CN108969447B - Skin care composition for repairing damaged cells and sensitive skin and preparation method thereof - Google Patents

Abstract

The invention relates to the field of skin care products, and discloses a composition for repairing damaged cells and sensitive skin and a preparation method thereof. The skin care composition comprises: 88-92% of an emollient, 6-10% of a skin conditioner, and 1-2% of a thickener; wherein the emollient comprises at least one of the following: squalane, shea butter, glycerol tri (ethyl hexanoate); wherein the skin conditioning agent comprises skin conditioning agent 1 and skin conditioning agent 2; skin conditioner 1 contains at least one component selected from brassinosterol, cetostearyl alcohol, radix Arnebiae extract, allantoin, oleum Lavandula Angustifolia, flos Rosae Rugosae oil, bisabolol, shea butter extract, waste wheat germ pulp wax, Aralia mandshurica kernel oil, rhizoma Zingiberis recens extract, glycerol, flos Matricariae Chamomillae extract, and hydroxyphenylpropionamide benzoic acid; skin conditioner 2 contains at least one of butanediol, 1, 2-pentanediol, herba Polygoni Hydropiperis extract, and xanthan gum; wherein the thickener comprises at least one of the following: polyethylene, vinyl dimethicone/methicone silsesquioxane crosspolymer.

Description

Skin care composition for repairing damaged cells and sensitive skin and preparation method thereof

Technical Field

The invention relates to the field of skin care products, in particular to a skin care product composition for repairing damaged cells and sensitive skin and a preparation method thereof.

Background

After birth, the newborn departs from long-term amniotic fluid soaking, leaves from the relatively stable temperature environment of the mother body, and generally needs 1-2 years for the skin structure and function to develop to be the same as those of adults. Therefore, the skin of the infant is very delicate and sensitive, is easy to be stimulated and even infected, and needs special care. Infantile eczema, saliva rash, diaper rash, pruritus, dryness, chap and the like are common problems of infantile skin.

Infantile eczema, i.e. Atopic Dermatitis (AD), also known as atopic dermatitis and atopic dermatitis, is a chronic, recurrent, inflammatory skin disease. More than in infancy and extending to childhood and adulthood. The eczema-like rash with severe pruritus and recurrent attacks is clinically characterized, and patients or families often have obvious atopy and seriously affect the quality of life. The etiology and pathogenesis of atopic dermatitis are not clear, and it is currently thought that these factors are related to genetic, environmental, immune, and biological factors, and the pathogenesis is mainly the combined action of genetic factors and environmental factors. The main cause is intolerance or allergy to food, inhalants or contact products. Environmental factors, particularly lifestyle changes (e.g., excessive washing, diet, infection, environmental changes, etc.), are important risk factors for the onset of the disease. The symptoms mainly include chronic and repeated pruritus, which affects sleep. Chronic recurrent dermatitis in the flexed side regions of the elbow and popliteal fossa is often characterized by erythema, followed by papules with dense granularities, papules or blisters with serous exudation and crusting. When acute eczema is treated improperly, subacute or chronic eczema can be converted, and if proper treatment is carried out timely, the acute eczema can be gradually improved but is easy to recur. In severe cases, large erythema may occur, with groups of papules, blisters, erosive fluid on the surface with thick scabs, which may also extend over the entire head, face or head and neck. Erythema, papule, herpes simplex, blister, and subjective pruritus appear around the focus. Erosion and scabbing can occur when the affected part is scratched, pus exudation occurs under the scab, small pustules exist at the edge, and local lymph nodes are swollen and tender. There may also be parallel linear erythema, papules and blisters from scratching near or distant sites.

The baby may cause saliva rash due to the running of saliva, the long-term nipple, candida infection and the like. The saliva of the newborn is more and contains digestive enzymes, so the saliva plays a digestive role in a human body, but if the enzymes stay on the surface of the skin for a long time, the horny layer of the skin is gradually decomposed to generate a dry phenomenon, so the skin inflammation is easily caused, and the saliva rash is caused; when a baby holds the nipple for a long time, the nipple is sucked to rub the skin around the mouth, so that the baby is easy to cause oral water eruption; in addition, candida infection also causes a red-red mouth with several raised red rashes.

