CN108992492A - A kind of preparation method of yellow fragrant particle - Google Patents
A kind of preparation method of yellow fragrant particle Download PDFInfo
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- A61K2236/50—Methods involving additional extraction steps
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Abstract
A kind of preparation method of yellow fragrant particle, the preparation of the preparation of preparation, Pogostemon cablin aqueous solution, the preparation of rheum officinale ethanol extract and yellow fragrant particle including Pogostemon cablin essential, Pogostemon cablin aqueous solution and rheum officinale ethanol extract are mixed, it is concentrated in vacuo under the conditions of 50-55 DEG C, obtains the clear cream that relative density under the conditions of 30~40 DEG C is 1.30-1.35；The cane sugar powder that fineness is 100-120 mesh is added into the clear cream, after mixing evenly, particle is made；Particle is less than or equal to 8% using 60-70 DEG C of heated-air drying to moisture content, uniformly sprays the Pogostemon cablin essential in particle surface after being cooled to room temperature, concussion absorbs essential oil to get yellow fragrant particle by particle.The advantages of yellow fragrant particle produced by the present invention is formed with the extract compatibility of rheum officinale, Pogostemon cablin, has preparation process simple, the aerial part complete utilization of Pogostemon cablin.
Description
Technical field
The present invention relates to a kind of preparation methods of yellow fragrant particle, belong to Chinese medicine processing technique field.
Background technique
Rheum officinale is being collectively referred to as the perennial plant of a variety of polygonaceae Rheums.In China, rheum officinale is used mainly as Chinese medicine.
Annual autumn end cauline leaf is withered to the germination of spring next year, and the root of rheum officinale plant is excavated, and removes radicula, scrapes off crust, valve cutting or
Chinese medicine " rheum officinale " is made after dry in section.Chinese medicine rheum officinale, which has, attacks the function such as stagnant, clearing away damp-heat, purging intense heat, cool blood, dissolving stasis, removing toxic substances
Effect.
Pogostemon cablin is often referred to Chinese medicine " Pogostemon cablin ", refers to the aerial part of the drying of Lamiaceae plant Pogostemon cablin；In the wide leaves of pulse plants
Fragrant branches and leaves are tapped when luxuriant, and solarization night is bored, handles to after being completely dried and obtains repeatedly.Pogostemon cablin, which has, eliminates dampness with aromatics and stops
Vomit, deliver relieving summer-heat and other effects, for turbi damp obstructing in middle-JIAO, the vomiting of gastral cavity ruffian, summer-heat and damp exterior syndrome, damp-warm syndrome from the beginning of, fever burnout, it is uncomfortable in chest it is not easypro,
Cold-dampness closes heat, abdominal pain vomiting and diarrhoea, nasosinusitis headache etc..
The patent of invention of Publication No. CN 104173470B discloses a kind of preparation method of yellow incense drug compositions, will
Two taste medicinal material Pogostemon cablin and rheum officinale mix after extracting in yellow incense drug compositions, then by special compound resin column and preferably
Technological parameter makes general anthraquinone and general flavone while obtaining maximum enriching and purifying, takes into account yield and purity, simplifies technique stream
Journey saves time resource.Total anthraquinones content is more than 35% in anthraquinone flavone mixture made from optimum process of the present invention, and yield is super
50% is crossed, general flavone content is more than 45%, and general flavone yield is more than 50%.
Summary of the invention
The purpose of the present invention is to provide a kind of preparation methods of yellow fragrant particle.
