CN109211737A - Sample testing apparatus, sample analyser and sample testing method - Google Patents
Sample testing apparatus, sample analyser and sample testing method Download PDFInfo
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- CN109211737A CN109211737A CN201710531665.9A CN201710531665A CN109211737A CN 109211737 A CN109211737 A CN 109211737A CN 201710531665 A CN201710531665 A CN 201710531665A CN 109211737 A CN109211737 A CN 109211737A
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- 238000012360 testing method Methods 0.000 title claims abstract description 92
- 239000007788 liquid Substances 0.000 claims abstract description 227
- 239000000523 sample Substances 0.000 claims abstract description 160
- 238000001514 detection method Methods 0.000 claims abstract description 88
- 238000005070 sampling Methods 0.000 claims abstract description 37
- 239000012472 biological sample Substances 0.000 claims abstract description 11
- 238000004140 cleaning Methods 0.000 claims description 125
- 239000003153 chemical reaction reagent Substances 0.000 claims description 66
- 239000002699 waste material Substances 0.000 claims description 36
- 238000005520 cutting process Methods 0.000 claims description 27
- 239000012530 fluid Substances 0.000 claims description 26
- 238000002360 preparation method Methods 0.000 claims description 10
- 210000000265 leukocyte Anatomy 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 210000003714 granulocyte Anatomy 0.000 claims description 3
- 238000007689 inspection Methods 0.000 claims description 3
- 210000003924 normoblast Anatomy 0.000 claims description 3
- 210000001995 reticulocyte Anatomy 0.000 claims description 2
- 230000000712 assembly Effects 0.000 claims 1
- 238000000429 assembly Methods 0.000 claims 1
- 238000010586 diagram Methods 0.000 description 7
- 238000012864 cross contamination Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 210000000601 blood cell Anatomy 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 238000004820 blood count Methods 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 239000003219 hemolytic agent Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000006226 wash reagent Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
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- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The present invention discloses a kind of sample testing apparatus, comprising: pipeline；Sampling component, is connected to one end of pipeline；Reaction component is connected to the first access point of pipeline, and reaction component is for handling to form prepare liquid biological sample；Detection components are connected to the second access point of pipeline, and the second access point is located between sampling component and the first access point, and detection components are for carrying out prepare liquid detection；And push away sample component, it is connected to the third access point of pipeline, third access point is between the first access point and the second access point, part of the pipeline between the second access point and third access point is that prepare liquid prepares section, sampling component is used to form negative pressure and prepares to push away sample component in section for prepare liquid to be prepared to the prepare liquid push-in detection components in section so that prepare liquid is drawn into prepare liquid.It is true that above-mentioned sample testing apparatus pushes away calibration.Invention additionally discloses a kind of sample analyser and a kind of sample testing methods.
Description
Technical field
The present invention relates to the field of medical instrument technology more particularly to a kind of sample testing apparatus, a kind of sample analyser with
And a kind of sample testing method.
Background technique
Core detection part is flow chamber in five classification blood cell analyzers.The detection part passes through light scattering method, inspection
Volume, the specific characteristics of content for surveying blood cell, provide cell counts and items according to these specific characteristics
Classification results.Due to the development of reagent system, after blood cell is handled by different reagents, it can be deduced that more specificity are special
Reference number provides valuable testing result to tell more exception informations for clinic.
To achieve the above object, blood cell analyzer includes actuator, pipeline and reaction system, actuator and flow chamber
The both ends of pipeline are connected to, reaction system is connected among pipeline.After blood sample is processed into prepare liquid by reaction system,
Prepare liquid enters pipeline, and actuator detects the prepare liquid push-in flow chamber for entering pipeline.Since pipeline is longer, actuator
When pushing prepare liquid, being easy, which leads to push away sample movement because of pipeline deformation, is deviated, and then leads to flow chamber testing result not
Accurate or error.
Summary of the invention
Technical problem to be solved by the present invention lies in provide one kind to push away the accurate sample testing apparatus of sample, sample analyser
And sample testing method.
To achieve the goals above, embodiment of the present invention adopts the following technical scheme that
On the one hand, a kind of sample testing apparatus is provided, comprising:
Pipeline；
Sampling component, is connected to one end of the pipeline；
Reaction component, is connected to the first access point of the pipeline, and the reaction component is used for biological sample
Reason is to form prepare liquid；
Detection components, are connected to the second access point of the pipeline, second access point be located at the sampling component with
Between first access point, the detection components are for carrying out prepare liquid detection；And
Sample component is pushed away, the third access point of the pipeline is connected to, the third access point is located at first access point
Between second access point, part of the pipeline between second access point and the third access point be to
It surveys liquid and prepares section, the sampling component is used to form negative pressure and is prepared in section so that the prepare liquid is drawn into the prepare liquid, institute
It states and pushes away sample component for the prepare liquid to be prepared to the prepare liquid push-in detection components in section.
Wherein, the sample testing apparatus further includes the first switch piece and the first cleaning assembly, first cleaning assembly
It is connected to the 4th access point of the pipeline, the 4th access point is located at first access point far from the third access point
Side, first cleaning assembly for provide the first cleaning reagent, first switch piece is located on the pipeline and position
Between first access point and the third access point, first switch piece is for realizing cutting off or be connected to.
Wherein, the sample testing apparatus further includes the second cleaning assembly, and second cleaning assembly is connected to described
Four access points or the 5th access point for being connected to the pipeline, the 5th access point are located at the 4th access point and described the
Between two access points, second cleaning assembly is for providing the second cleaning reagent, the cleaning performance of second cleaning reagent
It is better than first cleaning reagent.
