CN115267238A - Blood analyzer and detection method thereof - Google Patents
Blood analyzer and detection method thereof Download PDFInfo
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- CN115267238A CN115267238A CN202110483626.2A CN202110483626A CN115267238A CN 115267238 A CN115267238 A CN 115267238A CN 202110483626 A CN202110483626 A CN 202110483626A CN 115267238 A CN115267238 A CN 115267238A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
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Abstract
The application discloses a blood analyzer and a detection method thereof, wherein the blood analyzer comprises a sampling module, a blood routine detection module and a specific protein detection module; wherein: the sampling module is used for collecting a blood sample, and adding the blood sample into the blood routine detection module which is used for diluting the blood sample; the sampling module adds the diluted blood sample into the specific protein detection module, and the specific protein detection module is used for detecting specific protein in the diluted blood sample. Through the mode, the blood sample is diluted through the blood routine detection module, so that the specific protein concentration of the blood sample is prevented from being too high, and the detection accuracy of the blood analyzer is improved.
Description
Technical Field
The application relates to the technical field of blood detection, in particular to a blood analyzer and a detection method thereof.
Background
In clinical examination in hospitals, patients are usually collected and examined, various specific protein tests are required, and the condition of the patients is judged based on the test results of the specific protein tests.
The blood analyzer in the prior art comprises a specific protein detection pool and a sample collection module, wherein the sample collection module is used for collecting a sample and adding the sample into the specific protein detection pool so as to realize specific protein detection on the sample. The concentration of the specific protein in the sample collected by the collecting module is high, so that the detection result of the specific protein detection is inaccurate.
Disclosure of Invention
In order to solve the above problems, the present application provides a blood analyzer and a detection method thereof, wherein a blood sample is diluted by a blood routine detection module, so as to prevent the specific protein concentration of the blood sample from being too high, and improve the accuracy of specific protein detection.
The technical scheme adopted by the application is as follows: providing a blood analyzer, wherein the blood analyzer comprises a sampling module, a blood routine detection module and a specific protein detection module; wherein:
the sampling module is used for collecting a blood sample, and adding the blood sample into the blood routine detection module which is used for diluting the blood sample;
the sampling module adds the diluted blood sample into the specific protein detection module, and the specific protein detection module is used for detecting specific protein in the diluted blood sample.
The application adopts another technical scheme that: there is provided a detection method applied to the blood analyzer, the detection method including:
collecting a blood sample, and adding the blood sample into the blood routine detection module;
diluting the blood sample by the blood routine detection module;
and adding the diluted blood sample into the specific protein detection module to perform specific protein detection on the diluted blood sample.
The blood analyzer comprises a sampling module, a blood routine detection module and a specific protein detection module, wherein the sampling module is used for collecting a blood sample and adding the blood sample into the blood routine detection module, and the blood routine detection module is used for diluting the blood sample; the sampling module adds the diluted blood sample into the specific protein detection module, and the specific protein detection module is used for carrying out specific protein detection on the diluted blood sample; the blood sample is diluted by the blood routine detection module so as to prevent the specific protein concentration of the blood sample from being too high and improve the detection accuracy of the blood analyzer. In addition, the first blood routine detection pool of the blood routine detection module is used for performing blood routine detection on the diluted blood sample, and the specific protein detection pool is used for performing specific protein detection on the diluted blood sample, so that the blood analyzer can realize blood routine detection and specific protein detection at the same time, the detection efficiency of the blood analyzer is improved, and the trouble of multiple sampling on patients is avoided.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts. Wherein:
fig. 1 is a schematic configuration diagram of a first embodiment of a blood analyzer of the present application;
FIG. 2 is a schematic configuration diagram of a second embodiment of the blood analyzer of the present application;
FIG. 3 is a schematic structural view of a third embodiment of the blood analyzer of the present application;
FIG. 4 is a schematic structural view of a fourth embodiment of the blood analyzer of the present application;
FIG. 5 is a schematic flow chart of a first embodiment of the detection method of the present application;
fig. 6 is a schematic flow chart of a second embodiment of the detection method of the present application.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. It is to be understood that the specific embodiments described herein are merely illustrative of the application and are not limiting of the application. It should be further noted that, for the convenience of description, only some of the structures related to the present application are shown in the drawings, not all of the structures. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
The terms "first", "second", etc. in this application are used to distinguish between different objects and not to describe a particular order. Furthermore, the terms "include" and "have," as well as any variations thereof, are intended to cover non-exclusive inclusions. For example, a process, method, system, article, or apparatus that comprises a list of steps or elements is not limited to only those steps or elements listed, but may alternatively include other steps or elements not listed, or inherent to such process, method, article, or apparatus.
Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the application. The appearances of the phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. It is explicitly and implicitly understood by one skilled in the art that the embodiments described herein can be combined with other embodiments.
Referring to fig. 1, fig. 1 is a schematic structural diagram of a first embodiment of a blood analyzer according to the present application. The blood analyzer 10 of the present embodiment includes at least a sampling module 11, a blood-routine detecting module 12, and a specific-protein detecting module 13.
The sampling module 11 is used for collecting blood samples; in the blood analyzer 10, the blood routine detection is performed by the blood routine detection module 12, and the specific protein detection is performed by the specific protein detection module 13, so that the blood sample is a whole blood sample.
Among them, blood routine includes WBC (white blood cell), HGB (Hemoglobin), RBC (red blood cell), DIFF (differential, leukocyte five classification), or RET (reticulocyte count).
The sampling module 11 is configured to add the collected blood sample to the blood routine detecting module 12, and the blood routine detecting module 12 is configured to dilute the blood sample, that is, the blood routine detecting module 12 serves as a dilution pool of the specific protein detecting module 13 to dilute the blood sample. For example, the blood sample is mixed with a diluent in the blood routine test module 12, so that the blood routine test module 12 dilutes the blood sample.
The sampling module 11 is configured to draw a diluted blood sample from the blood routine detecting module 12, add the diluted blood sample to the specific protein detecting module 13, and the specific protein detecting module 13 is configured to perform specific protein detection on the diluted blood sample.
Wherein the specific protein includes one of SAA (serum amyloid a protein), CRP (C-reactive protein), TRF (transferrin ), hs-CRP (hypersensitive C-reactive protein), PCT (procalcitonin ), and D-Dimer (D-Dimer), and the diluted blood sample is subjected to CRP detection by, for example, the specific protein detection module 13.
The sampling module 11 of this embodiment adds the collected blood sample to the blood routine detecting module 12, the blood routine detecting module 12 is used for diluting the blood sample, the sampling module 11 adds the diluted blood sample to the specific protein detecting module 13, and the specific protein detecting module 13 is used for detecting specific protein in the diluted blood sample; namely, the blood routine detecting module 12 is used as a diluting pool of the specific protein detecting module 13 to dilute the blood sample, so as to prevent the specific protein concentration of the blood sample from being too high, and improve the detection accuracy of the blood analyzer 10. In addition, the blood analyzer 10 realizes routine blood detection and specific protein detection, improves the detection efficiency of the blood analyzer 10, and avoids the trouble of multiple sampling to patients.
Referring to fig. 2, fig. 2 is a schematic structural diagram of a second embodiment of the blood analyzer of the present application. The blood analyzer 10 includes a control module 14 connected to the sampling module 11, the blood routine detecting module 12, and the specific protein detecting module 13, respectively, the blood routine detecting module 12 includes a first blood routine detecting cell 121, and the specific protein detecting module 13 includes a specific protein detecting cell 131. In other embodiments, the blood routine detection module 12 includes a plurality of blood routine detection cells, and the specific protein detection module 13 includes a plurality of specific protein detection cells 131.
The first blood routine detecting cell 121 is configured to dilute a blood sample to obtain a diluted blood sample; the first blood routine test cell 121 is further used for performing blood routine tests on the diluted blood sample. The specific protein detection cell 131 is used for performing specific protein detection on the diluted blood sample, for example, the specific protein detection cell 131 is used for performing CRP detection on the diluted blood sample.
Wherein, the control module 14 is used for controlling the sampling module 11 to draw the blood sample from the blood sample test tube 15, that is, the control module 14 controls the sampling module 11 to draw the blood sample from the blood sample test tube 15 at the blood sampling position. For example, the blood analyzer 10 may include a test tube rack on which a plurality of blood sample tubes 15 are disposed, the test tube rack being configured to sequentially move the plurality of blood sample tubes 15 to a blood sampling position, which is a position where the sampling module 11 sucks a blood sample.
