CN109276495A - The preparation of Euphorbia maculata extract and its application in lotion - Google Patents
The preparation of Euphorbia maculata extract and its application in lotion Download PDFInfo
- Publication number
- CN109276495A CN109276495A CN201811201263.3A CN201811201263A CN109276495A CN 109276495 A CN109276495 A CN 109276495A CN 201811201263 A CN201811201263 A CN 201811201263A CN 109276495 A CN109276495 A CN 109276495A
- Authority
- CN
- China
- Prior art keywords
- extract
- euphorbia maculata
- lotion
- preparation
- euphorbia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
Invention belongs to daily chemicals field, and in particular to the preparation of Euphorbia maculata extract and its application in lotion.Euphorbia maculata extracts to obtain solid product using 70% ethanol water.Lotion is other than including the moisturizing composition of the emulsifier of 1.25%-3.0%, the thickener of 0.8%-1.0%, 11.0%-20.0%, the plant extracts of 3.0%-6.0%: Radix et Caulis Opuntiae Dillenii extract, Fructus Cucumidis sativi extract, Folium Artemisiae Argyi extract, aloe extract, also the Euphorbia maculata extract containing 0.01%-2.0%.The Euphorbia maculata extract that the present invention is added, has the function of inhibiting tyrosinase activity, can be applied in whitening product, assists whitening.
Description
Technical field
The invention belongs to daily chemicals fields, and in particular to the preparation of Euphorbia maculata extract and its application in lotion.
Background technique
Melanin is a kind of high-molecular weight compounds, is distributed widely in animal and plant, is to determine human skin and head
Send out the primary pigments of color.The melanin of human skin can protect skin to reduce the injury of ultraviolet light, however the excess of melanin
It generates and accumulation be easy to cause skin speckle and freckle.In order to reduce cutaneous pigmentation, it is necessary to inhibit the generation of melanin.
Melanin is generated by the melanocyte for being located at skin base layer by series of chemical, wherein tyrosinase (Tyros
Inase) be melanin formed key enzyme, L-DOPA can be oxidized to the form of quinone, and then other reactions occur and form black
Element generates melanin research shows that inhibiting tyrosinase activity and being able to suppress melanocyte, to reduce cutaneous pigmentation.
Euphorbia maculata is a kind of herbaceous plant, is distributed widely in South Korea, China and Japan, is usually used in folk medicine, is had anti-
The effect of bacterium, hemostasis and anti-inflammatory.
The effect of research about Euphorbia maculata extract more concentrates on its composition and removes free radical, is applied to
Cosmetics are also rarely reported, especially in skin-lightening cosmetic.This patent extracts Euphorbia maculata by using water, alcohol mixture, and will
Extract is applied in cosmetics, tests the activity of the inhibition tyrosinase of cosmetics, thus it is speculated that it, which has, inhibits melanin production
The effect of, show whether it has potential white-skinned face function with this.
Summary of the invention
The object of the present invention is to provide the preparation methods of Euphorbia maculata extract.
Another object of the present invention is to provide application of the Euphorbia maculata extract in lotion.
The preparation method of Euphorbia maculata extract and its application in lotion are achieved in that
The preparation method of Euphorbia maculata extract, step carries out in the following order
A. the stem of Euphorbia maculata and/or leaf are cleaned, dries, is cut into small pieces；
B. the ratio that Euphorbia maculata prepared by a step is 1:50 by weight is added to 70% ethanol water, in 60-80
It heats 2-4 hours, filters at DEG C；
C. filter residue uses 70% ethanol water to repeat to extract twice again, and filtrate, concentrated by rotary evaporation freeze concentrate three times for merging
It is dry to obtain solid product, it is saved at 4 DEG C.
In preparation method of the present invention, the temperature that boiling step b is most preferably heated is 70 DEG C, and heating time is 3 hours.
The Euphorbia maculata extract is applied in cosmetic emulsion.Its component and content weight percent are respectively as follows:
Beneficial effects of the present invention
Extraction step of the present invention can obtain the solid Euphorbia maculata extract of 20.2% yield.Test shows the extraction
Object also has the function of removing free radical DPPH, have anti-oxidant and latent other than having the function of inhibiting tyrosinase activity
White-skinned face function (see Fig. 1, Fig. 2).
Extracted Euphorbia maculata extract is applied to emulsion formulations, test shows under multiple concentration that samples of latex has suppression
The effect of tyrosinase activity processed (see Fig. 3), while sample shows stabilization at -20 DEG C, 0 DEG C, 20 DEG C and 48 DEG C.
Detailed description of the invention
Fig. 1 is the percent activity of tyrosinase after various concentration Euphorbia maculata extract-treated；
Fig. 2 is clearance rate of the tyrosinase to DPPH free radical；
Fig. 3 is the percent activity of tyrosinase after the processing of the lotion of the extract of Euphorbia maculata containing different weight percentage.Number
According to the increase shown with addition percentage (0.01%, 0.4%, 1.0%, 2.0%), the activity of tyrosinase is gradually decreased,
Illustrate that Euphorbia maculata extract plays a part of inhibiting tyrosinase activity in formula really.
Specific embodiment
Lotion of the present invention is described in further detail below with reference to embodiment.
The characteristics of first choosing to component of the present invention, points for attention describe in detail, illustrate.