Wherein, the reaction component includes the first reaction tank, the first branch, the second switch piece, the second reaction tank, second
Road and third switch piece；
First reaction tank is used to form the first prepare liquid, and the first branch is connected to first reaction tank and institute
It states between the first access point, second switch piece is located in the first branch, and second switch piece is for realizing cutting
Or connection；
Second reaction tank is used to form the second prepare liquid, and second prepare liquid is different from first prepare liquid,
The second branch is connected between second reaction tank and first access point, and the third switch piece is located at described
Two roads, the third switch piece is for realizing cutting off or be connected to.
Wherein, first access point includes spaced first sub- access point and the second son access on the pipeline
Point, the first branch connect the first sub- access point, and the second branch connects the second sub- access point.
Wherein, the reaction component further includes third reaction tank, third branch and the 4th switch piece, the third reaction
Pond is used to form third prepare liquid, and the third prepare liquid is different from first prepare liquid and second prepare liquid, described
Third branch is connected between the third reaction tank and first access point, and the 4th switch piece is located at the third branch
On the road, the 4th switch piece is for realizing cutting off or be connected to.
Wherein, first prepare liquid is for carrying out white blood cell count(WBC), erythroblast classification and basophilic granulocyte
Classification and Detection, second prepare liquid for carrying out leukocyte differential count detection, the third prepare liquid for carry out net knit it is red thin
Born of the same parents' count detection.
Wherein, the sampling component includes the first waste liquid pool and the 5th switch piece, forms negative pressure in first waste liquid pool,
5th switch piece is connected between first waste liquid pool and the pipeline, the 5th switch piece for realizing cutting and
Connection.
Wherein, the detection components include flow chamber, sheath liquid pool, the 6th switch piece, the second waste liquid pool and the 7th switching
Part, the flow chamber have prepare liquid entrance, sheath fluid entrance and outlet, prepare liquid entrance connection second access
Point, the sheath fluid entrance connect the sheath liquid pool, and the sheath liquid pool is connected to described for storing sheath fluid, the 6th switch piece
Between sheath liquid pool and the sheath fluid entrance, the 6th switch piece is for realizing cutting off and be connected to, the outlet connection described the
Two waste liquid pools, the 7th switch piece are connected between second waste liquid pool and the outlet, and the 7th switch piece is used for
It realizes and cuts off and be connected to.
Wherein, first cleaning assembly includes the first reagent and the 8th switch piece, and first reagent is for depositing
The first reagent is stored up, the 8th switch piece is connected between first reagent and the 4th access point, and the described 8th cuts
Part is changed for realizing cutting off and being connected to.
Wherein, second cleaning assembly includes the second reagent and the 9th switch piece, and second reagent is for depositing
The second reagent is stored up, the 9th switch piece is connected to second reagent and the 4th access point or the 5th access point
Between, the 9th switch piece is for realizing cutting off and be connected to.
On the other hand, a kind of sample analyser, including above-mentioned sample testing apparatus are also provided.
Yet another aspect, also provides a kind of sample testing method, the sample testing method using sample testing apparatus into
Row detection, the sample testing apparatus include pipeline, sampling component, reaction component, detection components and push away sample component, the pumping
Sample component is connected to one end of the pipeline, and the reaction component is connected to the first access point of the pipeline, the detection group
Part is connected to the second access point of the pipeline, second access point be located at the sampling component and first access point it
Between, the third access point for pushing away sample component and being connected to the pipeline, the third access point be located at first access point with
Between second access point, part of the pipeline between second access point and the third access point is to be measured
Liquid prepares section；
The sample testing method includes:
Reaction step: the reaction component processing biological sample is to form prepare liquid；
Sampling step: the prepare liquid is drawn into prepare liquid and prepared in section by the sampling component；And
Push away sample and detecting step: the sample component that pushes away is by the prepare liquid push-in inspection in prepare liquid preparation section
Component is surveyed to be detected.
Wherein, the sample testing apparatus further includes the first switch piece and the first cleaning assembly, first cleaning assembly
It is connected to the 4th access point of the pipeline, the 4th access point is located at first access point far from the third access point
Side, first switch piece is located on the pipeline and between first access point and the third access point；
After the sampling step, the sample testing method further includes the first cleaning step, the first cleaning step
Suddenly include:
First switch piece cuts off the pipeline；
First cleaning assembly cleans leading portion pipeline and the reaction component, wherein the leading portion pipeline is
The part between first switch piece and first cleaning assembly of the pipeline.
Wherein, first cleaning step pushes away sample and detecting step and carries out simultaneously with described.
Wherein, the sample testing apparatus further includes the second cleaning assembly, and second cleaning assembly is connected to described
Four access points or the 5th access point for being connected to the pipeline, the 5th access point are located at the 4th access point and described the
Between two access points；
It is described push away sample and detecting step after, the sample testing method further includes the second cleaning step, described second
Cleaning step includes:
First switch piece is connected to the pipeline；
Second cleaning assembly cleans common pall with the second cleaning reagent, wherein the common pall is
The part between second access point and the 4th access point of the pipeline；And
First cleaning assembly cleans the pipeline with the first cleaning reagent, wherein the second cleaning examination
The cleaning performance of agent is better than first cleaning reagent.
Wherein, the reaction component includes the first reaction tank and the second reaction tank, in the reaction step, described first
Reaction tank and second reaction tank are respectively formed the first prepare liquid and the second prepare liquid, successively pass through in first prepare liquid
The sampling step, it is described push away sample and detecting step and the second cleaning step after, second prepare liquid is sampled step
Suddenly.
