conditions, cross 200 orders～500 mesh sieves, and acetone extraction use in sterilization, must Placenta caprae seu ovis extract I; Or
Placenta caprae seu ovis after cleaning is pulverized under-15 ℃～-20 ℃ conditions, and lyophilisation, pulverizing under-15 ℃～-20 ℃ conditions again gets Placenta caprae seu ovis extract II;
Extract I, II or its mixing are Placenta caprae seu ovis extract of the present invention.
4, the preparation method of Placenta caprae seu ovis extract according to claim 3 is characterized in that: be 4～22 weeks Foetus Caprae seu Ovis age of the described Placenta caprae seu ovis of step a.
5, the preparation method of the Placenta caprae seu ovis extract of stating according to claim 4 is characterized in that: be 12～14 weeks Foetus Caprae seu Ovis age of the described Placenta caprae seu ovis of step a.
6, the preparation method of Placenta caprae seu ovis extract according to claim 3 is characterized in that: the described pulverizing temperature of step b is-20 ℃.
7, the preparation method of Placenta caprae seu ovis extract according to claim 3 is characterized in that: the described temperature of step b is-20 ℃ for the lyophilisation temperature.
8, claim becomes the Placenta caprae seu ovis extract that each described method of 1-7 is prepared from.
9, a kind of medicine or health food, it is to be active component by the described Placenta caprae seu ovis extract of claim 8, adds the medicament that acceptable accessories or complementary composition are prepared from.
10, medicine according to claim 9 or health food is characterized in that: described medicament is oral liquid, tablet, injection, granule, capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100203779A CN101028286A (en) | 2006-03-01 | 2006-03-01 | Sheep placenta extracts and preparation thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2006100203779A CN101028286A (en) | 2006-03-01 | 2006-03-01 | Sheep placenta extracts and preparation thereof |
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| CN101028286A true CN101028286A (en) | 2007-09-05 |
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| CNA2006100203779A Pending CN101028286A (en) | 2006-03-01 | 2006-03-01 | Sheep placenta extracts and preparation thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102327290A (en) * | 2011-07-12 | 2012-01-25 | 湖州康海斯生物科技有限公司 | Refined sheep placenta extract prepared from sheep embryo and sheep placental peptide and preparation method |
| CN102688176A (en) * | 2012-06-14 | 2012-09-26 | 扬州扬大联环药业基因工程有限公司 | Sheet embryo extract freeze-dried powder and preparation technology |
| CN105886586A (en) * | 2015-01-28 | 2016-08-24 | 张恒 | Sheep placenta peptide extraction method |
| CN107118257A (en) * | 2017-05-17 | 2017-09-01 | 兰州名德农牧科技有限公司 | A kind of industrialized Goat Placenta-peptide extracting method |
| CN108142939A (en) * | 2018-02-05 | 2018-06-12 | 内蒙古康肽生物工程有限公司 | A kind of oral liquid of the factor containing placenta stem-cell and preparation method thereof |
| CN108685828A (en) * | 2018-06-14 | 2018-10-23 | 成都医学院 | A kind of extracting method of placental hormone |
| CN109350627A (en) * | 2018-11-28 | 2019-02-19 | 广东冠龙生物科技有限公司 | A kind of freeze-dried sheep placenta extract powder and preparation method thereof |
| CN109568254A (en) * | 2018-12-18 | 2019-04-05 | 江西润泽药业有限公司 | A kind of Plancenta Histolysate's injection and preparation method thereof |
| CN114712323A (en) * | 2022-05-18 | 2022-07-08 | 贵州奇源生物制品有限公司 | Human placenta tablet and preparation method thereof |
-
2006
- 2006-03-01 CN CNA2006100203779A patent/CN101028286A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102327290A (en) * | 2011-07-12 | 2012-01-25 | 湖州康海斯生物科技有限公司 | Refined sheep placenta extract prepared from sheep embryo and sheep placental peptide and preparation method |
| CN102327290B (en) * | 2011-07-12 | 2013-02-13 | 湖州康海斯生物科技有限公司 | Refined sheep placenta extract prepared from sheep embryo and sheep placental peptide and preparation method |
| CN102688176A (en) * | 2012-06-14 | 2012-09-26 | 扬州扬大联环药业基因工程有限公司 | Sheet embryo extract freeze-dried powder and preparation technology |
| CN105886586A (en) * | 2015-01-28 | 2016-08-24 | 张恒 | Sheep placenta peptide extraction method |
| CN107118257A (en) * | 2017-05-17 | 2017-09-01 | 兰州名德农牧科技有限公司 | A kind of industrialized Goat Placenta-peptide extracting method |
| CN108142939A (en) * | 2018-02-05 | 2018-06-12 | 内蒙古康肽生物工程有限公司 | A kind of oral liquid of the factor containing placenta stem-cell and preparation method thereof |
| CN108685828A (en) * | 2018-06-14 | 2018-10-23 | 成都医学院 | A kind of extracting method of placental hormone |
| CN109350627A (en) * | 2018-11-28 | 2019-02-19 | 广东冠龙生物科技有限公司 | A kind of freeze-dried sheep placenta extract powder and preparation method thereof |
| CN109568254A (en) * | 2018-12-18 | 2019-04-05 | 江西润泽药业有限公司 | A kind of Plancenta Histolysate's injection and preparation method thereof |
| CN114712323A (en) * | 2022-05-18 | 2022-07-08 | 贵州奇源生物制品有限公司 | Human placenta tablet and preparation method thereof |
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