CN109223644A - A kind of cosmetic composition and its preparation method and application containing Herba Saussureae Involueratae extract - Google Patents
A kind of cosmetic composition and its preparation method and application containing Herba Saussureae Involueratae extract Download PDFInfo
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- CN109223644A CN109223644A CN201811297023.8A CN201811297023A CN109223644A CN 109223644 A CN109223644 A CN 109223644A CN 201811297023 A CN201811297023 A CN 201811297023A CN 109223644 A CN109223644 A CN 109223644A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The invention discloses a kind of cosmetic composition and its preparation method and application containing Herba Saussureae Involueratae extract, wherein cosmetic composition can abbreviation swirl snow precious jade grass；It is safe and effective, non-stimulated to be intended to provide one kind, pigmentation can be substantially reduced, highlight the composition of skin；Technical points are that the composition mainly includes the component of following parts by weight: 10-20 parts of Herba Saussureae Involueratae extract, 10-20 parts of fruit extracts, and 5-10 parts of ligule Rhizoma Seu Herba Bergeniae root extract；The fruit extracts are mainly made of the raw material of following weight parts: 20-40 parts of narrow leaf blueberry fruit, and 15-30 parts of Fructus Rubi；Belong to cosmetic technical field.
Description
Technical field
The invention discloses a kind of cosmetic compositions, specifically, being a kind of cosmetic composition containing Herba Saussureae Involueratae extract
And preparation method thereof, the invention also discloses the applications of the cosmetic composition, belong to cosmetic technical field.
Background technique
The color of human skin depends on the content and distribution of melanin, and melanin is a kind of protein, when ultraviolet light shines
It penetrates on the skin, chromatophore secretes Mai Laning element, activates tyrosinase, tyrosinase is to the hydroxylating of tyrosine and to DOPA
Oxidation, catalysis and tyrosinase-related protein-2 of the tyrosinase related protein-1 (dopachrome interconvertible enzyme) to dopachrome
The catalysis of (dihydroxy indole carboxylic oxidase) to dihydroxy indole carboxylic acid, the presence of active oxygen can then promote enzymic catalytic reaction
It carries out, the reproducibility pigment of light color can also be made to be oxidized to dark oxidisability melanin.Melanin granule is thin by melanin
Born of the same parents' dendritic processes are shifted to epithelial cells；The melanin granule for being transferred to epithelial cells goes upward to cuticula with epidermal cell,
And it falls off and drains with cuticula.But due to the shadow by the factors such as ultraviolet light, heredity, endocrine, inflammatory mediator, improper diet
It rings, melanin metabolic disorder and is unevenly distributed dermal melanin excessively rapid growth, will result in that local skin is excessively black and pigment sinks
, pigmentation etc. after chloasma, freckle and inflammation is shown as, this brings very big puzzlement to people's lives.
In order to meet pursuit of the people to beauty, be known as has effects that the product of skin lightening is innumerable in the market, skin
The mechanism of action is broadly divided into two classes:
One, inhibit tyrosinase activity and the proliferation and synthesis of melanocyte: the black pigment of skin inhibiting mechanism is the core of mechanism
Intracardiac appearance, can be by inhibiting tyrosinase activity or blocking tyrosine to generate the oxidative pathway of melanocyte, to reduce melanocyte
Generation achievees the effect that nti-freckle.
Two, antioxidation mechanism: the generating process of melanocyte is a more complicated process, which removes and tyrosine
Enzyme has outside the Pass, also closely related with the factors such as free radical.Studies have shown that the catalytic action of tyrosinase and DOPA quinone and its after
Auto-oxidation reaction be both needed to the participation of free radical, free radical number reduces the generation that can reduce melanocyte.Related research experiment is aobvious
Show that SOD content is substantially reduced in serum, propanedione (MDA) content increases after patient with chloasma treatment.To propose OFR and skin
The formation of melanocyte and pigmentation are related.Antioxidant SOD can effectively clear extra superoxide radical, subtract LPO, MDA formation
It is few, to prevent the generation of chloasma.
