CN108969447A - Repair damaged cell and the composite skin care product of sensitive skin and preparation method thereof - Google Patents
Repair damaged cell and the composite skin care product of sensitive skin and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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Abstract
The present invention relates to skin care fields, disclose a kind of reparation damaged cell and the composition of sensitive skin and preparation method thereof.The composite skin care product includes: 88~92 weight % of emollient, 6~10 weight % of skin conditioning agent, 1~2 weight % of thickener；Wherein the emollient includes at least one of following ingredient: saualane, Butyrospermum parkii fruit rouge, glycerol three (thylhexoic acid) ester；Wherein the skin conditioning agent includes skin conditioning agent 1 and skin conditioning agent 2；Skin conditioning agent 1 contains at least one of rape element sterol, cetostearyl alcohol, Asian puccoon root extract, allantoin, lavender oil, rose oil, bisabolol, Butyrospermum parkii fruit rouge extract, useless malt dregs of rice wax, Ci Agan tree benevolence oil, ginger extract, glycerol, german chamomile flower extract, hydroxy phenylpropionyl amine benzoic acid ingredient；Skin conditioning agent 2 contains at least one of butanediol, 1,2- pentanediol, Herba polygoni hydropiperis extract, xanthan gum ingredient；Wherein the thickener includes at least one of following ingredient: polyethylene, vinyldimethicone/polymethyl siloxane silsesquioxane cross-linked polymer.
Description
Technical field
The present invention relates to skin care field more particularly to a kind of composite skin care products for repairing damaged cell and sensitive skin
And preparation method thereof.
Background technique
It is impregnated after newborn's birth departing from long-term amniotic fluid, has left the metastable temperature environment of parent, skin knot
It is adult identical that structure and function needed for 1~2 year be just developed under normal circumstances.So infant skin is very delicate, sensitive, easily
Stimulated or even infection, needs special care.Infantile eczema, saliva rash, diaper rash, itch, drying, to be chapped from the cold etc. be children's skin
FAQs.
Infantile eczema, i.e. atopic dermatitis (atopic dermatitis, AD), also known as atopic dermatitis, dystopy
Property dermatitis, be a kind of chronic, recurrent, inflammatory dermatoses.It falls ill, and delays to children and adult more than infant period
Phase.With eczema sample fash, with violent itch, recurrent exerbation is clinical characters, often there is that apparent " spy answers in sufferer or family
Property ", seriously affect quality of life.The cause of disease and pathogenesis of atopic dermatitis are still not clear, it is now recognized that with heredity, environment,
It is immune, biological factor is related, morbidity is mainly the collective effect of inherent cause and environmental factor.Main cause be to ingestant,
Inhalation (inhalatio) or contactant do not tolerate or allergy caused by.Environmental factor especially living-pattern preservation (such as overwass, diet,
Infection, environment change etc.) it is the risk factor that this disease severe disease is wanted.Symptom mostly based on chronic repeatability itch, influences to sleep.
It is initial to damage to there is intensive grain on the basis of erythema often characterized by the chronic recurrent dermatitis of the sides in the wrong such as fossa cubitalis, popliteal nest
Grain size papule, papulo-vesicle or blister form rotten to the corn face, there is serosity exudation, form a scab after blister is broken.Acute eczema processing is not
When subacute or chronic eczema can be switched to, and such as appropriate treatment can gradually improve in time, but easy to recur.Severe one can occur large stretch of red
Spot is thereon papule in groups, papulo-vesicle, blister, erosive exudating, and there is thick scab on surface, can also extend to entire Head And Face or incidence.
There is erythematous papules, papulo-vesicle, blister, conscious itch in perilesional.Rotten to the corn, incrustation can occur for galling, have fester exudation under scab,
There are pimple, regional glandular enlargement, tenderness in edge.Nearby or remote part can also have scratching caused by parallel line shaped erythema,
Papule and blister.
Baby slobbers, containing nipple, monilial infection etc. all may cause saliva rash for a long time.Due to newborn's saliva compared with
More, saliva contains zymigen, and the role of digestion is played the part of in human body, if but these ferment in skin surface residence time mistake
Long, the cuticula of skin can easily cause chafing, cause saliva rash gradually by generation dry-out phenomenon is decomposed；Baby is long
Phase contains nipple, because sucking nipple friction mouth surrounding skin also be easy to cause saliva rash；In addition, monilial infection can also cause mouth
Side is red a piece of, several red measles of protrusion occurs.
