CN109011046B - 用于向目标输送流体的装置 - Google Patents
用于向目标输送流体的装置 Download PDFInfo
- Publication number
- CN109011046B CN109011046B CN201810953975.4A CN201810953975A CN109011046B CN 109011046 B CN109011046 B CN 109011046B CN 201810953975 A CN201810953975 A CN 201810953975A CN 109011046 B CN109011046 B CN 109011046B
- Authority
- CN
- China
- Prior art keywords
- plate
- fluid
- reservoir
- piezoelectric actuator
- capillary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000012530 fluid Substances 0.000 title claims abstract description 344
- 230000007246 mechanism Effects 0.000 claims abstract description 126
- 239000000463 material Substances 0.000 claims description 167
- 239000007921 spray Substances 0.000 claims description 94
- 229910002113 barium titanate Inorganic materials 0.000 claims description 29
- 238000004891 communication Methods 0.000 claims description 18
- 238000011068 loading method Methods 0.000 claims description 17
- 230000002829 reductive effect Effects 0.000 claims description 13
- 229910002902 BiFeO3 Inorganic materials 0.000 claims description 10
- 229910002115 bismuth titanate Inorganic materials 0.000 claims description 8
- 239000002033 PVDF binder Substances 0.000 claims description 7
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims description 7
- 238000000926 separation method Methods 0.000 claims description 7
- JRPBQTZRNDNNOP-UHFFFAOYSA-N barium titanate Chemical compound [Ba+2].[Ba+2].[O-][Ti]([O-])([O-])[O-] JRPBQTZRNDNNOP-UHFFFAOYSA-N 0.000 claims description 6
- 230000002093 peripheral effect Effects 0.000 claims description 5
- 239000002131 composite material Substances 0.000 claims description 4
- 229910052721 tungsten Inorganic materials 0.000 claims description 3
- 229910000906 Bronze Inorganic materials 0.000 claims description 2
- YPQJHZKJHIBJAP-UHFFFAOYSA-N [K].[Bi] Chemical compound [K].[Bi] YPQJHZKJHIBJAP-UHFFFAOYSA-N 0.000 claims description 2
- FSAJRXGMUISOIW-UHFFFAOYSA-N bismuth sodium Chemical compound [Na].[Bi] FSAJRXGMUISOIW-UHFFFAOYSA-N 0.000 claims description 2
- 239000010974 bronze Substances 0.000 claims description 2
- KUNSUQLRTQLHQQ-UHFFFAOYSA-N copper tin Chemical compound [Cu].[Sn] KUNSUQLRTQLHQQ-UHFFFAOYSA-N 0.000 claims description 2
- UYLYBEXRJGPQSH-UHFFFAOYSA-N sodium;oxido(dioxo)niobium Chemical compound [Na+].[O-][Nb](=O)=O UYLYBEXRJGPQSH-UHFFFAOYSA-N 0.000 claims description 2
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims description 2
- 239000010937 tungsten Substances 0.000 claims description 2
- 239000002355 dual-layer Substances 0.000 claims 1
- 230000009471 action Effects 0.000 abstract description 10
- 239000003708 ampul Substances 0.000 description 63
- 238000012360 testing method Methods 0.000 description 60
- 238000002347 injection Methods 0.000 description 58
- 239000007924 injection Substances 0.000 description 58
- 238000000034 method Methods 0.000 description 46
- 239000011734 sodium Substances 0.000 description 44
- 239000007789 gas Substances 0.000 description 42
- 210000001508 eye Anatomy 0.000 description 29
- 238000007789 sealing Methods 0.000 description 27
- 238000006073 displacement reaction Methods 0.000 description 25
- 238000000576 coating method Methods 0.000 description 24
- 230000008020 evaporation Effects 0.000 description 23
- 238000001704 evaporation Methods 0.000 description 23
- 239000010408 film Substances 0.000 description 23
- 229920000642 polymer Polymers 0.000 description 20
- 239000011248 coating agent Substances 0.000 description 19
- 238000000151 deposition Methods 0.000 description 19
- 230000000694 effects Effects 0.000 description 19
- 239000007788 liquid Substances 0.000 description 19
- 230000008021 deposition Effects 0.000 description 17
- 239000003814 drug Substances 0.000 description 16
- 229920001296 polysiloxane Polymers 0.000 description 16
- 238000002425 crystallisation Methods 0.000 description 15
- 230000008025 crystallization Effects 0.000 description 15
- 229940079593 drug Drugs 0.000 description 15
- 239000000919 ceramic Substances 0.000 description 14
- 238000011049 filling Methods 0.000 description 14
- 230000033001 locomotion Effects 0.000 description 14
- 238000004519 manufacturing process Methods 0.000 description 14
- 238000003860 storage Methods 0.000 description 14
- 239000010936 titanium Substances 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 230000006835 compression Effects 0.000 description 13
- 238000007906 compression Methods 0.000 description 13
- 230000013011 mating Effects 0.000 description 13
- 230000001954 sterilising effect Effects 0.000 description 13
- 238000004659 sterilization and disinfection Methods 0.000 description 13
- 108091006146 Channels Proteins 0.000 description 12
- 230000007423 decrease Effects 0.000 description 12
- 238000005259 measurement Methods 0.000 description 12
- 229910052700 potassium Inorganic materials 0.000 description 12
- 229910010252 TiO3 Inorganic materials 0.000 description 11
- 230000015572 biosynthetic process Effects 0.000 description 11
- 238000010168 coupling process Methods 0.000 description 11
- 239000013078 crystal Substances 0.000 description 11
- 239000006196 drop Substances 0.000 description 11
- 238000005755 formation reaction Methods 0.000 description 11
- 239000011148 porous material Substances 0.000 description 11
- 230000008569 process Effects 0.000 description 11
- 229910052708 sodium Inorganic materials 0.000 description 11
- 238000005507 spraying Methods 0.000 description 11
- 230000008878 coupling Effects 0.000 description 10
- 238000005859 coupling reaction Methods 0.000 description 10
- 230000002706 hydrostatic effect Effects 0.000 description 10