The common additive of skin lightening mainly has compound containing mercury and quinhydrones, kojic acid etc. at present.But due to compound containing mercury
The sensitization of toxicity and quinhydrones, kojic acid is under a cloud carcinogenesis, causes damages to human health.With people's consumption idea
It is increasingly mature, consumer is not only only that its is both effectiveness while also more focusing on its safety to the focal point of product.Therefore,
The cry of " component is naturally changed " and " going back to nature " has become the trend of cosmetics industry, the raw material of cosmetics naturally change by
Pay attention to.Therefore, it finds effectively and makeup is had become to native tyrosine enzyme inhibitor, the powerful antioxidant that human body has no adverse reaction
The trend of product industry research；There is provided a kind of prescription more rationally, effect more significantly reduce the group that pigmentation highlights skin
Object is closed, is one of the new issue that technical field scientific research personnel is badly in need of exploitation.
Summary of the invention
In view of the above deficiencies, the object of the present invention is to provide a kind of safely and effectively skin lightening combinations containing Herba Saussureae Involueratae extract
Object, this cosmetic composition abbreviation swirl avenge precious jade grass.
A second object of the present invention is to provide the preparation methods of above-mentioned cosmetic composition.
Third object of the present invention is to provide the applications of above-mentioned cosmetic composition.
In order to solve the above technical problems, first technical solution provided by the invention is such that
A kind of cosmetic composition containing Herba Saussureae Involueratae extract mainly includes the component of following parts by weight: Herba Saussureae Involueratae extract
10-20 parts, 10-20 parts of fruit extracts, 5-10 parts of ligule Rhizoma Seu Herba Bergeniae root extract；Wherein, the fruit extracts are main
It is made of the raw material of following weight parts: 20-40 parts of narrow leaf blueberry fruit, 15-30 parts of Fructus Rubi.
Further, the above-mentioned cosmetic composition containing Herba Saussureae Involueratae extract, the fruit extracts raw material further includes day
8-18 parts of this Callicarpa bodinieri Levl. fruit.
Further, the above-mentioned cosmetic composition containing Herba Saussureae Involueratae extract, the fruit extracts raw material further includes emerging
6-12 parts of raspberry seed of peace.
Another technical solution provided by the invention is to provide the preparation method of the cosmetic composition, successively includes following
Step:
1) 20-40 parts of narrow leaf blueberry fruit is weighed, 15-30 parts of Fructus Rubi, it is -18 to -10 DEG C that its whole, which is placed in temperature,
Freezen protective 10-15h；
2) it allows raw material to be extracted to melt 10-15min naturally, is sliced, be sent into airflow puffing tank, be warming up to 30-40 DEG C, very
Reciprocal of duty cycle control maintains 10-20min -0.2 to -0.1MPa, opens airflow puffing vacuum breaker and carries out at tissue extruding destruction
Reason, the 60-80% ethanol solution that 3-5 times of raw material (W/V) to be extracted is added is digestion agent, impregnates raw material 2-4h and stirs evenly；
3) the resulting material of step 2) is subjected in high-pressure-resistant vessel ultra high pressure treatment, temperature is kept to be 60-75 DEG C, press
Power is 20MPa, and HIGH PRESSURE TREATMENT 8-12min is filtered after pressure release, separates filter residue and filtrate, filtrate are extracting solution A；
4) ethyl alcohol of the 60-80% of 2-4 times of filter residue quality is added into the filter residue that step 3) obtains, carries out ultrasonic wave and mentions
It taking, ultrasound condition is frequency 30-50kHz, 60-70 DEG C of temperature, time 5-10min, filtrate is collected by filtration after ultrasonic treatment,
As extracting solution B；
5) extracting solution B made from extracting solution A made from step 3), step 4) is merged, it is true -0.2 to -0.1MPa
The 1/4-1/2 of original volume is concentrated under empty condition, temperature concentrated in vacuo is 50-70 DEG C, and concentrate is in -80 DEG C of ultra low temperature freezers
More than freezing for 24 hours, dry 12-24h, is uniformly dissolved after freeze-drying with mixed solution in freeze dryer, wherein berry active constituent
Content is 1-10wt% to get fruit extracts；
6) parts by weight described in accordance with the claim 1 weigh Herba Saussureae Involueratae extract, ligule Rhizoma Seu Herba Bergeniae root extract and step
4) fruit extracts in, be added 4-10 times of volume number of cosmetic composition total volume mixed solution to get.
Further, the preparation method of above-mentioned cosmetic composition, step 1) further include weighing 8-18 parts of Japanese Callicarpa bodinieri Levl. fruit.
