CN109316578B - 治疗风寒湿痹及筋脉拘挛的麝香宝珍膏及其制备方法 - Google Patents

治疗风寒湿痹及筋脉拘挛的麝香宝珍膏及其制备方法 Download PDF

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CN109316578B
CN109316578B CN201811384007.2A CN201811384007A CN109316578B CN 109316578 B CN109316578 B CN 109316578B CN 201811384007 A CN201811384007 A CN 201811384007A CN 109316578 B CN109316578 B CN 109316578B
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parts
layer
musk
treasure
ointment
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CN109316578A (zh
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俞帮和
徐�明
蒋志刚
周伟英
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Hangzhou Rende Pharmaceutical Co ltd
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Hangzhou Rende Pharmaceutical Co ltd
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Abstract

本发明涉及医疗用品领域，尤其涉及一种治疗风寒湿痹及筋脉拘挛的麝香宝珍膏及其制备方法。依次包括基布层、隔绝层、发热层与膏药层，基布层为非织造布，隔绝层包括聚醚蜡，发热层用于与空气接触时产生热量，膏药层为中药涂覆层，其涂覆面积大于发热层，将发热层完全覆盖，本发明通过将发热层设于隔绝层与膏药层之间，当温度较低时，可以通过揉搓等方式使得空气可以透过隔绝层从而与发热层接触并释放热量，当温度较高时，隔绝层会阻隔空气的流通，从而抑制发热层的放热，实现了热量的控释，延长了发热时间，使得宝珍膏的药效更持久，人体更易吸收，且不会由于过冷导致宝珍膏在皮肤上脱落。

Description

治疗风寒湿痹及筋脉拘挛的麝香宝珍膏及其制备方法
技术领域
本发明涉及医疗用品领域，尤其涉及一种治疗风寒湿痹及筋脉拘挛的麝香宝珍膏及其制备方法。
背景技术
风寒湿痹，为行痹、痛痹、著痹的合称，是风、寒、湿三气外邪侵袭经络，气血闭阻不畅引起的，该病症常见于现代医学诊断的风湿热、风湿性关节炎、类风湿性关节炎、纤维组织炎及神经痛等，筋脉拘挛是指肢体筋脉抽瘛，屈伸不利的症候，这类疾病的并发症很多，现有技术中治疗方法也比较多，但效果往往不尽如人意，这是由于传统的膏药贴没有热作用，敷在人体表面后，靠人体内部新陈代谢促使血液循环而发挥药效，但人体内部产生的热量则是有限的，以致发挥的药效有限，并且，膏药在使用时需要加热以增强敷贴的粘性，在环境温度较低时，膏药粘性下降，与皮肤的接触面积减少，更难以发挥全部的药性。