- 229910052744 lithium Inorganic materials 0.000 description 10
- 229910052748 manganese Inorganic materials 0.000 description 10
- 230000002685 pulmonary effect Effects 0.000 description 10
- 230000008859 change Effects 0.000 description 9
- 230000006870 function Effects 0.000 description 9
- 230000005484 gravity Effects 0.000 description 9
- 230000000670 limiting effect Effects 0.000 description 9
- 239000000523 sample Substances 0.000 description 9
- 229910052788 barium Inorganic materials 0.000 description 8
- 229910052791 calcium Inorganic materials 0.000 description 8
- 238000011109 contamination Methods 0.000 description 8
- 238000013016 damping Methods 0.000 description 8
- 230000007774 longterm Effects 0.000 description 8
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 8
- 230000009467 reduction Effects 0.000 description 8
- 229910052712 strontium Inorganic materials 0.000 description 8
- 229910052719 titanium Inorganic materials 0.000 description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
- 239000000853 adhesive Substances 0.000 description 7
- 230000001070 adhesive effect Effects 0.000 description 7
- 229910052751 metal Inorganic materials 0.000 description 7
- 239000002184 metal Substances 0.000 description 7
- -1 polyethylene Polymers 0.000 description 7
- 239000010935 stainless steel Substances 0.000 description 7
- 229910001220 stainless steel Inorganic materials 0.000 description 7
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 6
- 239000004696 Poly ether ether ketone Substances 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 239000003889 eye drop Substances 0.000 description 6
- 230000004048 modification Effects 0.000 description 6
- 238000012986 modification Methods 0.000 description 6
- 229910052758 niobium Inorganic materials 0.000 description 6
- 229920002530 polyetherether ketone Polymers 0.000 description 6
- 239000011253 protective coating Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 238000003466 welding Methods 0.000 description 6
- 230000004888 barrier function Effects 0.000 description 5
- 229940012356 eye drops Drugs 0.000 description 5
- 229910052746 lanthanum Inorganic materials 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 230000010355 oscillation Effects 0.000 description 5
- 239000013598 vector Substances 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000004743 Polypropylene Substances 0.000 description 4
- 230000004913 activation Effects 0.000 description 4
- 229910052782 aluminium Inorganic materials 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 230000000845 anti-microbial effect Effects 0.000 description 4
- 238000000429 assembly Methods 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 230000005540 biological transmission Effects 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- 238000005229 chemical vapour deposition Methods 0.000 description 4
- 230000005684 electric field Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 4
- 229910052737 gold Inorganic materials 0.000 description 4
- 239000010931 gold Substances 0.000 description 4
- 229920001903 high density polyethylene Polymers 0.000 description 4
- 239000004700 high-density polyethylene Substances 0.000 description 4
- GGXICVAJURFBLW-CEYXHVGTSA-N latanoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1 GGXICVAJURFBLW-CEYXHVGTSA-N 0.000 description 4
- 229960001160 latanoprost Drugs 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 238000005240 physical vapour deposition Methods 0.000 description 4
- 229920003023 plastic Polymers 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 229910052697 platinum Inorganic materials 0.000 description 4
- 229920001155 polypropylene Polymers 0.000 description 4
- 238000004088 simulation Methods 0.000 description 4
- 239000003351 stiffener Substances 0.000 description 4
- 229920001169 thermoplastic Polymers 0.000 description 4
- 239000004416 thermosoftening plastic Substances 0.000 description 4
- 229910003327 LiNbO3 Inorganic materials 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 239000004697 Polyetherimide Substances 0.000 description 3
- 239000004642 Polyimide Substances 0.000 description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 3
- 230000001133 acceleration Effects 0.000 description 3
- 229910052787 antimony Inorganic materials 0.000 description 3
- 230000000712 assembly Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 229910052733 gallium Inorganic materials 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 239000003595 mist Substances 0.000 description 3
- 229910052763 palladium Inorganic materials 0.000 description 3
- 229920001601 polyetherimide Polymers 0.000 description 3
- 229920001721 polyimide Polymers 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 230000036316 preload Effects 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 230000003014 reinforcing effect Effects 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 229910052709 silver Inorganic materials 0.000 description 3
- 239000004332 silver Substances 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 230000003068 static effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 229910052715 tantalum Inorganic materials 0.000 description 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- 239000004593 Epoxy Substances 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 229920000106 Liquid crystal polymer Polymers 0.000 description 2
- 239000004977 Liquid-crystal polymers (LCPs) Substances 0.000 description 2
- 229910003378 NaNbO3 Inorganic materials 0.000 description 2
