CN108883133A - 使用红细胞的治疗方法 - Google Patents

使用红细胞的治疗方法 Download PDF

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Publication number
CN108883133A
CN108883133A CN201680082308.2A CN201680082308A CN108883133A CN 108883133 A CN108883133 A CN 108883133A CN 201680082308 A CN201680082308 A CN 201680082308A CN 108883133 A CN108883133 A CN 108883133A
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cell
cells
red blood
rbcs
proteins
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Chinese (zh)
Inventor
伊丽莎白·卡斯滕
本·赫伯特
艾伦·利德尔
卡梅伦·希尔
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Shan Wei Biological Private Ltd
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Shan Wei Biological Private Ltd
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Priority claimed from AU2015905309A external-priority patent/AU2015905309A0/en
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Publication of CN108883133A publication Critical patent/CN108883133A/zh
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/18Erythrocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00Antineoplastic agents
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
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    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
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    • C12N2502/30Coculture with; Conditioned medium produced by tumour cells

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  • Transplantation (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201680082308.2A 2015-12-22 2016-12-22 使用红细胞的治疗方法 Pending CN108883133A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2015905309 2015-12-22
AU2015905309A AU2015905309A0 (en) 2015-12-22 Therapeutic methods using erythrocytes
PCT/AU2016/000404 WO2017106899A2 (en) 2015-12-22 2016-12-22 Therapeutic methods using erythrocytes

Publications (1)

Publication Number Publication Date
CN108883133A true CN108883133A (zh) 2018-11-23

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CN201680082308.2A Pending CN108883133A (zh) 2015-12-22 2016-12-22 使用红细胞的治疗方法

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Country Link
US (1) US11564948B2 (enExample)
EP (1) EP3393482A4 (enExample)
JP (2) JP2018538343A (enExample)
KR (1) KR20180102096A (enExample)
CN (1) CN108883133A (enExample)
AU (1) AU2016374643B2 (enExample)
CA (1) CA3009369A1 (enExample)
SG (1) SG11201805052YA (enExample)
WO (1) WO2017106899A2 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113337402B (zh) 2011-10-17 2024-11-29 麻省理工学院 细胞内传递
EP3848695A1 (en) 2013-08-16 2021-07-14 Massachusetts Institute Of Technology Selective delivery of material to cells
KR20170074235A (ko) 2014-10-31 2017-06-29 메사추세츠 인스티튜트 오브 테크놀로지 면역 세포로의 생체분자의 전달
CA2964138C (en) 2014-11-14 2023-11-14 Massachusetts Institute Of Technology Disruption and field enabled delivery of compounds and compositions into cells
US11125739B2 (en) 2015-01-12 2021-09-21 Massachusetts Institute Of Technology Gene editing through microfluidic delivery
SG10201912910PA (en) 2015-07-09 2020-02-27 Massachusetts Inst Technology Delivery of materials to anucleate cells
WO2017041051A1 (en) 2015-09-04 2017-03-09 Sqz Biotechnologies Company Intracellular delivery of biomolecules to cells comprising a cell wall
CN114019171A (zh) 2015-10-07 2022-02-08 善威生物私人有限公司 血液制备和图谱分析
WO2018112500A1 (en) * 2016-12-20 2018-06-28 Sangui Bio Pty. Ltd Blood profiling with protease inhibitors
WO2022192446A1 (en) * 2021-03-10 2022-09-15 Terasaki Institute For Biomedical Innovation Production of heme for cell-based meat products