In order to achieve the above objects and other related objects, present invention provide the technical scheme that a kind of system of yellow fragrant particle
Preparation Method, the preparation of preparation, Pogostemon cablin aqueous solution, the preparation of rheum officinale ethanol extract and yellow fragrant particle including Pogostemon cablin essential
Preparation；
The preparation of the Pogostemon cablin essential includes: to mix Pogostemon cablin leaf with distilled water 1:20 ~ 30 in mass ratio, is put into evaporating
Out in the cucurbit of liquid condensing collection device, heating cucurbit to fluidized state simultaneously continues under fluidized state, collects distillate,
Then distillate is centrifuged, collects upper layer oil reservoir and obtains Pogostemon cablin essential；
The preparation of the Pogostemon cablin aqueous solution includes: that cortical granule is made in the cortex of Pogostemon cablin limb, and core is made in remaining part
Material particle；
Cortical granule after 2-3 freeze thawing treatment obtains freeze thawing treatment is carried out to the cortical granule；The freeze thawing treatment be by
Cortical granule is placed in 2-3min in liquid nitrogen, and taking-up is placed on 2-3min in 87 ~ 93 DEG C of hot wind environment；
5-30 DEG C of water of the core material particles is impregnated into 60-120min, Steam explosion treatment is then carried out and obtains steam blasting
Core material particles that treated；
Cortical granule after freeze thawing treatment, the core material particles after Steam explosion treatment 1:4 ~ 6 in mass ratio are mixed, mixed
Material, the mixture is mixed with water 1:4 ~ 7 in mass ratio, is placed into the thermal extraction device with steam condensate collection device
In, 90-120min is extracted in boiling, is filtered extracting solution after the completion of extraction, obtained filtrate is Pogostemon cablin aqueous solution；
The preparation of the rheum officinale ethanol extract includes: that rheum officinale is crushed to 40-60 mesh, obtains Rhubarb Powder, by Rhubarb Powder and nothing
Water-ethanol 1:4 in mass ratio ~ 8 mixing, is subsequently placed in ultrasonic equipment and handles 20-30min, ultrasonic frequency 25-
35KHz, power density 0.4-0.5W/cm2；By after ultrasonication Rhubarb Powder and dehydrated alcohol mixture be placed into and have
In the thermal extraction device of ethyl alcohol condensate collection device, 90-120min is extracted in boiling；Extracting solution is filtered after the completion of extraction, is collected
Obtained filtrate is rheum officinale ethanol extract；
The preparation of the yellow fragrant particle includes: to mix the Pogostemon cablin aqueous solution and rheum officinale ethanol extract, in 50-55 DEG C of item
It is concentrated in vacuo under part, obtains the clear cream that relative density under the conditions of 30~40 DEG C is 1.30-1.35；Add into the clear cream
Refinement degree is the cane sugar powder of 100-120 mesh, after mixing evenly, particle is made；By particle using 60-70 DEG C of heated-air drying to moisture
Content is less than or equal to 8%, uniformly sprays the Pogostemon cablin essential in particle surface after being cooled to room temperature, concussion makes essential oil
It is absorbed by particle to get yellow fragrant particle.
Preferred technical solution are as follows: in the preparation process of the Pogostemon cablin essential, control the temperature of distillate condensate liquid
It is 25-40 DEG C；Revolving speed when centrifuge separation is 5000-7000r/min, time 8-15min.
Preferred technical solution are as follows: the Pogostemon cablin aqueous solution, rheum officinale ethanol extract, cane sugar powder and Pogostemon cablin essential it
Between mass ratio are as follows: 900-1100:900-1100:500-600:0.4-0.6.
Preferred technical solution are as follows: the technological parameter of the Steam explosion treatment are as follows: ratio of water to material 1:4-8, dimension pressure time 90-
180s, steam pressure 1.8-2.0MPa.
Preferred technical solution are as follows: in boiling extraction process, be in material in ultrasonic environment, ultrasonic frequency is
25-35KHz, power density 0.4-0.5W/cm2。
Since above-mentioned technical proposal is used, the present invention has the advantage, that compared with prior art
Yellow fragrant particle produced by the present invention is formed with the extract compatibility of rheum officinale, Pogostemon cablin, has preparation process simple, Pogostemon cablin
Aerial part complete utilization the advantages of.
Specific embodiment
Embodiments of the present invention are illustrated by particular specific embodiment below, those skilled in the art can be by this implementation
Content disclosed by example is understood other advantages and efficacy of the present invention easily.
The purpose of term used herein, which is only that, illustrates particular embodiment, it is not intended to be limited to the present invention.It removes
Non- context is explicitly shown, otherwise singular " one " used herein, "one" also include plural form.
When illustrating preferred embodiment, it is potentially based on clear purpose and uses special term；However, this specification institute
Revealer is not intended to be limited in the selected special term；And it is to be understood that each particular element includes having
Identical function, all equivalence techniques for operating in a similar manner and reaching similar effects.