- 229910003266 NiCo Inorganic materials 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 229920002292 Nylon 6 Polymers 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- 229920010741 Ultra High Molecular Weight Polyethylene (UHMWPE) Polymers 0.000 description 2
- 229910045601 alloy Inorganic materials 0.000 description 2
- 239000000956 alloy Substances 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 239000004599 antimicrobial Substances 0.000 description 2
- 230000001174 ascending effect Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 238000005266 casting Methods 0.000 description 2
- 229920001688 coating polymer Polymers 0.000 description 2
- 229910000152 cobalt phosphate Inorganic materials 0.000 description 2
- ZBDSFTZNNQNSQM-UHFFFAOYSA-H cobalt(2+);diphosphate Chemical compound [Co+2].[Co+2].[Co+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O ZBDSFTZNNQNSQM-UHFFFAOYSA-H 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 238000005336 cracking Methods 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000032798 delamination Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 125000003700 epoxy group Chemical group 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 210000000744 eyelid Anatomy 0.000 description 2
- 210000004907 gland Anatomy 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 229910052735 hafnium Inorganic materials 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 229910052741 iridium Inorganic materials 0.000 description 2
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000003446 memory effect Effects 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 238000009740 moulding (composite fabrication) Methods 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 229940054441 o-phthalaldehyde Drugs 0.000 description 2
- 229940023490 ophthalmic product Drugs 0.000 description 2
- 238000000879 optical micrograph Methods 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 238000011056 performance test Methods 0.000 description 2
- ZWLUXSQADUDCSB-UHFFFAOYSA-N phthalaldehyde Chemical compound O=CC1=CC=CC=C1C=O ZWLUXSQADUDCSB-UHFFFAOYSA-N 0.000 description 2
- 238000007747 plating Methods 0.000 description 2
- 230000010287 polarization Effects 0.000 description 2
- 229920003223 poly(pyromellitimide-1,4-diphenyl ether) Polymers 0.000 description 2
- 239000004417 polycarbonate Substances 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
- 229920000647 polyepoxide Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 229910052761 rare earth metal Inorganic materials 0.000 description 2
- 230000002787 reinforcement Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- HYXGAEYDKFCVMU-UHFFFAOYSA-N scandium(III) oxide Inorganic materials O=[Sc]O[Sc]=O HYXGAEYDKFCVMU-UHFFFAOYSA-N 0.000 description 2
- 239000003566 sealing material Substances 0.000 description 2
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 description 2
- 238000004544 sputter deposition Methods 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 229910000531 Co alloy Inorganic materials 0.000 description 1
- 229920001634 Copolyester Polymers 0.000 description 1
- 208000010412 Glaucoma Diseases 0.000 description 1
- 229910003334 KNbO3 Inorganic materials 0.000 description 1
- 206010023644 Lacrimation increased Diseases 0.000 description 1
- 229910004905 Li1−yNay Inorganic materials 0.000 description 1
- 229910012463 LiTaO3 Inorganic materials 0.000 description 1
- 229910016631 MNbO3 Inorganic materials 0.000 description 1
- 206010028347 Muscle twitching Diseases 0.000 description 1
- 229910052779 Neodymium Inorganic materials 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 229920002302 Nylon 6,6 Polymers 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 229910020698 PbZrO3 Inorganic materials 0.000 description 1
- 241000405070 Percophidae Species 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 102100034308 Potassium voltage-gated channel subfamily C member 1 Human genes 0.000 description 1
- 101710144499 Potassium voltage-gated channel subfamily C member 1 Proteins 0.000 description 1
- 238000003326 Quality management system Methods 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 229910052775 Thulium Inorganic materials 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 239000004775 Tyvek Substances 0.000 description 1
- 229920000690 Tyvek Polymers 0.000 description 1
- 229920004738 ULTEM® Polymers 0.000 description 1
- QXZUUHYBWMWJHK-UHFFFAOYSA-N [Co].[Ni] Chemical compound [Co].[Ni] QXZUUHYBWMWJHK-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 239000003732 agents acting on the eye Substances 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 229920000249 biocompatible polymer Polymers 0.000 description 1
- 238000012925 biological evaluation Methods 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 229910052797 bismuth Inorganic materials 0.000 description 1
- 230000004397 blinking Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 239000011195 cermet Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004581 coalescence Methods 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000012611 container material Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 238000007418 data mining Methods 0.000 description 1
- 238000013500 data storage Methods 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000009647 digital holographic microscopy Methods 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 238000009713 electroplating Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 230000000193 eyeblink Effects 0.000 description 1
- 238000010304 firing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000004317 lacrimation Effects 0.000 description 1