Further, the preparation method of above-mentioned cosmetic composition, step 1) further include weighing 6-12 parts of Xingan's raspberry seed.
Further, the preparation method of above-mentioned cosmetic composition, step 1) further include weighing 8-18 parts of Japanese Callicarpa bodinieri Levl. fruit,
6-12 parts of Xingan's raspberry seed.
Further, mixed solution described in the preparation method of above-mentioned cosmetic composition, step 5) and step 6) by
Deionized water and butanediol are mixed according to volume ratio for 1/2-2/1.
The last one technical solution provided by the invention is application of the swirl snow precious jade grass as skin-care product additive.
Compared with prior art, beneficial effects of the present invention:
1) cosmetic composition of the invention passes through Herba Saussureae Involueratae extract, fruit extracts, ligule Rhizoma Seu Herba Bergeniae root extract
Synergistic effect, can effectively inhibit the synthesis of the black phymatorhusin of B16 and inhibit tyrosinase activity, and have preferably anti-oxidant
Effect can effectively clear interior free yl effect, improve the work of body antioxidant reductase (such as copper-zinc superoxide dismutase)
Property, anti-lipid peroxidation reaction, it is obscure to be effectively improved skin, bright color, has significant light spot effect, and can effectively drop
The irritation of low product keeps product safer.
2) present invention combines extraction fruit extracts using ultra high pressure extraction and ultrasonic extraction, and the combination of the two ensure that
The adequacy of extraction, after super-pressure, ultrasonication, due to the squeezing action of super-pressure and cavitation, crushing of ultrasonic wave etc.
Special role, the collapse for the cavitation bubble for generating the cell of berry instantaneously in a solvent and rupture, so as to solvent penetration to cell
Inside, to make the effective component such as flavones in cell be dissolved among solvent, to accelerate to interpenetrate, dissolve.It is compared to general
Logical extracting method, active constituent yield has biggish promotion, and extraction time also shortens, and improves industrial production effect
Rate.
Specific embodiment
With reference to embodiment, claim of the invention is described in further detail, but do not constituted pair
Any restrictions of the invention, the modification of anyone limited times made in the claims in the present invention protection scope, still in this hair
Within bright claims.
It should be noted that raw material employed in technical solution provided by the invention, unless otherwise specified, by normal
The preparation of rule means is bought by commercial channel.Wherein, Herba Saussureae Involueratae extract is won medicine adornment technology (Shanghai) share purchased from Lay and is had
Limit company, ligule Rhizoma Seu Herba Bergeniae root extract are purchased from Guangzhou Ao Xue Chemical Co., Ltd..
A kind of cosmetic composition containing Herba Saussureae Involueratae extract provided in the embodiment of the present invention, abbreviation swirl avenge precious jade grass.
Embodiment 1
A kind of cosmetic composition containing Herba Saussureae Involueratae extract provided by the invention, is made of the component of following weight number: snow
Flos Nelumbinis extract 10g, fruit extracts 20g, ligule Rhizoma Seu Herba Bergeniae root extract 5g；
The fruit extracts are made of the raw material of following weight number: narrow leaf blueberry fruit 20g, Fructus Rubi 30g.
Embodiment 2
A kind of cosmetic composition containing Herba Saussureae Involueratae extract provided by the invention, is made of the component of following weight number: snow
Flos Nelumbinis extract 20g, fruit extracts 10g, ligule Rhizoma Seu Herba Bergeniae root extract 10g；
The fruit extracts are made of the raw material of following weight number: narrow leaf blueberry fruit 40g, Fructus Rubi 15g.
