CN109288063A - 一种增殖肠道益生菌的多联复合维生素制剂及其制作方法 - Google Patents
一种增殖肠道益生菌的多联复合维生素制剂及其制作方法 Download PDFInfo
- Publication number
- CN109288063A CN109288063A CN201811071599.2A CN201811071599A CN109288063A CN 109288063 A CN109288063 A CN 109288063A CN 201811071599 A CN201811071599 A CN 201811071599A CN 109288063 A CN109288063 A CN 109288063A
- Authority
- CN
- China
- Prior art keywords
- parts
- cernevit
- vitamin
- joint
- intestinal tract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000894006 Bacteria Species 0.000 title claims abstract description 46
- 210000001035 gastrointestinal tract Anatomy 0.000 title claims abstract description 35
- 230000009286 beneficial effect Effects 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 229940088594 vitamin Drugs 0.000 claims abstract description 33
- 239000011782 vitamin Substances 0.000 claims abstract description 33
- 229930003231 vitamin Natural products 0.000 claims abstract description 32
- 235000013343 vitamin Nutrition 0.000 claims abstract description 32
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 25
- 230000035755 proliferation Effects 0.000 claims abstract description 23
- 239000006041 probiotic Substances 0.000 claims abstract description 22
- 235000018291 probiotics Nutrition 0.000 claims abstract description 22
- 235000013406 prebiotics Nutrition 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 45
- 159000000007 calcium salts Chemical class 0.000 claims description 15
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 12
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 8
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 8
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 8
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 8
- 229920000053 polysorbate 80 Polymers 0.000 claims description 8
- 239000011719 vitamin A Substances 0.000 claims description 8
- 235000019155 vitamin A Nutrition 0.000 claims description 8
- 229940045997 vitamin a Drugs 0.000 claims description 8
- 244000199866 Lactobacillus casei Species 0.000 claims description 7
- 235000013958 Lactobacillus casei Nutrition 0.000 claims description 7
- 241000218588 Lactobacillus rhamnosus Species 0.000 claims description 7
- 229940017800 lactobacillus casei Drugs 0.000 claims description 7
- 239000011720 vitamin B Substances 0.000 claims description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 6
- 240000001046 Lactobacillus acidophilus Species 0.000 claims description 6
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 claims description 6
- 229930003268 Vitamin C Natural products 0.000 claims description 6
- 229930003427 Vitamin E Natural products 0.000 claims description 6
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 6
- 229940039695 lactobacillus acidophilus Drugs 0.000 claims description 6
