CN109302846B - 吲哚啉酮化合物及其在纤维化疾病治疗中的用途 - Google Patents
吲哚啉酮化合物及其在纤维化疾病治疗中的用途 Download PDFInfo
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- CN109302846B CN109302846B CN201680082097.2A CN201680082097A CN109302846B CN 109302846 B CN109302846 B CN 109302846B CN 201680082097 A CN201680082097 A CN 201680082097A CN 109302846 B CN109302846 B CN 109302846B
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- phenyl
- amino
- methylene
- methyl
- oxoindoline
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Otolaryngology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15202764.5 | 2015-12-24 | ||
| EP15202764 | 2015-12-24 | ||
| PCT/GB2016/054069 WO2017109513A1 (en) | 2015-12-24 | 2016-12-23 | Indolinones compounds and their use in the treatment of fibrotic diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109302846A CN109302846A (zh) | 2019-02-01 |
| CN109302846B true CN109302846B (zh) | 2021-05-11 |
Family
ID=55068868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680082097.2A Expired - Fee Related CN109302846B (zh) | 2015-12-24 | 2016-12-23 | 吲哚啉酮化合物及其在纤维化疾病治疗中的用途 |
Country Status (30)
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|---|---|
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| EP (2) | EP3722291B1 (enExample) |
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| CN (1) | CN109302846B (enExample) |
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| BR (1) | BR112018013033A2 (enExample) |
| CA (1) | CA3009778A1 (enExample) |
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| HR (1) | HRP20230833T1 (enExample) |
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| WO (1) | WO2017109513A1 (enExample) |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2909316T3 (es) | 2015-12-24 | 2022-05-06 | Univ California | Reguladores de CFTR y métodos de uso de los mismos |
| JP7039480B2 (ja) * | 2016-03-08 | 2022-03-22 | レスピバート・リミテツド | プロテインキナーゼ阻害剤としてのインドール誘導体およびそれらの使用 |
| KR20200044873A (ko) | 2017-08-24 | 2020-04-29 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 안구 제약학적 조성물 |
| CN109678810B (zh) * | 2019-01-23 | 2022-10-28 | 南京工业大学 | 一种1,2-氧氮杂环丁烷类化合物及其制备方法与应用 |
| EP4061373A4 (en) * | 2019-11-20 | 2023-11-15 | Angion Biomedica Corp. | METHOD FOR TREATING INFLAMMATORY BOWEL DISEASE |
| CN111789842B (zh) * | 2020-08-07 | 2021-09-21 | 南开大学 | 尼达尼布在制备用于治疗炎症性肠病的药物中的应用 |
| KR102739882B1 (ko) * | 2021-04-02 | 2024-12-06 | 연세대학교 원주산학협력단 | 로베글리타존을 유효성분으로 하는 안과질환 치료용 조성물 |
| CN113200936B (zh) * | 2021-05-19 | 2022-10-21 | 南京工业大学 | 10-甲基吩噁嗪衍生物、其锆金属有机框架材料及制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1509270A (zh) * | 2001-04-06 | 2004-06-30 | ���ָ��Ӣ��ķ�������Ϲ�˾ | 在6-位取代的吲哚满酮,其制法及其作为激酶抑制剂的用途 |
| WO2006067168A1 (en) * | 2004-12-24 | 2006-06-29 | Boehringer Ingelheim International Gmbh | Medicaments for the treatment or prevention of fibrotic diseases |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA75054C2 (uk) | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу |
| JP2004182726A (ja) | 2002-11-22 | 2004-07-02 | Yamanouchi Pharmaceut Co Ltd | ２−オキソインドリン誘導体 |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| CA2602389A1 (en) | 2005-07-13 | 2007-01-18 | Allergan, Inc. | Kinase inhibitors |
| EP2303841A1 (en) | 2008-07-14 | 2011-04-06 | Gilead Sciences, Inc. | Oxindolyl inhibitor compounds |
| JP7039480B2 (ja) | 2016-03-08 | 2022-03-22 | レスピバート・リミテツド | プロテインキナーゼ阻害剤としてのインドール誘導体およびそれらの使用 |
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- 2016-12-23 CN CN201680082097.2A patent/CN109302846B/zh not_active Expired - Fee Related
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2018
- 2018-06-24 IL IL260221A patent/IL260221A/en unknown
- 2018-06-25 CL CL2018001742A patent/CL2018001742A1/es unknown
- 2018-07-23 ZA ZA201804950A patent/ZA201804950B/en unknown
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2023
- 2023-09-18 CY CY20231100500T patent/CY1126258T1/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1509270A (zh) * | 2001-04-06 | 2004-06-30 | ���ָ��Ӣ��ķ�������Ϲ�˾ | 在6-位取代的吲哚满酮,其制法及其作为激酶抑制剂的用途 |
| WO2006067168A1 (en) * | 2004-12-24 | 2006-06-29 | Boehringer Ingelheim International Gmbh | Medicaments for the treatment or prevention of fibrotic diseases |
Non-Patent Citations (2)
| Title |
|---|
| Design, Synthesis, and Evaluation of Indolinones as Inhibitors of the Transforming Growth Factor;Gerald J. Roth等;《J.Med.Chem.》;20100410;第53卷(第20期);第7287–7295页 * |
| Design, Synthesis, and Evaluation of Indolinones as Triple Angiokinase Inhibitors and the Discovery of a;Gerald J. Roth等;《J. Med. Chem.》;20091206;第52卷(第14期);第4466–4480页 * |
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