CN112121086A - 一种用于透药治疗的中药酊剂及其制备方法 - Google Patents

一种用于透药治疗的中药酊剂及其制备方法 Download PDF

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CN112121086A
CN112121086A CN202011083456.0A CN202011083456A CN112121086A CN 112121086 A CN112121086 A CN 112121086A CN 202011083456 A CN202011083456 A CN 202011083456A CN 112121086 A CN112121086 A CN 112121086A
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郭翠
赵新红
郭燕舞
刘运林
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Abstract

本发明涉及中药，特别是一种用于透药治疗的中药酊剂及其制备方法。按重量比，各组分如下：川乌：草乌：秦艽：防风：当归：鸡血藤：五加皮：细辛：冰片：独活：桂枝：大黄：黄芩：乳香：没药＝2：2：2：2：2：4：2：1：1：2：1：1：1：2：2。中药酊剂的处方根据多年治疗腰椎间盘突出症的经验总结出来的，配伍合理全面，临床疗效佳；中药酊剂的配置方法操作简单，避免了部分中药（川乌、草乌）内服的毒副作用。

Description

一种用于透药治疗的中药酊剂及其制备方法
技术领域
本发明涉及中药，特别是一种用于透药治疗的中药酊剂及其制备方法。
背景技术
中医定向药透治疗（简称透药治疗）是一项融合了中频药物导入技术、中频仿生按摩技术及热磁技术，通过局部透皮输送和直流电作用将中药离子透入人体深部组织，从而发挥改善微循环、疏经通络、消炎镇痛、缓解疼痛等作用，达到治疗疾病的目的，临床上主要用于各类痹症的治疗。
在中医理论中,痹症是由于风、寒、湿、热等外邪侵袭人体，致使气血运行不畅，经络痹阻，引起以肌肉、筋骨、关节发生酸痛、麻木、重着、屈伸不利，甚或关节肿大灼热等为主要临床表现的病症。治疗上应以祛邪、通络、止痛为基本原则。
目前市面上中医定向透药主要采用以下几种药物组方：
1）统一的带有药物提取物的专用电极片（中药贴）贴于患者疼痛部位。专用电极片（中药贴）由透骨草、艾绒、田七、金银花、伸筋草、川芎、细辛、菊花、莲花、藏红花、当归、苍术、桑枝、白芷、丹参、红花等20多种草本植物提取液精制而成。
2）药透治疗贴（北京某公司生产）治疗。药透治疗贴药物组成：穿山甲、红花、川芎、当归、延胡索、威灵仙、透骨草、肉桂、丁香、乌药、徐长卿。
3）使用舒筋止痛水，由怀牛膝、当归、红花、樟脑、五加皮、三七粉等中药材经加工后制成。
4）以患处痛点为中心,上铺2层3 cm×10 cm纱布为衬垫,喷上某公司的云南白药气雾剂,以纱布湿而不淌为度,用北京某公司的电脑中频治疗仪,3 cm×10 cm电极为主电极置于棉质衬垫上。
以上各种透药治疗贴的药物方中，草本植物精华的透药治疗贴，田七、红花、莲花、藏红花价格相对高，临床上外用性价比不高，而且中药精华液提取操作相对酊剂的配置难度大；北京某公司生产的透药治疗贴适应于风寒湿痹患者；舒筋止痛水适合于跌打损伤、颈椎病、腰椎肩盘突出症以及肩周炎、腰肌劳损等风寒湿痹症；云南白药气雾剂仅适用于跌打损伤引起的疼痛。
发明内容
本发明的目的在于提供一种用于透药治疗的中药酊剂及其制备方法。
本发明的目的是通过如下途径实现的：一种用于透药治疗的中药酊剂，按重量比，各组分如下：川乌：草乌：秦艽：防风：当归：鸡血藤：五加皮：细辛：冰片：独活：桂枝：大黄：黄芩：乳香：没药＝2：2：2：2：2：4：2：1：1：2：1：1：1：2：2。
一种用于透药治疗的中药酊剂的制备方法，其制备步骤如下：取川乌5g、草乌5g、秦艽5g、防风5g、当归5g、鸡血藤10g、五加皮5g、细辛2.5g、冰片2.5g、独活5g、桂枝2.5g、大黄2.5g、黄芩2.5g、乳香5g、没药5g，共计67.5g，将上述药材研磨打粉成85目，装在纱布袋中，加入到500ml75%酒精中，密封浸泡一个月；
作为本方案的进一步优化，使用前用500ml灭菌注射用水稀释备用。
本发明一种用于透药治疗的中药酊剂及其制备方法，与现有技术比较，具有如下特点：
