CN109289022A - 一种抑制结直肠腺瘤的药物配方 - Google Patents

一种抑制结直肠腺瘤的药物配方 Download PDF

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CN109289022A
CN109289022A CN201811360867.2A CN201811360867A CN109289022A CN 109289022 A CN109289022 A CN 109289022A CN 201811360867 A CN201811360867 A CN 201811360867A CN 109289022 A CN109289022 A CN 109289022A
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pharmaceutical formulation
radix codonopsis
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孙燕来
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Shandong Institute of Cancer Prevention and Treatment
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Shandong Institute of Cancer Prevention and Treatment
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Abstract

本发明公开了一种抑制结直肠腺瘤的药物配方，包括路党参、白花蛇舌草、鳖甲、白术、乌梅、黄芪、黑枸杞、黄连、炮姜、海藻、薏苡仁、桑黄、仙鹤草、黄精和山慈菇。与现有技术相比，本发明能够抑制结直肠腺瘤的生长，具有显著的抗实体瘤和细胞瘤的活性，并且本发明的药味缺一不可，是一个科学的配方，具有推广应用的价值。

Description

一种抑制结直肠腺瘤的药物配方
技术领域
本发明涉及药物技术领域，尤其涉及一种抑制结直肠腺瘤的药物配方。
背景技术
结直肠腺瘤是起源于结直肠黏膜腺上皮的良性肿瘤，包括结肠腺瘤与直肠腺瘤，是常见的肠道良性肿瘤。因与大肠癌的发生关系密切，被认为是一种癌前病变。不同地区、不同年龄的发病率差别很大，40岁以下的发病率低，60岁以上较高，男女无明显差别。现有技术中，未见抑制结直肠腺瘤的药物，大多采用手术摘除，既不能根除，也增加了患者的痛苦，因此，存在改进空间。
发明内容
本发明的目的就在于为了解决上述问题而提供一种抑制结直肠腺瘤的药物配方。
本发明通过以下技术方案来实现上述目的：
本发明包括路党参、白花蛇舌草、鳖甲、白术、乌梅、黄芪、黑枸杞、黄连、炮姜、海藻、薏苡仁、桑黄、仙鹤草、黄精和山慈菇。
优选的，按重量比，每份含所述路党参5％、所述白花蛇舌草1％、所述鳖甲3％、所述白术3％、所述乌梅54％、所述黄芪3％、所述黑枸杞5％、所述黄连1％、所述炮姜2％、所述海藻2％、所述薏苡仁4％、所述桑黄5％、所述仙鹤草3％、所述黄精3％、所述山慈菇6％。
本发明制备方法包括以下步骤：
(1)将路党参风干切成片状；
(2)将路党参、白花蛇舌草、鳖甲、白术、乌梅、黄芪、黑枸杞、黄连、炮姜、海藻、薏苡仁、桑黄、仙鹤草、黄精和山慈菇放入容器中加入重量5倍的纯净水小火进行熬制，直至水量剩余1倍量，过滤取药汁备用；
(3)将过滤后的药渣进行研磨粉碎；
(4)将步骤(2)所得的药汁加入研磨物中搅拌，放入制粒机中制粒；
(5)将制粒药丸进行烘干、制粒，制成药丸即得成品。
本发明的有益效果在于：
本发明是一种抑制结直肠腺瘤的药物配方，与现有技术相比，本发明能够抑制结直肠腺瘤的生长，具有显著的抗实体瘤和细胞瘤的活性，并且本发明的药味缺一不可，是一个科学的配方，具有推广应用的价值。
具体实施方式
下面对本发明作进一步说明：
本发明包括路党参、白花蛇舌草、鳖甲、白术、乌梅、黄芪、黑枸杞、黄连、炮姜、海藻、薏苡仁、桑黄、仙鹤草、黄精和山慈菇。
优选的，按重量比，每份含所述路党参5％、所述白花蛇舌草1％、所述鳖甲3％、所述白术3％、所述乌梅54％、所述黄芪3％、所述黑枸杞5％、所述黄连1％、所述炮姜2％、所述海藻2％、所述薏苡仁4％、所述桑黄5％、所述仙鹤草3％、所述黄精3％、所述山慈菇6％。
本发明制备方法包括以下步骤：
(1)将路党参风干切成片状；
(2)将路党参、白花蛇舌草、鳖甲、白术、乌梅、黄芪、黑枸杞、黄连、炮姜、海藻、薏苡仁、桑黄、仙鹤草、黄精和山慈菇放入容器中加入重量5倍的纯净水小火进行熬制，直至水量剩余1倍量，过滤取药汁备用；
(3)将过滤后的药渣进行研磨粉碎；
(4)将步骤(2)所得的药汁加入研磨物中搅拌，放入制粒机中制粒；
(5)将制粒药丸进行烘干、制粒，制成药丸即得成品。
实验方法：
采用小鼠，预先饲养两周，给予单次小剂量偶氮氧甲烷(AOM 10mg/kg)腹腔注射联合三个循环DSS喂饲(2％DSS饮水1周+正常饮水2周为一个循环)，复制AOM-DSS诱导的炎性肠病相关的结直肠癌小鼠模型。
取瘤源裸鼠，取出瘤组织，切成0.3-0.4mm的小块，将瘤组织接种在裸鼠的背部皮下，共接种20只，于接种后24天，随机分成治疗组，本发明提供的具有抗肿瘤活性的中药组合物，灌胃给药，6g/kg，空白组，每组10只，连续用药21天，于末次给药后24h处死动物，剖取瘤组织称重，计算抑制率，述结果证明本发明提供的中药组合物显著改善肠病癌变小鼠不断进展的体质量下降、稀便及便血等症状，显示出很好的预防和治疗肠病癌变的发生和进展。
临床病例：
张某，女，66岁。主症：乏力，纳可，夜寐欠安，二便调，舌红苔薄黄，脉弦涩。患者为结直肠癌术后5年，每半年复查肠镜均为：多发结肠腺瘤，每半年行肠镜下摘除术。采用本发明的药丸15g，每日一剂，每日分两次温服。服药两月后，乏力症状好转，肠镜示：见白色瘢痕残留，粘膜光滑，其余大肠粘膜光滑，色泽正常，血管纹理清晰，未见腺瘤生长。
以上显示和描述了本发明的基本原理和主要特征及本发明的优点。本行业的技术人员应该了解，本发明不受上述实施例的限制，上述实施例和说明书中描述的只是说明本发明的原理，在不脱离本发明精神和范围的前提下，本发明还会有各种变化和改进，这些变化和改进都落入要求保护的本发明范围内。本发明要求保护范围由所附的权利要求书及其等效物界定。