Optionally, the blood analyzer 10 includes an optical coupler positioning component, which is disposed at the blood sampling position for determining whether the blood sample test tube 15 is located at the blood sampling position. For example, control module 14 is used for controlling the test-tube rack to remove a plurality of blood sample test tubes 15 in proper order to judge through opto-coupler positioning assembly that blood sample test tube 15 is located the blood sampling position, then stop the test-tube rack and remove a plurality of blood sample test tubes 15 in proper order.
The control module 14 is configured to control the sampling module 11 to add the blood sample into the first blood routine testing pool 121, so that the blood sample and the diluent in the first blood routine testing pool 121 are mixed uniformly, and a diluted blood sample is obtained. The first blood routine detecting pool 121 may store a fixed amount of diluent, and after the sampling module 11 adds the blood sample into the first blood routine detecting pool 121, the control module 14 may control the sampling module 11 to suck and push out the blood sample and the diluent, so as to mix the blood sample with the diluent in the first blood routine detecting pool 121. In other embodiments, a blending device is disposed at the bottom of the blood routine testing pool (e.g., the first blood routine testing pool 121), for example, the blending device is an air pump or a syringe, so as to blend the liquid in the blood routine testing pool.
The control module 14 is used for controlling the sampling module 11 to perform cleaning and sucking the diluted blood sample from the first blood routine measuring cell 121. In order to avoid contamination of the diluted blood sample of the first blood routine measuring cell 121, the sampling module 11 is cleaned; the control module 14 controls the sampling module 11 to draw a diluted blood sample from the first blood routine testing cell 121.
The control module 14 is configured to control the sampling module 11 to add the diluted blood sample into the specific protein detection cell 131, so that the diluted blood sample is uniformly mixed with the hemolytic agent and the latex reagent in the specific protein detection cell 131, and further perform specific protein detection on the diluted blood sample. For example, the blood analyzer 10 may include a reagent module, the control module 14 controls the reagent module to add a hemolytic agent and a latex reagent (also called an antibody reagent) to the specific protein detection cell 131 to mix the diluted blood sample, the hemolytic agent and the latex reagent, and the control module 14 performs specific protein detection on the diluted blood sample through the specific protein detection cell 131.
Wherein, control module 14 can control sampling module 11 and absorb and push out the blood sample after diluting, hemolytic agent and latex reagent, realizes the blood sample after diluting, hemolytic agent and latex reagent mixing. In other embodiments, a blending device is disposed at the bottom of the specific protein detection cell 131, for example, the blending device is an air pump or an injector, so as to blend the liquid in the specific protein detection cell 131.
Alternatively, the control module 14 determines whether the specific protein detection performed by the specific protein detection cell 131 on the diluted blood sample is abnormal. If yes, that is, the control module 14 determines that the specific protein detection performed on the diluted blood sample by the specific protein detection cell 131 is abnormal, the control module 14 controls the sampling module 11 to suck the diluted blood sample from the first blood routine detection cell 121 again, and adds the diluted blood sample into the specific protein detection cell 131, so that the specific protein detection cell 131 performs specific protein detection on the diluted blood sample again.
Optionally, the first blood routine detecting cell 121 is disposed between the specific protein detecting cell 131 and the blood sampling site, so that the distance that the sampling module 11 moves in the process of completing the detection of the blood analyzer 10 is shortest, the detection time of the blood analyzer 10 is shortened, and the detection efficiency of the blood analyzer 10 is improved.
Optionally, before the sampling module 11 draws the blood sample from the blood sample tube 15, the control module 14 further controls the sampling module 11 to draw the blood sample from the blood sample tube 15 and add the blood sample to the specific protein detection cell 131 to perform specific protein detection on the blood sample, so as to obtain a first detection result. The control module 14 judges whether the blood sample is a high-value sample based on the first detection result; if yes, that is, when the control module 14 determines that the blood sample is a high value sample, the control module 11 controls the blood sample tube 15 to draw the blood sample, so as to dilute the blood sample through the first blood routine testing pool 121. Therefore, the secondary sampling is realized through the sampling module 11, and the high-value sample is diluted, so that the detection accuracy of the blood analyzer 10 is improved.