The preparation method of embodiment 1 or the cosmetic composition as described in example 2 containing Herba Saussureae Involueratae extract successively includes
Following step:
1) narrow leaf blueberry fruit is weighed according to the mass number in embodiment 1 or embodiment 2, Fructus Rubi sets its whole
In temperature be -10 DEG C of freezen protective 15h；
2) it allows raw material to be extracted to melt 10min naturally, is sliced, be sent into airflow puffing tank, be warming up to 40 DEG C, vacuum degree control
System maintains 20min in -0.2MPa, opens airflow puffing vacuum breaker and carries out tissue extruding destruction processing, original to be extracted is added
80% ethanol solution for expecting 3 times (W/V) is digestion agent, impregnates raw material 2h and stirs evenly；
3) the resulting material of step 2) is subjected to ultra high pressure treatment in high-pressure-resistant vessel, keeping temperature is 60 DEG C, pressure
It is filtered after pressure release for 20MPa, HIGH PRESSURE TREATMENT 12min, separates filter residue and filtrate, filtrate are extracting solution A；
4) 2 times of filter residue quality of 80% ethyl alcohol is added into the filter residue that step 3) obtains, carries out ultrasonic wave extraction, ultrasound
Condition is frequency 30kHz, temperature 70 C, and filtrate, as extracting solution B is collected by filtration after ultrasonic treatment in time 5min；
5) extracting solution B made from extracting solution A made from step 3), step 4) is merged, in -0.2MPa vacuum condition
Under be concentrated into the 1/4 of original volume (the sum of extracting solution A and extracting solution B volume), temperature concentrated in vacuo is 70 DEG C, and concentrate is in -80
Freezed more than for 24 hours in DEG C ultra low temperature freezer, in freeze dryer it is dry for 24 hours, it is uniform with butanediol and deionized water dissolving after freeze-drying,
The volume ratio of the butanediol and deionized water is 1:1, and wherein the content of berry active constituent is that 10wt% mentions to get berry
Take object；
6) fruit extracts in the Herba Saussureae Involueratae extract of formulation dosage, ligule Rhizoma Seu Herba Bergeniae root extract and step 5) are used
The mixed solution that 4 volumes are measured again stir evenly to get.Wherein, the mixed solution is by deionized water and butanediol according to body
Product is mixed than 2:1.
Embodiment 3
A kind of cosmetic composition containing Herba Saussureae Involueratae extract provided by the invention, is made of the component of following weight number: snow
Flos Nelumbinis extract 15g, fruit extracts 15g, ligule Rhizoma Seu Herba Bergeniae root extract 8g；
The fruit extracts are made of the raw material of following weight number: narrow leaf blueberry fruit 30g, Fructus Rubi 22g, Japan
Callicarpa bodinieri Levl. fruit 8g.
Embodiment 4
A kind of cosmetic composition containing Herba Saussureae Involueratae extract provided by the invention, is made of the component of following weight number: snow
Flos Nelumbinis extract 12g, fruit extracts 18g, ligule Rhizoma Seu Herba Bergeniae root extract 6g；
The fruit extracts are made of the raw material of following weight number: narrow leaf blueberry fruit 25g, Fructus Rubi 26g, Xingan
Raspberry seed 12g.
A kind of preparation method of the cosmetic composition containing Herba Saussureae Involueratae extract provided in embodiment 3 or embodiment 4 is led to
Following step is crossed successively to be made:
1) narrow leaf blueberry fruit, Fructus Rubi, Xingan's raspberry are weighed according to the mass number in embodiment 3 or embodiment 4
Seed, it is -18 DEG C of freezen protective 10h that its whole, which is placed in temperature,；
2) it allows raw material to be extracted to melt 15min naturally, is sliced, be sent into airflow puffing tank, be warming up to 30 DEG C, vacuum degree control
System maintains 10min in -0.1MPa, opens airflow puffing vacuum breaker and carries out tissue extruding destruction processing, original to be extracted is added
80% ethanol solution for expecting 3 times (W/V) is digestion agent, impregnates raw material 3h and stirs evenly；
3) the resulting material of step 2) is subjected to ultra high pressure treatment in high-pressure-resistant vessel, keeping temperature is 75 DEG C, pressure
It is filtered after pressure release for 20MPa, HIGH PRESSURE TREATMENT 8min, separates filter residue and filtrate, filtrate are extracting solution A；
4) 4 times of filter residue quality of 60% ethyl alcohol is added into the filter residue that step 3) obtains, carries out ultrasonic wave extraction, ultrasound
Condition is frequency 50kHz, temperature 60 C, and filtrate, as extracting solution B is collected by filtration after ultrasonic treatment in time 10min；
5) extracting solution B made from extracting solution A made from step 3), step 4) is merged, in -0.2MPa vacuum condition
Under be concentrated into the 1/3 of original volume (the sum of extracting solution A and extracting solution B volume), temperature concentrated in vacuo is 50 DEG C, and concentrate is in -80
Freezed more than for 24 hours in DEG C ultra low temperature freezer, in freeze dryer it is dry for 24 hours, it is uniform with butanediol and deionized water dissolving after freeze-drying,
The volume ratio of the butanediol and deionized water is 1:2, and wherein the content of berry active constituent is that 5wt% mentions to get berry
Take object；
6) fruit extracts in the Herba Saussureae Involueratae extract of formulation dosage, ligule Rhizoma Seu Herba Bergeniae root extract and step 5) are used
The mixed solution that 7 volumes are measured again stir evenly to get.Wherein, the mixed solution is by deionized water and butanediol according to body
Product is mixed than 1:1.