A kind of embodiment one: preparation method of yellow fragrant particle
A kind of yellow fragrant particle and preparation method thereof, which is characterized in that include the following steps.
(1) Pogostemon cablin pre-processes
The Pogostemon cablin is the aerial part of Pogostemon cablin plant, is made through harvesting, cutting, drying.
Pogostemon cablin is placed in pneumatic separator, selection by winnowing wind speed is 5-7m/s, separates and collects light material and heavy respectively
Material；Light material is mainly Pogostemon cablin leaf, and heavier feeds are mainly Pogostemon cablin limb.
Pogostemon cablin limb is placed in crushing plant, the single-size that fineness is 10-12 mesh is broken into；Then CCD is used
Color-selection apparatus separates and collects the relatively deep and shallower particle of color respectively.The deeper particle of color is mainly the skin of Pogostemon cablin limb
Layer, the shallower particle of color is mainly the core material of Pogostemon cablin limb.
(2) Pogostemon cablin essential is prepared
Pogostemon cablin leaf is mixed with distilled water 1:25 in mass ratio, is put into the cucurbit with distillate condensate collection device,
Carry out air-distillation.Heating cucurbit to fluidized state and continues to keep, and the temperature after controlling distillate condensate liquid is 32 DEG C, receives
Collect distillate；When the distillate British plain spirits or condensing droplet of collection ooze current cleaned glass on piece is oil-free, stop distillation.It will
Distillate is put into centrifugation apparatus, and setting revolving speed is 6000r/min, is centrifuged 11min, collects upper layer oil reservoir, obtains Pogostemon cablin essence
Oil.
(3) Pogostemon cablin aqueous solution is prepared
The cortical granule of Pogostemon cablin limb is subjected to 2 fast freeze-thaw processing, i.e., cortical granule is placed in 3min in liquid nitrogen, rapidly
Taking-up is placed in 2.5min in 90 DEG C of hot wind environment；Then it is first placed in liquid nitrogen and hot wind environment and handles again, so recycle 2
It is secondary.
By the core material particles of Pogostemon cablin limb, 90min is impregnated at a temperature of 17 DEG C using enough distilled water；After impregnating
Core material particles be placed in steam blasting equipment, using ratio of water to material 1:6, dimension pressure time 135s, steam pressure 1.9MPa ginseng
Number carries out Steam explosion treatment.
Cortical granule after freeze thawing treatment, the core material particles after Steam explosion treatment 1:5 in mass ratio are mixed, mixed
Close material.Mixture is mixed with distilled water 1:5 in mass ratio, is placed into the thermal extraction device with steam condensate collection device
In, 105min is extracted in boiling；In extraction process, it is in material in ultrasonic environment, ultrasonic frequency 30KHz, power is close
Degree is 0.45W/cm2.After the completion of extraction, extracting solution is passed through into 100 mesh net filtrations, collects filtrate, it is spare.
(4) rheum officinale ethanol extract is prepared
The rheum officinale, the dried object after epidermis is removed for rheum officinale plant root.
Rheum officinale is crushed to 50 mesh, obtains Rhubarb Powder.Rhubarb Powder is mixed with dehydrated alcohol 1:5 in mass ratio, as super
25min, ultrasonic frequency 30KHz, power density 0.45W/cm are handled in acoustic wave device2；It will be big after ultrasonication
Bloom, dehydrated alcohol mixture are placed into the thermal extraction device with ethyl alcohol condensate collection device, and ethyl alcohol boiling is extracted
105min；After the completion of extraction, extracting solution is passed through into 100 mesh net filtrations, collects filtrate, it is spare.
(5) the yellow fragrant particle of preparation
The rheum officinale ethanol extract of the Pogostemon cablin aqueous solution of 1000 parts by weight, 1000 parts by weight is mixed, 52 DEG C are concentrated in vacuo to
Relative density be 1.32(35 DEG C) clear cream；The fineness that 550 parts by weight are added into clear cream is the cane sugar powder of 110 mesh, and stirring is equal
After even, it is crushed to uniform particle；65 DEG C of heated-air dryings are used for 8%, to be let cool to moisture to room temperature particle；By 0.5 weight
The Pogostemon cablin essential of part is uniformly sprayed in particle surface, and appropriateness is shaken, and fully absorbs essential oil by particle to get yellow perfume is arrived
Grain formulation products.