Diaper rash refers to redness of the skin around the anus, buttocks, perineum, etc. of a newborn, and is also called as erythema and herpes scattered in the macula or herpes of the newborn. Because the baby diaper is not changed frequently or washed cleanly and contacted for a long time; stimulating the skin of the infant; the diaper is hard in texture and is caused by local friction. Skin ulcers may develop after secondary bacterial or candida infections, aggravated and severe, especially in infants with chronic diarrhea, who are malnourished.

Compared with adults, the infant has the advantages that the epidermal layer and the dermal layer are not completely developed, the thickness is thin, the intercellular connection is few, the structure is immature, the function is incomplete, the appearance is smooth and tender, and the skin barrier function is easy to damage, so that the skin barrier function is abnormal. The skin mucosa of the infant is fine and thin, and the petrochemical raw material components such as chemical preservatives, coloring agents, essences, pigments, antibiotics, hormones and the like which are commonly used in skin care products have stimulation effects on the skin mucosa, influence the reconstruction of the skin barrier function, easily permeate into the body and have long-term influence on the growth and development of children. Therefore, the skin care product for nursing skin problems of infants should avoid selecting chemical raw materials such as petroleum, coal tar and the like, and should select raw materials which have the same or similar components with skin sebum, good compatibility with skin, no stimulation and high safety.

Disclosure of Invention

The invention aims to provide a skin care composition for repairing damaged cells and sensitive skin, and also aims to provide a preparation method of the skin care composition. The skin care product composition provided by the invention selects components which are the same as or similar to sebum and natural components in skin structures according to the bionics principle, supplements insufficient sebum secretion of children skin, enhances the barrier function of skin mucosa, and carries out skin care for non-treatment purposes.

The technical scheme for solving the technical problems is as follows: a skin care composition for repairing damaged cells and sensitive skin comprising: 88-92% of an emollient, 6-10% of a skin conditioner, and 1-2% of a thickener, wherein the weight parts are based on the total weight of the composition;

wherein the emollient comprises at least one of the following: squalane, shea butter, glycerol tri (ethyl hexanoate);

wherein the skin conditioning agent comprises skin conditioning agent 1 and skin conditioning agent 2; skin conditioner 1 contains at least one component selected from brassinosterol, cetostearyl alcohol, radix Arnebiae extract, allantoin, oleum Lavandula Angustifolia, flos Rosae Rugosae oil, bisabolol, shea butter extract, waste wheat germ pulp wax, Aralia mandshurica kernel oil, rhizoma Zingiberis recens extract, glycerol, flos Matricariae Chamomillae extract, and hydroxyphenylpropionamide benzoic acid; skin conditioner 2 contains at least one of butanediol, 1, 2-pentanediol, herba Polygoni Hydropiperis extract, and xanthan gum;

wherein the thickener comprises at least one of the following: polyethylene, vinyl dimethicone/methicone silsesquioxane crosspolymer.

Preferably, the skin conditioning agent comprises at least one of the following conditioning agents a to J:

conditioner A is composed of brassinosteroid and cetostearyl alcohol,

the conditioner B is composed of alkanna tinctoria root extract,

the conditioning agent C is composed of allantoin,

the conditioner D is composed of lavender oil,

the conditioner E is composed of rose oil,

the conditioner F is composed of bisabolol,

the conditioner G is composed of shea butter extract, waste malt meal wax and acalypha australis seed oil,

the conditioner H is composed of bisabolol and ginger extract,

the conditioner I is composed of water, glycerol and flos Matricariae Chamomillae extract,

conditioner J is composed of hydroxyphenylpropionamide benzoic acid,

preferably, the skin conditioner 1 comprises conditioner a, conditioner B, conditioner C, conditioner D, conditioner E, conditioner F, conditioner G, conditioner H, conditioner I and conditioner J; the skin conditioner 2 is composed of butanediol, 1, 2-pentanediol, herba Polygoni Hydropiperis extract, xanthan gum and water.