例如，一种在中国专利文献上公开的“一种治疗风寒湿痹症的中药及其制备方法”，其公告号CN105770763A，其公开了一种治疗风寒湿痹症的中药及其制备方法，所述治疗风寒湿痹症的中药包括以下贴敷药剂：以重量份计，所述贴敷药剂包含以下原料组分：当归25～35份、莪术25～35份、香附8～12份、青风藤25～35份、川芎8～12份、桂枝25～35份、甘草8～12份、川乌25～35份、苦参8～12份、徐长卿8～12份、豕甲8～12份和远红外粉10～30份，该发明配方中不含对皮肤刺激性药物，增加护肤养肤抗过敏作用的中药，用于治疗风寒湿痹症，在减少或者免除皮肤反应的同时恢复皮肤的弹性、厚度，使皮肤柔软光洁，患者易于接受，提高依从性。然而，该发明中的贴敷药剂在使用时需要加热以增强敷贴的粘性，在环境温度较低时，膏药粘性下降，与皮肤的接触面积减少，并且敷在人体表面后，靠人体内部新陈代谢促使血液循环而发挥药效，以致发挥的药效有限。
发明内容
本发明为了克服上述问题，提出了一种发热效果好，持续时间长的自发热用于治疗风寒湿痹及筋脉拘挛的麝香宝珍膏。
为了实现上述目的，本发明采用以下技术方案：
一种治疗风寒湿痹及筋脉拘挛的麝香宝珍膏，依次包括基布层、隔绝层、发热层与膏药层，所述基布层为非织造布，所述隔绝层包括聚醚蜡，所述发热层制备包括以下组分且各组分的质量配比为：丙烯腈20-30份，聚乙二醇40-80份，硝酸铈铵6-10份，四乙基四氟硼酸铵60-330份，锌粉0.5-3.5份，活性炭0.1-0.55份，发热层用于与空气接触时产生热量，所述膏药层为中药涂覆层，其涂覆面积大于发热层，将发热层完全覆盖。
本发明的麝香宝珍膏将非织造布作为基布层，这是由于非织造布柔韧性高，透气性好，并且具有较大的强度，在基布层的外侧涂覆有聚醚蜡作为隔绝层，这是由于当环境温度较低时，聚醚蜡为固态，固态时若用手揉搓宝珍膏，会使得聚醚蜡发生皲裂，此时空气会通过裂缝而透过隔绝层，而当环境温度较高时，聚醚蜡会逐渐软化，此时原本存在于聚醚蜡中的裂缝会逐渐消失，此时空气无法透过聚醚蜡层，起到隔绝空气的效果，因此，隔绝层能够随着环境温度的变化，从而调节空气的透过率，发热层与空气中的氧气接触时，会发生反应从而产生热量，当发热层放出热量较多，导致膏药层和体感温度过高时，此时隔绝层中的聚醚蜡逐渐软化，隔绝了发热层与空气的接触，使发热层无法放热，当发热层放热较少，导致膏药层与体感温度较低时，此时可以揉搓绝热层中的聚醚蜡再次使其开裂，使得空气与发热层能够接触，从而继续放热，使得膏药层始终维持在一个适宜的温度范围。
使用时，加热宝珍膏中的膏药层，使之始终维持在一个适宜的温度范围，使得膏药层不但能够更容易更大限度地释放其药效，而且膏药层也不会由于过冷而失去粘性，导致与患者的皮肤脱落；并且，热量通过膏药层传递到患者的皮肤上，皮肤上的毛孔会受热舒张，使得药效能够更容易得被人体吸收。
作为优选，所述膏药层包括中药药膏和基质，所述中药药膏由以下重量份数的原料制成：麝香1-4份，芸香膏180-220份，乳香15-25份，没药15-25份，公丁香15-25份，荆芥100-120份，肉桂80-90份，甘松130-150份，独活90-110份，广陵香30-50份，五加皮30-50份，青皮30-50份，春花30-50份，排草30-50份，牡丹皮60-80份，桂枝10-30份，川芎15-25份，木香15-25份，大黄800-840份，细辛80-100份，片姜黄80-100份，山奈80-100份，白芷140-160份，胡椒40-55份，高良姜80-100份，当归50-75份，羌活50-75份，麻黄50-75份，防风50-75份，赤芍50-70份，地黄50-70份，玄参50-70份，黄精50-70份，黄芩50-70份，乌药50-70份，毛姜50-70份，官桂30-50份，马钱子20-40份；所述基质包括枸胶与松香。
