CN102406870A - 一种治疗风湿痹痛的药物 - Google Patents
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Abstract
一种治疗风湿痹痛的药物，取精选、清水洗净的三七、红花、川牛膝、杜仲、防风、麻黄、威灵仙、当归、薏苡仁、黄藤、龟甲胶、鹿角胶、木瓜、杏仁、桃仁、天南星、半夏、水蛭、白花蛇、透骨草、土鳖虫、血竭、穿山甲、炙甘草、醋制附子、海马、全蝎、蜈蚣混合均匀，粉碎成100～120目的药粉，药粉加蜜起模、成型，灭菌消毒制得丸剂产品。本发明药物具有通经活络、搜风剔骨、滋补肝肾、强筋健体的功效，可用于风湿痹痛的治疗，具有疗效确切可靠，愈后不易复发的特点。临床观察其有效率为87.2%。
Description
技术领域
本发明涉及一种治疗风湿痹痛的药物，特别是涉及一种以中药为原料药制备的治疗风湿痹痛的中药。
背景技术
风湿痹痛是指因外邪侵袭肢体经脉而致肢节疼痛、麻木、肿大变形、屈伸不利的病症。常见的有风湿、类风湿性关节炎，强直性脊椎炎、创伤性关节炎、慢性肩周炎、坐骨神经痛、慢性腰肌劳损，颈、腰椎骨质增生症、腰椎间盘突出症、椎间孔狭窄症、妇女产后中风等。临床上具有渐进性、缠绵难愈、反复发作的特点，是一种治疗上颇为棘手的常见病和多发病，是一种极大地危害劳动人民身心健康的慢性疾病。
风湿痹痛传统的治疗方法主要分二大类：以理疗、针灸、牵引、封闭为主的治疗，只能一时缓解症状，而不能彻底根治；以口服激素及免疫抑制剂为主的治疗，副作用大，长期服用破坏人体免疫功能。
发明内容
本发明的目的是提供一种用于治疗风湿痹痛的药物，该药物由中药组成具有通经活络、搜风剔骨、滋补肝肾、强筋健体的功效，对风湿痹痛的治疗可以起到疗效确切可靠，愈后不易复发的目的。
本发明的药物是由以下重量份数的中药为原料药制备获得的：
三 七 14～22 红 花 11～17 川牛膝 11～17 杜 仲 11～17
防 风 11～17 麻 黄 11～17 威灵仙 11～17 当 归 11～17
薏苡仁 11～17 黄 藤 11～17 龟甲胶 11～17 鹿角胶11～17
木 瓜 11～17 杏 仁 9～15 桃 仁 9～15 天南星 9～15
半 夏 9～15 水 蛭 9～15 白花蛇 9～15 透骨草 9～15
土鳖虫 7～11 血 竭 7～11 穿山甲 7～11 炙甘草 7～11
醋制附子 5～9 海 马 5～ 9 全 蝎 5～ 9 蜈 蚣 9～15。
优选的，本发明的药物是由以下重量份数的中药为原料药制备获得的：
三 七 18 红 花 14 川牛膝 14 杜 仲 14
防 风 14 麻 黄 14 威灵仙 14 当 归 14
薏苡仁 14 黄 藤 14 龟甲胶 14 鹿角胶 14
木 瓜 14 杏 仁 12 桃 仁 12 天南星 12
半 夏 12 水 蛭 12 白花蛇 12 透骨草 12
土鳖虫 9 血 竭 9 穿山甲 9 炙甘草 9
醋制附子 7 海 马 7 全 蝎 7 蜈 蚣 12。
可以将上述药物制成药剂学上的任何一种剂型，如片剂、丸剂、散剂、胶囊剂等，本发明优选的剂型是丸剂。
将本发明药物制成丸剂的具体制备方法是：
将上述药物按所述重量份数混合均匀，粉碎成100～120目的药粉，按照常规方法药粉加蜜起模、成型，灭菌消毒制得丸剂产品。
