CN109152830B - 用于免疫疗法的核/壳结构平台 - Google Patents

用于免疫疗法的核/壳结构平台 Download PDF

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CN109152830B
CN109152830B CN201880001680.5A CN201880001680A CN109152830B CN 109152830 B CN109152830 B CN 109152830B CN 201880001680 A CN201880001680 A CN 201880001680A CN 109152830 B CN109152830 B CN 109152830B
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mrna
composition
cells
cancer
vaccine
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CN109152830A (zh
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沈海法
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Methodist Hospital
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Methodist Hospital
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4203—Receptors for growth factors
    • A61K40/4204—Epidermal growth factor receptors [EGFR]
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  • Life Sciences & Earth Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Medicinal Preparation (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201880001680.5A 2017-01-27 2018-01-26 用于免疫疗法的核/壳结构平台 Active CN109152830B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202310076857.0A CN115845040A (zh) 2017-01-27 2018-01-26 用于免疫疗法的核/壳结构平台

Applications Claiming Priority (3)

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US201762451575P 2017-01-27 2017-01-27
US62/451,575 2017-01-27
PCT/US2018/015601 WO2018140826A1 (en) 2017-01-27 2018-01-26 Core/shell structure platform for immunotherapy

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CN109152830B true CN109152830B (zh) 2023-11-03

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CN201880001680.5A Active CN109152830B (zh) 2017-01-27 2018-01-26 用于免疫疗法的核/壳结构平台

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US (2) US11382964B2 (enExample)
EP (3) EP4008344B1 (enExample)
JP (2) JP7181880B2 (enExample)
KR (2) KR102627347B1 (enExample)
CN (2) CN115845040A (enExample)
AU (1) AU2018212887B2 (enExample)
CA (1) CA3051136A1 (enExample)
DK (2) DK3573656T3 (enExample)
ES (2) ES2905591T3 (enExample)
SG (1) SG11201906744VA (enExample)
WO (1) WO2018140826A1 (enExample)

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EP3624810A4 (en) * 2017-05-18 2021-02-17 The Regents of The University of California NANO-ACTIVATED IMMUNOTHERAPY FOR CANCER DISEASES
US11433143B2 (en) 2017-05-18 2022-09-06 The Regents Of The University Of California Nano-enabled immunotherapy in cancer
EP3836964A1 (en) * 2018-08-15 2021-06-23 University of Florida Research Foundation, Inc. Methods of sensitizing tumors to treatment with immune checkpoint inhibitors
JP2022506839A (ja) * 2018-11-07 2022-01-17 モデルナティエックス インコーポレイテッド Ｒｎａがんワクチン
CN109260157A (zh) * 2018-11-19 2019-01-25 上海交通大学 一种正电荷多肽脂质体纳米制剂及其制备方法与应用
US20220088221A1 (en) * 2019-01-12 2022-03-24 The Methodist Hospital Self-assembled peptide nanoparticle and use thereof
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US20220370488A1 (en) * 2019-10-22 2022-11-24 The Johns Hopkins University Mucus penetrating particle compositions and methods of use thereof enhancing immune response
KR102579284B1 (ko) * 2020-09-22 2023-09-18 비피진 주식회사 신규의 cd47 바인더와 폴리뉴클레오티드를 포함하는 암 치료를 위한 리포좀 복합체
CN112245575B (zh) * 2020-10-26 2024-07-26 上海杏禾医疗科技有限公司 含支化聚合物和mRNA的核壳结构的抗肿瘤疫苗及其用途
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CN114699420A (zh) * 2022-03-08 2022-07-05 南方科技大学 一种用于治疗前列腺癌组合物及其制备方法与应用
CN114699538A (zh) * 2022-04-02 2022-07-05 中国药科大学 一种核-壳式高效基因药物递送系统及其制备方法
BE1031669B1 (fr) * 2023-06-02 2025-01-14 Inhatarget Therapeutics Composition pharmaceutique pour inhalation
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CN117045809B (zh) * 2023-09-27 2025-08-29 国家纳米科学中心 异种哺乳动物细胞来源的囊泡在制备疫苗载体中的应用
KR20250063352A (ko) * 2023-11-01 2025-05-08 가톨릭대학교 산학협력단 mRNA가 봉입된 이중 나노입자, 이의 제조방법 및 이의 약학적 용도
CN117442552B (zh) * 2023-11-20 2024-03-26 山东大学 一种淋巴结内t细胞区靶向纳米粒及其水凝胶
CN117883410A (zh) * 2024-01-22 2024-04-16 华中科技大学同济医学院附属协和医院 包封有mRNA及Acod1基因si-RNA的脂质体纳米颗粒及其应用
CN118001254B (zh) 2024-04-09 2024-07-26 北京悦康科创医药科技股份有限公司 靶向抗原呈递细胞的脂质组合物及其应用
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