Claims (3)

1.一种抑制结直肠腺瘤的药物配方，其特征在于：包括路党参、白花蛇舌草、鳖甲、白术、乌梅、黄芪、黑枸杞、黄连、炮姜、海藻、薏苡仁、桑黄、仙鹤草、黄精和山慈菇。
2.根据权利要求1所述的抑制结直肠腺瘤的药物配方，其特征在于：按重量比，每份含所述路党参5％、所述白花蛇舌草1％、所述鳖甲3％、所述白术3％、所述乌梅54％、所述黄芪3％、所述黑枸杞5％、所述黄连1％、所述炮姜2％、所述海藻2％、所述薏苡仁4％、所述桑黄5％、所述仙鹤草3％、所述黄精3％、所述山慈菇6％。
3.根据权利要求1所述的抑制结直肠腺瘤的药物配方，其特征在于，制备方法包括以下步骤：
(1)将路党参风干切成片状；
(2)将路党参、白花蛇舌草、鳖甲、白术、乌梅、黄芪、黑枸杞、黄连、炮姜、海藻、薏苡仁、桑黄、仙鹤草、黄精和山慈菇放入容器中加入重量5倍的纯净水小火进行熬制，直至水量剩余1倍量，过滤取药汁备用；
(3)将过滤后的药渣进行研磨粉碎；
(4)将步骤(2)所得的药汁加入研磨物中搅拌，放入制粒机中制粒；
(5)将制粒药丸进行烘干、制粒，制成药丸即得成品。
CN201811360867.2A 2018-11-15 2018-11-15 一种抑制结直肠腺瘤的药物配方 Pending CN109289022A (zh)

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Cited By (1)

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CN112121091A (zh) * 2020-10-21 2020-12-25 上海中医药大学附属岳阳中西医结合医院 一种防治肠腺瘤性息肉的中药组合物、其制备方法及应用

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