中医中的风湿痹痛，相当于现代医学的风湿性关节炎、类风湿关节炎。祖国医学认为：“不通则痛”，是指气血经络不通则疼痛，风湿痹痛突出的一个表现就是痛，所以治疗上首先要通经活络；同时中医认为“风、寒、湿三气杂至，合而为痹也”，盖痹者闭也，以气血为邪所闭，不得通行而病也。故宜行气活血，且攻闭必重通也。邪者，风、寒、湿三气也。风为百病之长，风性善行而易变，反映在病人身上就是关节疼痛游走不定，此起彼伏；寒属阴性，为阴邪，透骨侵肌，反映在病人身上多形寒肢冷，衣着厚重，不能接触寒凉，秋冬寒冷季节加重；湿，水气郁结为湿，因此大部分风湿痹痛患者害怕接触水，尤其是冷水凉水，所以治疗上要搜风剔骨，剔去侵入骨中的风寒湿邪。又由于风湿痹痛具有缠绵难愈的特点，所以治疗上还应该滋补肝肾、强筋健骨，肝主筋，肾主骨，滋补肝肾则能扶正祛邪，防止病痛反复发作。本组方中，三七止血散瘀、消肿止痛；红花活血通经、祛瘀止痛；川牛膝祛风利湿、通经散血；杜仲补肝肾、强筋骨；防风祛风解表，胜湿止痛；麻黄发汗散寒、利水消肿；威灵仙祛风湿、通经络；当归补血活血，调经止痛；薏苡仁利水消肿，舒筋除痹；黄藤利水消肿；龟甲胶滋阴补血；鹿角胶温补肝肾；木瓜平肝和胃、去湿舒筋；杏仁祛痰止咳、润肠；桃仁活血祛瘀；天南星祛风止痉、散结消肿；半夏燥湿化痰、消痞散结；水蛭破血逐瘀、通经；白花蛇祛风湿、透筋骨；透骨草祛风除湿、舒筋活血、止痛；土鳖虫破瘀血、续筋骨；血竭散瘀定痛、止血生肌；穿山甲消肿溃痈、搜风活络、通经；炙甘草补脾和胃、益气复脉、中和药性；醋制附子回阳救逆、补火助阳；海马补肾壮阳、调气活血；全蝎逐湿除风、息风通络；蜈蚣功毒散结、通络止痛。诸药合用，通经活络、搜风剔骨、滋补肝肾、强筋健体，用于风湿痹痛的治疗，具有疗效确切可靠，愈后不易复发的特点。
为进一步考察本发明药物的临床疗效和安全性，选择94例风湿痹痛患者对本发明药物的疗效进行了临床观察。
94例风湿痹痛患者，男30例，女64例，年龄18～70岁，平均45岁；病程一周～20年，上肢关节疼痛40例，下肢关节疼痛54例。
诊断标准根据《中医病症诊疗标准》风湿痹的诊断依据：1、以四肢大关节走串疼痛为主，伴重着、酸楚、麻木、关节屈伸不利，多有恶寒、发热症状；2病前多有咽痛乳蛾史，或涉水淋雨，久居湿地史；3部分患者可有低热，四肢环形红斑，或结节性红斑。常可心脏受累；4血沉增快，抗链球菌溶血素“0”大于500单位。
治疗方法：服用本发明丸剂产品，每日一次，一次1/3～2/3丸（每丸有效成分9克）（根据年龄、性别情况确定具体服用标准），3个月为一疗程。
疗效标准根据《中药治疗痹症的临床研究指导原则》，参照《痹症论治学》、《类风湿关节炎》有关内容拟定，分为治愈、好转、未愈。
治愈：症状消失，关节活动正常，实验室检查正常，1年内未复发。
好转：症状明显好转，实验室检查有改善。
无效：症状和实验室检查无进步。
统计治疗结果为，治愈77例，好转5例，无效12例，总有效率87.2%。
临床疗效观察结果证明，本发明药物治疗风湿痹痛标本兼治，具有确切效果和不反复的特点，近期与远期疗效均明显优于吲哚美辛等非甾体抗炎西药，无任何毒副作用。
具体实施方式
实施例1
取精选、清水洗净的三七140g、红花110g、川牛膝110g、杜仲110g、防风110g、麻黄110g、威灵仙110g、当归110g、薏苡仁110g、黄藤110g、龟甲胶110g、鹿角胶110g、木瓜110g、杏仁90g、桃仁90g、天南星90g、半夏90g、水蛭 90g、白花蛇90g、透骨草90g、土鳖虫70g、血竭70g、穿山甲70g、炙甘草70g、醋制附子50g、海马50g、全蝎50g、蜈蚣90g混合均匀，粉碎成100～120目的药粉，药粉加蜜起模、成型，灭菌消毒制得丸剂产品。
实施例2
取精选、清水洗净的三七220g、红花170g、川牛膝170g、杜仲170g、防风170g、麻黄170g、威灵仙170g、当归170g、薏苡仁170g、黄藤170g、龟甲胶170g、鹿角胶170g、木瓜170g、杏仁150g、桃仁150g、天南星150g、半夏150g、水蛭 150g、白花蛇150g、透骨草150g、土鳖虫110g、血竭110g、穿山甲110g、炙甘草110g、醋制附子90g、海马90g、全蝎90g、蜈蚣150g混合均匀，粉碎成100～120目的药粉，药粉加蜜起模、成型，灭菌消毒制得丸剂产品。