Alternatively, the control module 14 controls the tube rack to continue moving the blood sample tube 15 when the sampling module 11 finishes drawing the blood sample from the blood sample tube 15. When the control module 14 determines that the blood sample is a high value sample, the control module 14 controls the test tube rack to return the sampled blood sample tube 15 to the blood sampling position. When the control module 14 determines that the blood sample is not a high value sample, the blood sample tube 15 continues to move, which can improve the detection efficiency of the blood analyzer 10.
Referring to fig. 3, fig. 3 is a schematic structural diagram of a third embodiment of the blood analyzer of the present application. The blood analyzer 10 of the present embodiment includes a first container C1 for storing a diluent, and the sampling module 11 includes a driving device 111, a syringe 112, a controllable valve 113, and a sampling needle 114.
Wherein, the driving device 111 is respectively connected with the control module 14 and the injector 112, and the driving device 111 is used for driving the injector 112. The common end of the controllable valve 113 is connected to the syringe 112 through a pipeline, the first branch end of the controllable valve 113 is connected to the first container C1 through a pipeline, and the second branch end of the controllable valve 113 is connected to the sampling needle 114 through a pipeline. In other embodiments, the sampling module 11 may be provided with a fixed displacement pump for performing the functions of the drive means 111 and the syringe 112.
The control module 14 controls the communication between the common end and the first branch end of the controllable valve 113, so that the injector 112 is communicated with the controllable valve 113 and the first container C1 in sequence through a pipeline; the control module 14 controls the syringe 112 to draw the diluent from the first container C1 through the driving device 111. The control module 14 controls the common end and the second branch end of the controllable valve 113 to communicate with each other, so that the injector 112 communicates with the controllable valve 113 and the sampling needle 114 in sequence through a pipeline, and at this time, the injector 112 sucks or pushes the blood sample and the diluted blood sample through the sampling needle 114.
The controllable valve 113 may be a three-way valve, which includes a common terminal and two branch terminals, wherein the three-way valve enables gating of three ports by switching on and off, for example, the common terminal and the first branch terminal are gated when power is turned on, and the common terminal and the second branch terminal are gated when power is turned off. It should be understood by those skilled in the art that if the connection manner of the first branch end and the second branch end is exchanged and the gating of the three-way valve is controlled in the opposite manner, the same effect as that achieved by the above-mentioned embodiment should also fall within the scope of the present embodiment.
Optionally, the sampling module 11 comprises a cleaning swab 115, the cleaning swab 115 being arranged on the sampling needle 114 for cleaning the outer and inner walls of the sampling needle 114.
In addition, the sampling module 11 includes a moving component, the sampling needle 114 is disposed on the moving component, and the moving component is configured to drive the sampling needle 114 to move in a horizontal direction or a vertical direction, so as to drive the sampling needle 114 to move.
The first blood routine test cell 121 may include a WBC test cell, a RBC test cell, a DIFF test cell, or a RET test cell, among others. When the first blood routine detecting cell 121 is an RBC detecting cell, the control module 14 controls the sampling module 11 to add a diluent to the first blood routine detecting cell 121 to perform RBC detection through the first blood routine detecting cell 121 when the diluted blood sample is subjected to specific protein detection.
The detection flow of the blood analyzer 10 is described in detail below:
the control module 14 controls the movement of the sampling needle 114 to the blood sampling site to draw a blood sample from the blood sample tube 15 located at the blood sampling site. For example, the control module 14 controls the moving assembly to move the sampling needle 114 to a blood collection site, wherein the blood collection site is an initial position where the sampling needle 114 is moved.
The control module 14 controls the sampling needle 114 to move to the first blood routine detecting pool 121, and the blood sample is added into the first blood routine detecting pool 121; wherein the blood sample and the diluent in the first blood routine test cell 121 are mixed uniformly to obtain the diluted blood sample.
The control module 14 controls the movement of the sampling needle 114, and the cleaning swab 115 cleans the outer wall and the inner wall of the sampling needle 114, so as to prevent the blood sample retained by the sampling needle 114 from contaminating the diluted blood sample.
The control module 14 controls the sampling needle 114 to move to the first blood routine testing pool 121 to draw the diluted blood sample from the first blood routine testing pool 121; and controls the sampling needle 114 to move to the specific protein detection cell 131 to add the diluted blood sample to the specific protein detection cell 131.