Preferably, the skin care composition comprises 0.5-1.2 wt% of conditioner A, 0.5-1.2 wt% of conditioner B, 0.3-0.8 wt% of conditioner C, 0.01-0.1 wt% of conditioner D, 0.5-1.2 wt% of conditioner E, 0.1-0.5 wt% of conditioner F, 0.5-1.2 wt% of conditioner G, 0.05-0.15 wt% of conditioner H, 0.5-1.5 wt% of conditioner I, 0.05-0.15 wt% of conditioner J and 1.5-3 wt% of skin conditioner 2, wherein the weight parts are relative to the total weight of the conditioners in the composition.

Preferably, said conditioner a consists of 50% by weight brassinosteroid and 50% by weight cetearyl alcohol, said parts by weight being relative to the total weight of said conditioner a; the conditioner G consists of at least 70 wt% of shea butter extract, 5-10 wt% of waste malt meal wax and 10-25 wt% of argan oil, wherein the weight parts are relative to the total weight of the conditioner G; the conditioner H contains 0.1-1 wt% of ginger extract, and the weight parts are relative to the total weight of the conditioner H; the conditioner I contains 3-6 wt% of glycerin and 3-5 wt% of chamomile extract, and the weight parts are relative to the total weight of the conditioner I; the skin conditioner 2 contains 10-25 wt% of butanediol, 5-10 wt% of 1, 2-pentanediol, 1-5 wt% of polygonum hydropiper extract and 0.1-1 wt% of xanthan gum, wherein the weight parts are relative to the total weight of the skin conditioner 2.

According to one embodiment of the invention, the skin care composition for repairing damaged cells and sensitive skin comprises 88-92 wt% of an emollient, 6-10 wt% of a skin conditioner and 1-2 wt% of a thickening agent, wherein the weight percentages are based on the total weight of the composition.

According to one embodiment of the invention, the emollient is comprised of at least one of the following ingredients: squalane, shea butter, glycerol tri (ethyl hexanoate).

According to one embodiment of the invention, the skin conditioner consists of skin conditioner 1 and skin conditioner 2. The skin conditioner 1 comprises at least one component selected from brassinosterol, cetostearyl alcohol, radix Arnebiae extract, allantoin, oleum Lavandula Angustifolia, flos Rosae Rugosae oil, bisabolol, shea butter extract, waste wheat germ pulp wax, Arabian Gansu seed oil, rhizoma Zingiberis recens extract, glycerol, flos Matricariae Chamomillae extract, and hydroxyphenylpropionamide benzoic acid. The skin conditioner 2 comprises at least one of butanediol, 1, 2-pentanediol, herba Polygoni Hydropiperis extract, and xanthan gum.

According to one embodiment of the invention, the thickener is composed of at least one of the following components: polyethylene, vinyl dimethicone/methicone silsesquioxane crosspolymer.

According to one embodiment of the invention, the skin conditioning agent consists of at least one of the following conditioning agents a to J:

conditioner A is composed of brassinosteroid and cetostearyl alcohol,

the conditioner B is composed of alkanna tinctoria root extract,

the conditioning agent C is composed of allantoin,

the conditioner D is composed of lavender oil,

the conditioner E is composed of rose oil,

the conditioner F is composed of bisabolol,

the conditioner G is composed of shea butter extract, waste malt meal wax and acalypha australis seed oil,

the conditioner H is composed of bisabolol and ginger extract,

the conditioner I is composed of water, glycerol and flos Matricariae Chamomillae extract,

conditioner J is composed of hydroxyphenylpropionamide benzoic acid,

according to one embodiment of the present invention, said skin conditioner 1 consists of conditioner a, conditioner B, conditioner C, conditioner D, conditioner E, conditioner F, conditioner G, conditioner H, conditioner I and conditioner J. The skin conditioner 2 consists of butanediol, 1, 2-pentanediol, a polygonum hydropiper extract, xanthan gum and water.