- 229920000136 polysorbate Polymers 0.000 claims description 6
- 239000008213 purified water Substances 0.000 claims description 6
- 235000019156 vitamin B Nutrition 0.000 claims description 6
- 239000011718 vitamin C Substances 0.000 claims description 6
- 235000019154 vitamin C Nutrition 0.000 claims description 6
- 235000019165 vitamin E Nutrition 0.000 claims description 6
- 239000011709 vitamin E Substances 0.000 claims description 6
- 229940046009 vitamin E Drugs 0.000 claims description 6
- 229930003270 Vitamin B Natural products 0.000 claims description 5
- 229930003316 Vitamin D Natural products 0.000 claims description 5
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 235000019166 vitamin D Nutrition 0.000 claims description 5
- 239000011710 vitamin D Substances 0.000 claims description 5
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 5
- 229940046008 vitamin d Drugs 0.000 claims description 5
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 4
- 241001608472 Bifidobacterium longum Species 0.000 claims description 4
- 241000186840 Lactobacillus fermentum Species 0.000 claims description 4
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 4
- 230000008901 benefit Effects 0.000 claims description 4
- 229940009291 bifidobacterium longum Drugs 0.000 claims description 4
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 claims description 4
- 239000001354 calcium citrate Substances 0.000 claims description 4
- 229960004256 calcium citrate Drugs 0.000 claims description 4
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 4
- 239000001527 calcium lactate Substances 0.000 claims description 4
- 229960002401 calcium lactate Drugs 0.000 claims description 4
- 235000011086 calcium lactate Nutrition 0.000 claims description 4
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 claims description 4
- 235000021255 galacto-oligosaccharides Nutrition 0.000 claims description 4
- 150000003271 galactooligosaccharides Chemical class 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 235000013337 tricalcium citrate Nutrition 0.000 claims description 4
- 241000901050 Bifidobacterium animalis subsp. lactis Species 0.000 claims description 3
- 241000186016 Bifidobacterium bifidum Species 0.000 claims description 3
- 241000186605 Lactobacillus paracasei Species 0.000 claims description 3
- 241000186604 Lactobacillus reuteri Species 0.000 claims description 3
- 229940002008 bifidobacterium bifidum Drugs 0.000 claims description 3
- 229940009289 bifidobacterium lactis Drugs 0.000 claims description 3
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 claims description 3
- 239000001639 calcium acetate Substances 0.000 claims description 3
- 235000011092 calcium acetate Nutrition 0.000 claims description 3