使用上述药材制备得到的宝珍膏具有祛风除湿、温经散寒、活血行气、通痹止痛的功效，对于治疗风寒湿痹及筋脉拘挛腰疼痛具有较高的疗效。
作为优选，所述麝香宝珍膏的制备方法，包括以下制备步骤：
(1)将聚醚蜡在65-75℃下涂覆于非织造布上；
(2)将丙烯腈、聚乙二醇加入到去离子水中，在70-80℃下搅拌均匀，随后加入硝酸铈铵，在氩气的保护下，40-60℃反应8-13h，随后用去离子水洗涤，烘干得到聚(丙烯腈-乙二醇)嵌段共聚物；
(3)将聚(丙烯腈-乙二醇)嵌段共聚物溶于有机溶剂中，加入四乙基四氟硼酸铵、锌粉和活性炭，搅拌均匀，得到聚合物电解质溶液；
(4)将聚合物电解质溶液涂覆于聚醚蜡上，真空下挥发至干燥，得到发热层；
(5)将膏药层原料中除麝香、芸香膏外的原料碾碎成细粉，制成流浸膏，随后加入枸胶与松香组成的基质，随后再将麝香与芸香膏碾碎，加入其中，搅拌均匀后，涂覆在发热层上，并将发热层完全覆盖，得到膏药层，随后切段，盖衬，得到麝香宝珍膏成品。
本发明制备方法中，首先将聚醚蜡涂覆于基层非织造布上，得到隔绝层，在发热层的制备方法中，首先使用丙烯腈和聚乙二醇进行聚合，得到聚(丙烯腈-乙二醇)嵌段共聚物，随后，将聚(丙烯腈-乙二醇)嵌段共聚物溶于溶剂中，加入电解质盐四乙基四氟硼酸铵，混入锌粉和活性炭，得到了聚合物电解质溶液，将其涂覆在聚醚蜡上，真空烘干后得到自发热的凝胶聚合物电解质，其发热原理是当该凝胶聚合物电解质接触空气时，活性炭具有强大的空气吸附能力，在局部形成了大量的以锌粉作为负极的金属空气电池，金属空气电池产生短路电流后释放热量，并且，当其隔绝空气后，能够停止放热，实现热量的控制释放；在发热层涂覆之后，将各味中药制备成流浸膏，再加入枸胶与松香组成的基质和麝香与芸香膏，快速或在真空下涂覆于发热层上，并将发热层覆盖，使其与空气隔绝，随后切段，盖衬，得到麝香宝珍膏成品。
作为优选，所述丙烯腈与聚乙二醇的质量比为1:2-4。
作为优选，所述聚(丙烯腈-乙二醇)嵌段共聚物、有机溶剂和四乙基四氟硼酸铵的质量比为1:10-20:1-3。
体系中，四乙基四氟硼酸铵作为电解质盐，其含量不宜过大或过小，当其含量过小时，导电离子的数目较少，导致发热层中的凝胶聚合物电解质电导率降低，使发热效率和持续时间下降，而当四乙基四氟硼酸铵含量过大时，部分四乙基四氟硼酸铵在体系中结晶，阻碍了离子运动，同样降低了发热层中凝胶聚合物电解质的电导率，使发热效率和持续时间下降。
作为优选，步骤(3)中所述聚(丙烯腈-乙二醇)嵌段共聚物、锌粉和活性炭的质量比100:1-3:0.2-0.5。
在发热层凝胶聚合物电解质中，锌粉作为负极，若其含量过小，使得发热效率和持续时间下降，若其含量过大，会发热层的发热量过大，不宜控制，且容易导致宝珍膏使用完之后还在持续不必要的发热，增加了生产成本。
作为优选，步骤(3)中所述有机溶剂为N,N-二甲基甲酰胺或N,N-二甲基乙酰胺。
作为优选，步骤(4)中所述发热层的涂覆厚度为3-5mm。
因此，本发明具有如下有益效果：本发明通过将发热层设于隔绝层与膏药层之间，当温度较低时，可以通过揉搓等方式使得空气可以透过隔绝层从而与发热层接触并释放热量，当温度较高时，隔绝层会阻隔空气的流通，从而抑制发热层的放热，实现了热量的控释，延长了发热时间，使得宝珍膏的药效更持久，人体更易吸收，且不会由于过冷导致宝珍膏在皮肤上脱落。
具体实施方式