- HFGPZNIAWCZYJU-UHFFFAOYSA-N lead zirconate titanate Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[Ti+4].[Zr+4].[Pb+2] HFGPZNIAWCZYJU-UHFFFAOYSA-N 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 230000005499 meniscus Effects 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000005459 micromachining Methods 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000002366 mineral element Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000006855 networking Effects 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000065 noncytotoxic Toxicity 0.000 description 1
- 230000002020 noncytotoxic effect Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 229940037201 oris Drugs 0.000 description 1
- 230000003534 oscillatory effect Effects 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920001470 polyketone Polymers 0.000 description 1
- 230000001144 postural effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000001739 rebound effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 229910052703 rhodium Inorganic materials 0.000 description 1
- 239000010948 rhodium Substances 0.000 description 1
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 229910052701 rubidium Inorganic materials 0.000 description 1
- 238000001878 scanning electron micrograph Methods 0.000 description 1
- 238000004626 scanning electron microscopy Methods 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 239000013464 silicone adhesive Substances 0.000 description 1
- 229910001923 silver oxide Inorganic materials 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 230000009974 thixotropic effect Effects 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 238000007740 vapor deposition Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
- B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
- B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
- B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
- B05B17/0638—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers spray being produced by discharging the liquid or other fluent material through a plate comprising a plurality of orifices
- B05B17/0646—Vibrating plates, i.e. plates being directly subjected to the vibrations, e.g. having a piezoelectric transducer attached thereto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
- A61M15/025—Bubble jet droplet ejection devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
- B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
- B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
- B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
- B05B17/0653—Details
- B05B17/0661—Transducer materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
- B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
- B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
- B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
- B05B17/0653—Details
- B05B17/0676—Feeding means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0612—Eyes
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
- Closures For Containers (AREA)
- Details Or Accessories Of Spraying Plant Or Apparatus (AREA)
- Nozzles (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261636559P | 2012-04-20 | 2012-04-20 | |
| US201261636565P | 2012-04-20 | 2012-04-20 | |
| US61/636,565 | 2012-04-20 | ||
| US61/636,559 | 2012-04-20 | ||
| US201261643150P | 2012-05-04 | 2012-05-04 | |
| US61/643,150 | 2012-05-04 | ||
| US201261722611P | 2012-11-05 | 2012-11-05 | |
| US201261722616P | 2012-11-05 | 2012-11-05 | |
| US61/722,611 | 2012-11-05 | ||
| US61/722,616 | 2012-11-05 | ||
| CN201380031873.2A CN104755180B (zh) | 2012-04-20 | 2013-04-19 | 用于向表面上喷射流体的喷射装置 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380031873.2A Division CN104755180B (zh) | 2012-04-20 | 2013-04-19 | 用于向表面上喷射流体的喷射装置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109011046A CN109011046A (zh) | 2018-12-18 |
| CN109011046B true CN109011046B (zh) | 2021-10-01 |
Family
ID=48471083
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810953975.4A Active CN109011046B (zh) | 2012-04-20 | 2013-04-19 | 用于向目标输送流体的装置 |
| CN201380031873.2A Active CN104755180B (zh) | 2012-04-20 | 2013-04-19 | 用于向表面上喷射流体的喷射装置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380031873.2A Active CN104755180B (zh) | 2012-04-20 | 2013-04-19 | 用于向表面上喷射流体的喷射装置 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20130299607A1 (enExample) |
| EP (1) | EP2838669B1 (enExample) |
| JP (1) | JP6462563B2 (enExample) |
| KR (2) | KR102108588B1 (enExample) |
| CN (2) | CN109011046B (enExample) |
| AU (1) | AU2013249108A1 (enExample) |
| BR (1) | BR112014026171A2 (enExample) |
| CA (2) | CA3121535C (enExample) |
| EA (1) | EA201491906A1 (enExample) |
| ES (1) | ES2663879T3 (enExample) |
| IL (1) | IL235281B (enExample) |
| MX (1) | MX2014012702A (enExample) |
| SG (1) | SG11201406716WA (enExample) |
| WO (1) | WO2013158967A2 (enExample) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013212314B2 (en) | 2012-01-24 | 2017-08-17 | Vapotherm, Inc | Systems and methods for providing respiratory therapy |
| AU2013245946A1 (en) | 2012-04-10 | 2014-11-27 | Eyenovia, Inc. | Spray ejector mechanisms and devices providing charge isolation and controllable droplet charge, and low dosage volume opthalmic administration |
| SG11201406716WA (en) | 2012-04-20 | 2015-03-30 | Eyenovia Inc | Spray ejector device and methods of use |
| US9463486B2 (en) | 2012-05-14 | 2016-10-11 | Eyenovia, Inc. | Laminar flow droplet generator device and methods of use |
| JP6240170B2 (ja) | 2012-05-15 | 2017-11-29 | アイノビア,インコーポレイティド | エジェクタ装置,並びにその方法,ドライバ,及び回路 |
| US11278682B2 (en) | 2014-11-09 | 2022-03-22 | Sipnose Ltd. | Device and method for aerosolized delivery of substance to a natural orifice of the body |