A kind of embodiment two: preparation method of yellow fragrant particle
A kind of preparation method of yellow fragrant particle, the preparation of preparation, Pogostemon cablin aqueous solution including Pogostemon cablin essential, rheum officinale ethyl alcohol mention
Take the preparation of liquid and the preparation of yellow fragrant particle；
The preparation of the Pogostemon cablin essential includes: to mix Pogostemon cablin leaf with distilled water 1:20 in mass ratio, is put into distillating
In the cucurbit of liquid condensing collection device, heating cucurbit to fluidized state simultaneously continues under fluidized state, collects distillate, so
Distillate is centrifuged afterwards, upper layer oil reservoir is collected and obtains Pogostemon cablin essential；
The preparation of the Pogostemon cablin aqueous solution includes: that cortical granule is made in the cortex of Pogostemon cablin limb, and core is made in remaining part
Material particle；
Cortical granule after 2 freeze thawing treatments obtain freeze thawing treatment is carried out to the cortical granule；The freeze thawing treatment is by skin
Layer particle is placed in 2min in liquid nitrogen, and taking-up is placed on 2min in 87 DEG C of hot wind environment；
5 DEG C of water of the core material particles is impregnated into 60min, after then progress Steam explosion treatment obtains Steam explosion treatment
Core material particles；
Cortical granule after freeze thawing treatment, the core material particles after Steam explosion treatment 1:4 in mass ratio are mixed, mixed
Material, the mixture is mixed with water 1:4 in mass ratio, is placed into the thermal extraction device with steam condensate collection device,
90min is extracted in boiling, is filtered extracting solution after the completion of extraction, obtained filtrate is Pogostemon cablin aqueous solution；
The preparation of the rheum officinale ethanol extract includes: that rheum officinale is crushed to 40 mesh, obtains Rhubarb Powder, by Rhubarb Powder and anhydrous second
Alcohol 1:4 in mass ratio mixing, is subsequently placed in ultrasonic equipment and handles 20min, ultrasonic frequency 25KHz, and power density is
0.4W/cm2；By after ultrasonication Rhubarb Powder and dehydrated alcohol mixture be placed into the heat with ethyl alcohol condensate collection device
In extraction element, 90min is extracted in boiling；Extracting solution is filtered after the completion of extraction, the filtrate collected is that rheum officinale ethyl alcohol mentions
Take liquid；
The preparation of the yellow fragrant particle includes: to mix the Pogostemon cablin aqueous solution and rheum officinale ethanol extract, in 50 DEG C of conditions
Under be concentrated in vacuo, obtain the clear cream that under the conditions of 30 DEG C relative density is 1.30；It is 100 that fineness is added into the clear cream
Particle is made after mixing evenly in purpose cane sugar powder；60 DEG C of heated-air dryings are used for 7%, to be cooled to room to moisture content particle
The Pogostemon cablin essential is uniformly sprayed in particle surface after temperature, concussion absorbs essential oil to get yellow fragrant particle by particle.
Preferred embodiment are as follows: in the preparation process of the Pogostemon cablin essential, control the temperature of distillate condensate liquid
It is 25 DEG C；Revolving speed when centrifuge separation is 5000r/min, time 8min.
Preferred embodiment are as follows: the Pogostemon cablin aqueous solution, rheum officinale ethanol extract, cane sugar powder and Pogostemon cablin essential it
Between mass ratio are as follows: 900:900:500:0.4.
Preferred embodiment are as follows: the technological parameter of the Steam explosion treatment are as follows: ratio of water to material 1:4, dimension pressure time 90s,
Steam pressure 1.8MPa.
Preferred embodiment are as follows: in boiling extraction process, be in material in ultrasonic environment, ultrasonic frequency is
25KHz, power density 0.4W/cm2。
A kind of embodiment three: preparation method of yellow fragrant particle
A kind of preparation method of yellow fragrant particle, the preparation of preparation, Pogostemon cablin aqueous solution including Pogostemon cablin essential, rheum officinale ethyl alcohol mention
Take the preparation of liquid and the preparation of yellow fragrant particle；
The preparation of the Pogostemon cablin essential includes: to mix Pogostemon cablin leaf with distilled water 1:30 in mass ratio, is put into distillating
In the cucurbit of liquid condensing collection device, heating cucurbit to fluidized state simultaneously continues under fluidized state, collects distillate, so
Distillate is centrifuged afterwards, upper layer oil reservoir is collected and obtains Pogostemon cablin essential；
The preparation of the Pogostemon cablin aqueous solution includes: that cortical granule is made in the cortex of Pogostemon cablin limb, and core is made in remaining part
Material particle；
Cortical granule after 3 freeze thawing treatments obtain freeze thawing treatment is carried out to the cortical granule；The freeze thawing treatment is by skin
Layer particle is placed in 3min in liquid nitrogen, and taking-up is placed on 3min in 93 DEG C of hot wind environment；
5-30 DEG C of water of the core material particles is impregnated into 60-120min, Steam explosion treatment is then carried out and obtains steam blasting
Core material particles that treated；
Cortical granule after freeze thawing treatment, the core material particles after Steam explosion treatment 1:6 in mass ratio are mixed, mixed
Material, the mixture is mixed with water 1:7 in mass ratio, is placed into the thermal extraction device with steam condensate collection device,
120min is extracted in boiling, is filtered extracting solution after the completion of extraction, obtained filtrate is Pogostemon cablin aqueous solution；
The preparation of the rheum officinale ethanol extract includes: that rheum officinale is crushed to 60 mesh, obtains Rhubarb Powder, by Rhubarb Powder and anhydrous second
Alcohol 1:8 in mass ratio mixing, is subsequently placed in ultrasonic equipment and handles 30min, ultrasonic frequency 35KHz, and power density is
0.5W/cm2；By after ultrasonication Rhubarb Powder and dehydrated alcohol mixture be placed into the heat with ethyl alcohol condensate collection device
In extraction element, 120min is extracted in boiling；Extracting solution is filtered after the completion of extraction, the filtrate collected is that rheum officinale ethyl alcohol mentions
Take liquid；
The preparation of the yellow fragrant particle includes: to mix the Pogostemon cablin aqueous solution and rheum officinale ethanol extract, in 55 DEG C of conditions
Under be concentrated in vacuo, obtain the clear cream that under the conditions of 40 DEG C relative density is 1.35；It is 120 that fineness is added into the clear cream
Particle is made after mixing evenly in purpose cane sugar powder；70 DEG C of heated-air dryings are used for 6%, to be cooled to room to moisture content particle
The Pogostemon cablin essential is uniformly sprayed in particle surface after temperature, concussion absorbs essential oil to get yellow fragrant particle by particle.
Preferred embodiment are as follows: in the preparation process of the Pogostemon cablin essential, control the temperature of distillate condensate liquid
It is 40 DEG C；Revolving speed when centrifuge separation is 7000r/min, time 15min.
Preferred embodiment are as follows: the Pogostemon cablin aqueous solution, rheum officinale ethanol extract, cane sugar powder and Pogostemon cablin essential it
Between mass ratio are as follows: 1100:1100:600:0.6.
Preferred embodiment are as follows: the technological parameter of the Steam explosion treatment are as follows: ratio of water to material 1:8, dimension pressure time 180s,
Steam pressure 2.0MPa.
Preferred embodiment are as follows: in boiling extraction process, be in material in ultrasonic environment, ultrasonic frequency is
35KHz, power density 0.5W/cm2。
As described above is only to be not intended to tool to explain the preferred embodiments of the invention to do any shape to the present invention
Limitation in formula should all wrap therefore all have any modification or change for making the related present invention under identical spirit
It includes in the scope that the invention is intended to protect.
Claims (5)
1. a kind of preparation method of yellow fragrant particle, it is characterised in that: the system of preparation, Pogostemon cablin aqueous solution including Pogostemon cablin essential
The preparation of standby, rheum officinale ethanol extract preparation and yellow fragrant particle；
The preparation of the Pogostemon cablin essential includes: to mix Pogostemon cablin leaf with distilled water 1:20 ~ 30 in mass ratio, is put into evaporating
Out in the cucurbit of liquid condensing collection device, heating cucurbit to fluidized state simultaneously continues under fluidized state, collects distillate,
Then distillate is centrifuged, collects upper layer oil reservoir and obtains Pogostemon cablin essential；
The preparation of the Pogostemon cablin aqueous solution includes: that cortical granule is made in the cortex of Pogostemon cablin limb, and core is made in remaining part
Material particle；
Cortical granule after 2-3 freeze thawing treatment obtains freeze thawing treatment is carried out to the cortical granule；The freeze thawing treatment be by
Cortical granule is placed in 2-3min in liquid nitrogen, and taking-up is placed on 2-3min in 87 ~ 93 DEG C of hot wind environment；
5-30 DEG C of water of the core material particles is impregnated into 60-120min, Steam explosion treatment is then carried out and obtains steam blasting
Core material particles that treated；
Cortical granule after freeze thawing treatment, the core material particles after Steam explosion treatment 1:4 ~ 6 in mass ratio are mixed, mixed
Material, the mixture is mixed with water 1:4 ~ 7 in mass ratio, is placed into the thermal extraction device with steam condensate collection device
In, 90-120min is extracted in boiling, is filtered extracting solution after the completion of extraction, obtained filtrate is Pogostemon cablin aqueous solution；
The preparation of the rheum officinale ethanol extract includes: that rheum officinale is crushed to 40-60 mesh, obtains Rhubarb Powder, by Rhubarb Powder and nothing
Water-ethanol 1:4 in mass ratio ~ 8 mixing, is subsequently placed in ultrasonic equipment and handles 20-30min, ultrasonic frequency 25-
35KHz, power density 0.4-0.5W/cm2；By after ultrasonication Rhubarb Powder and dehydrated alcohol mixture be placed into and have
In the thermal extraction device of ethyl alcohol condensate collection device, 90-120min is extracted in boiling；Extracting solution is filtered after the completion of extraction, is collected
Obtained filtrate is rheum officinale ethanol extract；
The preparation of the yellow fragrant particle includes: to mix the Pogostemon cablin aqueous solution and rheum officinale ethanol extract, in 50-55 DEG C of item
It is concentrated in vacuo under part, obtains the clear cream that relative density under the conditions of 30~40 DEG C is 1.30-1.35；Add into the clear cream
Refinement degree is the cane sugar powder of 100-120 mesh, after mixing evenly, particle is made；By particle using 60-70 DEG C of heated-air drying to moisture
Content is less than or equal to 8%, uniformly sprays the Pogostemon cablin essential in particle surface after being cooled to room temperature, concussion makes essential oil
It is absorbed by particle to get yellow fragrant particle.
2. the preparation method of yellow fragrant particle according to claim 1, it is characterised in that: in the preparation of the Pogostemon cablin essential
In the process, the temperature for controlling distillate condensate liquid is 25-40 DEG C；Revolving speed when centrifuge separation is 5000-7000r/min, time
For 8-15min.
3. the preparation method of yellow fragrant particle according to claim 1, it is characterised in that: the Pogostemon cablin aqueous solution, rheum officinale
Mass ratio between ethanol extract, cane sugar powder and Pogostemon cablin essential are as follows: 900-1100:900-1100:500-600:0.4-
0.6。
4. the preparation method of yellow fragrant particle according to claim 1, it is characterised in that: the technique of the Steam explosion treatment
Parameter are as follows: ratio of water to material 1:4-8, dimension pressure time 90-180s, steam pressure 1.8-2.0MPa.
5. the preparation method of yellow fragrant particle according to claim 1, it is characterised in that: in boiling extraction process, make material
In ultrasonic environment, ultrasonic frequency 25-35KHz, power density 0.4-0.5W/cm2。
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| CN105796609A (en) * | 2016-03-09 | 2016-07-27 | 孙继勇 | Quenching treatment based ganoderma spore powder wall breaking method |
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| CN105796609A (en) * | 2016-03-09 | 2016-07-27 | 孙继勇 | Quenching treatment based ganoderma spore powder wall breaking method |
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| Title |
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| 国家药品监督管理局: "《国家中成药标准汇编 中成药地方标准上升国家标准部分 内科 心系 分册》", 31 December 2002 * |
| 易军鹏等: "蒸汽爆破提取牛膝多糖工艺优化及抗氧化性研究", 《食品与机械》 * |
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Application publication date: 20181214 |