The diluted blood sample, the hemolytic agent and the latex reagent in the specific protein detection cell 131 are mixed uniformly to perform specific protein detection on the diluted blood sample. Meanwhile, the control module 14 controls the sampling needle 114 to move to the first blood routine detecting pool 121, so as to add the diluent into the first blood routine detecting pool 121, and further, the diluted blood sample is diluted and uniformly mixed again, and the RBC signal is detected, thereby realizing RBC detection.
The control module 14 controls the movement of the sampling needle 114, and the outer wall and the inner wall of the sampling needle 114 are cleaned by the cleaning swab 115.
The RBC detecting cell of this embodiment is used as a diluting cell of the specific protein detecting module 13 to dilute the blood sample, so as to prevent the specific protein concentration of the blood sample from being too high, and improve the detecting accuracy of the blood analyzer 10. In addition, the RBC detection pool is used for carrying out RBC detection on the diluted blood sample, so that the RBC detection and the specific protein detection are realized, the detection efficiency of the blood analyzer 10 is improved, and the trouble of repeated sampling on patients is avoided.
Referring to fig. 4, fig. 4 is a schematic structural diagram of a fourth embodiment of the blood analyzer of the present application. The blood routine testing module 12 of the present embodiment also includes a second blood routine testing reservoir 122.
Wherein the control module 14 is used for controlling the sampling module 11 to draw the blood sample from the blood sample tube 15. The control module 14 is configured to control the sampling module 11 to add the blood sample into the first blood routine testing pool 121, so that the blood sample and the diluent in the first blood routine testing pool 121 are mixed uniformly, and a diluted blood sample is obtained.
The control module 14 is used for controlling the sampling module 11 to perform cleaning and sucking the diluted blood sample from the first blood routine measuring cell 121. The control module 14 is configured to control the sampling module 11 to add the diluted blood sample into the specific protein detection cell 131, so that the diluted blood sample is uniformly mixed with the hemolytic agent and the latex reagent in the specific protein detection cell 131, and then the diluted blood sample is subjected to specific protein detection.
The control module 14 is configured to control the sampling module 11 to add the diluted blood sample into the second blood routine testing pool 122, so as to perform blood routine testing simultaneously through the first blood routine testing pool 121 and the second blood routine testing pool 122. The diluted blood sample is added into the second blood routine detecting pool 122 in the sampling module 11, and the diluted blood sample and the diluent in the second blood routine detecting pool 122 are uniformly mixed, so that the second blood routine detecting pool 122 is used for performing blood routine detection.
In this embodiment, the first blood conventional detection cell 121 is a WBC detection cell, the second blood conventional detection cell 122 is an RBC detection cell, and the detection flow of the blood analyzer 10 is described in detail as follows:
the control module 14 controls the movement of the sampling needle 114 to the blood sampling site to draw a blood sample from the blood sample tube 15 located at the blood sampling site.
The control module 14 controls the sampling needle 114 to move to the first blood routine detecting pool 121, and the blood sample is added into the first blood routine detecting pool 121; wherein the blood sample and the diluent in the first blood routine detecting cell 121 are mixed uniformly to obtain the diluted blood sample.
The control module 14 controls the movement of the sampling needle 114, and the outer wall and the inner wall of the sampling needle 114 are cleaned by the cleaning swab 115, so that the blood sample left in the sampling needle 114 is prevented from polluting the diluted blood sample.
The control module 14 controls the sampling needle 114 to move to the first blood routine testing pool 121 to draw the diluted blood sample from the first blood routine testing pool 121; and controls the sampling needle 114 to move to the specific protein detection cell 131 to add the diluted blood sample to the specific protein detection cell 131.
The diluted blood sample, the hemolytic agent and the latex reagent in the specific protein detection cell 131 are mixed uniformly to perform specific protein detection on the diluted blood sample.
The control module 14 controls the sampling needle 114 to move to the first blood routine testing cell 121 to draw the diluted blood sample from the first blood routine testing cell 121.