| DE202013105715U1 (de) | 2013-08-22 | 2014-02-19 | Sipnose Ltd. | Vorrichtung zur Abgabe einer vorbestimmten Menge einer Substanz an eine natürliche Öffnung des Körpers |
| US11471618B2 (en) | 2014-11-09 | 2022-10-18 | Sipnose Ltd. | Adjustable dosing delivery and multi sectioned drug compartment |
| US12329902B2 (en) | 2013-08-22 | 2025-06-17 | Sipnose Ltd. | Drug delivery devices and methods for administering substances to a body cavity by heterogenous aerosolization |
| US12491325B2 (en) | 2013-08-22 | 2025-12-09 | Aptargroup, Inc. | Drug delivery devices and methods for administering substances to a body cavity by heterogenous aerosolization for treatment of binge-eating disorders and/or obesity |
| US11116914B2 (en) * | 2014-11-09 | 2021-09-14 | Sipnose Ltd. | Device and method for aerosolized delivering of substance to a natural orifice of the body |
| US11992604B2 (en) | 2014-11-09 | 2024-05-28 | Sipnose Ltd. | Devices and methods for delivering a substance to a body cavity |
| WO2015114139A1 (en) | 2014-01-31 | 2015-08-06 | Eye-Go Labs Aps | A device for applying an ophthalmic fluid |
| WO2015167543A1 (en) | 2014-04-30 | 2015-11-05 | Hewlett-Packard Development Company, L.P. | Electrocaloric device |
| CA2953939A1 (en) * | 2014-07-23 | 2016-01-28 | Microdose Therapeutx, Inc. | Dry powder nebulizer |
| CN107106325B (zh) | 2015-01-12 | 2021-05-25 | 科达莱昂治疗公司 | 微滴递送设备和方法 |
| CN116328114A (zh) * | 2015-02-16 | 2023-06-27 | 微邦科技股份有限公司 | 可分离式微雾化装置 |
| AU2016246060B2 (en) | 2015-04-10 | 2020-10-22 | Bausch + Lomb Ireland Limited | Piezoelectric dispenser with replaceable ampoule |
| WO2017003865A1 (en) * | 2015-06-29 | 2017-01-05 | Dow Global Technologies Llc | Process for in situ production of microcapillary dispensing system for flexible pouch |
| BR112017025931A2 (pt) * | 2015-06-29 | 2018-08-14 | Dow Global Technologies Llc | processo para a produção de recipiente flexível com sistema de dispensação microcapilar |
| CN109069750B (zh) | 2016-04-25 | 2021-09-07 | 科斯卡家族有限公司 | 药物输送系统 |
| US11285274B2 (en) | 2016-05-03 | 2022-03-29 | Pneuma Respiratory, Inc. | Methods for the systemic delivery of therapeutic agents to the pulmonary system using a droplet delivery device |
| EP4624054A3 (en) * | 2016-05-03 | 2025-11-19 | Pneuma Respiratory, Inc. | Methods for generating and delivering droplets to the pulmonary system using a droplet delivery device |
| US11285284B2 (en) | 2016-05-03 | 2022-03-29 | Pneuma Respiratory, Inc. | Methods for treatment of pulmonary lung diseases with improved therapeutic efficacy and improved dose efficiency |
| EP3452150B1 (en) * | 2016-05-03 | 2024-01-17 | Pneuma Respiratory, Inc. | Droplet delivery device for delivery of fluids to the pulmonary system |
| WO2017192782A1 (en) | 2016-05-03 | 2017-11-09 | Pneuma Respiratory, Inc. | Systems and methods comprising a droplet delivery device and a breathing assist device for therapeutic treatment |
| CA3039106A1 (en) | 2017-01-20 | 2018-07-26 | Kedalion Therapeutics, Inc. | Piezoelectric fluid dispenser |
| CN106583140B (zh) * | 2017-01-23 | 2022-08-26 | 佛山市科日压电器件有限公司 | 微孔雾化片安装头 |
| KR102660867B1 (ko) * | 2017-03-23 | 2024-04-26 | 스템포드 디바이시즈 리미티드 | 에어로졸 전달 장치 |
| US11413407B2 (en) | 2017-03-23 | 2022-08-16 | Stamford Devices Ltd. | Aerosol delivery device |
| CA3064005C (en) | 2017-05-19 | 2023-03-07 | Pneuma Respiratory, Inc. | Dry powder delivery device and methods of use |
| CN115300226A (zh) | 2017-06-10 | 2022-11-08 | 艾诺维亚股份有限公司 | 用于将一体积的流体输送到眼睛的设备 |
| CN107417267B (zh) * | 2017-08-09 | 2020-01-03 | 歌尔股份有限公司 | 铁酸铋多铁性陶瓷及其制备方法 |
| JP2020536614A (ja) | 2017-10-04 | 2020-12-17 | ニューマ・リスパイラトリー・インコーポレイテッド | 呼吸により電気的に作動するインライン液滴送達装置および使用方法 |
| US11458267B2 (en) | 2017-10-17 | 2022-10-04 | Pneuma Respiratory, Inc. | Nasal drug delivery apparatus and methods of use |
| CN109674576B (zh) * | 2017-10-19 | 2024-02-27 | 深圳市启明医药科技有限公司 | 流体供应单元及微液滴喷射驱动装置、发生装置 |
| CN111479604B (zh) | 2017-11-08 | 2022-12-30 | 精呼吸股份有限公司 | 具有小体积安瓿的电动呼吸致动直列液滴输送装置及使用方法 |
| CN111615409A (zh) | 2017-11-17 | 2020-09-01 | 科斯卡家族有限公司 | 用于流体输送歧管的系统和方法 |
| AU2018380433B2 (en) | 2017-12-08 | 2024-10-10 | Bausch + Lomb Ireland Limited | Fluid delivery alignment system |
| US12350194B1 (en) | 2018-04-12 | 2025-07-08 | Bausch + Lomb Ireland Limited | Topical ocular delivery of fluids with controlled mass dosing and wireless communication |
| US20190314197A1 (en) | 2018-04-12 | 2019-10-17 | Kedalion Therapeutics, Inc. | Topical Ocular Delivery Methods and Devices for Use in the Same |
| US12017242B2 (en) * | 2018-05-16 | 2024-06-25 | Philip Morris Products S.A. | Atomiser assembly with oscillation chamber |
| US11919023B2 (en) * | 2018-05-16 | 2024-03-05 | Philip Morris Products S.A. | Atomizer and a mesh therefor |
| MX2020012961A (es) | 2018-05-31 | 2021-04-28 | Vapotherm Inc | Maquina nebulizadora proxima. |
| AU2019279002A1 (en) * | 2018-05-31 | 2020-12-17 | Vapotherm, Inc. | Cannula-based vibrating mesh nebulizer |
| WO2020010116A1 (en) | 2018-07-03 | 2020-01-09 | Kedalion Therapeutics, Inc. | Topical ocular delivery devices and methods for using the same |
| US20220001122A1 (en) * | 2018-10-01 | 2022-01-06 | Pneuma Respiratory, Inc. | Delivery of low surface tension compositions to the pulmonary system via electronic breath actuated droplet delivery device |
| JP2022525012A (ja) * | 2019-03-04 | 2022-05-11 | アイノビア・インコーポレイテッド | ピロカルピンを液滴のマイクロドーズストリームとして眼に送達するための方法および装置 |
| US11679028B2 (en) | 2019-03-06 | 2023-06-20 | Novartis Ag | Multi-dose ocular fluid delivery system |
| US12097145B2 (en) | 2019-03-06 | 2024-09-24 | Bausch + Lomb Ireland Limited | Vented multi-dose ocular fluid delivery system |
| EP3905908B1 (en) | 2019-06-20 | 2025-01-08 | Shaheen Innovations Holding Limited | Personal ultrasonic atomizer device |