- 229960005147 calcium acetate Drugs 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- 229960003563 calcium carbonate Drugs 0.000 claims description 3
- 235000010216 calcium carbonate Nutrition 0.000 claims description 3
- 239000004227 calcium gluconate Substances 0.000 claims description 3
- 229960004494 calcium gluconate Drugs 0.000 claims description 3
- 235000013927 calcium gluconate Nutrition 0.000 claims description 3
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 3
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 3
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 3
- 229940001882 lactobacillus reuteri Drugs 0.000 claims description 3
- 241000196324 Embryophyta Species 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 abstract description 8
- 230000036541 health Effects 0.000 abstract description 4
- 238000000354 decomposition reaction Methods 0.000 abstract description 3
- 230000036039 immunity Effects 0.000 abstract description 3
- 239000000654 additive Substances 0.000 abstract description 2
- 230000000996 additive effect Effects 0.000 abstract description 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 2
- 235000013365 dairy product Nutrition 0.000 abstract description 2
- 239000002552 dosage form Substances 0.000 abstract description 2
- 239000002245 particle Substances 0.000 abstract description 2
- 239000006187 pill Substances 0.000 abstract description 2
- 239000000843 powder Substances 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 8
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 240000006024 Lactobacillus plantarum Species 0.000 description 4
- 235000013965 Lactobacillus plantarum Nutrition 0.000 description 4
- 238000011049 filling Methods 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 229940072205 lactobacillus plantarum Drugs 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 229960005069 calcium Drugs 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 3
- 239000011691 vitamin B1 Substances 0.000 description 3
- 239000011647 vitamin D3 Substances 0.000 description 3
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 3
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 206010021135 Hypovitaminosis Diseases 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 235000013410 fast food Nutrition 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 239000011499 joint compound Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- NCYCYZXNIZJOKI-IOUUIBBYSA-N 11-cis-retinal Chemical compound O=C/C=C(\C)/C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-IOUUIBBYSA-N 0.000 description 1
- 208000000412 Avitaminosis Diseases 0.000 description 1
- 241000186000 Bifidobacterium Species 0.000 description 1