Diaper rash refers in neonatal anal area, buttocks, perineum etc. rubefaction, be dispersed in maculopapule or
Bleb, also known as neonate diaper dermatitis.It is to be contacted for a long time because baby' diaper replacement is not diligent or washing is not clean；Stimulate baby's skin
Skin；Diaper quality is harder, local friction occurs and causes.It is aggravated after secondary bacterial or monilial infection, serious person especially seeks
Undesirable chronic diarrhea baby is supported, skin ulcer can occur.
Infant is relative to adult, and epidermis and skin corium development are incomplete, and thickness is thin, Cell tracking is few, structure
It is immature, function is not perfect, appearance is smooth, delicate, it is easier to be damaged, cause skin barrier function abnormal.Infant skin is viscous
Film is fine and smooth thin tender, and the petrochemical industries such as common chemical preservative, colorant, essence, pigment, antibiotic, hormone are former in skin care item
Expect that ingredient itself influences the reconstruction of skin barrier function to mucocutaneous irritating effect, and readily permeable entrance is in vivo, it is right
Upgrowth and development of children generates long-range influence.Therefore, the skin care item for the nursing of infant skin problem, which should be avoided, selects petroleum, coal tar
The chemical raw materials such as oil should select, with the compatibility of skin good, non-stimulated, safety the same or similar with the ingredient of skin sebum
The high raw material of property.
Summary of the invention
It is of the invention the purpose of the present invention is to provide a kind of reparation damaged cell and the composite skin care product of sensitive skin
Purpose, which also resides in, provides the preparation method of the composite skin care product.Composite skin care product of the invention, according to bionics principle, choosing
It takes and the same or similar ingredient of natural constituents in sebum and skin texture, supplement child skin hyposteatosis, enhancing
Mucocutaneous barrier function, the carry out skin nursing of non-treatment purpose.
The technical scheme to solve the above technical problems is that a kind of skin care for repairing damaged cell and sensitive skin
Product composition includes: 88~92 weight % of emollient, 6~10 weight % of skin conditioning agent, thickener 1~2 weight %, described
Parts by weight are based on the total weight of the composition；
Wherein the emollient includes at least one of following ingredient: saualane, Butyrospermum parkii fruit rouge, three (ethyl of glycerol
Caproic acid) ester；
Wherein the skin conditioning agent includes skin conditioning agent 1 and skin conditioning agent 2；Skin conditioning agent 1 contains rape element
Sterol, cetostearyl alcohol, Asian puccoon root extract, allantoin, lavender oil, rose oil, bisabolol, Butyrospermum parkii fruit rouge mention
Take object, useless malt dregs of rice wax, Ci Agan tree benevolence oil, ginger extract, glycerol, german chamomile flower extract, in hydroxy phenylpropionyl amine benzoic acid
At least one ingredient；Skin conditioning agent 2 containing at least one of butanediol, 1,2- pentanediol, Herba polygoni hydropiperis extract, xanthan gum at
Point；
Wherein the thickener includes at least one of following ingredient: polyethylene, vinyldimethicone/poly- first
Radical siloxane silsesquioxane cross-linked polymer.
Preferably, the skin conditioning agent includes at least one of following conditioner A to conditioner J:
Conditioner A is made of rape element sterol and cetostearyl alcohol,
Conditioner B is made of Asian puccoon root extract,
Conditioner C is made of allantoin,
Conditioner D is made of lavender oil,
Conditioner E is made of rose oil,
Conditioner F is made of bisabolol,
Conditioner G is made of Butyrospermum parkii fruit rouge extract, useless malt dregs of rice wax, Ci Agan tree benevolence oil,
Conditioner H is made of bisabolol, ginger extract,
Conditioner I is made of water, glycerol, german chamomile flower extract,
Conditioner J is made of hydroxy phenylpropionyl amine benzoic acid,
Preferably, the skin conditioning agent 1 includes conditioner A, conditioner B, conditioner C, conditioner D, conditioner E, adjusts
Manage agent F, conditioner G, conditioner H, conditioner I and conditioner J；The skin conditioning agent 2 is by butanediol, 1,2- pentanediol, peppery
Knotweed extract, xanthan gum, water composition.
Preferably, the composite skin care product includes the tune of the conditioner A of 0.5~1.2 weight %, 0.5~1.2 weight %
Manage the conditioner of agent B, the conditioner C of 0.3~0.8 weight %, the conditioner D of 0.01~0.1 weight %, 0.5~1.2 weight %
E, the conditioner F of 0.1~0.5 weight %, the conditioner G of 0.5~1.2 weight %, 0.05~0.15 weight % conditioner H,
The skin conditioning agent 2 of the conditioner I of 0.5~1.5 weight %, the conditioner J of 0.05~0.15 weight %, 1.5~3 weight %,
The parts by weight are relative to the conditioner total weight in the composition.