| US20220296823A1 (en) * | 2019-06-27 | 2022-09-22 | Pneuma Respiratory, Inc. | Delivery of small droplets to the respiratory system via electronic breath actuated droplet delivery device |
| WO2021062214A1 (en) | 2019-09-26 | 2021-04-01 | Vapotherm, Inc. | Internal cannula mounted nebulizer |
| US20210128349A1 (en) * | 2019-11-06 | 2021-05-06 | Mistifeye, Inc. | Eye misting device |
| US12496218B1 (en) | 2019-11-12 | 2025-12-16 | Bausch + Lomb Ireland Limited | Fractionated topical ocular drug delivery methods and devices for use in the same |
| AU2020399803A1 (en) * | 2019-12-11 | 2022-06-23 | Eyenovia, Inc. | Systems and devices for delivering fluids to the eye and methods of use |
| EP4292632B1 (en) | 2019-12-15 | 2025-08-27 | Shaheen Innovations Holding Limited | Ultrasonic mist inhaler |
| US11730193B2 (en) | 2019-12-15 | 2023-08-22 | Shaheen Innovations Holding Limited | Hookah device |
| US11730191B2 (en) | 2019-12-15 | 2023-08-22 | Shaheen Innovations Holding Limited | Hookah device |
| HUE067026T2 (hu) | 2019-12-15 | 2024-09-28 | Shaheen Innovations Holding Ltd | Ultrahangos pára inhalátor |
| IL295717B2 (en) | 2019-12-15 | 2024-05-01 | Shaheen Innovations Holding Ltd | Steam inhaler devices |
| US11666713B2 (en) * | 2019-12-15 | 2023-06-06 | Shaheen Innovations Holding Limited | Mist inhaler devices |
| US12233207B2 (en) | 2019-12-15 | 2025-02-25 | Shaheen Innovations Holding Limited | Mist inhaler devices |
| US12121056B2 (en) | 2019-12-15 | 2024-10-22 | Shaheen Innovations Holding Limited | Hookah device |
| US12201144B2 (en) | 2019-12-15 | 2025-01-21 | Shaheen Innovations Holding Limited | Hookah device |
| US11589610B2 (en) | 2019-12-15 | 2023-02-28 | Shaheen Innovations Holding Limited | Nicotine delivery device having a mist generator device and a driver device |
| PL4031216T3 (pl) | 2019-12-15 | 2025-06-09 | Shaheen Innovations Holding Limited | Mgiełkowy inhalator ultradźwiękowy |
| EP4031218A4 (en) | 2019-12-15 | 2023-06-07 | Shaheen Innovations Holding Limited | ULTRASONIC NEBULIZER |
| ES3028096T3 (en) | 2019-12-15 | 2025-06-18 | Shaheen Innovations Holding Ltd | Ultrasonic mist inhaler |
| US12290472B2 (en) | 2020-04-17 | 2025-05-06 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
| WO2021212038A1 (en) | 2020-04-17 | 2021-10-21 | Kedalion Therapeutics, Inc. | Hydrodynamically actuated preservative free dispensing system having a collapsible liquid reservoir |
| US11938057B2 (en) | 2020-04-17 | 2024-03-26 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
| IL297215A (en) | 2020-04-17 | 2022-12-01 | Kedallon Therapeutics Inc | A hydrodynamically activated preservative free distribution system |
| US11298472B2 (en) * | 2020-04-24 | 2022-04-12 | SOSD Health & Medical Innovations Inc. | Ultrasonic nebulizer |
| USD1052082S1 (en) | 2020-06-01 | 2024-11-19 | Koska Family Limited | Sealed fluid container |
| EP4659870A2 (en) | 2021-06-22 | 2025-12-10 | Pneuma Respiratory, Inc. | Droplet delivery device with push ejection |
| USD992110S1 (en) | 2021-08-10 | 2023-07-11 | Koska Family Limited | Sealed fluid container |
| CN114242454B (zh) * | 2021-11-09 | 2023-12-29 | 北京工业大学 | 一种钛酸铋钠基四元系高温稳定的高介无铅陶瓷电容器介质材料及制备 |
| US12419979B2 (en) | 2021-12-03 | 2025-09-23 | Eyenovia, Inc. | Pulsed ultraviolet in-line sterilization system for primary drug containers |
| US20230188901A1 (en) | 2021-12-15 | 2023-06-15 | Shaheen Innovations Holding Limited | Apparatus for transmitting ultrasonic waves |
| US20240226461A1 (en) * | 2022-01-10 | 2024-07-11 | Andrew Pittner | Ophthalmic Nebulizing Delivery System |
| EP4489919A1 (en) * | 2022-03-09 | 2025-01-15 | Pneuma Respiratory, Inc. | Droplet ejector with treated surface |
| CN117263684B (zh) * | 2022-06-15 | 2025-07-25 | 中国石油天然气集团有限公司 | 一种兼具高储能密度和高储能效率的弛豫铁电块体材料及其制备方法 |
| US12161795B2 (en) | 2022-07-18 | 2024-12-10 | Pneuma Respiratory, Inc. | Small step size and high resolution aerosol generation system and method |
| US20250276134A1 (en) * | 2024-03-04 | 2025-09-04 | Pneuma Respiratory, Inc. | Optimizing contact force for aerosol delivery |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1054916A (zh) * | 1989-12-12 | 1991-10-02 | 比斯帕克公共有限公司 | 喷雾装置 |
| CN1347349A (zh) * | 1999-03-08 | 2002-05-01 | 约翰逊父子公司 | 压电件的改进连接方法 |
| EP1219314B1 (en) * | 2000-12-29 | 2004-03-17 | Instrumentarium Corporation | Liquid discharge apparatus having magnetic valve |
| CN101274850A (zh) * | 2007-03-26 | 2008-10-01 | Tdk株式会社 | 压电陶瓷组合物 |
| CN101663097A (zh) * | 2007-03-31 | 2010-03-03 | 微点生物技术有限公司 | 微机械加工的流体喷射器 |
| WO2012009706A1 (en) * | 2010-07-15 | 2012-01-19 | Corinthian Ophthalmic, Inc. | Drop generating device |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2698619A (en) * | 1952-04-22 | 1955-01-04 | Cutter Lab | Flexible bag having self-sealing entryway |
| US3892235A (en) * | 1971-07-27 | 1975-07-01 | Respiratory Care | Multi-use inhalation therapy apparatus |
| AU553251B2 (en) | 1981-10-15 | 1986-07-10 | Matsushita Electric Industrial Co., Ltd. | Arrangement for ejecting liquid |
| GB8528032D0 (en) | 1985-11-13 | 1985-12-18 | Ici Plc | Ocular treatment |
| DE68902989T2 (de) | 1988-12-20 | 1993-04-15 | Step Soc Tech Pulverisation | Vorrichtung zum spenden einer fluessigkeit oder einer creme in tropfen kleinen volumens. |
| GB8916133D0 (en) | 1989-07-14 | 1989-08-31 | Raychem Ltd | Laser machining |
| ES2077844T5 (es) | 1990-02-20 | 2001-02-01 | Procter & Gamble | Estructuras de canales capilares abiertos, procedimiento mejorado para producir estructuras de canales capilares, y boquilla de extrusion para uso en el mismo. |
| JP2810575B2 (ja) | 1991-02-01 | 1998-10-15 | キヤノン株式会社 | 通信装置 |