The Euphorbia maculata 50.0g being cut into small pieces is weighed in stainless-steel pan, 70% ethanol water 2500.0g is added,
Under stirring, it is heated to 70 DEG C, heating filtered out filter residue after 3 hours, repeated extraction twice, merged filtrate three times, at 37 DEG C, used
Rotary Evaporators concentrated extracting solution after transfer vessel, is frozen into solid with liquid nitrogen, is put into freeze dryer and removes remaining liq, obtain
10.1g solid is sealed and is saved at 4 DEG C stand-by.
The present invention is extracted Euphorbia maculata, and extract is applied in lotion, while paying close attention to the moistening effect of lotion.It selects
Simple emollient, a variety of moisturizing plant extract raw materials of arranging in pairs or groups, such as aloe extract, Fructus Cucumidis sativi extract, Radix et Caulis Opuntiae Dillenii extract
And Folium Artemisiae Argyi extract；In addition, being also especially added with Euphorbia maculata extract, which is more applied to drug, rare to incite somebody to action
It is used in cosmetic emulsion.
Other than Euphorbia maculata extract is solid, other plant extract is extracting solution.
Embodiment I-IV
Using effect test of the present invention
From Fig. 1 and Fig. 2 can be seen that Euphorbia maculata extract have inhibit tyrosinase activity and remove DPPH free radical
Effect, and with the raising of concentration, the ability for inhibiting tyrosinase activity and removing DPPH free radical gradually rises, Ke Yiyong
In whitening and anti-aging product formula.It adds it in emulsion formulations (see Fig. 3), it can be seen that equally there is good inhibition
The effect of tyrosinase activity increases with percentage is added, and effect is stronger, illustrates that the product can be applied in whitening product,
It can assist reinforcing effect.
Claims (5)
1. the preparation method of Euphorbia maculata extract, step carries out in the following order:
A. the stem of Euphorbia maculata and/or leaf are cleaned, dries, is cut into small pieces；
B. the ratio that Euphorbia maculata prepared by a step is 1:50 by weight is added to 70% ethanol water, at 60-80 DEG C
Heating 2-4 hours, filtering；
C. filter residue uses 70% ethanol water to repeat to extract twice again, and concentrate is lyophilized for filtrate, concentrated by rotary evaporation three times for merging
To solid product, saved at 4 DEG C.
2. preparation method according to claim 1, it is characterised in that: the temperature of heating is 70 DEG C, and heating time is 3 hours.
3. application of the Euphorbia maculata extract in cosmetic emulsion described in claim 1.
4. application as claimed in claim 3 also accounts for lotion weight 0.01%- in addition to containing the acceptable general composition of lotion
2.0% Euphorbia maculata extract.
5. application according to claim 3, the component and its content weight percent of lotion are respectively as follows:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811201263.3A CN109276495A (en) | 2018-10-16 | 2018-10-16 | The preparation of Euphorbia maculata extract and its application in lotion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811201263.3A CN109276495A (en) | 2018-10-16 | 2018-10-16 | The preparation of Euphorbia maculata extract and its application in lotion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109276495A true CN109276495A (en) | 2019-01-29 |
Family
ID=65177012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811201263.3A Withdrawn CN109276495A (en) | 2018-10-16 | 2018-10-16 | The preparation of Euphorbia maculata extract and its application in lotion |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109276495A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102119953A (en) * | 2010-11-17 | 2011-07-13 | 首都医科大学 | Application of euphorbia humifusa wild extract |
| CN102209517A (en) * | 2008-11-11 | 2011-10-05 | 高露洁-棕榄公司 | Composition with a color marker |
| CN105233257A (en) * | 2015-11-18 | 2016-01-13 | 桂林华诺威基因药业有限公司 | Repairing and whitening composition |
| KR101671852B1 (en) * | 2015-11-12 | 2016-11-03 | 원광대학교산학협력단 | Skin whitening composition containing extract or fraction of Euphorbia maculata or Euphorbia supina |
| CN106727061A (en) * | 2017-03-13 | 2017-05-31 | 广州市嘉美化妆品有限公司 | A kind of tender skin Essence |
| CN107137262A (en) * | 2017-04-18 | 2017-09-08 | 拉芳家化股份有限公司 | A kind of facial treatment milk combined containing Chinese herbal medicine extract |
-
2018
- 2018-10-16 CN CN201811201263.3A patent/CN109276495A/en not_active Withdrawn
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102209517A (en) * | 2008-11-11 | 2011-10-05 | 高露洁-棕榄公司 | Composition with a color marker |
| CN102119953A (en) * | 2010-11-17 | 2011-07-13 | 首都医科大学 | Application of euphorbia humifusa wild extract |
| KR101671852B1 (en) * | 2015-11-12 | 2016-11-03 | 원광대학교산학협력단 | Skin whitening composition containing extract or fraction of Euphorbia maculata or Euphorbia supina |
| CN105233257A (en) * | 2015-11-18 | 2016-01-13 | 桂林华诺威基因药业有限公司 | Repairing and whitening composition |
| CN106727061A (en) * | 2017-03-13 | 2017-05-31 | 广州市嘉美化妆品有限公司 | A kind of tender skin Essence |
| CN107137262A (en) * | 2017-04-18 | 2017-09-08 | 拉芳家化股份有限公司 | A kind of facial treatment milk combined containing Chinese herbal medicine extract |
Non-Patent Citations (1)
| Title |
|---|
| SA-HAENG KANG等: ""Antioxidant and skin-whitening effects of aerial part of Euphorbia supina Raf.Extract"", 《BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE》 * |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20190129 |