以下结合具体实施例对本发明方案进行更加清楚、完整地描述，显然所描述实施例仅为本发明一部分实施例，而不是全部实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明的保护范围。
实施例1：宝珍膏的制备包括以下步骤：
(1)将聚醚蜡在65℃下涂覆于非织造布上，聚醚蜡的涂覆厚度为3mm；
(2)将50g丙烯腈、100g聚乙二醇加入到去离子水中，在70℃下搅拌均匀，随后加入1.5g硝酸铈铵，在氩气的保护下，40℃反应13h，随后用去离子水洗涤，烘干得到聚(丙烯腈-乙二醇)嵌段共聚物；
(3)将20g聚(丙烯腈-乙二醇)嵌段共聚物溶于200gN,N-二甲基乙酰胺中，加入35g四乙基四氟硼酸铵、0.4g锌粉和0.04g活性炭，搅拌均匀，得到聚合物电解质溶液；
(4)将聚合物电解质溶液涂覆于聚醚蜡上，真空下挥发至干燥，得到1mm厚的发热层；
(5)取重量份数为麝香1份，芸香膏220份，乳香20份，没药15份，公丁香25份，荆芥110份，肉桂80份，甘松150份，独活100份，广陵香30份，五加皮50份，青皮40份，春花30份，排草50份，牡丹皮70份，桂枝10份，川芎25份，木香20份，大黄800份，细辛100份，片姜黄90份，山奈80份，白芷160份，胡椒50份，高良姜80份，当归75份，羌活60份，麻黄50份，防风75份，赤芍60份，地黄50份，玄参70份，黄精65份，黄芩50份，乌药70份，毛姜60份，官桂30份，马钱子40份作为膏药层原料，将膏药层原料中除麝香、芸香膏外的原料碾碎成细粉，制成流浸膏，随后加入枸胶与松香组成的基质，随后再将麝香与芸香膏碾碎，加入其中，搅拌均匀后，涂覆在发热层上，并将发热层完全覆盖，得到膏药层，随后切段，盖衬，得到麝香宝珍膏成品。
实施例2：宝珍膏的制备包括以下步骤：
(1)将聚醚蜡在75℃下涂覆于非织造布上，聚醚蜡的涂覆厚度为5mm；
(2)将50g丙烯腈、200g聚乙二醇加入到去离子水中，在70-80℃下搅拌均匀，随后加入2.5g硝酸铈铵，在氩气的保护下，60℃反应8h，随后用去离子水洗涤，烘干得到聚(丙烯腈-乙二醇)嵌段共聚物；
(3)将20g聚(丙烯腈-乙二醇)嵌段共聚物溶于400gN,N-二甲基甲酰胺中，加入20g四乙基四氟硼酸铵、0.2g锌粉和0.08g活性炭，搅拌均匀，得到聚合物电解质溶液；
(4)将聚合物电解质溶液涂覆于聚醚蜡上，真空下挥发至干燥，得到2mm厚的发热层；
(5)取重量份数为麝香2份，芸香膏180份，乳香25份，没药20份，公丁香15份，荆芥120份，肉桂85份，甘松130份，独活110份，广陵香40份，五加皮30份，青皮50份，春花40份，排草30份，牡丹皮80份，桂枝20份，川芎15份，木香25份，大黄820份，细辛80份，片姜黄100份，山奈90份，白芷140份，胡椒55份，高良姜90份，当归50份，羌活75份，麻黄60份，防风50份，赤芍70份，地黄60份，玄参50份，黄精70份，黄芩65份，乌药50份，毛姜70份，官桂40份，马钱子20份作为膏药层原料，将膏药层原料中除麝香、芸香膏外的原料碾碎成细粉，制成流浸膏，随后加入枸胶与松香组成的基质，随后再将麝香与芸香膏碾碎，加入其中，搅拌均匀后，涂覆在发热层上，并将发热层完全覆盖，得到膏药层，随后切段，盖衬，得到麝香宝珍膏成品。
实施例3：宝珍膏的制备包括以下步骤：
(1)将聚醚蜡在68℃下涂覆于非织造布上，聚醚蜡的涂覆厚度为4.5mm；
(2)将50g丙烯腈、150g聚乙二醇加入到去离子水中，在75℃下搅拌均匀，随后加入0.2g硝酸铈铵，在氩气的保护下，50℃反应10h，随后用去离子水洗涤，烘干得到聚(丙烯腈-乙二醇)嵌段共聚物；