According to one embodiment of the invention, the conditioner of the composition comprises 0.5 to 1.2 wt% of conditioner A, 0.5 to 1.2 wt% of conditioner B, 0.3 to 0.8 wt% of conditioner C, 0.01 to 0.1 wt% of conditioner D, 0.5 to 1.2 wt% of conditioner E, 0.1 to 0.5 wt% of conditioner F, 0.5 to 1.2 wt% of conditioner G, 0.05 to 0.15 wt% of conditioner H, 0.5 to 1.5 wt% of conditioner I, 0.05 to 0.15 wt% of conditioner J, and 1.5 to 3 wt% of skin conditioner 2, wherein the weight percentages are based on the total weight of the composition.

The preparation method of the composition for repairing damaged cells and sensitive skin of the invention is shown in figure 1, and comprises the following steps:

(1) respectively and quantitatively weighing each raw material according to a production formula;

(2) adding emollient and thickener into emulsifying pot, stirring, heating to 80-90 deg.C, preferably 81 deg.C, 82 deg.C, 85 deg.C, 87 deg.C, 88 deg.C, 89 deg.C, homogenizing for 5-15min, preferably 7min, 8min, 10min, 12min, and 14min, until the material is fine;

(3) adding skin conditioner A, B, C, G, J, vacuumizing, and keeping the temperature for 10-15min, preferably 11min, 12min, 13min, and 14 min;

(4) cooling to 35-45 deg.C, preferably 37 deg.C, 39 deg.C, 41 deg.C, 43 deg.C, vacuum-pumping, adding skin conditioner 2, D, E, F, H, I, and stirring;

(5) discharging after the materials are qualified through inspection to prepare the composition.

According to the bionic principle, components which are the same as or similar to sebum and natural components in skin structures, such as squalane, shea butter and glycerol tri (ethyl hexanoate), are selected to supplement the sebum, and enhance and restore the barrier function of skin mucosa of children; selecting natural raw materials such as grass root extract, lavender oil, rose oil, shea butter fruit resin extract, argan oil, ginger extract, chamomile extract, polygonum hydropiper extract and the like; and other safe, mild raw materials.

The skin care product composition does not contain any chemical components from petroleum and coking coal, and does not contain additives such as essence, coloring agent, chemical preservative, hormone and the like which can cause adverse reaction. All the components adopted by the invention are the existing products of pharmaceutical grade or food grade.

The skin care composition provided by the invention is in the dosage form of ointment, is tasteless and is beige; mainly aims at tender and sensitive skin of infants, repairs skin damage caused by various problems of eczema, oral rash, diaper rash, red swelling, pruritus, dryness, chap and the like, relieves sensitive symptoms, enhances the immunity of the skin, and is also suitable for adults and sensitive skin crowds; the skin care product can repair damaged skin cells, relieve sensitivity, supplement insufficient sebum secretion of children's skin, enhance barrier of skin mucosa, relieve pruritus, moisten and preserve moisture, and dispel erythema, and is completely selected from natural, pollution-free and safe components, does not contain chemical synthetic raw materials derived from petroleum, coal tar and the like, and does not contain additives such as hormone, chemical preservatives and the like. Has the advantages of mild and non-irritant to skin, no side effect, environmental protection, good nursing effect and the like.

The using method comprises the following steps: after the damaged skin is cleaned, a proper amount of the skin care product composition is smeared on the damaged part of the skin and is gently massaged until the skin is absorbed.

Drawings

FIG. 1 is a flow chart of a process for producing the composition of the present invention

FIG. 2 is a photograph showing the comparison of the treatment before and after eczema treatment of infant 1

FIG. 3 is a photograph showing the comparison of the treatment before and after eczema treatment for infant 2

FIG. 4 is a photograph showing the comparison of the treatment before and after 3 eczema treatment for infants

FIG. 5 is a photograph showing 4 infant water eruptions before and after treatment

Detailed Description

The principles and features of this invention are described below in conjunction with specific embodiments, which are intended to be illustrative only and not limiting as to the scope of the invention.