Preferably, the conditioner A is made of the rape element sterol of 50 weight % and the cetostearyl alcohol of 50 weight %, institute
Stating parts by weight is relative to the conditioner A total weight；The conditioner G is mentioned by at least Butyrospermum parkii fruit rouge of 70 weight %
The Ci Agan tree benevolence oil composition of object, the useless malt dregs of rice wax of 5~10 weight %, 10~25 weight % are taken, the parts by weight are phase
For the conditioner G total weight；The conditioner H contains the ginger extract of 0.1~1 weight %, and the parts by weight are phase
For the conditioner H total weight；The Flos Chrysanthemi of glycerol and 3~5 weight % that the conditioner I contains 3~6 weight % extracts
Object, the parts by weight are relative to the conditioner I total weight；Fourth of the skin conditioning agent 2 containing 10~25 weight %
Glycol, 1, the 2- pentanediol of 5~10 weight %, the Herba polygoni hydropiperis extract of 1~5 weight %, 0.1~1 weight % xanthan gum, it is described
Parts by weight are relative to 2 total weight of skin conditioning agent.
According to embodiment of the present invention, the composite skin care product for repairing damaged cell and sensitive skin, by
88~92 weight % of emollient, 6~10 weight % of skin conditioning agent, 1~2 weight % of thickener composition, the weight percent contain
Amount is based on the composition total weight.
According to embodiment of the present invention, the emollient is made of at least one of following ingredient: saualane, ox
Oily fruit tree fruit rouge, glycerol three (thylhexoic acid) ester.
According to embodiment of the present invention, the skin conditioning agent is by 2 structure of skin conditioning agent 1 and skin conditioning agent
At.Skin conditioning agent 1 by rape element sterol, cetostearyl alcohol, Asian puccoon root extract, allantoin, lavender oil, rose oil,
Bisabolol, Butyrospermum parkii fruit rouge extract, useless malt dregs of rice wax, Ci Agan tree benevolence oil, ginger extract, glycerol, Flos Chrysanthemi extract
At least one of object, hydroxy phenylpropionyl amine benzoic acid ingredient is constituted.Skin conditioning agent 2 is by butanediol, 1,2- pentanediol, polygonum flaccidum
At least one of extract, xanthan gum ingredient is constituted.
According to embodiment of the present invention, the thickener is made of at least one of following ingredient: polyethylene, second
Alkenyl dimethyl silicone polymer/polymethyl siloxane silsesquioxane cross-linked polymer.
According to embodiment of the present invention, the skin conditioning agent is by least the one of following conditioner A to conditioner J
Kind is constituted:
Conditioner A is made of rape element sterol and cetostearyl alcohol,
Conditioner B is made of Asian puccoon root extract,
Conditioner C is made of allantoin,
Conditioner D is made of lavender oil,
Conditioner E is made of rose oil,
Conditioner F is made of bisabolol,
Conditioner G is made of Butyrospermum parkii fruit rouge extract, useless malt dregs of rice wax, Ci Agan tree benevolence oil,
Conditioner H is made of bisabolol, ginger extract,
Conditioner I is made of water, glycerol, german chamomile flower extract,
Conditioner J is made of hydroxy phenylpropionyl amine benzoic acid,
According to embodiment of the present invention, the skin conditioning agent 1 is by conditioner A, conditioner B, conditioner C, tune
Agent D, conditioner E, conditioner F, conditioner G, conditioner H, conditioner I and conditioner J is managed to constitute.The skin conditioning agent 2 by
Butanediol, 1,2- pentanediol, Herba polygoni hydropiperis extract, xanthan gum and water composition.
According to embodiment of the present invention, the conditioner of the composition by 0.5~1.2 weight % conditioner A,
The conditioner B of 0.5~1.2 weight %, the conditioner C of 0.3~0.8 weight %, the conditioner D of 0.01~0.1 weight %, 0.5
The conditioner E of~1.2 weight %, the conditioner F of 0.1~0.5 weight %, the conditioner G of 0.5~1.2 weight %, 0.05~
The conditioner H of 0.15 weight %, the conditioner I of 0.5~1.5 weight %, the conditioner J of 0.05~0.15 weight %, 1.5~3
The skin conditioning agent 2 of weight % is constituted, wherein the weight percentage is based on the total weight of the composition.