- 206010006956 Calcium deficiency Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 201000010538 Lactose Intolerance Diseases 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 206010057249 Phagocytosis Diseases 0.000 description 1
- 102000004330 Rhodopsin Human genes 0.000 description 1
- 108090000820 Rhodopsin Proteins 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 229930003448 Vitamin K Natural products 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 201000009840 acute diarrhea Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000000675 anti-caries Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 235000021152 breakfast Nutrition 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000009514 concussion Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000007366 host health Effects 0.000 description 1
- 235000003642 hunger Nutrition 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000033065 inborn errors of immunity Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 244000000074 intestinal pathogen Species 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 230000008782 phagocytosis Effects 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 208000028529 primary immunodeficiency disease Diseases 0.000 description 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 150000003612 tocotrienol derivatives Chemical class 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940046001 vitamin b complex Drugs 0.000 description 1
- 208000030401 vitamin deficiency disease Diseases 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/18—Lipids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/113—Acidophilus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/125—Casei
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/143—Fermentum
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/165—Paracasei
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/169—Plantarum
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/173—Reuteri
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/175—Rhamnosus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/517—Bifidum
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/531—Lactis
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/533—Longum
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
本发明公布了一种增殖肠道益生菌的多联复合维生素制剂及其制作方法，该复合维生素按以下重量份数的原料制成：维生素50~200份、益生菌5~25份、益生元15~75份。本发明的增殖肠道益生菌的多联复合维生素制剂由维生素、益生菌、益生元制成，能够补充人体所需的多种维生素，并有效调节肠道菌群，促进益生菌在肠道内增殖生长，益生菌在抗菌和增强免疫力的同时也可产生各种维生素，并抑制某些维生素的分解来保障供养；本发明的复合维生素制剂可以加工成片剂、粉剂、散剂、颗粒，丸剂等不同的剂型，也可以作为添加剂添加到其他产品(乳制品等)中，是一种安全健康的保健品。
Description
技术领域
本发明属于营养保健食品领域，具体涉及一种增殖肠道益生菌的多联复合维生素制剂及其制作方法。
背景技术
维生素是维持人体生命活动必需的一类有机物质，也是保持人体健康的重要活性物质。维生素在体内的含量很少，但在人体生长、代谢、发育过程中却发挥着重要的作用。各种维生素的化学结构以及性质虽然不同，但它们却有着以下共同点：维生素均以维生素原的形式存在于食物中；维生素不是构成机体组织和细胞的组成成分，也不会产生能量，但它的作用主要是参与机体代谢的调节是机体酶系统中辅酶的重要组成成分。人体对维生素的需要量很小，日需要量常以毫克(mg)或微克(ug)计算，但一旦缺乏就会引发相应的维生素缺乏，对人体健康造成损害。大多数的维生素，机体不能合成或合成量不足，不能满足机体的需要，必须经常通过食物中获得。健康人的胃肠道内寄居着种类繁多的微生物，这些微生物称为肠道菌群。肠道益生菌的生理作用之一是补充人体维生素，益生菌产生各种维生素，同时抑制某些的分解来保障供养。