Example 1

The skin care composition for repairing damaged cells and sensitive skin comprises the following raw materials in parts by weight:

and (3) an emollient: 28g of squalane, 27g of shea butter and 35g of glycerol tri (ethyl hexanoate);

conditioner:

skin conditioner 1:

conditioner a: brassinosteroids 0.5g, cetostearyl alcohol 0.5 g;

conditioner B: 1g of alkannin root extract;

conditioner C: allantoin 0.8 g;

conditioner D: 0.1g of lavender oil;

conditioner E: rose oil 0.8 g;

conditioner F: 0.5g of bisabolol;

conditioner G: 0.7g of shea butter extract, 0.1g of waste malt meal wax and 0.2g of acanthopanax oil;

conditioner H: 0.1485g of bisabolol and 0.0015g of ginger extract;

conditioner I: 0.445g of water, 0.03g of glycerol and 0.025g of chamomile extract;

conditioner J: 0.05g of hydroxyphenylpropionamide benzoic acid;

skin conditioner 2: 1.77g of water, 0.75g of butanediol, 0.3g of 1, 2-pentanediol, 0.15g of polygonum hydropiper extract and 0.03g of xanthan gum;

thickening agent: 0.1g of polyethylene, 1g of vinyl polydimethylsiloxane/polymethylsiloxane silsesquioxane crosspolymer;

the composition is prepared according to the following method:

(1) respectively and quantitatively weighing each raw material according to a production formula;

(2) adding emollient and thickener into emulsifying pot, stirring, heating to 80 deg.C, and homogenizing for 8min until the material is fine;

(3) adding skin conditioner A, B, C, G, J, vacuumizing, and keeping the temperature for 12 min;

(4) cooling to 40 deg.C, vacuum-pumping, adding skin conditioner 2, D, E, F, H, I, and stirring;

(5) discharging after the materials are qualified through inspection to prepare the composition.

Example 2

The skin care composition for repairing damaged cells and sensitive skin comprises the following raw materials in parts by weight:

and (3) an emollient: 25g of squalane, 31g of shea butter and 32g of glycerol tri (ethyl hexanoate);

conditioner:

skin conditioner 1:

conditioner a: brassinosteroids 0.6g, cetostearyl alcohol 0.6 g;

conditioner B: 1.2g of alkannin root extract;

conditioner C: allantoin 0.8 g;

conditioner D: 0.1g of lavender oil;

conditioner E: 1.2g of rose oil;

conditioner F: 0.5g of bisabolol;

conditioner G: 0.8g of shea butter extract, 0.05g of waste malt meal wax and 0.15g of acanthopanax oil;

conditioner H: 0.099g of bisabolol and 0.001g of ginger extract;

conditioner I: 0.89g of water, 0.06g of glycerol and 0.05g of chamomile extract;

conditioner J: 0.1g of hydroxyphenylpropionamide benzoic acid;

skin conditioner 2: 2.072g of water, 0.28g of butanediol, 0.28g of 1, 2-pentanediol, 0.14g of polygonum hydropiper extract and 0.028g of xanthan gum;

thickening agent: 1g of polyethylene, 1g of vinyl polydimethylsiloxane/polymethylsiloxane silsesquioxane crosspolymer;

the composition is prepared according to the following method:

(1) respectively and quantitatively weighing each raw material according to a production formula;

(2) adding emollient and thickener into emulsifying pot, stirring, heating to 85 deg.C, and homogenizing for 10min until the material is fine;

(3) adding skin conditioner A, B, C, G, J, vacuumizing, and keeping the temperature for 10 min;

(4) cooling to 37 deg.C, vacuum-pumping, adding skin conditioner 2, D, E, F, H, I, and stirring;

(5) discharging after the materials are qualified through inspection to prepare the composition.