(3)将20g聚(丙烯腈-乙二醇)嵌段共聚物溶于300gN,N-二甲基甲酰胺中，加入60g四乙基四氟硼酸铵、0.6g锌粉和0.1g活性炭，搅拌均匀，得到聚合物电解质溶液；
(4)将聚合物电解质溶液涂覆于聚醚蜡上，真空下挥发至干燥，得到3mm厚的发热层；
(5)取重量份数为麝香4份，芸香膏200份，乳香15份，没药25份，公丁香20份，荆芥100份，肉桂90份，甘松140份，独活90份，广陵香50份，五加皮40份，青皮30份，春花50份，排草40份，牡丹皮60份，桂枝30份，川芎20份，木香15份，大黄840份，细辛90份，片姜黄80份，山奈100份，白芷150份，胡椒40份，高良姜100份，当归70份，羌活50份，麻黄75份，防风65份，赤芍50份，地黄70份，玄参60份，黄精50份，黄芩70份，乌药60份，毛姜50份，官桂50份，马钱子30份作为膏药层原料，将膏药层原料中除麝香、芸香膏外的原料碾碎成细粉，采用渗滤法制成比重为1.4的流浸膏，随后加入3.7倍枸胶与松香组成的基质，随后再将原料中的麝香与芸香膏碾碎，加入其中，搅拌均匀后，涂覆在发热层上，并将发热层完全覆盖，得到膏药层，随后切段，盖衬，得到麝香宝珍膏成品。
宝珍膏含膏量测定方法：将精密称定质量后的宝珍膏成品放入有盖玻璃仪器中，加入正己烷直至浸没，浸泡2-4小时后取出，再采用正己烷洗涤三次，将洗涤后的宝珍膏置于105℃下干燥0.5h，随后冷却，精密称定重量，计算减少的质量，按面积计算含膏量，其中含膏量在1.7g/100cm2以上符合药品检验要求。
含膏量(g/100cm<sup>2</sup>)
实施例1 1.85
实施例2 2.03
实施例3 1.98
以上三个实施例的含膏量均大于1.7g/100cm2，因此均符合药品检验要求。
对比例1：与实施例1的区别在于，步骤(3)中四乙基四氟硼酸铵的添加量为10g，聚(丙烯腈-乙二醇)嵌段共聚物与四乙基四氟硼酸铵的质量比为1:0.5。
对比例2：与实施例1的区别在于，步骤(3)中四乙基四氟硼酸铵的添加量为50g，聚(丙烯腈-乙二醇)嵌段共聚物与四乙基四氟硼酸铵的质量比为1:5。
对比例3：与实施例1的区别在于，步骤(3)中锌粉的添加量为0.1g，聚(丙烯腈-乙二醇)嵌段共聚物与锌粉的质量比为200:1。
将与实施例1和对比例1、2、3中宝珍膏的发热层置于20℃环境下中，测量膏药层高于30℃的持续时间，结果如下表所示。
持续时间
实施例1 51h
对比例1 23h
对比例2 28h
对比例3 20h
如上表持续时间可知，四乙基四氟硼酸铵的使用量过高或过低，均将降低宝珍膏的发热持续时间，并且，当锌粉的使用量过低时，宝珍膏的发热持续时间也将下降。

Claims (7)

1.一种治疗风寒湿痹及筋脉拘挛的麝香宝珍膏，其特征在于，麝香宝珍膏依次包括基布层、隔绝层、发热层与膏药层，所述基布层为非织造布，所述隔绝层包括聚醚蜡，所述发热层制备包括以下组分且各组分的质量配比为：丙烯腈20-30份，聚乙二醇40-80份，硝酸铈铵6-10份，四乙基四氟硼酸铵60-330份，锌粉0.5-3.5份，活性炭0.1-0.55份，发热层用于与空气接触时产生热量，所述膏药层为中药涂覆层，其涂覆面积大于发热层，将发热层完全覆盖；