随着现代生活节奏加快，工作紧张程度增强，不少的年轻人，尤其是白领一族，因没时间调理膳食，多以快餐充饥。早餐匆匆抓个馒头或两根油条了事，中餐则不是康师傅方便就是洋快餐。热量、脂肪勉强能够满足人体需要，但由于没有蔬菜水果而使维生素缺乏。如此长期下去极易引起维生素缺乏症，使身体内许多酶的代谢活性下降，免疫力低下，抗病能力差。
发明内容
有鉴于此，本发明的目的是提供一种增殖肠道益生菌的多联复合维生素制剂，该复合维生素制剂在补充维生素的同时能够有效调节肠道菌群，促进益生菌在肠道内增值生长。
本发明的另一目的是提供一种增殖肠道益生菌的多联复合维生素制剂的制作方法。
为了实现上述目的，本发明采用的技术方案是提供一种增殖肠道益生菌的多联复合维生素制剂，该复合维生素按以下重量份数的原料制成：维生素50~200份、益生菌5~25份、益生元15~75份。
作为优选地，制备所述增殖肠道益生菌的多联复合维生素制剂的原料还包括钙盐、吐温80和甘油，所述钙盐的重量份数为10~30份，所述吐温80的重量份数为20~30份，所述甘油的重量份数为20~30份。
作为优选地，按以下重量份数的原料制成：维生素80~150份、益生菌10~16份、益生元25~50份、钙盐14~23份、吐温80 24~27份、甘油25~26份。
作为优选地，所述维生素为维生素A、维生素B、维生素C、维生素D、维生素E中的两种或多种。
作为优选地，所述益生菌为鼠李糖乳杆菌、乳双歧杆菌、罗伊氏乳杆菌、长双歧杆菌、两歧双歧杆菌、植物乳杆菌、干酪乳杆菌、嗜酸乳杆菌、发酵乳杆菌、副干酪乳杆菌中的三种或多种。
作为优选地，所述益生菌的活菌量为109-1010CFU/g。
作为优选地，所述益生元为低聚果糖、低聚木糖、低聚半乳糖、低聚异麦芽糖、低聚麦芽糖中的一种或多种。
作为优选地，所述钙盐为碳酸钙、醋酸钙、柠檬酸钙、磷酸氢钙、乳酸钙、葡萄糖酸钙中的一种或多种。
本发明还提供一种增殖肠道益生菌的多联复合维生素制剂的制作方法，其特征在于：包括以下步骤：
（1）按配方比将维生素、吐温、甘油和纯化水混合，搅拌均匀，得到混合物；
（2）向步骤（1）的混合物中加入配方量的益生菌、益生元和钙盐，混合均匀，即得有增殖肠道益生菌的多联复合维生素制剂。
本发明的增殖肠道益生菌的多联复合维生素制剂由维生素、益生菌、益生元制成，能够补充人体所需的多种维生素，并有效调节肠道菌群，促进益生菌在肠道内增殖生长，益生菌在抗菌和增强免疫力的同时也可产生各种维生素，并抑制某些维生素的分解来保障供养；本发明的复合维生素制剂可以加工成片剂、粉剂、散剂、颗粒，丸剂等不同的剂型，也可以作为添加剂添加到其他产品(乳制品等)中，是一种安全健康的保健品。
具体实施方式
以下是本发明的具体实施例，对本发明的技术方案作进一步的描述，但本发明并不限于这些实施例。
本发明的增殖肠道益生菌的多联复合维生素制剂按以下重量份数的原料制成：维生素50~200份、益生菌5~25份、益生元15~75份、钙盐10~30份、吐温80 20~30份、甘油20~30份。甘油可对脂溶性的维生素进行包被，增加了维生素在水中的稳定性，同时增加了在水中的溶解性和提高了动物的吸收利用；吐温80能够保持各种维生素相对的独立，减少了维生素相互间的影响，特别是维生素C与维生素B族之间的反应；益生元是指不易被消化的食品成分通过选择性的刺激一种或几种菌落中的细菌的生长与活性而对寄主产生有益的影响从而改善寄主健康的物质；钙盐可治疗急性血钙缺乏症、防治慢性营养性钙缺乏症、抗炎、抗过敏。
进一步的，该增殖肠道益生菌的多联复合维生素制剂按以下重量份数的原料制成：维生素80~150份、益生菌10~16份、益生元25~50份、钙盐14~23份、吐温80 24~27份、甘油25~26份。
本发明的维生素为维生素A、维生素B、维生素C、维生素D、维生素E中的两种或多种。维生素 A 具有促进生长，维持上皮组织正常功能的作用，并参与视紫红质的合成，增强视网膜的感光力。缺少维生素A易患夜盲症。维生素B包括B1、B2、B6、B12、生物素、叶酸、烟酸、泛酸。维生素D有五种化合物，能调节钙、磷的代谢，促进骨骼的正常生长，对健康关系较密切的是维生素D2和维生素D3。维生素 E 包括生育酚类、三烯生育酚类，都有抗氧化功能，为正常生长和生育所必需。
本发明的益生菌为鼠李糖乳杆菌、乳双歧杆菌、罗伊氏乳杆菌、长双歧杆菌、两歧双歧杆菌、植物乳杆菌、干酪乳杆菌、嗜酸乳杆菌、发酵乳杆菌、副干酪乳杆菌中的三种或多种。鼠李糖乳杆菌具有高效降胆固醇，促进细胞分裂，可起到调节肠道菌群、预防和治疗腹泻、排除毒素、预防龋齿、提高机体免疫力及抗癌等重要的生理保健功能。嗜酸乳杆菌在肠道内发酵后，可产生乳酸和醋酸，能提高钙、磷、铁的利用率，促进铁和维生素D的吸收，产生维生素K及维生素B，还可以减少胆固醇的吸收，并能降低辐射对人体的伤害。植物乳杆菌具有很多的保健作用，如有一定的免疫调节作用对致病菌有抑制作用，降低血清胆固醇含量和预防心血管疾病，维持肠道内菌群平衡，促进营养物质吸收，缓解乳糖不耐症，抑制肿瘤细胞的形成等。干酪乳杆菌具有良好的耐酸及胆汁抗性，可降低血浆胆固醇，增强宿主对微生物病原体的非特异性抵抗力，加快清除肠道内病原体，治疗肠道菌群紊乱和增强肠道透性，从而防止食物过敏和急性腹泻。此外，干酪乳杆菌还可使抗低密度氧化脂抗体和淋巴细胞增加，使粒细胞的噬菌作用明显增强，对宿主进行免疫调节，防止肿瘤的产生。
本发明的益生菌的活菌量为109-1010CFU/g。
本发明的益生元为低聚果糖、低聚木糖、低聚半乳糖、低聚异麦芽糖、低聚麦芽糖中的一种或多种。
本发明的钙盐为碳酸钙、醋酸钙、柠檬酸钙、磷酸氢钙、乳酸钙、葡萄糖酸钙中的一种或多种。
本发明的增殖肠道益生菌的多联复合维生素制剂的制作方法包括以下步骤：（1）按配方比将维生素、吐温、甘油和纯化水混合，搅拌均匀，得到混合物；（2）向步骤（1）的混合物中加入配方量的益生菌、益生元和钙盐，混合均匀，即得有增殖肠道益生菌的多联复合维生素制剂。
实施例1
将20g维生素A、15g维生素B1、15g维生素B6、20g吐温80、20g甘油和纯化水混合，搅拌均匀，得到混合物；向上述混合物中加入2g鼠李糖乳杆菌、2g长双歧杆菌、1g植物乳杆菌、15g低聚果糖和10g乳酸钙，混合均匀，即得有增殖肠道益生菌的多联复合维生素制剂。
实施例2