Example 3

The skin care composition for repairing damaged cells and sensitive skin comprises the following raw materials in parts by weight:

and (3) an emollient: 25g of squalane, 38g of shea butter and 29g of glycerol tri (ethyl hexanoate);

conditioner:

skin conditioner 1:

conditioner a: brassinosteroids 0.25g, cetearyl alcohol 0.25 g;

conditioner B: radix Arnebiae extract 0.5 g;

conditioner C: allantoin 0.5 g;

conditioner D: 0.1g of lavender oil;

conditioner E: rose oil 0.6 g;

conditioner F: 0.5g of bisabolol;

conditioner G: 0.375g of shea butter extract, 0.025g of waste malt meal wax and 0.1g of acanthopanax oil;

conditioner H: 0.1485g of bisabolol and 0.0015g of ginger extract;

conditioner I: 0.47g of water, 0.015g of glycerol and 0.015g of chamomile extract;

conditioner J: 0.15g of hydroxyphenylpropionamide benzoic acid;

skin conditioner 2: 2.235g of water, 0.45g of butanediol, 0.15g of 1, 2-pentanediol, 0.15g of polygonum hydropiper extract and 0.015g of xanthan gum;

thickening agent: 0.1g of polyethylene, 0.9g of vinyl polydimethylsiloxane/polymethylsiloxane silsesquioxane crosspolymer;

the composition is prepared according to the following method:

(1) respectively and quantitatively weighing each raw material according to a production formula;

(2) adding emollient and thickener into emulsifying pot, stirring, heating to 87 deg.C, and homogenizing for 12min until the material is fine;

(3) adding skin conditioner A, B, C, G, J, vacuumizing, and keeping the temperature for 10 min;

(4) cooling to 42 deg.C, vacuum-pumping, adding skin conditioner 2, D, E, F, H, I, and stirring;

(5) discharging after the materials are qualified through inspection to prepare the composition.

Comparative example

1. The formulation ingredients of example 1 and comparative examples 1-3 are shown in table 1.

Table 1 formulation ingredients

2. Production process

The compositions of example 1 and comparative example 2 were prepared using the same method:

(1) respectively and quantitatively weighing each raw material according to a production formula;

(2) adding emollient and thickener (i.e. raw materials 1,2, 3, 4, and 5 in Table 1) into emulsifying pot, stirring, heating to 80 deg.C, and homogenizing for 8min until the material is fine;

(3) adding skin conditioners A, B, C, G and J (i.e. raw materials 6, 7, 8, 12, 15 in Table 1), vacuumizing, and keeping the temperature for 12 min;

(4) cooling to 40 deg.C, vacuum-pumping, adding skin conditioners 2, D, E, F, H and I (i.e. raw materials 9, 10, 11, 13, 14 and 16 in Table 1), and stirring;

(5) discharging after the materials are qualified through inspection to prepare the composition.

The compositions of comparative example 1 and comparative example 3 were prepared using the same method:

(1) respectively and quantitatively weighing each raw material according to a production formula;

(2) adding emollient and thickener (i.e. raw materials 1,2, 3, 4, and 5 in Table 1) into emulsifying pot, stirring, heating to 80 deg.C, and homogenizing for 8min until the material is fine;

(3) adding skin conditioners A, B, C, E, F, G, H and J (i.e. raw materials 6, 7, 8, 10, 11, 12, 13, and 15 in Table 1), vacuumizing, and keeping the temperature for 12 min;

(4) cooling to 40 deg.C, vacuum-pumping, adding skin conditioners 2, D and I (i.e. raw materials 9, 14 and 16 in Table 1), and stirring;

(5) discharging after the materials are qualified through inspection to prepare the composition.

3. Sensory index

Sensory indexes of the skin care composition obtained in example 1, example 2 and example 3 are as follows:

color: yellow, translucent; the state is as follows: the paste is in a paste shape, and the paste thickness is moderate; odor: is tasteless.

The sensory indices of the skin care composition obtained in comparative example 1 were as follows:

color: yellow, translucent; the state is as follows: the paste is pasty, has slightly hard texture and is not suitable for the skin of infants; odor: is tasteless.