Wherein, the detection components include flow chamber and the sheath liquid pool for connecting the flow chamber, are equipped in the flow chamber
Detection sensor, the sheath liquid pool memory store up sheath fluid, described to push away sample and detecting step includes:
It is described to push away the prepare liquid that sample component prepares the prepare liquid in section and be pushed into the flow chamber, while the sheath
Liquid enters the flow chamber；
The prepare liquid and the sheath fluid form liquid stream to be measured；And
The detection sensor detects the prepare liquid stream.
Compared to the prior art, the invention has the following advantages:
Sample between first access point and second access point namely described is pushed away due to the third access point
Component between the detection components and the reaction component, therefore it is described push away between sample component and the detection components away from
From shorter, the pipeline is located at the part (namely the prepare liquid prepares section) pushed away between sample component and the detection components
Length it is shorter, bring pushes away sample deviation so as to avoiding due to pipeline deforms, and it is true that the sample testing apparatus pushes away calibration,
Advantageously ensure that the accuracy of the detection components testing result.It is described to push away since prepare liquid preparation section is shorter
Sample component pushes away that sample resistance is smaller, difficulty is lower, meanwhile, the reaction component, which forms the less amount of prepare liquid, to be met
Detection demand is conducive to the popularization of the sample testing apparatus so having saved biological sample.
Detailed description of the invention
In order to illustrate more clearly of technical solution of the present invention, attached drawing needed in embodiment will be made below
Simply introduce, it should be apparent that, the accompanying drawings in the following description is only some embodiments of the present invention, general for this field
For logical technical staff, without creative efforts, other attached drawings can also be obtained such as these attached drawings.
Fig. 1 is a kind of schematic diagram of sample testing apparatus provided in an embodiment of the present invention；
Fig. 2 is the schematic diagram of the reaction component of sample testing apparatus shown in Fig. 1 and a kind of connection type of pipeline；
Fig. 3 is the schematic diagram of the reaction component of sample testing apparatus shown in Fig. 1 and another connection type of pipeline；
Fig. 4 is the schematic diagram one of the part-structure of sample testing apparatus shown in Fig. 1；
Fig. 5 is the schematic diagram for building pressure component of sample testing apparatus shown in Fig. 1；
Fig. 6 is the schematic diagram two of the part-structure of sample testing apparatus shown in Fig. 1；
Fig. 7 is the schematic diagram three of the part-structure of sample testing apparatus shown in Fig. 1.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention is described, and shows
So, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based on the reality in the present invention
Example is applied, every other embodiment obtained by those of ordinary skill in the art without making creative efforts all belongs to
In the scope of protection of the invention.
In addition, the explanation of following embodiment is referred to the additional illustration, the spy that can be used to implement to illustrate the present invention
Determine embodiment.Direction terms mentioned in the present invention, for example, "upper", "lower", "front", "rear", "left", "right", "inner",
"outside", " side " etc. are only the directions with reference to annexed drawings, and therefore, the direction term used is to more preferably, more clearly say
The bright and understanding present invention, rather than indicate or imply signified device or element and must have a particular orientation, with specific square
Position construction and operation, therefore be not considered as limiting the invention.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " installation ", " phase
Even ", " connection ", " be arranged exist ... on " shall be understood in a broad sense, for example, it may be being fixedly connected, be also possible to removably connect
It connects, or is integrally connected；It can be mechanical connection；It can be directly connected, can also indirectly connected through an intermediary, it can
To be the connection inside two elements.For the ordinary skill in the art, above-mentioned term can be understood with concrete condition
Concrete meaning in the present invention.
In addition, in the description of the present invention, unless otherwise indicated, the meaning of " plurality " is two or more.In addition,
Refer to the numerical value for recording "~" front and back as minimum value and maximum value with the numberical range that "~" indicates in this specification
The range being included.In the accompanying drawings, structurally similar or identical unit is indicated by the same numeral.
Referring to Fig. 1, the embodiment of the present invention provides a kind of sample analyser.The sample analyser can be used for carrying out biology
Sample analysis, the biological sample can be blood, urine etc..
The sample analyser includes sample testing apparatus 100.The sample testing apparatus 100 includes pipeline 1, groups of samples
Part 2, reaction component 3, detection components 4 and push away sample component 5.The sampling component 2 is connected to one end 11 of the pipeline 1.Institute
The first access point 12 that reaction component 3 is connected to the pipeline 1 is stated, the reaction component 3 is for handling biological sample
To form prepare liquid.The detection components 4 are connected to the second access point 13 of the pipeline 1, and second access point 13 is located at
Between the sampling component 2 and first access point 12, the detection components 4 are for carrying out prepare liquid detection.It is described to push away sample
Component 5 is connected to the third access point 14 of the pipeline 1, the third access point 14 be located at first access point 12 with it is described
Between second access point 13.Part of the pipeline 1 between second access point 13 and the third access point 14 is
Prepare liquid prepares section 15.The sampling component 2 is used to form negative pressure and prepares section so that the prepare liquid is drawn into the prepare liquid
In 15, the prepare liquid for pushing away sample component 5 for preparing the prepare liquid in section 15 is pushed into the detection components 4.
In the present embodiment, since the third access point 14 is located at first access point 12 and second access point
Between 13 namely the sample component 5 that pushes away is between the detection components 4 and the reaction component 3, therefore described pushes away sample component
The distance between 5 and the detection components 4 are shorter, and the pipeline 1 is located at described push away between sample component 5 and the detection components 4
Part (namely the prepare liquid prepare section 15) length it is shorter, so as to avoid due to pipeline 1 deforms, bring is pushed away
Sample deviation, the sample testing apparatus 100 push away that calibration is true, advantageously ensure that the accuracy of 4 testing result of detection components.By
It is shorter to prepare section 15 in the prepare liquid, therefore the sample component 5 that pushes away pushes away that sample resistance is smaller, difficulty is lower, meanwhile, it is described anti-
Detection demand can be met by answering component 3 to form the less amount of prepare liquid, so having saved biological sample, be conducive to described
The popularization of sample testing apparatus 100.