Embodiment 5
A kind of cosmetic composition containing Herba Saussureae Involueratae extract provided by the invention, is made of the component of following weight number: snow
Flos Nelumbinis extract 18g, fruit extracts 13g, ligule Rhizoma Seu Herba Bergeniae root extract 7g；
The fruit extracts are made of the raw material of following weight number: narrow leaf blueberry fruit 35g, Fructus Rubi 20g, Japan
Callicarpa bodinieri Levl. fruit 18g, Xingan raspberry seed 6g.
Embodiment 6
A kind of cosmetic composition containing Herba Saussureae Involueratae extract provided by the invention, is made of the component of following weight number: snow
Flos Nelumbinis extract 15g, fruit extracts 15g, ligule Rhizoma Seu Herba Bergeniae root extract 8g；
The fruit extracts are made of the raw material of following weight number: narrow leaf blueberry fruit 30g, Fructus Rubi 27g, Japan
Callicarpa bodinieri Levl. fruit 13g, Xingan raspberry seed 9g.
A kind of preparation method of the cosmetic composition containing Herba Saussureae Involueratae extract provided in embodiment 5 or embodiment 6 is led to
Following step is crossed successively to be made:
1) narrow leaf blueberry fruit, Fructus Rubi, Japan's purple are weighed according to the mass number provided in embodiment 5 or embodiment 6
Pearl fruit and Xingan's raspberry seed, it is -18 to -10 DEG C of freezen protective 12h that its whole, which is placed in temperature,；
2) it allows raw material to be extracted to melt 13min naturally, is sliced, be sent into airflow puffing tank, be warming up to 35 DEG C, vacuum degree control
System maintains 15min in -0.15MPa, opens airflow puffing vacuum breaker and carries out tissue extruding destruction processing, is added to be extracted
4 times of raw material (W/V) of 70% ethanol solution is digestion agent, impregnates raw material 4h and stirs evenly；
3) the resulting material of step 2) is subjected to ultra high pressure treatment in high-pressure-resistant vessel, keeping temperature is 70 DEG C, pressure
It is filtered after pressure release for 20MPa, HIGH PRESSURE TREATMENT 10min, separates filter residue and filtrate, filtrate are extracting solution A；
4) 3 times of filter residue quality of 60% ethyl alcohol is added into the filter residue that step 3) obtains, carries out ultrasonic wave extraction, ultrasound
Condition is frequency 40kHz, temperature 70 C, and filtrate, as extracting solution B is collected by filtration after ultrasonic treatment in time 7min；
5) extracting solution B made from extracting solution A made from step 3), step 4) is merged, in -0.2MPa vacuum condition
Under be concentrated into the 1/2 of original volume (the sum of extracting solution A and extracting solution B volume), temperature concentrated in vacuo is 50 DEG C, and concentrate is in -80
It freezing more than for 24 hours in DEG C ultra low temperature freezer, dry 18h, uniform with butanediol and deionized water dissolving after freeze-drying in freeze dryer,
The volume ratio of the butanediol and deionized water is 2:1, and wherein the content of berry active constituent is that 1wt% mentions to get berry
Take object；
6) fruit extracts in the Herba Saussureae Involueratae extract of formulation dosage, ligule Rhizoma Seu Herba Bergeniae root extract and step 5) are used
The mixed solution that 7 volumes are measured again stir evenly to get.Wherein, the mixed solution is by deionized water and butanediol according to body
Product is mixed than 1:2.
A kind of cosmetic composition containing Herba Saussureae Involueratae extract prepared by the present invention, can be directly appended to various doses in low temperature
In the skin care item of type, such as aqua, essence, gel, lotion, cream, additive amount 2-12%, preferably 4-8%.
In order to prove effect of the invention, the applicant is also provided with following comparative example, with embodiment provided by the present application
Carry out Contrast on effect:
Comparative example 1
Containing only Herba Saussureae Involueratae extract 10g.