The control module 14 controls the sampling needle 114 to move to the second blood routine detecting pool 122, so as to add the diluted blood sample into the second blood routine detecting pool 122, and further, the diluted blood sample is uniformly mixed with the diluent in the second blood routine detecting pool 122, so as to detect RBC signals, thereby realizing RBC detection. Meanwhile, the control module 14 controls the reagent module to add a hemolytic agent to the first blood routine detecting cell 121, and the diluted blood sample and the hemolytic agent are mixed uniformly to detect WBC signals, thereby implementing WBC detection.
The control module 14 controls the movement of the sampling needle 114, and the outer wall and the inner wall of the sampling needle 114 are cleaned by the cleaning swab 115.
The WBC detection cell of the present embodiment is used as a dilution cell of the specific protein detection module 13 to dilute the blood sample, so as to prevent the specific protein concentration of the blood sample from being too high, and improve the detection accuracy of the blood analyzer 10. In addition, the diluted blood sample is added into the RBC detection pool, so that the diluted blood sample and the diluent in the RBC detection pool are uniformly mixed, the diluent does not need to be added into the RBC detection pool, and the detection efficiency is improved. In addition, WBC detection, RBC detection and specific protein detection are realized, the detection efficiency of the blood analyzer 10 is improved, and troubles caused by repeated sampling to patients are avoided.
Referring to fig. 5, fig. 5 is a schematic flow chart of a first embodiment of the detection method of the present application. The detection method of the present embodiment is applied to the blood analyzer 10 disclosed in the above embodiment, and includes the following steps:
s501: a blood sample is collected and added to the blood routine test module 12.
A blood sample is collected by the sampling module 11 and added to the blood routine test module 12.
S502: the blood sample is diluted by the blood routine test module 12.
Wherein the blood routine detecting module 12 is used as a diluting pool of the specific protein detecting module 13 to dilute the blood sample. For example, the blood sample and the diluent in the blood routine testing module 12 are mixed to dilute the blood sample by the blood routine testing module 12.
S503: the diluted blood sample is added to the specific protein detection module 13 to perform specific protein detection on the diluted blood sample.
The diluted blood sample is collected by the sampling module 11, and the diluted blood sample is added to the specific protein detection module 13, so as to perform specific protein detection on the diluted blood sample.
Wherein, step S501 includes: the control sampling module 11 draws a blood sample from the blood sample tube 15 and adds the blood sample to the first blood routine test cell 121. That is, the control module 14 controls the sampling module 11 to draw a blood sample from the blood sample tube 15 and add the blood sample to the first blood routine measuring cell 121.
Step S502 includes: the blood sample and the diluent in the first blood routine testing cell 121 are mixed uniformly by the first blood routine testing cell 121 to obtain the diluted blood sample.
Step S503 includes: controlling the sampling module 11 to clean and suck the diluted blood sample from the first blood routine testing pool 121; the sampling module 11 is controlled to add the diluted blood sample into the specific protein detection cell 131, so that the diluted blood sample is uniformly mixed with the hemolytic agent and the latex reagent in the specific protein detection cell 131, and further the diluted blood sample is subjected to specific protein detection.
Wherein the control module 14 controls the sampling module 11 to perform the cleaning and to draw the diluted blood sample from the first blood routine measuring cell 121. The control module 14 controls the sampling module 11 to add the diluted blood sample into the specific protein detection cell 131, so that the diluted blood sample is uniformly mixed with the hemolytic agent and the latex reagent in the specific protein detection cell 131, and further the specific protein detection is performed on the diluted blood sample.
In this embodiment, the collected blood sample is added to the blood routine detecting module 12 through the sampling module 11, and the blood sample is diluted through the blood routine detecting module 12, that is, the blood routine detecting module 12 is used as a diluting pool of the specific protein detecting module 13 to dilute the blood sample, so as to prevent the specific protein concentration of the blood sample from being too high, and improve the detecting accuracy of the blood analyzer 10. In addition, the conventional blood detection and the specific protein detection are realized, the detection efficiency of the blood analyzer 10 is improved, and the trouble of the patient caused by multiple sampling is avoided.
Referring to fig. 6, fig. 6 is a schematic flow chart of a detection method according to a second embodiment of the present application. The detection method of the embodiment comprises the following steps:
s601: the blood sample is collected and added into the specific protein detection module 13 to perform specific protein detection on the blood sample.
A blood sample is collected by the sampling module 11. The blood sample is added into the specific protein detection module 13 through the sampling module 11 to perform specific protein detection on the blood sample, so that a first detection result can be obtained.