Referring to Fig. 1, the sample testing apparatus 100 further includes the first switch piece 6 and as a kind of alternative embodiment
One cleaning assembly 7.First cleaning assembly 7 is connected to the 4th access point 16 of the pipeline 1, and described 4th access point 16
In side of first access point 12 far from the third access point 14, first cleaning assembly 7 is clear for providing first
Wash reagent.First switch piece 6 is located on the pipeline 1 and is located at first access point 12 and the third access point 14
Between, first switch piece 6 is for realizing cutting off or be connected to.
In the present embodiment, after the reaction component 3 forms the prepare liquid, be connected to first switch piece 6, it is described to
After survey liquid enters prepare liquid preparation section 15, first switch piece 6 is cut off.At this point, it is described push away sample component 5 push it is described to
It surveys the prepare liquid that liquid prepares in section 15 to be detected into the detection components 4, first cleaning assembly 7 can be simultaneously
The part 17 between first switch piece 6 and first cleaning assembly 7 of the pipeline 1 is cleaned (before hereinafter referred to as
Duan Guanlu 17) and the reaction component 3, enable the reaction component 3 after being cleaned to handle new biological sample in time,
To improve the working efficiency of the sample testing apparatus 100, be conducive to the detection speed for promoting the sample analyser.
Optionally, first cleaning reagent is dilution.
Referring to Fig. 1, the sample testing apparatus 100 further includes the second cleaning assembly 8 as a kind of alternative embodiment.
Second cleaning assembly 8 is connected to the 4th access point 16 or is connected to the 5th access point 18 of the pipeline 1, and described
Five access points 18 are between the 4th access point 16 and second access point 13.With the 5th access point 18 in Fig. 1
It is illustrated between second access point 13 and the third access point 14, the 5th access point 18 leans at this time
The nearly third access point 14 is arranged.In other embodiments, it is small black can also to be located at other in Fig. 1 for the 5th access point 18
Point position.Second cleaning assembly 8 is for providing the second cleaning reagent, the cleaning performance of second cleaning reagent
It is better than first cleaning reagent.
In the present embodiment, second cleaning assembly 8 of the sample testing apparatus 100 is connected to the 4th access
16 or described 5th access points 18 of point namely second cleaning assembly 8 setting are therefore described in 4 upstream of detection components
Second cleaning assembly 8 can common pall 19 before the entrance to the detection components 4 (common pall 19 is the pipeline
1 part between second access point 13 and the 5th access point 18, the common pall 19 are described to be measured
Liquid preparation section 15 a part) cleaned, thus reduce because the different prepare liquids be both needed to through the common pall 19 into
Enter the detection components 4 and the risk of cross contamination occurs.It is clear that the cleaning performance of second cleaning reagent is better than described first
Reagent is washed, is conducive to more thoroughly wash the common pall 19.
It should be understood that effective detection part (referring to the adopted part of detection data) of the prepare liquid be entirely located in or
Almost all is located in the common pall 19, to improve the accuracy in detection of the sample testing apparatus 100.
Optionally, the 5th access point 18 makes between the third access point 14 and second access point 13
The complete prepare liquid preparation section 15 can be cleaned by obtaining second cleaning assembly 8, to further decrease generation
The risk of cross contamination.
Optionally, second cleaning reagent is hemolytic agent.
Also referring to Fig. 1 to Fig. 3, as a kind of alternative embodiment, the reaction component 3 include the first reaction tank 31,
The first branch 32, the second switch piece 33, the second reaction tank 34, second branch 35 and third switch piece 36.First reaction
Pond 31 is used to form the first prepare liquid.The first branch 32 is connected to first reaction tank 31 and first access point 12
Between.Second switch piece 33 is located in the first branch 32, and second switch piece 33 is for realizing cutting off or be connected to.
Second reaction tank 34 is used to form the second prepare liquid, and second prepare liquid is different from first prepare liquid.Described
Two branches 35 are connected between second reaction tank 34 and first access point 12.The third switch piece 36 is located at described
In second branch 35, the third switch piece 36 is for realizing cutting off or be connected to.
Optionally, for first prepare liquid for carrying out white blood cell count(WBC) detection, second prepare liquid is white for carrying out
Cell classification detection.In one embodiment, first prepare liquid is also used to carry out erythroblast classification and basophilic
Property granulocyte classification and Detection.
In one embodiment, multi-pass part 121 is set on first access point 12, for being connected to the pipeline 1
With the first branch 32 and the second branch 35.
In another embodiment, first access point 12 includes spaced first son on the pipeline 1
Access point 122 and the second sub- access point 123.The first branch 32 connects the described first sub- access point 122, the second branch
The 35 connection second sub- access points 123.At this point, on the first sub- access point 122 and the second sub- access point 123
Three-way piece is set.
Optionally, the reaction component 3 further includes third reaction tank 37, third branch 38 and the 4th switch piece 39.Institute
It states third reaction tank 37 and is used to form third prepare liquid, the third prepare liquid is different from first prepare liquid and described second
Prepare liquid.The third branch 38 is connected between the third reaction tank 37 and first access point 12.Described 4th cuts
It changes part 39 to be located on the third branch 38, the 4th switch piece 39 is for realizing cutting off or be connected to.At this point, described first connects
The multi-pass part 121 in access point 12 is also used to be connected to the third branch 38；Alternatively, first access point 12 further includes
Three sub- access points 124, the sub- access point 124 of third and the described first sub- access point 122 and the second sub- access point 123 are equal
Interval setting.Settable three-way piece on the sub- access point 124 of third.