Comparative example 2
Containing only fruit extracts 20g, the fruit extracts are made of the raw material of following weight number: narrow leaf blueberry fruit
20g, Fructus Rubi 30g.
Comparative example 3
Containing only ligule Rhizoma Seu Herba Bergeniae root extract 5g.
The fruit extracts are made of the raw material of following weight number: narrow leaf blueberry fruit 20g, Fructus Rubi 30g.
Comparative example 4
Difference from example 1 is that the fruit extracts are only made of the narrow leaf blueberry fruit of 50g.
Comparative example 5
Difference from example 1 is that the fruit extracts are only made of the Fructus Rubi of 50g.
The test of 1 whitening effect of test example
1) test philosophy: the variation of skin color can be measured using skin complexion measuring instrument.It generally adopts at present
The measurement method for quantifying skin color is the colorimeter system as defined in International Commission on Illumination (CIE) (Lab colorimeter system)
The variation of skin color is measured, method quantization is more accurate, can reflect the variation of skin color Spatial Multi-Dimensional, make the quantization of the colour of skin
It is more reliable.Test index is dermal melanin content MI value (measurement numerical value is higher, illustrates that melanin content is higher in skin), skin
Skin whiteness brightness L value (it is white balance that L value, which characterizes L*, and value is bigger, and color is more biased to white).It thus can be by measuring skin angle
Matter layer melanin content, skin coloration judge the whitening effects of cosmetics.
2) test sample
1-6 of the present invention and comparative example 1-5 is prepared into composition, is added directly in cosmetics routine cream matrix, stirs
It mixes uniformly, additive amount is the 6wt% of cream total volume.
3) test apparatus
Skin chromatism test probe and Multi-functional skin test macro (CL400 and MPA6, German CK)；
Skin red and black pigment tester and test probe (Mexameter MX18, German CK company).
4) experimental method
Screening volunteer 110 is randomly divided into 11 groups, and every group 10 are used as trier.Before sample on probation to its face into
Row melanin and the test of chromatism data collection analysis, data are as skin background values.Trier on every Mondays, three, five evenings use
Carbonic acid facial mask is used continuously 3 months 3 times a week.Data acquisition is carried out before and after use.It evaluates and tests subject and uses makeup
The variation of skin whiteness (brightness) and dermal melanin content before and after product, thus the effect of test sample.
5) experimental result
Dermal melanin MI value and skin brightness L* value test result before and after 1 use of table
| Sample | Use preceding MI value | Use rear MI value | △MI | Use preceding L* value | Use rear L* value | △L* |
| 1 cream of embodiment | 220.50 | 203.27 | 17.23 | 55.56 | 57.14 | 1.58 |
| 2 cream of embodiment | 214.93 | 198.25 | 16.68 | 57.47 | 59.09 | 1.62 |
| 3 cream of embodiment | 222.98 | 204.16 | 18.82 | 56.28 | 58.06 | 1.78 |
| 4 cream of embodiment | 217.85 | 198.81 | 19.04 | 54.29 | 56.12 | 1.83 |
| 5 cream of embodiment | 219.48 | 198.85 | 20.63 | 57.18 | 59.12 | 1.94 |
| 6 cream of embodiment | 221.06 | 200.28 | 20.78 | 56.53 | 58.49 | 1.96 |
| 1 cream of comparative example | 216.42 | 211.17 | 5.25 | 58.12 | 58.66 | 0.54 |
| 2 cream of comparative example | 210.58 | 203.35 | 7.23 | 54.35 | 55.02 | 0.67 |
| 3 cream of comparative example | 216.35 | 212.94 | 3.41 | 55.64 | 56.12 | 0.48 |
| 4 cream of comparative example | 220.45 | 208.92 | 11.53 | 57.72 | 58.79 | 1.07 |
| 5 cream of comparative example | 212.84 | 201.03 | 11.81 | 56.48 | 57.52 | 1.04 |
As it can be seen from table 1 dermal melanin content lowers, skin using after the cream of embodiment 1-6 and comparative example
Brightness increases, and more than what the melanin content of comparative example product was reduced using the cream of embodiment 1-6, and skin is bright
Spend it is increased become apparent from, this illustrates that the composition of the invention containing Herba Saussureae Involueratae extract is able to suppress the production of melanin, improve
The brightness of skin, the effect of reaching skin lightening.