The sensory indexes of the skin care composition obtained in comparative example 2 were as follows:

color: white, slightly yellowish; the state is as follows: the paste is light and thin, has poor repairing effect on skin after being smeared, and has slightly inferior appearance to the skin care product composition obtained in the embodiment 1; odor: is tasteless.

The sensory indexes of the skin care composition obtained in comparative example 3 were as follows:

color: white; the state is as follows: the skin care product is pasty, light and thin in cream, has partial granular substances and rough feeling, has poor repairing effect on skin after being smeared, has a slightly better appearance than the skin care product composition obtained in the comparative example 1, and is not suitable for the skin of infants; odor: is tasteless.

It can be seen that the content and preparation method of example 1 are significantly better than those of comparative examples 1-3 in sensory index, showing the best color and condition. The inventors also made extensive screening of other amounts and preparation methods, and found that the overall sensory index was significantly lower than that of example 1, even lower than that of comparative examples 1-3 (experimental data not shown), and was eliminated at the early stage of the experiment, so that other amounts and preparation methods were not suitable for preparing the skin care composition of the present invention.

Examples of the experiments

1. The skin care product composition obtained in example 1 is subjected to toxic substance limit detection, microbial detection and hormone detection, and the results are shown in tables 2-4.

TABLE 2 test for limiting amounts of hazardous substances

Inspection item	Index (I)
		Mercury	≤1mg/kg
Lead (in lead)	≤10mg/kg
		Arsenic (measured as arsenic)	≤2mg/kg
Cadmium (Cd)	≤5mg/kg
		Dioxane(s)	≤30mg/kg
Asbestos	Cannot be detected
		Heat resistance	Keeping the temperature at (40 +/-1) DEG C for 24h, and no obvious character difference exists between the room temperature and the room temperature before the test
Cold-resistant	Keeping the temperature at (10 +/-5) ℃ for 24h, and no obvious character difference exists between the room temperature and the room temperature before the test

TABLE 3 microbiological assay

Inspection item	Index (I)
		Total number of colonies	≤500CFU/g
Total number of yeasts and molds	≤100CFU/g
		Heat-resistant coliform group	Undetected/g
Staphylococcus aureus	Undetected/g
		Pseudomonas aeruginosa	Undetected/g

TABLE 4 hormone test

Inspection item	Index (I)
		41 sugar skin hormone	None was detected/g
7 sex hormones	None was detected/g

2. Trial effect

The infant with eczema of cheek or oral eczema of 0-3 years old and mild skin damage severity is collected through the Internet, the nature is unlimited, the guardian signs an informed consent and is willing to carry out the test according to the experimental requirements, and the infant is subjected to skin detection and revisits on time. According to the wishes of the guardian, 35 infants are respectively selected and sent to one part of the skin care composition sample prepared in the example 1 and one part of the questionnaire, and the other 35 infants are sent to one part of the erythromycin ointment and one part of the questionnaire. After the parents were asked to wash the infant eczema or oral rash with clean water, samples of the skin care composition prepared in example 1 or erythromycin ointment were applied to the eczema or oral rash 3 times a day. After two weeks, 70 parts of the questionnaire were withdrawn altogether and subjected to statistical analysis. FIGS. 2 to 5 are comparative graphs before and after the skin care composition prepared in example 1 was used by infants.

Effect determination criteria:

and (3) healing: the skin lesions subside by 100%, and the pruritus symptom disappears;

the effect is shown: the skin damage is reduced by more than 70 percent, and the pruritus is obviously relieved;

the method has the following advantages: the skin lesions are faded by more than 30 percent, and the pruritus symptom is improved;

and (4) invalidation: the skin lesions subsided less than 30%, and the pruritus was not relieved or the clinical symptoms worsened.

TABLE 5 trial comparison of the results of example 1 with erythromycin ointment

Experimental agent	Number of examples	Recovery method	Show effect	Is effective	Invalidation	Total effective rate
							Example 1 skin Care composition	35	26	6	2	1	97.1％
Erythromycin ointment	35	14	9	6	6	82.8％

As shown in Table 5, the skin care composition has an effective rate of 97.1% for the test patients with eczema and oral rash, which is obviously higher than the effective rate of 82.8% for the erythromycin ointment.

The skin care product composition disclosed by the invention is mild and non-irritant to the skin, has good itching relieving and repairing effects, and can be applied to nursing sensitive and damaged skin.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (3)

1. A composition having the efficacy of repairing damaged cells and sensitive skin, characterized in that:

the composition comprises 88-92 wt% of an emollient, 6-10 wt% of a skin conditioner and 1-2 wt% of a thickener, wherein the weight percentages are based on the total weight of the composition;

wherein the emollient is comprised of squalane, shea butter and glycerol tri (ethyl hexanoate);

wherein the skin conditioner consists of skin conditioner 1 and skin conditioner 2;

the skin conditioner 1 consists of a conditioner A, a conditioner B, a conditioner C, a conditioner D, a conditioner E, a conditioner F, a conditioner G, a conditioner H, a conditioner I and a conditioner J;

wherein the composition comprises the following skin conditioning agents in percentage by weight: 0.5 to 1.2 weight percent of conditioner A, 0.5 to 1.2 weight percent of conditioner B, 0.3 to 0.8 weight percent of conditioner C, 0.01 to 0.1 weight percent of conditioner D, 0.5 to 1.2 weight percent of conditioner E, 0.1 to 0.5 weight percent of conditioner F, 0.5 to 1.2 weight percent of conditioner G, 0.05 to 0.1 weight percent of conditioner H, 1 to 1.5 weight percent of conditioner I, 0.1 to 0.15 weight percent of conditioner J, 1.5 to 2.8 weight percent of skin conditioner 2, the weight percentages being based on the total weight of the composition;

conditioning agent A consists of 50% by weight of brassinosteroid and 50% by weight of cetostearyl alcohol, the percentages by weight being relative to the total weight of conditioning agent A,

the conditioner B is composed of alkanna tinctoria root extract,

the conditioning agent C is composed of allantoin,

the conditioner D is composed of lavender oil,

the conditioner E is composed of rose oil,

the conditioner F is composed of bisabolol,

the conditioner G is composed of at least 80 wt% of shea butter extract, 5-10 wt% of waste malt meal wax and 10-25 wt% of argan oil, wherein the weight percentages are relative to the total weight of the conditioner G,

the conditioner H consists of bisabolol and 0.1-1 wt% of ginger extract, wherein the weight percentage is relative to the total weight of the conditioner H,

the conditioner I comprises water, 3-6 wt% of glycerin and 3-5 wt% of chamomile extract, wherein the weight percentage is relative to the total weight of the conditioner I,

conditioner J is composed of hydroxyphenylpropionamide benzoic acid;

the skin conditioner 2 is composed of water, 10-25 wt% of butanediol, 5-10 wt% of 1, 2-pentanediol, 1-5 wt% of polygonum hydropiper extract and 0.1-1 wt% of xanthan gum, wherein the weight percentages are relative to the total weight of the skin conditioner 2;

wherein the thickener is comprised of polyethylene and a vinyl dimethicone/methicone silsesquioxane crosspolymer;

the preparation method of the composition comprises the following steps:

(1) respectively and quantitatively weighing each raw material according to a production formula;

(2) adding emollient and thickener into emulsifying pot, stirring, heating to 80-90 deg.C, and homogenizing for 5-15min until the material is fine;

(3) adding skin conditioner A, B, C, G, J, vacuumizing, and keeping the temperature for 10-15 min;

(4) cooling to 35-45 deg.C, vacuumizing, adding skin conditioner 2, D, E, F, H, I, and stirring;

(5) discharging after the materials are qualified through inspection to prepare the composition.

2. The composition according to claim 1, wherein in the production method, in the step (2), the temperature after the temperature rise is 80 ℃.

3. The composition according to claim 1, wherein in the preparation method, the temperature after temperature reduction in the step (4) is 40 ℃.

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