S602: and entering the step of collecting the blood sample when the blood sample is judged to be a high-value sample.
And judging whether the blood sample is a high-value sample or not based on the first detection result, wherein the high-value sample refers to the blood sample with the specific protein concentration larger than a certain threshold value. If yes, determining that the blood sample is a high value sample, and entering step S603; if not, the blood analyzer 10 performs a test on the next blood sample.
S603: a blood sample is collected and added to the blood routine test module 12.
S604: the blood sample is diluted by the blood routine test module 12.
S605: the diluted blood sample is added to the specific protein detection module 13 to perform specific protein detection on the diluted blood sample.
Steps S603 to S605 are the same as steps S501 to S503 in the detection method of the first embodiment, and are not described again here.
When the first blood routine test cell 121 is an RBC test cell, the test method further includes: when the diluted blood sample is subjected to specific protein detection, the sampling module 11 is controlled to add a diluent to the first blood routine detecting pool 121 so as to perform RBC detection through the first blood routine detecting pool 121. The control module 14 controls the sampling module 11 to add diluent to the first blood routine detecting cell 121 to perform RBC detection through the first blood routine detecting cell 121.
Alternatively, the blood routine testing module 12 includes a second blood routine testing cell 122, and the testing method further includes: the control sampling module 11 adds the diluted blood sample to the second blood routine testing pool 122 to perform blood routine testing simultaneously through the first blood routine testing pool 121 and the second blood routine testing pool 122.
The control module 14 controls the sampling module 11 to add the diluted blood sample to the second blood routine testing pool 122, so as to perform blood routine testing simultaneously through the first blood routine testing pool 121 and the second blood routine testing pool 122. The diluted blood sample is added into the second blood routine detecting cell 122 in the sampling module 11, and the diluted blood sample and the diluent in the second blood routine detecting cell 122 are mixed uniformly, so as to perform blood routine detection through the second blood routine detecting cell 122.
The present embodiment improves the accuracy of the blood analyzer 10 by collecting blood samples twice to dilute high value samples by the blood routine detecting module 12.
To sum up, the blood routine detection module 12 of the present application is used as a dilution pool of the specific protein detection module 13 to dilute the blood sample, so as to prevent the specific protein concentration of the blood sample from being too high, and improve the detection accuracy of the blood analyzer 10. In addition, the blood analyzer 10 realizes routine blood detection and specific protein detection at the same time, so that the detection efficiency of the blood analyzer 10 is improved, and troubles of patients caused by multiple sampling are avoided.
In the several embodiments provided in the present application, it should be understood that the disclosed apparatus may be implemented in other manners. For example, the above-described device embodiments are merely illustrative, and for example, the division of the modules or units is only one logical division, and other divisions may be realized in practice, for example, a plurality of units or components may be combined or integrated into another system, or some features may be omitted, or not executed.
The units described as separate parts may or may not be physically separate, and parts displayed as units may or may not be physical units, may be located in one place, or may be distributed on a plurality of network units. Some or all of the units can be selected according to actual needs to achieve the purpose of the embodiment.
In addition, functional units in the embodiments of the present application may be integrated into one processing unit, or each of the units may exist alone physically, or two or more units may be integrated into one unit. The integrated unit can be realized in a form of hardware, and can also be realized in a form of a software functional unit.
The above description is only for the purpose of illustrating embodiments of the present application and is not intended to limit the scope of the present application, and all modifications of equivalent structures and equivalent processes, which are made according to the content of the present specification and the accompanying drawings, or which are directly or indirectly applied to other related technical fields, are also included in the scope of the present application.
Claims (11)
1. A blood analyzer, comprising a sampling module, a blood routine detection module, and a specific protein detection module; wherein:
the sampling module is used for collecting a blood sample, and adding the blood sample into the blood routine detection module which is used for diluting the blood sample;
the sampling module adds the diluted blood sample into the specific protein detection module, and the specific protein detection module is used for detecting specific protein in the diluted blood sample.
2. The blood analyzer of claim 1, wherein the blood routine testing module comprises a first blood routine testing cell for diluting the blood sample and for performing blood routine testing on the diluted blood sample;
the specific protein detection module comprises a specific protein detection pool, and the specific protein detection pool is used for performing specific protein detection on the diluted blood sample.