所述膏药层包括中药药膏和基质，所述中药药膏由以下重量份数的原料制成：麝香1-4份，芸香膏180-220份，乳香15-25份，没药15-25份，公丁香15-25份，荆芥100-120份，肉桂80-90份，甘松130-150份，独活90-110份，广陵香30-50份，五加皮30-50份，青皮30-50份，春花30-50份，排草30-50份，牡丹皮60-80份，桂枝10-30份，川芎15-25份，木香15-25份，大黄800-840份，细辛80-100份，片姜黄80-100份，山奈80-100份，白芷140-160份，胡椒40-55份，高良姜80-100份，当归50-75份，羌活50-75份，麻黄50-75份，防风50-75份，赤芍50-70份，地黄50-70份，玄参50-70份，黄精50-70份，黄芩50-70份，乌药50-70份，毛姜50-70份，官桂30-50份，马钱子20-40份；所述基质包括柏胶与松香；
所述治疗风寒湿痹及筋脉拘挛的麝香宝珍膏的制备方法包括以下步骤：
（1）将聚醚蜡在65-75℃下涂覆于非织造布上；
（2）将丙烯腈、聚乙二醇加入到去离子水中，在70-80℃下搅拌均匀，随后加入硝酸铈铵，在氩气的保护下，40-60℃反应8-13h，随后用去离子水洗涤，烘干得到聚（丙烯腈-乙二醇）嵌段共聚物；
（3）将聚（丙烯腈-乙二醇）嵌段共聚物溶于有机溶剂中，加入四乙基四氟硼酸铵、锌粉和活性炭，搅拌均匀，得到聚合物电解质溶液；所述聚（丙烯腈-乙二醇）嵌段共聚物和四乙基四氟硼酸铵的质量比为1:1-3；所述聚（丙烯腈-乙二醇）嵌段共聚物和锌粉的质量比为100:1-3；
（4）将聚合物电解质溶液涂覆于聚醚蜡上，真空下挥发至干燥，得到发热层；
（5）将膏药层原料中除麝香、芸香膏外的原料碾碎成细粉，制成流浸膏，随后加入柏胶与松香组成的基质，随后再将麝香与芸香膏碾碎，加入其中，搅拌均匀后，涂覆在发热层上，并将发热层完全覆盖，得到膏药层，随后切段，盖衬，得到麝香宝珍膏成品。
2.根据权利要求1所述的一种治疗风寒湿痹及筋脉拘挛的麝香宝珍膏，其特征在于，步骤（1）中所述聚醚蜡的涂覆厚度为3-5mm。
3.根据权利要求1所述的一种治疗风寒湿痹及筋脉拘挛的麝香宝珍膏，其特征在于，步骤（2）中所述丙烯腈与聚乙二醇的质量比为1:2-4。
4.根据要求3所述的一种治疗风寒湿痹及筋脉拘挛的麝香宝珍膏，其特征在于，步骤（3）中所述聚（丙烯腈-乙二醇）嵌段共聚物、有机溶剂和四乙基四氟硼酸铵的质量比为1:10-20:1-3。
5.根据要求1所述的一种治疗风寒湿痹及筋脉拘挛的麝香宝珍膏，其特征在于，步骤（3）中所述聚（丙烯腈-乙二醇）嵌段共聚物、锌粉和活性炭的质量比为100:1-3:0.2-0.5。
6.根据权利要求1或4所述的一种治疗风寒湿痹及筋脉拘挛的麝香宝珍膏，其特征在于，步骤（3）中所述有机溶剂为N,N-二甲基甲酰胺或N,N-二甲基乙酰胺。
7.根据权利要求1所述的一种治疗风寒湿痹及筋脉拘挛的麝香宝珍膏，其特征在于，步骤（4）中所述发热层的涂覆厚度为1-3mm。
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CN1834194A (zh) * 2006-04-12 2006-09-20 刘永录 一种与空气接触后释热的复合物
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CN1834194A (zh) * 2006-04-12 2006-09-20 刘永录 一种与空气接触后释热的复合物
CN201658464U (zh) * 2010-03-19 2010-12-01 雷强 新型自发热外用贴剂
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