Optionally, the third prepare liquid is for carrying out reticulocyte count detection.
Optionally, first prepare liquid, second prepare liquid and the third prepare liquid can be suitable according to being formed
The either order of sequence enters the detection components 4 and is detected, to improve the detection speed of the sample testing apparatus 100.When
So, in other embodiments, first prepare liquid, second prepare liquid and the third prepare liquid can also be according to
Other preset orders sequentially enter the detection components 4 and are detected.
Also referring to Fig. 1 to Fig. 5, as a kind of alternative embodiment, the sampling component 2 includes 21 He of the first waste liquid pool
5th switch piece 22.Negative pressure is formed in first waste liquid pool 21.5th switch piece 22 is connected to first waste liquid pool
Between 21 and the pipeline 1, the 5th switch piece 22 is for realizing cutting off and be connected to.5th switch piece 22 is connected to described
When first waste liquid pool 21 is with the pipeline 1, first switch piece 6 is connected to the prepare liquid and prepares section 15 and the reaction component
3, the prepare liquid of the reaction component 3 enters the prepare liquid and prepares section 15.
Optionally, the sample testing apparatus 100 further includes waste drains pump 23.The waste drains pump 23 connects first waste liquid
Pond 21, for the liquid in first waste liquid pool 21 to be discharged into outside machine.The waste drains pump 23 is also used to useless for described first
Liquid pool 21 establishes negative pressure.
Optionally, the sample testing apparatus 100 further includes building pressure component 9.The pressure component 9 of building includes air pump 91 and the
One air accumulator 92, the air pump 91 is for establishing negative pressure in first air accumulator 92.The negative pressure can be -40kPa.Institute
It states after the first waste liquid pool 21 is connected to first air accumulator 92, forms the negative pressure in first waste liquid pool 21.Described
Settable bolster 93 between one waste liquid pool 21 and first air accumulator 92, for avoiding the liquid in first waste liquid pool 21
Body flows backward into first air accumulator 92.
Optionally, the pressure component 9 of building further includes the second air accumulator 96, and the air pump 91 is connected to second air accumulator
96, for establishing the first positive pressure in second air accumulator 96.First positive pressure can be 120kPa.It is described to build pressure component
9 may also include third air accumulator 94 and the 4th air accumulator 95.When second air accumulator 96 is connected to the third air accumulator 94,
The second positive pressure can be established in the third air accumulator 94 using first positive pressure.Second positive pressure can be 90kPa.
It, can be using first positive pressure in the 4th air accumulator when second air accumulator 96 is connected to four air accumulator 95
Third positive pressure is established in 95.The third positive pressure can be 50kPa.
Certainly, in other embodiments, the air pump 91 can also be directly in the third air accumulator 94 and described
The built-in pressure of attentioning of four air accumulator 95.
Also referring to Fig. 1 to Fig. 6, as a kind of alternative embodiment, the detection components 4 include flow chamber 41, sheath fluid
Pond 42, the 6th switch piece 43, the second waste liquid pool 44 and the 7th switch piece 45.The flow chamber 41 have prepare liquid entrance 411,
Sheath fluid entrance 412 and outlet 413.The prepare liquid entrance 411 connects second access point 13.The sheath fluid entrance 412
The sheath liquid pool 42 is connected, the sheath liquid pool 42 is for storing sheath fluid.6th switch piece 43 is connected to the sheath liquid pool 42
Between the sheath fluid entrance 412, the 6th switch piece 43 is for realizing cutting off and be connected to.Described in 413 connection of outlet
Second waste liquid pool 44.7th switch piece 45 is connected between second waste liquid pool 44 and the outlet 413, and the described 7th
Switch piece 45 is for realizing cutting off and be connected to.
When the flow chamber 41 is detected, the 7th switch piece 45 is connected to second waste liquid pool 44 and the outlet
413, the 6th switch piece 43 is connected to the sheath liquid pool 42 and the sheath fluid entrance 412, the sheath in the sheath liquid pool 42
Liquid enters the flow chamber 41 from the sheath fluid entrance 412, while the sample component 5 that pushes away pushes the prepare liquid to prepare in section 15
The prepare liquid enter the flow chamber 41 from the prepare liquid entrance 411, the sheath fluid wrap up the prepare liquid formed to
Liquid stream is surveyed to be detected, the liquid stream to be measured after detection enters second waste liquid pool 44 from the outlet 413.
Optionally, the sheath liquid pool 42 connects the third air accumulator 94, when the two is connected to, the second positive pressure expulsion institute
It states sheath fluid and flows into the flow chamber 41.
Optionally, be equipped with detection sensor 414 in the flow chamber 41, the detection sensor 414 be used for it is described to
Liquid stream is surveyed to be detected.
Optionally, second waste liquid pool 44 is connected to atmosphere or negative pressure.
Optionally, second waste liquid pool 44 connects first waste liquid pool 21 by shut-off valve 46.Second waste liquid
Liquid in pond 44 is successively discharged to outside machine through first waste liquid pool 21 and the waste drains pump 23.
Also referring to Fig. 1 to Fig. 7, as a kind of alternative embodiment, first cleaning assembly 7 includes the first reagent
71 and the 8th switch piece 72.First reagent 71 is connected to described for storing the first reagent, the 8th switch piece 72
Between first reagent 71 and the 4th access point 16, the 8th switch piece 72 is for realizing cutting off and be connected to.
Optionally, the 4th air accumulator 95 connects first reagent 71.8th switch piece 72 is connected to described
When first reagent 71 is with four access point 16, the 4th air accumulator 95 is connected to first reagent 71, for pushing away
First reagent moved in first reagent 71 enters the pipeline 1.