3. The blood analyzer of claim 2, comprising a control module connected to the sampling module, the blood routine detection module, and the specific protein detection module, respectively, the control module configured to:
controlling the sampling module to draw the blood sample from a blood sample tube;
controlling the sampling module to add the blood sample into the first blood routine detection pool so as to uniformly mix the blood sample with diluent in the first blood routine detection pool to obtain the diluted blood sample;
controlling the sampling module to clean and suck the diluted blood sample from the first blood routine testing pool;
and controlling the sampling module to add the diluted blood sample into the specific protein detection pool so as to uniformly mix the diluted blood sample with a hemolytic agent and a latex reagent of the specific protein detection pool, and further performing specific protein detection on the diluted blood sample.
4. The blood analyzer of claim 3, wherein the blood routine testing module comprises a second blood routine testing cell, and the control module is configured to control the sampling module to add the diluted blood sample to the second blood routine testing cell for performing blood routine testing simultaneously by the first blood routine testing cell and the second blood routine testing cell.
5. The blood analyzer of claim 3, wherein the first blood conventional detection cell is an RBC detection cell, and when the diluted blood sample is subjected to specific protein detection, the control module controls the sampling module to add diluent to the first blood conventional detection cell so as to perform RBC detection through the first blood conventional detection cell.
6. The hematology analyzer of any one of claims 2-4, wherein the first blood routine detection cell comprises a WBC/HGB detection cell, a RBC detection cell, a DIFF detection cell, or a RET detection cell;
the specific protein comprises one of SAA, CRP, TRF, hs-CRP, PCT and D-Dimer.
7. A detection method applied to the blood analyzer according to any one of claims 1 to 6, the detection method comprising:
collecting a blood sample, and adding the blood sample into the blood routine detection module;
diluting the blood sample by the blood routine detection module;
and adding the diluted blood sample into the specific protein detection module to perform specific protein detection on the diluted blood sample.
8. The test method of claim 7, wherein prior to the step of collecting a blood sample, the test method further comprises:
collecting the blood sample;
adding the blood sample to the specific protein detection module to perform specific protein detection on the blood sample;
and entering the step of collecting the blood sample when the blood sample is judged to be a high-value sample.
9. The method of claim 7 or 8, wherein the blood routine test module comprises a first blood routine test cell, the protein-specific test module comprises a protein-specific test cell, and the step of collecting the blood sample and adding the blood sample to the blood routine test module comprises:
controlling the sampling module to draw the blood sample from a blood sample tube and add the blood sample to the first blood routine test cell;
the step of diluting the blood sample by the blood routine testing module comprises:
uniformly mixing the blood sample with the diluent in the first blood routine detection pool through the first blood routine detection pool to obtain the diluted blood sample;
the step of adding the diluted blood sample to the specific protein detection module to perform specific protein detection on the diluted blood sample comprises:
controlling the sampling module to clean and draw the diluted blood sample from the first blood routine test pool;
and controlling the sampling module to add the diluted blood sample into the specific protein detection pool so as to uniformly mix the diluted blood sample with a hemolytic agent and a latex reagent of the specific protein detection pool, and further performing specific protein detection on the diluted blood sample.
10. The detection method according to claim 9, wherein the first blood routine detection cell is an RBC detection cell, the detection method further comprising:
when the diluted blood sample is subjected to specific protein detection, the sampling module is controlled to add diluent into the first blood routine detection pool so as to perform RBC detection through the first blood routine detection pool.
11. The testing method of claim 9, wherein the blood routine testing module comprises a second blood routine testing cell, the testing method further comprising:
controlling the sampling module to add the diluted blood sample into the second blood routine testing pool so as to simultaneously carry out blood routine testing through the first blood routine testing pool and the second blood routine testing pool.
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| CN116359525A (en) * | 2023-06-01 | 2023-06-30 | 深圳市帝迈生物技术有限公司 | Blood analysis device and control method thereof |
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| CN116359525A (en) * | 2023-06-01 | 2023-06-30 | 深圳市帝迈生物技术有限公司 | Blood analysis device and control method thereof |
| CN116359525B (en) * | 2023-06-01 | 2023-11-24 | 深圳市帝迈生物技术有限公司 | Blood analysis device and control method thereof |
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