实施例3
取精选、清水洗净的三七180g、红花140g、川牛膝140g、杜仲140g、防风140g、麻黄140g、威灵仙140g、当归140g、薏苡仁140g、黄藤140g、龟甲胶140g、鹿角胶140g、木瓜140g、杏仁120g、桃仁120g、天南星120g、半夏120g、水蛭 120g、白花蛇120g、透骨草120g、土鳖虫90g、血竭90g、穿山甲90g、炙甘草90g、醋制附子70g、海马70g、全蝎70g、蜈蚣120g混合均匀，粉碎成100～120目的药粉，药粉加蜜起模、成型，灭菌消毒制得丸剂产品。
Claims (3)
1.一种治疗风湿痹痛的药物，是由下述重量份数的中药为原料药制备获得的：
三 七 14～22 红 花 11～17 川牛膝 11～17 杜 仲 11～17
防 风 11～17 麻 黄 11～17 威灵仙 11～17 当 归 11～17
薏苡仁 11～17 黄 藤 11～17 龟甲胶 11～17 鹿角胶11～17
木 瓜 11～17 杏 仁 9～15 桃 仁 9～15 天南星 9～15
半 夏 9～15 水 蛭 9～15 白花蛇 9～15 透骨草 9～15
土鳖虫 7～11 血 竭 7～11 穿山甲 7～11 炙甘草 7～11
醋制附子 5～9 海 马 5～ 9 全 蝎 5～ 9 蜈 蚣 9～15。
2.根据权利要求1所述的治疗风湿痹痛的药物，是由下述重量份数的中药为原料药制备获得的：
三 七 18 红 花 14 川牛膝 14 杜 仲 14
防 风 14 麻 黄 14 威灵仙 14 当 归 14
薏苡仁 14 黄 藤 14 龟甲胶 14 鹿角胶 14
木 瓜 14 杏 仁 12 桃 仁 12 天南星 12
半 夏 12 水 蛭 12 白花蛇 12 透骨草 12
土鳖虫 9 血 竭 9 穿山甲 9 炙甘草 9
醋制附子 7 海 马 7 全 蝎 7 蜈 蚣 12。
3.根据权利要求1或2所述的治疗风湿痹痛的药物，其特征是将所述药物制成丸剂。
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| CN102641348A (zh) * | 2012-05-14 | 2012-08-22 | 柴玉华 | 通络祛痛散及其制备方法 |
| CN103028022A (zh) * | 2012-12-23 | 2013-04-10 | 丁常燕 | 一种治疗痹症的中药组合物 |
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| CN1400007A (zh) * | 2002-06-10 | 2003-03-05 | 郭好建 | 一种治疗骨关节疾病的口服中药 |
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| CN102641348A (zh) * | 2012-05-14 | 2012-08-22 | 柴玉华 | 通络祛痛散及其制备方法 |
| CN102641348B (zh) * | 2012-05-14 | 2013-09-25 | 柴玉华 | 通络祛痛散及其制备方法 |
| CN103028022A (zh) * | 2012-12-23 | 2013-04-10 | 丁常燕 | 一种治疗痹症的中药组合物 |
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