1）从组方分析：组方适应症广，对于痹症效果佳，而且配合全面合理。川乌、草乌、秦艽、独活，祛风除湿、舒筋止痛；鸡血藤、五加皮、当归，补血养血、舒筋活络；黄芩、大黄、冰片，清热燥湿止痛；防风、细辛、桂枝，祛风解表散寒，温通经络；乳香、没药，活血化瘀、消肿止痛。
2）从酊剂配置分析：采用酒精做溶剂，有利于中药中有效成分的浸出；有利于提高中药中有效活性成分的生物利用度；有利于提高药效；使用定向透药仪器，透皮效果更好。
3）从临床效果分析：从我院临床治疗情况来看，平均一台中医定向药透治疗仪使用量为40人次/天左右，均为颈肩腰腿痛患者。以膝关节为例，风寒湿痹和风湿热痹患者各50例，使用该中药酊剂7次后，47例风寒湿痹患者，38例风湿热痹患者NRS疼痛评分均由中、重度转为轻度疼痛；同比其他治疗，患者舒适度和治疗满意度都明显提高。
4）配置成本低，操作简单，符合中药传统制剂的制作优势，低投入，高产出。以上单剂量中药酊剂的配置成本约为：中草药11.46元+灭菌注射用水500ml2.2元+75%酒精500ml8.7元＝24.55元，即可配置30~40人次的透药贴，平均成本0.613~0.818元/对。市面上的药透治疗帖均与中医定向透药治疗仪捆绑消费，平均20元/对，成本高。
综上所述，从组方配伍、治疗适应症、临床治疗效果、配置方法、产品成本等方面综合考虑，相比其他透药治疗贴，本中药酊剂的应用具有一定的优势。
具体实施方式
本发明一种用于透药治疗的中药酊剂，按重量比，各组分如下：川乌：草乌：秦艽：防风：当归：鸡血藤：五加皮：细辛：冰片：独活：桂枝：大黄：黄芩：乳香：没药＝2：2：2：2：2：4：2：1：1：2：1：1：1：2：2。
一种用于透药治疗的中药酊剂的制备方法，其制备步骤如下：取川乌5g、草乌5g、秦艽5g、防风5g、当归5g、鸡血藤10g、五加皮5g、细辛2.5g、冰片2.5g、独活5g、桂枝2.5g、大黄2.5g、黄芩2.5g、乳香5g、没药5g，共计67.5g，将上述药材研磨打粉成85目，装在纱布袋中，加入到500ml75%酒精中，密封浸泡一个月，使用前用500ml灭菌注射用水稀释备用。
药物成分 作用
川乌、草乌、细辛 善于祛风湿、温经止痛，有明显止痛作用
秦艽、独活 祛风除湿、舒筋止痛
防风 祛风解表、胜湿止痛，誉为祛风的圣药
鸡血藤、五加皮、当归 舒筋活络，补血又活血
乳香、没药 活血化瘀、消肿止痛，也适用于外伤后局部肿胀疼痛
黄芩、大黄、冰片 配伍反佐，避免君药过燥，减轻对皮肤的刺激；大黄中的成分还能促进软组织修复；冰片则增加患者透皮的感觉
组方适应症广，主要适合于风寒痹症（行痹、着痹、痛痹），起到祛风除湿、散寒止痛、活血化瘀的作用；对于风湿热痹患者也能起到一定的作用。
使用方法：将上述中药酊剂进行过滤，舍去药渣，把10cm*8cm的8层纱布块浸泡药水后使用拧干备用，替代市面上的专用电极片，用于中医定向药透的治疗。此外也可根据不同型号的中医定向药透仪器，制作符合相应电极片大小的透药纱布贴。
本发明涉及中药，特别是一种用于透药治疗的中药酊剂及其制备方法。按重量比，各组分如下：川乌：草乌：秦艽：防风：当归：鸡血藤：五加皮：细辛：冰片：独活：桂枝：大黄：黄芩：乳香：没药＝2：2：2：2：2：4：2：1：1：2：1：1：1：2：2。中药酊剂的处方根据多年治疗腰椎间盘突出症的经验总结出来的，配伍合理全面，临床疗效佳；中药酊剂的配置方法操作简单，避免了部分中药（川乌、草乌）内服的毒副作用。

Claims (3)

1.一种用于透药治疗的中药酊剂，其特征在于：按重量比，各组分如下：川乌：草乌：秦艽：防风：当归：鸡血藤：五加皮：细辛：冰片：独活：桂枝：大黄：黄芩：乳香：没药＝2：2：2：2：2：4：2：1：1：2：1：1：1：2：2。
2.一种用于透药治疗的中药酊剂制备方法，其特征在于：其制备步骤如下：取川乌5g、草乌5g、秦艽5g、防风5g、当归5g、鸡血藤10g、五加皮5g、细辛2.5g、冰片2.5g、独活5g、桂枝2.5g、大黄2.5g、黄芩2.5g、乳香5g、没药5g，共计67.5g，将上述药材研磨打粉成85目，装在纱布袋中，加入到500ml75%酒精中，密封浸泡一个月。
3.如权利要求2所示的一种用于透药治疗的中药酊剂制备方法，其特征在于：在使用前用500ml灭菌注射用水稀释。
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