As a kind of alternative embodiment, second cleaning assembly 8 includes the second reagent 81 and the 9th switch piece 82.Institute
State the second reagent 81 for store the second reagent, the 9th switch piece 82 is connected to second reagent 81 and described the
Between four access points 16 or the 5th access point 18, the 9th switch piece 82 is for realizing cutting off and be connected to.
Optionally, the 4th air accumulator 95 connects second reagent 81.9th switch piece 82 is connected to described
When second reagent 81 is with the 4th access point 16 or five access point 18, the 4th air accumulator 95 is connected to described the
Two reagents 81, for pushing second reagent of second reagent 81 to enter the pipeline 1.
Also referring to Fig. 1 to Fig. 7, as a kind of alternative embodiment, the sample component 5 that pushes away includes syringe, to steady
Push the prepare liquid to prepare the liquid (such as described prepare liquid) in section 15 surely.Certainly, it can also be used in the sample component 5 that pushes away
The device for the liquid that he steadily can at the uniform velocity push the prepare liquid to prepare in section 15.
Also referring to Fig. 1 to Fig. 7, the embodiment of the present invention also provides a kind of sample testing method, the pattern detection side
Method is detected using sample testing apparatus 100 described in above-described embodiment.The sample testing apparatus 100 includes pipeline 1, sampling
Component 2, reaction component 3, detection components 4 and sample component 5 being pushed away, the sampling component 2 is connected to one end 11 of the pipeline 1,
The reaction component 3 is connected to the first access point 12 of the pipeline 1, and the detection components 4 are connected to the second of the pipeline 1
Access point 13, second access point 13 are described to push away sample component between the sampling component 2 and first access point 12
5 are connected to the third access point 14 of the pipeline 1, and the third access point 14 is located at first access point 12 and described second
Between access point 13, part of the pipeline 1 between second access point 13 and the third access point 14 is to be measured
Liquid prepares section 15.
The sample testing method includes:
Reaction step: the reaction component 3 handles to form prepare liquid biological sample；
Sampling step: the prepare liquid is drawn into prepare liquid and prepared in section 15 by the sampling component 2；And
Push away sample and detecting step: the sample component 5 that pushes away is by the prepare liquid push-in institute in prepare liquid preparation section 15
Detection components 4 are stated to be detected.
In the present embodiment, described to be measured since the distance between the sample component 5 and the detection components 4 of pushing away is shorter
Liquid prepare section 15 length it is shorter, therefore can be avoided because pipeline 1 deform due to bring pushes away sample deviation, it is described to push away sample and detection
Sample step is accurate for pushing away in step, and the testing result accuracy of the sample testing method is high.
Also referring to Fig. 1 to Fig. 7, as a kind of alternative embodiment, the sample testing apparatus 100 further includes first cutting
Change part 6 and the first cleaning assembly 7.First cleaning assembly 7 is connected to the 4th access point 16 of the pipeline 1, and the described 4th
Access point 16 is located at side of first access point 12 far from the third access point 14.First switch piece 6 is located at institute
It states on pipeline 1 and between first access point 12 and the third access point 14.
After the sampling step, the sample testing method further includes the first cleaning step, the first cleaning step
Suddenly include:
First switch piece 6 cuts off the pipeline 1；With
First cleaning assembly 7 cleans leading portion pipeline 17 and the reaction component 3, wherein the leading portion pipe
Road 17 is the part between first switch piece 6 and first cleaning assembly 7 of the pipeline 1.
In the present embodiment, first switch piece 6 has separated the prepare liquid preparation section 15 and the leading portion pipeline 17,
So that sample and the detecting step of pushing away is not interfere with each other with first cleaning step, two steps can one in front and one in back into
Row, can also carry out simultaneously, so that the sample testing method is more flexible, can meet more diversified demand.
Optionally, first cleaning step pushes away sample and detecting step and carries out simultaneously with described.At this point, the pattern detection
The working efficiency of method is higher, detects fast speed, is conducive to promote the sample testing apparatus 100 and the sample analyser
Detection speed.
Also referring to Fig. 1 to Fig. 7, as a kind of alternative embodiment, the sample testing apparatus 100 further includes second clear
Wash component 8.Second cleaning assembly 8 is connected to the 4th access point 16 or is connected to the 5th access point of the pipeline 1
18, the 5th access point 18 is between the 4th access point 16 and second access point 13.
It is described push away sample and detecting step after, the sample testing method further includes the second cleaning step, described second
Cleaning step includes:
First switch piece 6 is connected to the pipeline 1；
Second cleaning assembly 8 cleans common pall 19 with the second cleaning reagent, wherein the common pall
19 be the part between second access point 13 and the 4th access point 16 of the pipeline 1；And
First cleaning assembly 7 cleans the pipeline 1 with the first cleaning reagent, wherein second cleaning
The cleaning performance of reagent is better than first cleaning reagent.
In the present embodiment, second cleaning step uses two step cleaning ways, carries out by force to the common pall 19
Power cleaning, so as to reduce due to the different prepare liquids is both needed to enter through the common pall 19 detection components 4
The risk that cross contamination occurs, improves the accuracy in detection of the sample testing method.
Optionally, second cleaning reagent is hemolytic agent.
Optionally, first cleaning reagent is diluent.
In one embodiment, second cleaning step includes:
First switch piece 6 is connected to the pipeline 1；
First cleaning assembly 7 cleans common pall 19 with the first cleaning reagent；
Second cleaning assembly 8 cleans common pall 19 with the second cleaning reagent, wherein the common pall
19 be the part between second access point 13 and the 4th access point 16 of the pipeline 1, second cleaning
The cleaning performance of reagent is better than first cleaning reagent；And
First cleaning assembly 7 cleans the pipeline 1 with the first cleaning reagent.