Embodiment 1 and comparative example 1-3 are compared as it can be seen that Herba Saussureae Involueratae extract, fruit extracts, ligule Rhizoma Seu Herba Bergeniae root extract
Effect when three kinds of compoundings is substantially better than the effect of independent role, illustrates that three is synergistic effect；Embodiment 1 and comparative example 4-
5 comparisons both illustrate as it can be seen that both narrow leaf blueberry fruit and Fructus Rubi in fruit extracts could promote effect when sharing
It is synergistic effect synergy.
2 skin irritation test of test example
1) test sample
1-6 of the present invention and comparative example 1-5 is prepared into composition.
2) test method
The age is chosen in the 20-50 years old volunteer for there are allergies 25 (male 10, women 15), is taken with syringe
0.03ml sample is placed in the coyote hole of spot examination adhesive tape, is immediately affixed on the spot for being equipped with sample examination adhesive tape longitudinal direction since lower part left front
On the normal skin of arm, while light pressing room and is uniformly distributed trier one by one to drive away air.Experiment position carries out mark
Note, to observe.Half an hour after patch is opened, then is checked according to the term of CTFA guide (1981).Paste skin knot
The 2-3 days after beam, continue to observe tardy.It identifies with table 2 as standard progress.
Table 2
| Grade | Symbol | Standard of perfection |
| 0 | - | Negative reaction: non-stimulated, without erythema |
| 1 | ± | Suspicious reaction: slight erythema |
| 2 | + | Weakly positive reaction: erythema |
| 3 | ++ | Strong positive reaction: erythema, papule, bubble |
| 4 | +++ | Extremely strong positive reaction: serious edema, bulla |
Table 3
| Sample | 0.5h | 2nd day | 3rd day |
| Embodiment 1 | 0 | 0 | 0 |
| Embodiment 2 | 0 | 0 | 0 |
| Embodiment 3 | 0 | 0 | 0 |
| Embodiment 4 | 0 | 0 | 0 |
| Embodiment 5 | 0 | 0 | 0 |
| Embodiment 6 | 0 | 0 | 0 |
| Comparative example 1 | 0 | Once ± | 0 |
| Comparative example 2 | 0 | 0 | 0 |
| Comparative example 3 | Once ± | 0 | 0 |
| Comparative example 4 | 0 | 0 | 0 |
| Comparative example 5 | 0 | 0 | 0 |
By this test result it is found that embodiment 1-6 composition is non-stimulated, and the stimulation of 1,3 pair of skin of comparative example has one
Secondary suspicious reaction illustrates that the cosmetic composition of the invention containing Herba Saussureae Involueratae extract is safe and non-stimulating.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (9)
1. a kind of cosmetic composition containing Herba Saussureae Involueratae extract, which is characterized in that it mainly includes the component of following parts by weight: snow
10-20 parts of Flos Nelumbinis extract, 10-20 parts of fruit extracts, 5-10 parts of ligule Rhizoma Seu Herba Bergeniae root extract；
The fruit extracts are mainly made of the raw material of following weight parts: 20-40 parts of narrow leaf blueberry fruit, Fructus Rubi 15-
30 parts.
2. a kind of cosmetic composition containing Herba Saussureae Involueratae extract according to claim 1, which is characterized in that the berry mentions
Taking raw material further includes 8-18 parts of Japanese Callicarpa bodinieri Levl. fruit.
3. a kind of cosmetic composition containing Herba Saussureae Involueratae extract according to claim 1 or 2, which is characterized in that the slurry
Berry extract raw material further includes 6-12 parts of Xingan's raspberry seed.