| US5938117A (en) | 1991-04-24 | 1999-08-17 | Aerogen, Inc. | Methods and apparatus for dispensing liquids as an atomized spray |
| JP2553592Y2 (ja) * | 1991-12-05 | 1997-11-05 | ティーディーケイ株式会社 | 給液手段付き霧化器 |
| JP2849647B2 (ja) | 1991-12-04 | 1999-01-20 | ザ テクノロジー パートナーシップ ピーエルシー | 流体の小水滴製造装置及びその方法 |
| US5607410A (en) | 1993-02-16 | 1997-03-04 | Branch; John D. | Vision directed eye wash |
| JP3659593B2 (ja) | 1993-12-09 | 2005-06-15 | ティーティーピー グループ ピーエルシー | 液体スプレー装置及び方法 |
| GB9405952D0 (en) | 1994-03-25 | 1994-05-11 | Zeneca Ltd | Aqueous ophthalmic sprays |
| US6011062A (en) | 1994-12-22 | 2000-01-04 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
| US6427682B1 (en) * | 1995-04-05 | 2002-08-06 | Aerogen, Inc. | Methods and apparatus for aerosolizing a substance |
| US6378780B1 (en) * | 1999-02-09 | 2002-04-30 | S. C. Johnson & Son, Inc. | Delivery system for dispensing volatiles |
| FR2797189A1 (fr) * | 1999-08-02 | 2001-02-09 | Jean Pierre Lenfant | Dispositif permettant de diffuser un parfum dans un local |
| JP2001064027A (ja) * | 1999-08-24 | 2001-03-13 | Hamamatsu Photonics Kk | キャピラリ部材 |
| US6530370B1 (en) * | 1999-09-16 | 2003-03-11 | Instrumentation Corp. | Nebulizer apparatus |
| US20020085067A1 (en) | 2000-12-29 | 2002-07-04 | Robert Palifka | Ink jet printing module |
| US6758837B2 (en) | 2001-02-08 | 2004-07-06 | Pharmacia Ab | Liquid delivery device and method of use thereof |
| US6550472B2 (en) | 2001-03-16 | 2003-04-22 | Aerogen, Inc. | Devices and methods for nebulizing fluids using flow directors |
| US6976639B2 (en) | 2001-10-29 | 2005-12-20 | Edc Biosystems, Inc. | Apparatus and method for droplet steering |
| FR2832987B1 (fr) * | 2001-12-04 | 2004-07-09 | Valois Sa | Distributeur de produit fluide |
| WO2003068412A1 (en) | 2002-02-11 | 2003-08-21 | Sara Lee/De N.V. | Liquid spray-head, apparatus comprising a liquid spray-head and container therefore |
| US7427115B2 (en) | 2002-03-28 | 2008-09-23 | Xerox Corporation | Fluid ejector including a drop size symbol, a method of disposing a drop size symbol in a fluid ejector, and an image forming device including a marking fluid ejector with a drop size symbol |
| US20040039355A1 (en) | 2002-08-26 | 2004-02-26 | Gonzalez Jose M. | Fluid dispensing devices and methods |
| US20070211212A1 (en) | 2002-09-26 | 2007-09-13 | Percy Bennwik | Eye state sensor |
| US7074827B2 (en) | 2002-10-24 | 2006-07-11 | Sucampo Ag (Usa) Inc. | Method for treating ocular hypertension and glaucoma |
| US7883031B2 (en) | 2003-05-20 | 2011-02-08 | James F. Collins, Jr. | Ophthalmic drug delivery system |
| US20100222752A1 (en) * | 2003-05-20 | 2010-09-02 | Collins Jr James F | Ophthalmic fluid delivery system |
| US8545463B2 (en) * | 2003-05-20 | 2013-10-01 | Optimyst Systems Inc. | Ophthalmic fluid reservoir assembly for use with an ophthalmic fluid delivery device |
| FR2862009B1 (fr) * | 2003-11-07 | 2007-01-05 | Valois Sas | Tete de pulverisation de produit fluide et pompe de distribution comportant une telle tete. |
| CN101693132B (zh) | 2004-04-02 | 2013-05-22 | 美国政府健康及人类服务部,疾病控制和预防中心 | 气雾化输送系统和方法 |
| US7658478B2 (en) | 2004-10-04 | 2010-02-09 | Kodak Graphic Communications Canada Company | Non-conductive fluid droplet forming apparatus and method |
| CN101581265B (zh) | 2005-04-18 | 2011-07-20 | 株式会社电装 | 燃料喷射阀 |
| US7828232B2 (en) | 2005-04-18 | 2010-11-09 | Denso Corporation | Injection valve having nozzle hole |
| US7954730B2 (en) | 2005-05-02 | 2011-06-07 | Hong Kong Piezo Co. Ltd. | Piezoelectric fluid atomizer apparatuses and methods |
| DE102005038619A1 (de) * | 2005-08-16 | 2007-02-22 | Pari GmbH Spezialisten für effektive Inhalation | Inhalationstherapievorrichtung mit einer Ampulle für die Bevorratung eines zu vernebelnden Medikaments |
| US8672648B2 (en) | 2006-05-23 | 2014-03-18 | Nuventix, Inc. | Methods for reducing the non-linear behavior of actuators used for synthetic jets |
| CN101479046B (zh) | 2006-09-01 | 2012-06-27 | 株式会社神户制钢所 | 加速喷嘴及喷射喷嘴装置 |
| WO2008029650A1 (en) | 2006-09-08 | 2008-03-13 | Canon Kabushiki Kaisha | Liquid discharge head and method of manufacturing the same |
| EP2050478A1 (en) * | 2007-10-16 | 2009-04-22 | GE Healthcare Finland Oy | Device for delivery and regulation of volatile fluids into inspiratory gas |
| EP2214727B1 (en) * | 2007-11-20 | 2012-04-11 | Zobele Holding S.P.A. | Nebulising device for liquid substances |
| US20090212133A1 (en) | 2008-01-25 | 2009-08-27 | Collins Jr James F | Ophthalmic fluid delivery device and method of operation |
| US7891580B2 (en) | 2008-04-30 | 2011-02-22 | S.C. Johnson & Son, Inc. | High volume atomizer for common consumer spray products |
| FR2934128B1 (fr) * | 2008-07-24 | 2012-12-14 | Oreal | Tete de diffusion melangeuse. |
| FR2938207B1 (fr) | 2008-11-12 | 2010-12-24 | Imaje Sa | Imprimante munie d'un generateur de gouttes a jet continu binaire a deflexion et vitesse d'impression optimales |
| WO2010089822A1 (ja) * | 2009-02-09 | 2010-08-12 | 株式会社村田製作所 | 霧化部材及びそれを備える霧化器 |
| US20100211408A1 (en) | 2009-02-17 | 2010-08-19 | Carl Hyunsuk Park | Systems and methods for generating medical diagnoses |
| ES2590354T3 (es) * | 2010-01-11 | 2016-11-21 | Koninklijke Philips N.V. | Acoplamiento magnético para aparato de generación de aerosol |
| US8205971B2 (en) | 2010-01-19 | 2012-06-26 | Xerox Corporation | Electrically grounded inkjet ejector and method for making an electrically grounded inkjet ejector |
| TW201132414A (en) * | 2010-03-24 | 2011-10-01 | Micro Base Technology Corp | Atomizing assembly |
| JP5585768B2 (ja) * | 2010-04-14 | 2014-09-10 | セイコーエプソン株式会社 | 液体噴射ヘッド、液体噴射装置および圧電素子 |
| KR20170129298A (ko) | 2010-07-15 | 2017-11-24 | 아이노비아 인코포레이티드 | 안과용 약물 전달 |