The present invention repairs the preparation method of the composition of damaged cell and sensitive skin as shown in Figure 1, including the following steps:
(1) factory formula is pressed, quantitatively weighs each raw material respectively；
(2) emulsion pot is added in emollient and thickener, stirring is warming up to 80-90 DEG C, preferably 81 DEG C, 82 DEG C, 85 DEG C, 87
DEG C, 88 DEG C, 89 DEG C, homogeneous 5-15min, preferably 7min, 8min, 10min, 12min, 14min, until Material is fine and smooth；
(3) skin conditioning agent A, B, C, G, J is added, vacuumizes, keep the temperature 10-15min, preferably 11min, 12min, 13min,
14min；
(4) be cooled to 35-45 DEG C, preferably 37 DEG C, 39 DEG C, 41 DEG C, 43 DEG C put vacuum, be added skin conditioning agent 2, D, E,
F, H, I are stirred evenly；
(5) it discharges after the assay was approved, composition is made.
The present invention according to bionics principle, choose with the natural constituents in sebum and skin texture it is the same or similar at
Point, as saualane, Butyrospermum parkii fruit rouge, glycerol three (thylhexoic acid) ester enhance and restore child skin mucous membrane to supplement sebum
Barrier function；Choose grass roots extract, lavender oil, rose oil, Butyrospermum parkii fruit rouge extract, Ci Agan tree benevolence it is oily,
The natural materials such as ginger extract, german chamomile flower extract, Herba polygoni hydropiperis extract；And other safety, mild raw material.
Composite skin care product of the invention does not add any chemical components from petroleum, coking coal, without essence, coloring
Agent, chemical preservative, hormone etc. may cause the additive of adverse reaction.Above-mentioned whole components of the present invention are doctor
The existing product of medicine grade or food-grade.
Composite skin care product dosage form provided by the invention be paste, it is tasteless, be in ecru；It is delicate quick mainly for infant
Feel skin, skin is impaired caused by repairing because of eczema, saliva rash, diaper rash, redness, itch, drying, the various problems such as be chapped from the cold,
Alleviate condition susceptible, enhance skin immunity, adult and sensitive skin crowd is also applicable in；It can repair skin damage cell,
Releive sensitive, supplement child skin hyposteatosis, enhance mucocutaneous barrier, alleviate itch, moisten moisturizing, dispel it is red
Spot, and all select natural, pollution-free, safe ingredient, without containing by the sources such as petroleum, coal tar chemical industry synthesis raw material,
Without containing additives such as hormone, chemical preservatives.With to mild non-stimulated, without side-effects, the environmentally protective, nursing efficacy of skin
The advantages such as good.
Application method: after cleaning impaired skin, taking appropriate composite skin care product of the invention to be applied at skin damage,
Gently massage is until absorb.
Detailed description of the invention
Fig. 1 is the production technological process of the present composition
Fig. 2 is the comparison photo before and after 1 eczema treatment of baby
Fig. 3 is the comparison photo before and after 2 eczema treatment of baby
Fig. 4 is the comparison photo before and after 3 eczema treatment of baby
Fig. 5 is the pretherapy and post-treatment comparison photo of 4 mouthfuls of water rash of baby
Specific embodiment
Principles and features of the present invention are described below in conjunction with specific embodiment, illustrated embodiment is served only for explaining this
Invention, is not intended to limit the scope of the present invention.
Embodiment 1
The composite skin care product for repairing damaged cell and sensitive skin of the present embodiment, the raw material including following weight:
Emollient: saualane 28g, Butyrospermum parkii fruit rouge 27g, (thylhexoic acid) ester of glycerol three 35g；
Conditioner:
Skin conditioning agent 1:
Conditioner A: rape element sterol 0.5g, cetostearyl alcohol 0.5g；
Conditioner B: Asian puccoon root extract 1g；
Conditioner C: allantoin 0.8g；
Conditioner D: lavender oil 0.1g；
Conditioner E: rose oil 0.8g；
Conditioner F: bisabolol 0.5g；
Conditioner G: Butyrospermum parkii fruit rouge extract 0.7g, give up the malt dregs of rice wax 0.1g, Ci Agan tree benevolence oil 0.2g；
Conditioner H: bisabolol 0.1485g, ginger extract 0.0015g；
Conditioner I: water 0.445g, glycerol 0.03g, german chamomile flower extract 0.025g；
Conditioner J: hydroxy phenylpropionyl amine benzoic acid 0.05g；
Skin conditioning agent 2: water 1.77g, butanediol 0.75g, 1,2- pentanediol 0.3g, Herba polygoni hydropiperis extract 0.15g, xanthan gum
0.03g；
Thickener: polyethylene 0.1g, vinyldimethicone/polymethyl siloxane silsesquioxane cross-linked polymeric
Object 1g；
The composition is prepared as follows:
(1) factory formula is pressed, quantitatively weighs each raw material respectively；
(2) emulsion pot is added in emollient and thickener, stirring is warming up to 80 DEG C, homogeneous 8min, until Material is fine and smooth；
(3) skin conditioning agent A, B, C, G, J is added, vacuumizes, keep the temperature 12min；
(4) 40 DEG C are cooled to, vacuum is put, skin conditioning agent 2, D, E, F, H, I is added, stirs evenly；
(5) it discharges after the assay was approved, composition is made.
Embodiment 2
The composite skin care product for repairing damaged cell and sensitive skin of the present embodiment, the raw material including following weight:
Emollient: saualane 25g, Butyrospermum parkii fruit rouge 31g, (thylhexoic acid) ester of glycerol three 32g；
Conditioner:
Skin conditioning agent 1:
Conditioner A: rape element sterol 0.6g, cetostearyl alcohol 0.6g；
Conditioner B: Asian puccoon root extract 1.2g；
Conditioner C: allantoin 0.8g；
Conditioner D: lavender oil 0.1g；
Conditioner E: rose oil 1.2g；
Conditioner F: bisabolol 0.5g；
Conditioner G: Butyrospermum parkii fruit rouge extract 0.8g, give up the malt dregs of rice wax 0.05g, Ci Agan tree benevolence oil 0.15g；
Conditioner H: bisabolol 0.099g, ginger extract 0.001g；
Conditioner I: water 0.89g, glycerol 0.06g, german chamomile flower extract 0.05g；
Conditioner J: hydroxy phenylpropionyl amine benzoic acid 0.1g；
Skin conditioning agent 2: water 2.072g, butanediol 0.28g, 1,2- pentanediol 0.28g, Herba polygoni hydropiperis extract 0.14g, xanthan
Glue 0.028g；
Thickener: polyethylene 1g, vinyldimethicone/polymethyl siloxane silsesquioxane cross-linked polymer
1g；
The composition is prepared as follows:
(1) factory formula is pressed, quantitatively weighs each raw material respectively；
(2) emulsion pot is added in emollient and thickener, stirring is warming up to 85 DEG C, homogeneous 10min, until Material is fine and smooth；
(3) skin conditioning agent A, B, C, G, J is added, vacuumizes, keep the temperature 10min；
(4) 37 DEG C are cooled to, vacuum is put, skin conditioning agent 2, D, E, F, H, I is added, stirs evenly；
(5) it discharges after the assay was approved, composition is made.
Embodiment 3
The composite skin care product for repairing damaged cell and sensitive skin of the present embodiment, the raw material including following weight:
Emollient: saualane 25g, Butyrospermum parkii fruit rouge 38g, (thylhexoic acid) ester of glycerol three 29g；
Conditioner:
Skin conditioning agent 1:
Conditioner A: rape element sterol 0.25g, cetostearyl alcohol 0.25g；
Conditioner B: Asian puccoon root extract 0.5g；
Conditioner C: allantoin 0.5g；
Conditioner D: lavender oil 0.1g；
Conditioner E: rose oil 0.6g；
Conditioner F: bisabolol 0.5g；
Conditioner G: Butyrospermum parkii fruit rouge extract 0.375g, give up the malt dregs of rice wax 0.025g, Ci Agan tree benevolence oil 0.1g；
Conditioner H: bisabolol 0.1485g, ginger extract 0.0015g；
Conditioner I: water 0.47g, glycerol 0.015g, german chamomile flower extract 0.015g；
Conditioner J: hydroxy phenylpropionyl amine benzoic acid 0.15g；
Skin conditioning agent 2: water 2.235g, butanediol 0.45g, 1,2- pentanediol 0.15g, Herba polygoni hydropiperis extract 0.15g, xanthan
Glue 0.015g；
Thickener: polyethylene 0.1g, vinyldimethicone/polymethyl siloxane silsesquioxane cross-linked polymeric
Object 0.9g；
The composition is prepared as follows:
(1) factory formula is pressed, quantitatively weighs each raw material respectively；
(2) emulsion pot is added in emollient and thickener, stirring is warming up to 87 DEG C, homogeneous 12min, until Material is fine and smooth；
(3) skin conditioning agent A, B, C, G, J is added, vacuumizes, keep the temperature 10min；
(4) 42 DEG C are cooled to, vacuum is put, skin conditioning agent 2, D, E, F, H, I is added, stirs evenly；
(5) it discharges after the assay was approved, composition is made.
Comparative example
1, the formula components of embodiment 1 and comparative example 1-3, as shown in table 1.
1 formula components of table
2, production technology
The composition of embodiment 1 and comparative example 2 is prepared using identical method:
(1) factory formula is pressed, quantitatively weighs each raw material respectively；
(2) emulsion pot being added in emollient and thickener (raw material 1,2,3,4,5 i.e. in table 1), stirring is warming up to 80 DEG C,
Homogeneous 8min, until Material is fine and smooth；
(3) skin conditioning agent A, B, C, G and J (raw material 6,7,8,12,15 i.e. in table 1) is added, vacuumizes, keeps the temperature
12min；
(4) 40 DEG C are cooled to, puts vacuum, be added skin conditioning agent 2, D, E, F, H and I (raw material 9 i.e. in table 1,10,11,
13, it 14,16), stirs evenly；
(5) it discharges after the assay was approved, composition is made.
The composition of comparative example 1 and comparative example 3 is prepared using identical method:
(1) factory formula is pressed, quantitatively weighs each raw material respectively；
(2) emulsion pot being added in emollient and thickener (raw material 1,2,3,4,5 i.e. in table 1), stirring is warming up to 80 DEG C,
Homogeneous 8min, until Material is fine and smooth；
(3) skin conditioning agent A, B, C, E, F, G, H and J (raw material 6,7,8,10,11,12,13,15 i.e. in table 1) is added,
It vacuumizes, keep the temperature 12min；
(4) 40 DEG C are cooled to, vacuum is put, skin conditioning agent 2, D and I (raw material 9,14,16 i.e. in table 1), stirring is added
Uniformly；
(5) it discharges after the assay was approved, composition is made.It (is vacuumized in step 3, may I ask Huang work, whether had corresponding
Put vacuumizing, if there is putting the operation of vacuum, which is in several progress of step)
3, organoleptic indicator
Embodiment 1, embodiment 2, the organoleptic indicator of 3 gained composite skin care product of embodiment are as follows:
Color: yellow, it is translucent；State: paste, lotion thickness are moderate；Smell: tasteless.
The organoleptic indicator of 1 gained composite skin care product of comparative example is as follows:
Color: yellow, it is translucent；State: paste, lotion quality is slightly hard, is not particularly suitable for infant's skin；Smell: tasteless.
The organoleptic indicator of 2 gained composite skin care product of comparative example is as follows:
Color: white, yellowish；State: paste, lotion is slightly frivolous, not good enough to the repairing effect of skin after smearing,
Appearance is slightly inferior to 1 gained composite skin care product of embodiment；Smell: tasteless.
The organoleptic indicator of 3 gained composite skin care product of comparative example is as follows:
Color: white；State: paste, lotion is frivolous, there is partial particulate substance, has harsh feeling, repairs after smearing to skin
Multiple ineffective, appearance slightly in 1 gained composite skin care product of comparative example, is unsuitable for infant's skin；Smell: tasteless.
It can be seen that the content and preparation method using embodiment 1 are substantially better than comparative example 1-3 in terms of organoleptic indicator,
Show optimal color and state.Inventor has also done a large amount of screening to other contents and preparation method, finds comprehensive sense
Official's index is significantly lower than embodiment 1, even lower than comparative example 1-3 (experimental data is not shown), is eliminated in experiment early stage,
Therefore other contents and preparation method are unsuitable for the preparation of composite skin care product of the invention.
Experimental example
1, by 1 gained composite skin care product of embodiment, noxious material limitation inspection, Micro biological Tests, hormone test are carried out,
It the results are shown in Table 2~4.
2 specified risk material of table limitation is examined
| Inspection project | Index |
| Mercury | ≤1mg/kg |
| Lead (in terms of lead) | ≤10mg/kg |
| Arsenic (in terms of arsenic) | ≤2mg/kg |
| Cadmium | ≤5mg/kg |
| Dioxanes | ≤30mg/kg |
| Asbestos | It must not detect |
| It is heat-resisting | (40 ± 1) DEG C are kept for 24 hours, preceding without obvious Traits change with test after restoring to room temperature |
| It is cold-resistant | (10 ± 5) DEG C are kept for 24 hours, preceding without obvious Traits change with test after restoring to room temperature |
3 Micro biological Tests of table
| Inspection project | Index |
| Total plate count | ≤500CFU/g |
| Yeast and total number of molds | ≤100CFU/g |
| Heat-resisting coliform | / g is not detected |
| Staphylococcus aureus | / g is not detected |
| Pseudomonas aeruginosa | / g is not detected |
4 hormone of table is examined
| Inspection project | Index |
| 41 sugar skin hormones | / g is not detected |
| 7 sex hormone | / g is not detected |
2, trial effect
0-3 years old cheek portion eczema or saliva rash are collected by internet and the skin being grievously injured degree is the baby of light moderate, property
Not unlimited, guardian signs informed consent form, and is ready to carry out according to requirement of experiment, receives skin detection and pays a return visit on time.It presses
According to guardian's wish, 35 babies are chosen respectively, issue one, 1 made composite skin care product sample of embodiment and application form one
Part and another 35 babies, issue erythromycin ointment one and application form is a.It is required that subject parent cleans baby with clear water
After at eczema or saliva rash, the made composite skin care product sample of embodiment 1 or erythromycin ointment are applied at eczema or saliva rash,
3 times a day.It withdraws 70 parts of application form altogether after two weeks, carries out statistics analysis.Fig. 2~5 are that baby uses the made shield of embodiment 1
Comparison diagram before and after skin product composition sample.
Effect criterion:
Recovery from illness: skin lesion recession 100%, pruritis disappears；
Effective: 70% or more skin lesion recession, itch is substantially reduced；
Effective: 30% or more skin lesion recession, pruritis makes moderate progress；
Invalid: skin lesion is subsided not to 30%, and itch has no that mitigation or clinical symptoms deteriorate.
The trial effect comparing result of table 5 embodiment 1 and erythromycin ointment
| Agent is used in experiment | Number of cases | Recovery from illness | It is effective | Effectively | In vain | Total effective rate |
| The made composite skin care product of embodiment 1 | 35 | 26 | 6 | 2 | 1 | 97.1% |
| Erythromycin ointment | 35 | 14 | 9 | 6 | 6 | 82.8% |
As shown in Table 5, composite skin care product of the invention is 97.1% for eczema, saliva rash trier's effective percentage, bright
The aobvious effective percentage 82.8% higher than erythromycin ointment.
Composite skin care product of the invention, it is mild to skin it is non-stimulated, have preferable antipruritic, repair, can be applied to quick
Impression damage skin nursing.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all in spirit of the invention and
Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (8)
1. a kind of have effects that repair the composition of damaged cell and sensitive skin, it is characterised in that:
The composition includes:
88~92 weight % of emollient, 6~10 weight % of skin conditioning agent, 1~2 weight % of thickener, the parts by weight with
Based on the total weight of the composition；
Wherein the emollient includes at least one of following ingredient: saualane, Butyrospermum parkii fruit rouge, glycerol three (thylhexoic acid)
Ester；
Wherein the skin conditioning agent includes skin conditioning agent 1 and skin conditioning agent 2；Skin conditioning agent 1 containing rape element sterol,
Cetostearyl alcohol, Asian puccoon root extract, allantoin, lavender oil, rose oil, bisabolol, Butyrospermum parkii fruit rouge extract,
Useless malt dregs of rice wax, Ci Agan tree benevolence oil, ginger extract, glycerol, german chamomile flower extract, in hydroxy phenylpropionyl amine benzoic acid at least
A kind of ingredient；Skin conditioning agent 2 contains at least one of butanediol, 1,2- pentanediol, Herba polygoni hydropiperis extract, xanthan gum ingredient；
Wherein the thickener includes at least one of following ingredient: polyethylene, vinyldimethicone/poly- methyl silicon
Oxygen alkane silsesquioxane cross-linked polymer.
2. composition according to claim 1, wherein the skin conditioning agent 1 includes following conditioner A to conditioner J's
It is at least one:
Conditioner A is made of rape element sterol and cetostearyl alcohol,
Conditioner B is made of Asian puccoon root extract,
Conditioner C is made of allantoin,
Conditioner D is made of lavender oil,
Conditioner E is made of rose oil,
Conditioner F is made of bisabolol,
Conditioner G is made of Butyrospermum parkii fruit rouge extract, useless malt dregs of rice wax, Ci Agan tree benevolence oil,
Conditioner H is made of bisabolol, ginger extract,
Conditioner I is made of water, glycerol, german chamomile flower extract,
Conditioner J is made of hydroxy phenylpropionyl amine benzoic acid.
3. composition according to claim 2, wherein the skin conditioning agent 1 includes conditioner A, conditioner B, conditioner
C, conditioner D, conditioner E, conditioner F, conditioner G, conditioner H, conditioner I and conditioner J；The skin conditioning agent 2 by
Butanediol, 1,2- pentanediol, Herba polygoni hydropiperis extract, xanthan gum, water composition.
4. composition according to claim 3, wherein the composition includes the conditioner A of 0.5~1.2 weight %, 0.5
The conditioner B of~1.2 weight %, the conditioner C of 0.3~0.8 weight %, the conditioner D of 0.01~0.1 weight %, 0.5~
The conditioner E of 1.2 weight %, the conditioner F of 0.1~0.5 weight %, the conditioner G of 0.5~1.2 weight %, 0.05~0.15
The conditioner H of weight %, the conditioner I of 0.5~1.5 weight %, the conditioner J of 0.05~0.15 weight %, 1.5~3 weights
The skin conditioning agent 2 of % is measured, the parts by weight are based on the total weight of the composition.
5. composition according to claim 4, wherein rape element sterol and 50 weights of the conditioner A by 50 weight %
The cetostearyl alcohol composition of % is measured, the parts by weight are relative to the conditioner A total weight；The conditioner G is by least
The Ci Agan tree benevolence of the Butyrospermum parkii fruit rouge extract of 70 weight %, the useless malt dregs of rice wax of 5~10 weight %, 10~25 weight %
Oil composition, the parts by weight are relative to the conditioner G total weight；The conditioner H contains the ginger of 0.1~1 weight %
Extract, the parts by weight are relative to the conditioner H total weight；The conditioner I contains the glycerol of 3~6 weight %
With the german chamomile flower extract of 3~5 weight %, the parts by weight are relative to the conditioner I total weight；The skin condition
Butanediol of the agent 2 containing 10~25 weight %, the 1,2- pentanediol of 5~10 weight %, 1~5 weight % Herba polygoni hydropiperis extract,
The xanthan gum of 0.1~1 weight %, the parts by weight are relative to 2 total weight of skin conditioning agent.
6. a kind of preparation method of composition according to any one of claims 1 to 5 comprising following steps:
(1) factory formula is pressed, quantitatively weighs each raw material respectively；
(2) emulsion pot is added in emollient and thickener, stirring is warming up to 80-90 DEG C, homogeneous 5-15min, until Material is fine and smooth；
(3) skin conditioning agent A, B, C, G, J is added, vacuumizes, keep the temperature 10-15min；
(4) it is cooled to 35-45 DEG C, puts vacuum, skin conditioning agent 2, D, E, F, H, I is added, stirs evenly；
(5) it discharges after the assay was approved, composition is made.
7. preparation method according to claim 6, wherein the temperature after heating is 80 DEG C in the step (2).
8. preparation method according to claim 6, wherein the temperature after cooling is 40 DEG C in the step (4).
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109453098A (en) * | 2018-12-24 | 2019-03-12 | 广州环亚化妆品科技有限公司 | One kind is releived composition and its preparation method and application |
| CN110974767A (en) * | 2019-12-28 | 2020-04-10 | 佛山市奥姿美生物科技有限公司 | Composition for skin barrier regeneration repair and application thereof |
| CN112137931A (en) * | 2020-10-21 | 2020-12-29 | 上海科颜生物科技有限公司 | High-efficiency composition for relieving sensitive skin and application thereof |
| CN113398016A (en) * | 2021-07-30 | 2021-09-17 | 上海新高姿化妆品有限公司 | Skin soothing and repairing composition and cosmetic composition |
| WO2023284221A1 (en) * | 2021-07-15 | 2023-01-19 | 广州环亚化妆品科技股份有限公司 | Composition with soothing and repairing effects, and preparation method therefor and use thereof |
| EP4450131A1 (en) * | 2023-04-21 | 2024-10-23 | Medela Holding AG | Massage oil |
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2018
- 2018-10-17 CN CN201811208191.5A patent/CN108969447B/en active Active
Non-Patent Citations (1)
| Title |
|---|
| 北京润熙怡和科技有限公司: ""恩姆花园蓝甘菊多效修护膏"", 《HTTP://FTBA.NMPA.GOV.CN:8181/FTBAN/ITOWNET/HZP_BA/FW/PZ.JSP?PROCESSID=201801191630080Q4QZ&NID=201801191630080Q4QZ》 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109453098A (en) * | 2018-12-24 | 2019-03-12 | 广州环亚化妆品科技有限公司 | One kind is releived composition and its preparation method and application |
| CN109453098B (en) * | 2018-12-24 | 2021-08-31 | 广州环亚化妆品科技有限公司 | Soothing composition and preparation method and application thereof |
| CN110974767A (en) * | 2019-12-28 | 2020-04-10 | 佛山市奥姿美生物科技有限公司 | Composition for skin barrier regeneration repair and application thereof |
| CN112137931A (en) * | 2020-10-21 | 2020-12-29 | 上海科颜生物科技有限公司 | High-efficiency composition for relieving sensitive skin and application thereof |
| CN112137931B (en) * | 2020-10-21 | 2023-09-22 | 上海科颜生物科技有限公司 | Composition for relieving sensitive skin and application thereof |
| WO2023284221A1 (en) * | 2021-07-15 | 2023-01-19 | 广州环亚化妆品科技股份有限公司 | Composition with soothing and repairing effects, and preparation method therefor and use thereof |
| CN113398016A (en) * | 2021-07-30 | 2021-09-17 | 上海新高姿化妆品有限公司 | Skin soothing and repairing composition and cosmetic composition |
| EP4450131A1 (en) * | 2023-04-21 | 2024-10-23 | Medela Holding AG | Massage oil |
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