In the present embodiment, second cleaning step uses three step cleaning ways, increases relative to two step cleaning ways
Cleaning of one step to the common pall 19, so that it is more thorough to the cleaning of the common pall 19, so as to reduce
Because the different prepare liquids is both needed to that the risk of cross contamination occurs due to entering detection components 4 through the common pall 19,
Improve the accuracy in detection of the sample testing method.
Also referring to Fig. 1 to Fig. 7, as a kind of alternative embodiment, the reaction component 3 includes 31 He of the first reaction tank
Second reaction tank 34.In the reaction step, first reaction tank 31 and second reaction tank 34 are respectively formed first
Prepare liquid and the second prepare liquid, first prepare liquid successively by the sampling step, it is described push away sample and detecting step with
And second after cleaning step, second prepare liquid is sampled step.
In the present embodiment, first prepare liquid and second prepare liquid sequentially enter the detection components 4 and carry out
Detection.The detection operation (including the sampling step and described push away sample and detecting step) and described second of first prepare liquid
The second cleaning step, Neng Gouyou are provided between prepare liquid movement (including the sampling step and described push away sample and detecting step)
Effect reduces by first prepare liquid to cross contamination caused by second prepare liquid, to improve second prepare liquid
Accuracy in detection, the accuracy in detection of sample testing method described in effective guarantee.
It should be understood that in other embodiments, the detection order of first prepare liquid and second prepare liquid
It can exchange.
Also referring to Fig. 1 to Fig. 7, as a kind of alternative embodiment, the detection components 4 include flow chamber 41 and connection
The sheath liquid pool 42 of the flow chamber 41, the flow chamber 41 is interior to be equipped with detection sensor 414, stores sheath in the sheath liquid pool 42
Liquid.
It is described to push away sample and detecting step includes:
The sample component 5 that pushes away is by the prepare liquid push-in flow chamber 41 in prepare liquid preparation section 15, simultaneously
The sheath fluid enters the flow chamber 41；
The prepare liquid and the sheath fluid form liquid stream to be measured；And
The detection sensor 414 detects the prepare liquid stream.
Optionally, the sheath fluid can be enabled to be introduced into the flow chamber 41, then the sheath fluid and the prepare liquid and advanced
Enter the flow chamber 41, to save the prepare liquid.
The embodiment of the present invention has been described in detail above, specific case used herein to the principle of the present invention and
Embodiment is expounded, and the above description of the embodiment is only used to help understand the method for the present invention and its core ideas；
At the same time, for those skilled in the art can in specific embodiments and applications according to the thought of the present invention
There is change place, in conclusion the contents of this specification are not to be construed as limiting the invention.
Claims (18)
1. a kind of sample testing apparatus characterized by comprising
Pipeline；
Sampling component, is connected to one end of the pipeline；
Reaction component, is connected to the first access point of the pipeline, the reaction component be used to handle biological sample with
Form prepare liquid；
Detection components, are connected to the second access point of the pipeline, second access point be located at the sampling component with it is described
Between first access point, the detection components are for carrying out prepare liquid detection；And
Sample component is pushed away, the third access point of the pipeline is connected to, the third access point is located at first access point and institute
It states between the second access point, part of the pipeline between second access point and the third access point is prepare liquid
Prepare section, the sampling component is used to form negative pressure and prepares in section so that the prepare liquid is drawn into the prepare liquid, described to push away
The prepare liquid that sample component is used to prepare the prepare liquid in section is pushed into the detection components.
2. sample testing apparatus as described in claim 1, which is characterized in that the sample testing apparatus further includes the first switching
Part and the first cleaning assembly, first cleaning assembly are connected to the 4th access point of the pipeline, the 4th access point
In side of first access point far from the third access point, first cleaning assembly is for providing the first cleaning examination
Agent, first switch piece is located on the pipeline and between first access point and the third access point, described
First switch piece is for realizing cutting off or be connected to.
3. sample testing apparatus as claimed in claim 2, which is characterized in that the sample testing apparatus further includes the second cleaning
Component, second cleaning assembly are connected to the 4th access point or are connected to the 5th access point of the pipeline, and described
For five access points between the 4th access point and second access point, second cleaning assembly is clear for providing second
Reagent is washed, the cleaning performance of second cleaning reagent is better than first cleaning reagent.
4. sample testing apparatus as claimed in any one of claims 1 to 3, which is characterized in that the reaction component includes first
Reaction tank, the first branch, the second switch piece, the second reaction tank, second branch and third switch piece；
First reaction tank is used to form the first prepare liquid, and the first branch is connected to first reaction tank and described the
Between one access point, second switch piece is located in the first branch, second switch piece for realizing cut off or even
It is logical；
Second reaction tank is used to form the second prepare liquid, and second prepare liquid is different from first prepare liquid, described
Second branch is connected between second reaction tank and first access point, and the third switch piece is located at described second
On the road, the third switch piece is for realizing cutting off or be connected to.
5. sample testing apparatus as claimed in claim 4, which is characterized in that first access point includes on the pipeline
Spaced first sub- access point and the second sub- access point, the first branch connect the first sub- access point, and described the
Two branches connect the second sub- access point.
6. sample testing apparatus as claimed in claim 4, which is characterized in that the reaction component further include third reaction tank,
Third branch and the 4th switch piece, the third reaction tank are used to form third prepare liquid, and the third prepare liquid is different from
First prepare liquid and second prepare liquid, the third branch are connected to the third reaction tank and first access
Between point, the 4th switch piece is located at third branch road, and the 4th switch piece is for realizing cutting off or be connected to.