将50g维生素A、20g维生素D3、50g维生素E、20g维生素B1、20g维生素B2、10g维生素B6、5g维生素B12、20g维生素C、5g生物素、30g吐温80、30g甘油和纯化水混合，搅拌均匀，得到混合物；向上述混合物中加入5g鼠李糖乳杆菌、4g长双歧杆菌、3g嗜酸乳杆菌、4g干酪乳杆菌、4g发酵乳杆菌、25g低聚果糖、25g低聚麦芽糖、25g低聚木糖、15g柠檬酸钙、15g葡萄糖酸钙，混合均匀，即得有增殖肠道益生菌的多联复合维生素制剂。
实施例3
将25g维生素A、25g维生素D3、25g维生素E、25g维生素B1、25g维生素C、25g吐温80、25.5g甘油和纯化水混合，搅拌均匀，得到混合物；向上述混合物中加入3g鼠李糖乳杆菌、4g两歧双歧杆菌、3g嗜酸乳杆菌、5g干酪乳杆菌、10g低聚果糖、12g低聚半乳糖、13g低聚异麦芽糖，混合均匀，即得增殖肠道益生菌的多联复合维生素制剂。
功能试验
受试动物：体重为20± 2g的SPF级昆明种雌性小鼠20只。每10只分为一组，共2组。每组分别对应空白组、实施例1的增殖肠道益生菌的多联复合维生素制剂进行试验。
剂量及用法：以灌胃方式给予受试动物，每日灌胃1次，灌胃体积为0.2ml/10g.bw，空白对照组灌给予等量蒸馏水，连续灌胃14d。
试验方法：肠道菌群的计数：给予受试物前及最后一次给受试药物后24h，无菌采取小鼠粪便，放入已灭菌的装有3ml稀释液的试管中，称重后震荡摇匀，使粪便完全均质于稀释液中。采取10倍系列稀释至10-8。选择合适的稀释度分别接种在各培养基上培养益生菌。培养48～72h后，以菌落形态，革兰氏染色镜检计数菌落，计算每克湿便中的各益生菌菌落数，去对数后进行统计处理。
测试结果见表1。从表中数据可以看出，本发明的增殖肠道益生菌的多联复合维生素制剂可有效增值肠道益生菌，调整肠道菌群。
表1
虽然已经通过示例对本发明的一些特定实施例进行了详细说明，但是本领域的技术人员应该理解，以上示例仅是为了进行说明，而不是为了限制本发明的范围，本发明所属技术领域的技术人员可以对所描述的具体实施例来做出各种各样的修改或补充或采用类似的方式替代，但并不会偏离本发明的方向或者超越所附权利要求书所定义的范围。本领域的技术人员应该理解，凡是依据本发明的技术实质对以上实施方式所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围。
Claims (9)
1.一种增殖肠道益生菌的多联复合维生素制剂，其特征在于：按以下重量份数的原料制成：维生素50~200份、益生菌5~25份、益生元15~75份。
2.根据权利要求1所述的增殖肠道益生菌的多联复合维生素制剂，其特征在于：制备所述增殖肠道益生菌的多联复合维生素制剂的原料还包括钙盐、吐温80和甘油，所述钙盐的重量份数为10~30份，所述吐温80的重量份数为20~30份，所述甘油的重量份数为20~30份。
3.根据权利要求2所述的增殖肠道益生菌的多联复合维生素制剂，其特征在于：按以下重量份数的原料制成：维生素80~150份、益生菌10~16份、益生元25~50份、钙盐14~23份、吐温80 24~27份、甘油25~26份。
4.根据权利要求1所述的增殖肠道益生菌的多联复合维生素制剂，其特征在于：所述维生素为维生素A、维生素B、维生素C、维生素D、维生素E中的两种或多种。
5.根据权利要求1所述的增殖肠道益生菌的多联复合维生素制剂，其特征在于：所述益生菌为鼠李糖乳杆菌、乳双歧杆菌、罗伊氏乳杆菌、长双歧杆菌、两歧双歧杆菌、植物乳杆菌、干酪乳杆菌、嗜酸乳杆菌、发酵乳杆菌、副干酪乳杆菌中的三种或多种。
6.根据权利要求1所述的增殖肠道益生菌的多联复合维生素制剂，其特征在于：所述益生菌的活菌量为109-1010CFU/g。
7.根据权利要求1所述的增殖肠道益生菌的多联复合维生素制剂，其特征在于：所述益生元为低聚果糖、低聚木糖、低聚半乳糖、低聚异麦芽糖、低聚麦芽糖中的一种或多种。
8.根据权利要求1所述的增殖肠道益生菌的多联复合维生素制剂，其特征在于：所述钙盐为碳酸钙、醋酸钙、柠檬酸钙、磷酸氢钙、乳酸钙、葡萄糖酸钙中的一种或多种。
9.一种增殖肠道益生菌的多联复合维生素制剂的制作方法，其特征在于：包括以下步骤：
（1）按配方比将维生素、吐温、甘油和纯化水混合，搅拌均匀得到混合物；
（2）向步骤（1）的混合物中加入配方量的益生菌、益生元和钙盐，混合均匀，即得有增殖肠道益生菌的多联复合维生素制剂。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811071599.2A CN109288063A (zh) | 2018-09-14 | 2018-09-14 | 一种增殖肠道益生菌的多联复合维生素制剂及其制作方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811071599.2A CN109288063A (zh) | 2018-09-14 | 2018-09-14 | 一种增殖肠道益生菌的多联复合维生素制剂及其制作方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109288063A true CN109288063A (zh) | 2019-02-01 |
Family
ID=65166895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811071599.2A Pending CN109288063A (zh) | 2018-09-14 | 2018-09-14 | 一种增殖肠道益生菌的多联复合维生素制剂及其制作方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109288063A (zh) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110547469A (zh) * | 2019-09-18 | 2019-12-10 | 深圳市中航生命健康科技有限公司 | 益生菌组合物及其制备方法 |
| CN111000106A (zh) * | 2019-12-27 | 2020-04-14 | 刘俊 | 一种复合益生菌固体饮料 |
| CN112704234A (zh) * | 2020-12-15 | 2021-04-27 | 广州市金龟寿药品有限公司 | 一种含有复合肽和益生菌的营养组合物及其制备方法 |