| EA201390121A8 (ru) | 2010-07-15 | 2014-02-28 | Коринтиан Офтэлмик, Инк. | Способ и система для выполнения дистанционного лечения и контроля |
| DE102011013192A1 (de) | 2011-03-05 | 2012-09-06 | Dietmar Przytulla | Palettenbehälter |
| US8485503B2 (en) * | 2011-04-14 | 2013-07-16 | Skip A. Lei | Multi stream wine aerating device |
| TWM417925U (en) * | 2011-06-14 | 2011-12-11 | Microbase Technology Corp | Portable atomization device |
| TWM432471U (en) * | 2011-11-18 | 2012-07-01 | Microbase Technology Corp | Atomizing device with negative pressure structure |
| WO2013090459A1 (en) * | 2011-12-12 | 2013-06-20 | Corinthian Ophthalmic, Inc. | Ejector mechanism, ejector device, and methods of use |
| WO2013105096A1 (en) * | 2012-01-12 | 2013-07-18 | Scentcom Ltd | An ultrasonic micro valve array unit for production of mist |
| AU2013245946A1 (en) | 2012-04-10 | 2014-11-27 | Eyenovia, Inc. | Spray ejector mechanisms and devices providing charge isolation and controllable droplet charge, and low dosage volume opthalmic administration |
| SG11201406716WA (en) | 2012-04-20 | 2015-03-30 | Eyenovia Inc | Spray ejector device and methods of use |
| US9463486B2 (en) | 2012-05-14 | 2016-10-11 | Eyenovia, Inc. | Laminar flow droplet generator device and methods of use |
| JP6240170B2 (ja) | 2012-05-15 | 2017-11-29 | アイノビア,インコーポレイティド | エジェクタ装置,並びにその方法,ドライバ,及び回路 |
| USD705924S1 (en) | 2012-11-02 | 2014-05-27 | Corinthian Ophthalmic, Inc. | Droplet ejection device |
-
2013
- 2013-04-19 SG SG11201406716WA patent/SG11201406716WA/en unknown
- 2013-04-19 AU AU2013249108A patent/AU2013249108A1/en not_active Abandoned
- 2013-04-19 US US13/866,783 patent/US20130299607A1/en not_active Abandoned
- 2013-04-19 WO PCT/US2013/037326 patent/WO2013158967A2/en not_active Ceased
- 2013-04-19 MX MX2014012702A patent/MX2014012702A/es unknown
- 2013-04-19 KR KR1020147032639A patent/KR102108588B1/ko active Active
- 2013-04-19 EP EP13724433.1A patent/EP2838669B1/en active Active
- 2013-04-19 CN CN201810953975.4A patent/CN109011046B/zh active Active
- 2013-04-19 JP JP2015507212A patent/JP6462563B2/ja active Active
- 2013-04-19 CA CA3121535A patent/CA3121535C/en active Active
- 2013-04-19 KR KR1020207012369A patent/KR102234046B1/ko active Active
- 2013-04-19 CN CN201380031873.2A patent/CN104755180B/zh active Active
- 2013-04-19 CA CA2870966A patent/CA2870966C/en active Active
- 2013-04-19 EA EA201491906A patent/EA201491906A1/ru unknown
- 2013-04-19 ES ES13724433.1T patent/ES2663879T3/es active Active
- 2013-04-19 BR BR112014026171A patent/BR112014026171A2/pt not_active IP Right Cessation
-
2014
- 2014-10-22 IL IL235281A patent/IL235281B/en active IP Right Grant
-
2016
- 2016-06-29 US US15/197,033 patent/US11285504B2/en active Active
-
2022
- 2022-03-25 US US17/704,395 patent/US12023700B2/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1054916A (zh) * | 1989-12-12 | 1991-10-02 | 比斯帕克公共有限公司 | 喷雾装置 |
| CN1347349A (zh) * | 1999-03-08 | 2002-05-01 | 约翰逊父子公司 | 压电件的改进连接方法 |
| EP1219314B1 (en) * | 2000-12-29 | 2004-03-17 | Instrumentarium Corporation | Liquid discharge apparatus having magnetic valve |
| CN101274850A (zh) * | 2007-03-26 | 2008-10-01 | Tdk株式会社 | 压电陶瓷组合物 |
| CN101663097A (zh) * | 2007-03-31 | 2010-03-03 | 微点生物技术有限公司 | 微机械加工的流体喷射器 |
| WO2012009706A1 (en) * | 2010-07-15 | 2012-01-19 | Corinthian Ophthalmic, Inc. | Drop generating device |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20200047781A (ko) | 2020-05-07 |
| EA201491906A1 (ru) | 2015-03-31 |
| CN104755180B (zh) | 2018-09-21 |
| IL235281A0 (en) | 2014-12-31 |
| KR102108588B1 (ko) | 2020-05-07 |
| CA3121535C (en) | 2024-01-23 |
| KR20150020542A (ko) | 2015-02-26 |
| US12023700B2 (en) | 2024-07-02 |
| EP2838669A2 (en) | 2015-02-25 |
| US20130299607A1 (en) | 2013-11-14 |
| SG11201406716WA (en) | 2015-03-30 |
| KR102234046B1 (ko) | 2021-03-30 |
| US20170136484A1 (en) | 2017-05-18 |
| BR112014026171A2 (pt) | 2017-07-18 |
| JP2015514515A (ja) | 2015-05-21 |
| EP2838669B1 (en) | 2018-01-03 |
| JP6462563B2 (ja) | 2019-01-30 |
| HK1211536A1 (en) | 2016-05-27 |
| ES2663879T3 (es) | 2018-04-17 |
| WO2013158967A3 (en) | 2013-12-12 |
| CA3121535A1 (en) | 2013-10-24 |
| CN104755180A (zh) | 2015-07-01 |
| US11285504B2 (en) | 2022-03-29 |
| AU2013249108A1 (en) | 2014-12-04 |
| CA2870966C (en) | 2021-07-27 |
| US20220355329A1 (en) | 2022-11-10 |
| MX2014012702A (es) | 2015-08-14 |
| CN109011046A (zh) | 2018-12-18 |
| WO2013158967A2 (en) | 2013-10-24 |
| CA2870966A1 (en) | 2013-10-24 |
| IL235281B (en) | 2019-12-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109011046B (zh) | 用于向目标输送流体的装置 | |
| US10639194B2 (en) | High modulus polymeric ejector mechanism, ejector device, and methods of use | |
| US10583038B2 (en) | Piezoelectric dispenser with replaceable ampoule | |
| US20100222752A1 (en) | Ophthalmic fluid delivery system | |
| HK40001838B (en) | An ejector device for ejecting fluid onto a surface | |
| HK40001838A (en) | An ejector device for ejecting fluid onto a surface | |
| ES2817024T3 (es) | Pulverizador de aerosol aséptico | |
| HK1211536B (zh) | 用於向表面上喷射流体的喷射装置 | |
| HK40078878A (en) | Systems and devices for delivering fluids to the eye and methods of use |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 40001838 Country of ref document: HK |
|
| EE01 | Entry into force of recordation of patent licensing contract | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20181218 Assignee: Jimu biology Co.,Ltd. Assignor: CORINTHIAN OPHTHALMIC, Inc. Contract record no.: X2021990000497 Denomination of invention: Device for delivering fluid to target License type: Exclusive License Record date: 20210818 |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant |