CN109893608A - A kind of preparation method of Chinese patent drug gastrodia capsule content - Google Patents
A kind of preparation method of Chinese patent drug gastrodia capsule content Download PDFInfo
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- CN109893608A CN109893608A CN201910279338.8A CN201910279338A CN109893608A CN 109893608 A CN109893608 A CN 109893608A CN 201910279338 A CN201910279338 A CN 201910279338A CN 109893608 A CN109893608 A CN 109893608A
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Abstract
The invention belongs to medical production technical fields, it is related to the preparation method of Chinese patent drug gastrodia capsule content, raw material is crushed first, then volatile oil is extracted to Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis and Radix Angelicae Sinensis, gained material residue is extracted with remaining five tastes raw material using superhigh pressure technique, is added after extracting solution concentration through the processed Rhizoma Gastrodiae of the micro-nano wall breaking technology of low temperature and monkshood (system), then be spray-dried, most sprayed into afterwards through volatile oil and etc., obtain the content of gastrodia capsule.The invention patent advantage: 1) destroying the cell wall of Rhizoma Gastrodiae and monkshood (system) using the micro-nano wall breaking technology of low temperature, discharge effective ingredient faster, and the drug effect time is reduced；2) ultra high pressure extraction technology is used, recovery rate can be improved and save extraction time.3) molecular distillation technique is used, the loss of effective medicinal component is reduced.4) broken wall Tall Gastrodis Tuber, monkshood (system) powder are added in concentrate and are spray-dried, more can be reduced the loss of effective ingredient than conventional drying mode.
Description
Technical field
The present invention relates to medical production technical field more particularly to the preparation methods of Chinese patent drug gastrodia capsule content.
Background technique
Gastrodia capsule be with Chinese medicine Rhizoma Gastrodiae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Cortex Eucommiae (salt stir-fry), radix achyranthis bidentatae, hypoglaucous collett yam rhizome, monkshood (system), when
Return, glutinous rehmannia, radix scrophulariae be raw material made of pure Chinese medicine extract formulation, it is curative for effect according to clinical verification.This product major function is to dispel
Wind dehumidifying, channels sootheing and network vessel quickening, promoting blood circulation and stopping pain.Limbs muscular constricture, numb in every limb, waist and leg ache are cured mainly, there is good curative effect.
The preparation process of gastrodia capsule content described in national drug standards WS3-B-0500-91-2004 are as follows: Rhizoma Et Radix Notopterygii
Half amount, Rhizoma Gastrodiae, monkshood be ground into fine powder, sieving for standby；Remaining Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Angelicae Sinensis extract volatile oil, the dregs of a decoction and remaining
The five tastes add water to cook secondary, 3 hours first times, second 2 hours, and collecting decoction, filtration, filtrate is condensed into cream, in addition stating medicine
Powder is mixed, be dry, pulverize, and is pelletized, dry, sprays into the volatile oil such as Rhizoma Et Radix Notopterygii, mix to get.China Patent Publication No. is
The patent of invention of CN104189521A discloses " a kind of gastrodia capsule and preparation method thereof ", preparation process are as follows: 50% weight
Rhizoma Et Radix Notopterygii, Rhizoma Gastrodiae, radix aconiti lateralis preparata be ground into fine powder, sieving for standby；The Rhizoma Et Radix Notopterygii of 50% weight, Radix Angelicae Pubescentis, Radix Angelicae Sinensis extract volatile oil, gained
The dregs of a decoction and remaining gomi herbs, add water to cook secondary, 3 hours first times, second 2 hours, collecting decoction, filtration, and filtrate is dense
Shorten thick paste into；Thick paste and fine powder are mixed, dry, whole grain adds the volatile oil after beta-cyclodextrin inclusion compound, mix to get.
The preparation method of above two gastrodia capsule content, in raw material crushing, volatile oil extracting, the decoction of medicinal material, the preparation of particle
Etc. it is almost the same, but there is also several respects disadvantages.Firstly, Rhizoma Gastrodiae and monkshood are the addition gastrodia capsules in the form of crude drug powder
In, although being ground into fine powder, compared with the powder after breaking-wall cell, the infiltration rate of effective component in human body is not
Fastly；Secondly, decocting herbs waste a large amount of time, high temperature decoction for a long time and concentration are also possible to destroy effective in Chinese medicine
Ingredient；Finally, medicinal powder mixing, drying process is added after being condensed into cream in filtrate, when may have uneven mixing and drying
Between too long drug effect lose the problems such as.
Summary of the invention
Technical problem to be solved by the present invention lies in the defect for overcoming above-mentioned technology of preparing, provide it is a kind of preferably at
The preparation method of medicine gastrodia capsule content.
The technical proposal of the invention is realized in this way, it the following steps are included:
(1) raw material Rhizoma Et Radix Notopterygii is divided into two parts, a part is ground into fine powder, another part and raw material Radix Angelicae Pubescentis, Radix Angelicae Sinensis, ox
Knee, glutinous rehmannia, radix scrophulariae, hypoglaucous collett yam rhizome, Cortex Eucommiae (salt stir-fry) are equally ground into 30~40 mesh, remaining raw material Rhizoma Gastrodiae, monkshood (system) are ground into
Ultramicro-powders more than 300 mesh obtains corresponding powder；
(2) gastrodia elata submicron powder obtained in step (1) and monkshood (system) Ultramicro-powder are used into the micro-nano wall breaking technology of low temperature
Breaking-wall cell processing is carried out, broken wall powder is obtained；
(3) Incised Notoptetygium Rhizome or Root obtained in step (1) (30~40 mesh), Doubleteeth Pubesscent Angelica Root and Chinese Angelica Root are taken, is used after mixing
Steam distillation prepares volatile oil；
(4) remaining material residue and twotoothed achyranthes root, glutinous rehmannia powder, Figwort Root, powder Bi after preparing volatile oil in step (3) are taken
Collettii powder, Cortex Eucommiae (salt stir-fry) powder are put into resistance to bag pressing after merging, and ultra high pressure extraction technology is used to carry out by solvent of purified water
It extracts, collects extracting solution；
(5) extracting solution in step (4) is filtered, be concentrated, cooled, then by Rhizoma Et Radix Notopterygii fine powder and step obtained in step (1)
Suddenly broken wall Tall Gastrodis Tuber, broken wall monkshood (system) powder prepared in (2) is added in concentrate, is spray-dried, obtains after mixing evenly
To dry powder；
(6) then the dry granulation that obtains step (5), drying spray into volatile oil prepared by step (3) dried
In particle, closed placement certain time, obtains the content of Chinese patent drug gastrodia capsule after mixing.
The preferable technical solution of the present invention is: the raw materials used parts by weight of Chinese patent drug gastrodia capsule are as follows: Rhizoma Et Radix Notopterygii fine powder 50
Part, 50 parts of Rhizoma Et Radix Notopterygii powder (30~40 mesh), 60 parts of Rhizoma Gastrodiae powder, 50 parts of Radix Angelicae Pubescentis powder, 60 parts of radix achyranthis bidentatae powder, 60 parts of bloom, radix scrophulariae powder 60
Part, 60 parts of hypoglaucous collett yam rhizome powder, 100 parts of angelica powder, Cortex Eucommiae (salt stir-fry) 70 parts of powder, 10 parts of powder of monkshood (system).
The preferable technical solution of the present invention is: in the step (2), the micro-nano broken wall of low temperature is first to place powder
Make its freezing under -170 DEG C of low temperature environment, then room temperature melts again, and 4~7 times repeatedly, so that cell wall is broken.
The preferable technical solution of the present invention is: in the step (4), being mentioned using ultra high pressure extraction equipment to raw material
It takes, extraction solid-liquid ratio is 1: 5~8 (m/m), and extraction pressure is 110~140Mpa, and Extracting temperature is 40~45 DEG C, extraction time
For 11~15min, pressure rising time is 2~3 minutes, and the release time is 3~5 seconds, is extracted 2 times.
The preferable technical solution of the present invention is: in the step (5), being concentrated using molecular distillation technique, molecule
The pressure of distillation be 20~30Pa, evaporating temperature be 30~35 DEG C, 0~10 DEG C of condensation temperature, 1.0~2.0L/ of material flow
min。
The preferable technical solution of the present invention is: in the step (5), Rhizoma Et Radix Notopterygii fine powder, broken wall Tall Gastrodis Tuber, broken wall is added
In concentrate after monkshood (system) powder, the content of solid content controls the spray dryer inlet temperature between 15%~18%
It is 200~210 DEG C, outlet temperature is 80~90 DEG C.
The invention patent has the advantage that
(1) the invention patent destroys the cell wall of Rhizoma Gastrodiae and monkshood (system) using the micro-nano wall breaking technology of low temperature,
It can make effective medicinal ingredient faster from intracellular release, to reduce the drug effect time；
(2) the invention patent uses ultra high pressure extraction technology, and broken wall effect when using its decompression, which improves, extracts yield, also
Extraction time can greatly be saved.
(3) temperature when the invention patent reduces concentration using molecular distillation technique, reduces the damage of effective medicinal component
It loses.
(4) broken wall Tall Gastrodis Tuber, broken wall monkshood (system) powder are added in concentrate, then are carried out using spray drying technology
It is dry, drying time can be effectively reduced, the loss of effective medicinal component is reduced, and material mixing can also be made more evenly.
Specific embodiment
Embodiment 1
Raw material Rhizoma Et Radix Notopterygii is taken to be divided into two parts, portion is ground into fine powder, another is crushed to 30 mesh；Take raw material Radix Angelicae Pubescentis, Radix Angelicae Sinensis, ox
Knee, glutinous rehmannia, radix scrophulariae, hypoglaucous collett yam rhizome, Cortex Eucommiae (salt stir-fry), are all ground into 30 mesh；Raw material Rhizoma Gastrodiae, monkshood (system) are taken again, are ground into 300 mesh
Above Ultramicro-powder.
Take 10 parts of 60 parts of gastrodia elata submicron powder, monkshood (system) Ultramicro-powder cryogenic freezings to -170 DEG C, then room temperature is melted, weight
Multiple freezing, thawing step 4 times.
50 parts of Incised Notoptetygium Rhizome or Root (30 mesh), 50 parts of Doubleteeth Pubesscent Angelica Root, 100 parts of Chinese Angelica Root are taken, steam distillation is used after merging
Method prepares volatile oil, collects volatile oil and raw material residue respectively.
Will volatilize 60 parts of remaining raw material residue and twotoothed achyranthes root after oil extract, 60 parts of glutinous rehmannia powder, 60 parts of Figwort Root,
60 parts of hypoglaucous collett yam rhizome powder, Cortex Eucommiae (salt stir-fry) 70 parts of powder put into ultra high pressure extraction tank together, and 2600 parts of purified waters are then added, open
Pressure rise to 140Mpa is then heated to 45 rapidly in 2~3 minutes after the air discharge in container by dynamic high-pressure pump
DEG C, 15min is extracted under this pressure and temperature.The valve removal pressure that control high pressure is quickly opened after extraction, when release
Between be 3 seconds, release extracting solution.It is extracted with same parameter for second time.
After extracting solution is filtered using plate filter, extracting solution is concentrated using molecular distillation technique, molecule steams
The pressure evaporated be 20Pa, evaporating temperature be 30 DEG C, 0 DEG C of condensation temperature, material flow 1.0L/min.After concentrate cools, by Qiang
50 parts of fine powder of work, broken wall Tall Gastrodis Tuber, broken wall monkshood (system) powder are added in concentrate, stir evenly, solid content in liquid
Content is 16.9%, is then spray-dried, and spray dryer inlet temperature is 208 DEG C, and outlet temperature is 86 DEG C, obtains powder
End.
Above-mentioned powder is granulated, is dried, is then uniformly sprayed into the volatile oil prepared in particle, after mixing
It is closed to place 8 hours, obtain the content of Chinese patent drug gastrodia capsule.
Embodiment 2
Raw material Rhizoma Et Radix Notopterygii is taken to be divided into two parts, portion is ground into fine powder, another is crushed to 40 mesh；Take raw material Radix Angelicae Pubescentis, Radix Angelicae Sinensis, ox
Knee, glutinous rehmannia, radix scrophulariae, hypoglaucous collett yam rhizome, Cortex Eucommiae (salt stir-fry), are all ground into 40 mesh；Raw material Rhizoma Gastrodiae, monkshood (system) are taken again, are ground into 300 mesh
Above Ultramicro-powder.
Take 10 parts of 60 parts of gastrodia elata submicron powder, monkshood (system) Ultramicro-powder cryogenic freezings to -170 DEG C, then room temperature is melted, weight
Multiple freezing, thawing step 5 times.
50 parts of Incised Notoptetygium Rhizome or Root (30 mesh), 50 parts of Doubleteeth Pubesscent Angelica Root, 100 parts of Chinese Angelica Root are taken, steam distillation is used after merging
Method prepares volatile oil, collects volatile oil and raw material residue respectively.
Will volatilize 60 parts of remaining raw material residue and twotoothed achyranthes root after oil extract, 60 parts of glutinous rehmannia powder, 60 parts of Figwort Root,
60 parts of hypoglaucous collett yam rhizome powder, Cortex Eucommiae (salt stir-fry) 70 parts of powder put into ultra high pressure extraction tank together, and 3100 parts of purified waters are then added, open
Pressure rise to 130Mpa is then heated to 43 rapidly in 2~3 minutes after the air discharge in container by dynamic high-pressure pump
DEG C, 11min is extracted under this pressure and temperature.The valve removal pressure that control high pressure is quickly opened after extraction, when release
Between be 3 seconds, release extracting solution.It is extracted with same parameter for second time.
After extracting solution is filtered using plate filter, extracting solution is concentrated using molecular distillation technique, molecule steams
The pressure evaporated be 25Pa, evaporating temperature be 33 DEG C, 4 DEG C of condensation temperature, material flow 1.5L/min.After concentrate cools, by Qiang
50 parts of fine powder of work, broken wall Tall Gastrodis Tuber, broken wall monkshood (system) powder are added in concentrate, stir evenly, solid content in liquid
Content is 15.6%, is then spray-dried, and spray dryer inlet temperature is 206 DEG C, and outlet temperature is 82 DEG C, obtains powder
End.
Above-mentioned powder is granulated, is dried, is then uniformly sprayed into the volatile oil prepared in particle, after mixing
It is closed to place 8 hours, obtain the content of Chinese patent drug gastrodia capsule.
Embodiment 3
Raw material Rhizoma Et Radix Notopterygii is taken to be divided into two parts, portion is ground into fine powder, another is crushed to 30 mesh；Take raw material Radix Angelicae Pubescentis, Radix Angelicae Sinensis, ox
Knee, glutinous rehmannia, radix scrophulariae, hypoglaucous collett yam rhizome, Cortex Eucommiae (salt stir-fry), are all ground into 30 mesh；Raw material Rhizoma Gastrodiae, monkshood (system) are taken again, are ground into 300 mesh
Above Ultramicro-powder.
Take 10 parts of 60 parts of gastrodia elata submicron powder, monkshood (system) Ultramicro-powder cryogenic freezings to -170 DEG C, then room temperature is melted, weight
Multiple freezing, thawing step 6 times.
50 parts of Incised Notoptetygium Rhizome or Root (30 mesh), 50 parts of Doubleteeth Pubesscent Angelica Root, 100 parts of Chinese Angelica Root are taken, steam distillation is used after merging
Method prepares volatile oil, collects volatile oil and raw material residue respectively.
Will volatilize 60 parts of remaining raw material residue and twotoothed achyranthes root after oil extract, 60 parts of glutinous rehmannia powder, 60 parts of Figwort Root,
60 parts of hypoglaucous collett yam rhizome powder, Cortex Eucommiae (salt stir-fry) 70 parts of powder put into ultra high pressure extraction tank together, and 3600 parts of purified waters are then added, open
Pressure rise to 110Mpa is then heated to 40 rapidly in 2~3 minutes after the air discharge in container by dynamic high-pressure pump
DEG C, 13min is extracted under this pressure and temperature.The valve removal pressure that control high pressure is quickly opened after extraction, when release
Between be 4 seconds, release extracting solution.It is extracted with same parameter for second time.
After extracting solution is filtered using plate filter, extracting solution is concentrated using molecular distillation technique, molecule steams
The pressure evaporated be 30Pa, evaporating temperature be 35 DEG C, 7 DEG C of condensation temperature, material flow 1.8L/min.After concentrate cools, by Qiang
50 parts of fine powder of work, broken wall Tall Gastrodis Tuber, broken wall monkshood (system) powder are added in concentrate, stir evenly, solid content in liquid
Content is 17.4%, is then spray-dried, and spray dryer inlet temperature is 202 DEG C, and outlet temperature is 88 DEG C, obtains powder
End.
Above-mentioned powder is granulated, is dried, is then uniformly sprayed into the volatile oil prepared in particle, after mixing
It is closed to place 8 hours, obtain the content of Chinese patent drug gastrodia capsule.
Above-described embodiment is technical conception and technical characteristics to illustrate the invention, can not limit the present invention with this
Protection scope.The equivalent transformation or modification that all essence according to the present invention is done, should all cover in protection model of the invention
Within enclosing.
Claims (6)
1. a kind of preparation method of Chinese patent drug gastrodia capsule content, which is characterized in that including the following steps:
(1) raw material Rhizoma Et Radix Notopterygii is divided into two parts, a part is ground into fine powder, another part and raw material Radix Angelicae Pubescentis, Radix Angelicae Sinensis, radix achyranthis bidentatae,
Huang, radix scrophulariae, hypoglaucous collett yam rhizome, Cortex Eucommiae (salt stir-fry) are equally ground into 30~40 mesh, remaining raw material Rhizoma Gastrodiae, monkshood (system) are ground into 300 mesh
Above Ultramicro-powder obtains corresponding powder；
(2) gastrodia elata submicron powder obtained in step (1) and monkshood (system) Ultramicro-powder are carried out using the micro-nano wall breaking technology of low temperature
Breaking-wall cell processing, obtains broken wall powder；
(3) Incised Notoptetygium Rhizome or Root obtained in step (1) (30~40 mesh), Doubleteeth Pubesscent Angelica Root and Chinese Angelica Root are taken, is steamed after mixing using water
Steam distillation method prepares volatile oil；
(4) remaining material residue and twotoothed achyranthes root, glutinous rehmannia powder, Figwort Root, hypoglaucous collett yam rhizome powder after preparing volatile oil in step (3) are taken
End, Cortex Eucommiae (salt stir-fry) powder are put into resistance to bag pressing after merging, and ultra high pressure extraction technology is used to extract by solvent of purified water,
Collect extracting solution；
(5) extracting solution in step (4) is filtered, be concentrated, cooled, then by Rhizoma Et Radix Notopterygii fine powder obtained in step (1) and step (2)
Broken wall Tall Gastrodis Tuber, broken wall monkshood (system) powder of middle preparation are added in concentrate, are spray-dried, are done after mixing evenly
Powder；
(6) volatile oil prepared by step (3) is then sprayed into dried particle by the dry granulation that obtains step (5), drying
In, closed placement certain time, obtains the content of Chinese patent drug gastrodia capsule after mixing.
2. a kind of preparation method of Chinese patent drug gastrodia capsule content according to claim 1, which is characterized in that Chinese patent drug
The raw materials used parts by weight of gastrodia capsule are as follows: 50 parts of Rhizoma Et Radix Notopterygii fine powder, 50 parts of Rhizoma Et Radix Notopterygii powder (30~40 mesh), 60 parts of Rhizoma Gastrodiae powder, solely
Living 50 parts of powder, 60 parts of radix achyranthis bidentatae powder, 60 parts of bloom, 60 parts of radix scrophulariae powder, 60 parts of hypoglaucous collett yam rhizome powder, 100 parts of angelica powder, Cortex Eucommiae (salt stir-fry)
70 parts of powder, 10 parts of powder of monkshood (system).
3. a kind of preparation method of Chinese patent drug gastrodia capsule content according to claim 1, which is characterized in that described
In step (2), the micro-nano broken wall of low temperature is first to be placed in powder under -170 DEG C of low temperature environment to make its freezing, then room temperature again
Melt, 4~7 times repeatedly, so that cell wall is broken.
4. a kind of preparation method of Chinese patent drug gastrodia capsule content according to claim 1, which is characterized in that described
In step (4), raw material is extracted using ultra high pressure extraction equipment, extraction solid-liquid ratio is 1: 5~8 (m/m), extracts pressure and is
110~140Mpa, Extracting temperature are 40~45 DEG C, and extraction time is 11~15min, and pressure rising time is 2~3 minutes, when release
Between be 3~5 seconds, extract 2 times.
5. a kind of preparation method of Chinese patent drug gastrodia capsule content according to claim 1, which is characterized in that described
It in step (5), is concentrated using molecular distillation technique, the pressure of molecular distillation is 20~30Pa, and evaporating temperature is 30~35
DEG C, 0~10 DEG C of condensation temperature, 1.0~2.0L/min of material flow.
6. a kind of preparation method of Chinese patent drug gastrodia capsule content according to claim 1, which is characterized in that described
In step (5), in the concentrate after Rhizoma Et Radix Notopterygii fine powder, broken wall Tall Gastrodis Tuber, broken wall monkshood (system) powder is added, the content of solid content
Between 15%~18%, spray dryer inlet temperature is 200~210 DEG C for control, and outlet temperature is 80~90 DEG C.
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| CN114796159A (en) * | 2022-05-18 | 2022-07-29 | 中山大学 | Gastrodia elata micro-capsule and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110393765A (en) * | 2019-08-14 | 2019-11-01 | 沈阳东松药业有限责任公司 | A kind of preparation method of Chinese medicine muskiness bone-knitting capsules |
| CN114796159A (en) * | 2022-05-18 | 2022-07-29 | 中山大学 | Gastrodia elata micro-capsule and preparation method and application thereof |
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Application publication date: 20190618 |