| CN113892656A (zh) * | 2021-08-19 | 2022-01-07 | 广东绿宝堂健康科技有限公司 | 一种益生元组合物 |
| CN114574391A (zh) * | 2022-03-11 | 2022-06-03 | 南昌恒赋健康管理有限公司 | 一种促长高提高免疫力的菌剂及其在配方奶粉上的应用 |
| CN114984130A (zh) * | 2022-06-30 | 2022-09-02 | 大连医科大学 | 一种益生菌联合药食同源材料的组合物及其制备方法和应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101099749A (zh) * | 2007-07-25 | 2008-01-09 | 上海交大昂立股份有限公司 | 一种含嗜酸乳杆菌和长双歧杆菌的组合物及其应用 |
| CN101099861A (zh) * | 2007-07-25 | 2008-01-09 | 上海交大昂立股份有限公司 | 一种含嗜酸乳杆菌的组合物及其应用 |
-
2018
- 2018-09-14 CN CN201811071599.2A patent/CN109288063A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101099749A (zh) * | 2007-07-25 | 2008-01-09 | 上海交大昂立股份有限公司 | 一种含嗜酸乳杆菌和长双歧杆菌的组合物及其应用 |
| CN101099861A (zh) * | 2007-07-25 | 2008-01-09 | 上海交大昂立股份有限公司 | 一种含嗜酸乳杆菌的组合物及其应用 |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110547469A (zh) * | 2019-09-18 | 2019-12-10 | 深圳市中航生命健康科技有限公司 | 益生菌组合物及其制备方法 |
| CN111000106A (zh) * | 2019-12-27 | 2020-04-14 | 刘俊 | 一种复合益生菌固体饮料 |
| CN112704234A (zh) * | 2020-12-15 | 2021-04-27 | 广州市金龟寿药品有限公司 | 一种含有复合肽和益生菌的营养组合物及其制备方法 |
| CN113892656A (zh) * | 2021-08-19 | 2022-01-07 | 广东绿宝堂健康科技有限公司 | 一种益生元组合物 |
| CN114574391A (zh) * | 2022-03-11 | 2022-06-03 | 南昌恒赋健康管理有限公司 | 一种促长高提高免疫力的菌剂及其在配方奶粉上的应用 |
| CN114574391B (zh) * | 2022-03-11 | 2022-10-21 | 南昌恒赋健康管理有限公司 | 一种促长高提高免疫力的菌剂及其在配方奶粉上的应用 |
| CN114984130A (zh) * | 2022-06-30 | 2022-09-02 | 大连医科大学 | 一种益生菌联合药食同源材料的组合物及其制备方法和应用 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109288063A (zh) | 一种增殖肠道益生菌的多联复合维生素制剂及其制作方法 | |
| EP1478246B1 (en) | Dietetic and/or pharmaceutical compositions for human and/or animal use based on probiotic microbial preparations | |
| CN109287920A (zh) | 一种多元维生素与多联益生菌的固体饮料及其制作方法 | |
| CN108244252A (zh) | 益生菌多元蛋白粉及其制备方法 | |
| CN110141585A (zh) | 一种用于调节肠道菌群的复合益生菌发酵菌剂及其制备方法 | |
| CN105053866B (zh) | 一种润肠通便的复合胚芽粉及其制备方法 | |
| CN109771470A (zh) | 一种含益生菌的组合物及其制备方法 | |
| CN103271274B (zh) | 一种营养保健粥 | |
| CN109069555A (zh) | 面向新生儿的用于改善脑功能的组合物 | |
| CN103636946A (zh) | 一种黄鳝用中草药免疫增强剂的制备方法及应用 | |
| CN107019211A (zh) | 制备具有补肾强肾功能的植物酵素的发酵组合物及制法 | |
| CN106617092A (zh) | 一种防癌抗癌益生菌制剂及其制备方法 | |
| CN102742653B (zh) | 一种健脑安神益生菌羊奶片及其制备方法 | |
| CN106689672A (zh) | 合生元组合物、合生元制剂、制备方法及其应用 | |
| CN106858577A (zh) | 制备具有保肝护肝、调节脂肪肝代谢功能的植物酵素的发酵组合物及制法 | |
| CN103918795A (zh) | 一种茶多酚益生菌羊奶片及其制备方法 | |
| CN106617095A (zh) | 一种阿胶益生菌口服液及其制备方法 | |
| CN112638164A (zh) | 改进的人类食物产品 | |
| CN102742654B (zh) | 一种养颜美容益生菌羊奶片及其制备方法 | |
| TWI593352B (zh) | 一種具有抗氧化／消除自由基能力之黑蒜頭發酵乳及其製造方法 | |
| CN107950864A (zh) | 一种合生元谷蔬代餐粉及其制备方法和应用 | |
| CN107693547A (zh) | 一种益生菌组合物的制备方法及用途 | |
| KR20120122532A (ko) | 미생물이 첨가된 맛김의 제조방법 | |
| CN107019212A (zh) | 制备具有增强儿童免疫力和益智功能的植物酵素的发酵组合物及制法 | |
| CN109527308A (zh) | 一种具有调理肠胃功能的益生菌饮品及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190201 |
|
| RJ01 | Rejection of invention patent application after publication |