4. a kind of preparation method of cosmetic composition containing Herba Saussureae Involueratae extract described in claim 1, which is characterized in that including
Following steps:
1) 20-40 parts of narrow leaf blueberry fruit is weighed, 15-30 parts of Fructus Rubi, it is -18 to -10 DEG C of freezings that its whole, which is placed in temperature,
Save 10-15h；
2) it allows raw material to be extracted to melt 10-15min naturally, is sliced, be sent into airflow puffing tank, be warming up to 30-40 DEG C, vacuum degree
Control maintains 10-20min -0.2 to -0.1MPa, opens airflow puffing vacuum breaker and carries out tissue extruding destruction processing,
The 60-80% ethanol solution that 3-5 times of raw material (W/V) to be extracted is added is digestion agent, impregnates raw material 2-4h and stirs evenly；
3) the resulting material of step 2) is subjected to ultra high pressure treatment in high-pressure-resistant vessel, holding temperature is 60-75 DEG C, pressure is
20MPa, HIGH PRESSURE TREATMENT 8-12min are filtered after pressure release, separate filter residue and filtrate, filtrate are extracting solution A；
4) ethyl alcohol of the 60-80% of 2-4 times of filter residue quality is added into the filter residue that step 3) obtains, carries out ultrasonic wave extraction, surpasses
Sound condition is frequency 30-50kHz, 60-70 DEG C of temperature, time 5-10min, filtrate is collected by filtration after ultrasonic treatment, as
Extracting solution B；
5) extracting solution B made from extracting solution A made from step 3), step 4) is merged, in -0.2 to -0.1MPa vacuum item
The 1/4-1/2 of original volume is concentrated under part, temperature concentrated in vacuo is 50-70 DEG C, and concentrate freezes in -80 DEG C of ultra low temperature freezers
More than for 24 hours, dry 12-24h, is uniformly dissolved after freeze-drying with mixed solution, wherein the content of berry active constituent in freeze dryer
It is 1-10wt% to get fruit extracts；
6) parts by weight described in accordance with the claim 1 weigh in Herba Saussureae Involueratae extract, ligule Rhizoma Seu Herba Bergeniae root extract and step 5)
Fruit extracts, be added 4-10 times of volume number of cosmetic composition total volume mixed solution to get.
5. a kind of preparation method of cosmetic composition containing Herba Saussureae Involueratae extract according to claim 4, which is characterized in that
Step 1) further includes weighing 8-18 parts of Japanese Callicarpa bodinieri Levl. fruit.
6. a kind of preparation method of cosmetic composition containing Herba Saussureae Involueratae extract according to claim 4, which is characterized in that
Step 1) further includes weighing 6-12 parts of Xingan's raspberry seed.
7. a kind of preparation method of cosmetic composition containing Herba Saussureae Involueratae extract according to claim 4, which is characterized in that
Step 1) further includes weighing 8-18 parts of Japanese Callicarpa bodinieri Levl. fruit, 6-12 parts of Xingan's raspberry seed.
8. a kind of preparation method of cosmetic composition containing Herba Saussureae Involueratae extract according to claim 4, which is characterized in that
Mixed solution described in step 5) and step 6) is mixed by deionized water and butanediol according to volume ratio for 1/2-2/1.
9. a kind of application of the cosmetic composition containing Herba Saussureae Involueratae extract described in claim 1 as skin-care product additive.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1965794A (en) * | 2006-11-20 | 2007-05-23 | 吴桂谦 | Whitening skin-care composition containing snow lotus |
| CN101785552B (en) * | 2009-12-03 | 2012-05-23 | 汤真 | Raspberry seed extractive and extraction process |
| CN104398416A (en) * | 2014-10-31 | 2015-03-11 | 广州丹奇日用化工厂有限公司 | Tibetan medicine composition and preparation method and application thereof |
| CN105640871A (en) * | 2016-04-12 | 2016-06-08 | 王义金 | Skin whitening and nourishing emulsion containing saussurea involucrata extract |
| CN107137263A (en) * | 2017-04-19 | 2017-09-08 | 北京赛尔佳人化妆品有限公司 | A kind of anti-ageing face mask liquid and preparation method thereof |
-
2018
- 2018-11-01 CN CN201811297023.8A patent/CN109223644B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1965794A (en) * | 2006-11-20 | 2007-05-23 | 吴桂谦 | Whitening skin-care composition containing snow lotus |
| CN101785552B (en) * | 2009-12-03 | 2012-05-23 | 汤真 | Raspberry seed extractive and extraction process |
| CN104398416A (en) * | 2014-10-31 | 2015-03-11 | 广州丹奇日用化工厂有限公司 | Tibetan medicine composition and preparation method and application thereof |
| CN105640871A (en) * | 2016-04-12 | 2016-06-08 | 王义金 | Skin whitening and nourishing emulsion containing saussurea involucrata extract |
| CN107137263A (en) * | 2017-04-19 | 2017-09-08 | 北京赛尔佳人化妆品有限公司 | A kind of anti-ageing face mask liquid and preparation method thereof |
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