7. sample testing apparatus as claimed in claim 6, which is characterized in that first prepare liquid is by carrying out based on leucocyte
Number, erythroblast classification and basophilic granulocyte classification and Detection, second prepare liquid is for carrying out leukocyte differential count inspection
It surveys, the third prepare liquid is for carrying out reticulocyte count detection.
8. sample testing apparatus as claimed in any one of claims 1 to 3, which is characterized in that the sampling component includes first
Waste liquid pool and the 5th switch piece, first waste liquid pool is interior to form negative pressure, and the 5th switch piece is connected to first waste liquid
Between pond and the pipeline, the 5th switch piece is for realizing cutting off and be connected to.
9. sample testing apparatus as claimed in any one of claims 1 to 3, which is characterized in that the detection components include flowing
There is prepare liquid entrance, sheath fluid to enter for room, sheath liquid pool, the 6th switch piece, the second waste liquid pool and the 7th switch piece, the flow chamber
Mouth and outlet, the prepare liquid entrance connect second access point, and the sheath fluid entrance connects the sheath liquid pool, the sheath
Liquid pool is for storing sheath fluid, and the 6th switch piece is connected between the sheath liquid pool and the sheath fluid entrance, and the described 6th cuts
Part is changed for realizing cutting off and being connected to, the outlet connects second waste liquid pool, and the 7th switch piece is connected to described the
Between two waste liquid pools and the outlet, the 7th switch piece is for realizing cutting off and be connected to.
10. sample testing apparatus as claimed in claim 2 or claim 3, which is characterized in that first cleaning assembly includes the first examination
Agent pond and the 8th switch piece, first reagent are connected to described first for storing the first reagent, the 8th switch piece
Between reagent and the 4th access point, the 8th switch piece is for realizing cutting off and be connected to.
11. sample testing apparatus as claimed in claim 3, which is characterized in that second cleaning assembly includes the second reagent
Pond and the 9th switch piece, second reagent are connected to second examination for storing the second reagent, the 9th switch piece
Between agent pond and the 4th access point or the 5th access point, the 9th switch piece is for realizing cutting off and be connected to.
12. a kind of sample analyser, which is characterized in that including sample testing apparatus as claimed in any one of claims 1 to 11.
13. a kind of sample testing method, which is characterized in that the sample testing method is detected using sample testing apparatus,
The sample testing apparatus includes pipeline, sampling component, reaction component, detection components and pushes away sample component, the sampling component
It is connected to one end of the pipeline, the reaction component is connected to the first access point of the pipeline, the detection components connection
In the second access point of the pipeline, second access point is between the sampling component and first access point, institute
It states and pushes away the third access point that sample component is connected to the pipeline, the third access point is located at first access point and described the
Between two access points, part of the pipeline between second access point and the third access point is prepare liquid preparation
Section；
The sample testing method includes:
Reaction step: the reaction component processing biological sample is to form prepare liquid；
Sampling step: the prepare liquid is drawn into prepare liquid and prepared in section by the sampling component；And
Push away sample and detecting step: the sample component that pushes away is by the prepare liquid push-in detection group in prepare liquid preparation section
Part is detected.
14. sample testing method as claimed in claim 13, which is characterized in that the sample testing apparatus further includes first cutting
Part and the first cleaning assembly are changed, first cleaning assembly is connected to the 4th access point of the pipeline, the 4th access point
Side positioned at first access point far from the third access point, first switch piece are located on the pipeline and are located at
Between first access point and the third access point；
After the sampling step, the sample testing method further includes the first cleaning step, the first cleaning step packet
It includes:
First switch piece cuts off the pipeline；
First cleaning assembly cleans leading portion pipeline and the reaction component, wherein the leading portion pipeline is described
The part between first switch piece and first cleaning assembly of pipeline.
15. sample testing method as claimed in claim 14, which is characterized in that first cleaning step and it is described push away sample and
Detecting step carries out simultaneously.
16. the sample testing method as described in claims 14 or 15, which is characterized in that the sample testing apparatus further includes
Two cleaning assemblies, second cleaning assembly are connected to the 4th access point or are connected to the 5th access point of the pipeline,
5th access point is between the 4th access point and second access point；
It is described push away sample and detecting step after, the sample testing method further includes the second cleaning step, it is described second cleaning
Step includes:
First switch piece is connected to the pipeline；
Second cleaning assembly cleans common pall with the second cleaning reagent, wherein the common pall is described
The part between second access point and the 4th access point of pipeline；And
First cleaning assembly cleans the pipeline with the first cleaning reagent, wherein second cleaning reagent
Cleaning performance is better than first cleaning reagent.
17. sample testing method as claimed in claim 16, which is characterized in that the reaction component include the first reaction tank and
Second reaction tank, in the reaction step, first reaction tank and second reaction tank are respectively formed the first prepare liquid
With the second prepare liquid, in first prepare liquid successively by the sampling step, described push away sample and detecting step and second
After cleaning step, second prepare liquid is sampled step.
18. sample testing method as claimed in claim 16, which is characterized in that the detection components include flow chamber and connection
The sheath liquid pool of the flow chamber, is equipped with detection sensor in the flow chamber, and the sheath liquid pool memory stores up sheath fluid, it is described push away sample and
Detecting step includes:
It is described to push away the prepare liquid that sample component prepares the prepare liquid in section and be pushed into the flow chamber, at the same the sheath fluid into
Enter the flow chamber；
The prepare liquid and the sheath fluid form liquid stream to be measured；And
The detection sensor detects the prepare liquid stream.
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| CN201710531665.9A CN109211737A (en) | 2017-06-30 | 2017-06-30 | Sample testing apparatus, sample analyser and sample testing method |
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| CN201710531665.9A CN109211737A (en) | 2017-06-30 | 2017-06-30 | Sample testing apparatus, sample analyser and sample testing method |
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