CN109071542B - 可用作rsk抑制剂的羧酰胺衍生物 - Google Patents

可用作rsk抑制剂的羧酰胺衍生物 Download PDF

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CN109071542B
CN109071542B CN201780024735.XA CN201780024735A CN109071542B CN 109071542 B CN109071542 B CN 109071542B CN 201780024735 A CN201780024735 A CN 201780024735A CN 109071542 B CN109071542 B CN 109071542B
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CN109071542A (zh
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桑德拉·E·邓恩
阿西·贾扬坦
亚伊帕尔·瑞迪·纳吉瑞迪
苏哈什·安内迪
约翰·H·范德利
蒂莫西·S·戴纳德
黄麦麦
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
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CN201780024735.XA 2016-02-19 2017-02-17 可用作rsk抑制剂的羧酰胺衍生物 Active CN109071542B (zh)

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US201662297522P 2016-02-19 2016-02-19
US62/297,522 2016-02-19
PCT/IB2017/000237 WO2017141116A1 (en) 2016-02-19 2017-02-17 Carboxamide derivatives useful as rsk inhibitors

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EP (2) EP3416964B1 (https=)
JP (2) JP6912486B2 (https=)
KR (1) KR102746242B1 (https=)
CN (2) CN109071542B (https=)
AU (1) AU2017220738B2 (https=)
CO (1) CO2018008846A2 (https=)
DK (1) DK3416964T3 (https=)
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IL (1) IL261170B (https=)
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US20170327501A1 (en) 2017-11-16
KR102746242B1 (ko) 2024-12-23
PL3416964T3 (pl) 2021-10-18
EP3416964A4 (en) 2019-09-18
US9771366B2 (en) 2017-09-26
JP6912486B2 (ja) 2021-08-04
JP7289876B2 (ja) 2023-06-12
EP3416964B1 (en) 2020-12-16
BR112018016968A2 (pt) 2019-01-08
WO2017141116A1 (en) 2017-08-24
US20170240549A1 (en) 2017-08-24
PT3416964T (pt) 2021-03-09
CN113620950A (zh) 2021-11-09
IL261170B (en) 2021-12-01
MX2018010028A (es) 2019-01-21
ES2858753T3 (es) 2021-09-30
CN109071542A (zh) 2018-12-21
AU2017220738A1 (en) 2018-08-30
MX376974B (es) 2025-03-07
JP2019505541A (ja) 2019-02-28
US20210186961A1 (en) 2021-06-24
DK3416964T3 (da) 2021-02-22
US20190134029A1 (en) 2019-05-09
EP3848373A1 (en) 2021-07-14
CO2018008846A2 (es) 2018-11-13
US10081632B2 (en) 2018-09-25
JP2021176857A (ja) 2021-11-11
EP3416964A1 (en) 2018-12-26
CA3014395A1 (en) 2017-08-24
US10758530B2 (en) 2020-09-01
KR20180129783A (ko) 2018-12-05
AU2017220738B2 (en) 2022-02-24
IL261170A (en) 2018-10-31

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