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858358A (en) * 1992-04-07 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Methods for selectively stimulating proliferation of T cells
FR2778851A1 (fr) * 1998-05-19 1999-11-26 Aetsrn Composition a base d'inhibiteurs de cysteine-proteases pour retarder la senescence, l'autodestruction et l'hemolyse des erythrocytes
US20120195869A1 (en) * 1999-08-30 2012-08-02 Terman David S Sickled Erythrocytes with Anti-tumor Agents Induce Tumor Vaso-occlusion and Tumoricidal Effects
WO2013045885A1 (en) * 2011-09-28 2013-04-04 St George's Hospital Medical School Treatment for mitrochondrial neurogastrointestinal encephalomyopathy (mngie)
WO2013139906A1 (en) * 2012-03-21 2013-09-26 Erytech Pharma Medicament for the treatment of acute myeloid leukemia (aml)
WO2014181309A1 (en) * 2013-05-10 2014-11-13 Erydel S.P.A. Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes
WO2015156586A1 (ko) * 2014-04-07 2015-10-15 한양대학교 산학협력단 적혈구계 세포의 인 비트로 확장

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4931276A (en) 1987-10-30 1990-06-05 Franco Robert S Method for introducing desired agents into red blood cells
WO1992005801A1 (en) 1990-10-04 1992-04-16 University Of Virginia Alumni Patents Foundation Primate erythrocyte bound monoclonal antibody heteropolymers
MXPA03000765A (es) * 2000-07-24 2004-05-21 Gendel Ltd Suministro de polipeptido il-2.
PT1495328E (pt) 2002-04-16 2014-09-09 Vlaams Interuniv Inst Biotech Um marcador para medir cirrose hepática
GB0325483D0 (en) 2003-10-31 2003-12-03 Plasmacute As Assay
US20080095749A1 (en) * 2004-03-22 2008-04-24 Sudeepta Aggarwal Mesenchymal stem cells and uses therefor
US7378054B2 (en) 2004-04-16 2008-05-27 Savvipharm Inc Specimen collecting, processing and analytical assembly
US20060166223A1 (en) 2005-01-26 2006-07-27 Reed Michael W DNA purification and analysis on nanoengineered surfaces
WO2006123253A2 (en) 2005-03-29 2006-11-23 Inverness Medical Switzerland Gmbh Device and method of monitoring a patient
US20100184049A1 (en) 2007-04-27 2010-07-22 Steve Goodison Glycoprotein Profiling of Bladder Cancer
FR2919804B1 (fr) * 2007-08-08 2010-08-27 Erytech Pharma Composition et vaccin therapeutique anti-tumoral
US20110245092A1 (en) 2008-03-04 2011-10-06 John Bilello Diagnosing and monitoring depression disorders based on multiple serum biomarker panels
CA3150872A1 (en) * 2008-05-06 2009-11-12 Astellas Institute For Regenerative Medicine Methods for producing enucleated erythroid cells derived from pluripotent stem cells
WO2010147621A1 (en) 2009-06-16 2010-12-23 The Trustees Of Columbia University In The City Of New York Methods for ameliorating adverse effects associated with transfusion of aged red blood cells
CN102472744B (zh) 2009-08-13 2015-11-25 巴斯夫欧洲公司 诊断甲状腺疾病的手段和方法
WO2011091154A2 (en) * 2010-01-21 2011-07-28 The Regents Of The University Of California Use of human erythrocytes for prevention and treatment of cancer dissemination and growth
WO2011127056A2 (en) 2010-04-05 2011-10-13 The Uab Research Foundation Biomarkers for assessing exposure to ionizing radiation and absorbed dose
SG195180A1 (en) 2011-05-31 2013-12-30 Singapore Health Serv Pte Ltd Method for detecting disease biomarkers
BR112013032659B1 (pt) * 2011-07-06 2021-04-06 Histocell S.L. Método para o tratamento de células-tronco mesenquimais, que compreende a obtenção e o isolamento das células-tronco mesenquimais e a cultura das células em um meio de tratamento; e uso das células
HU230341B1 (hu) * 2012-04-20 2016-02-29 Advancell Diagnosztika Kft. A vörösvérsejt-membrán kvantitatív biomarkerei
JP6329537B2 (ja) 2012-07-11 2018-05-23 サンガモ セラピューティクス, インコーポレイテッド 生物学的薬剤の送達のための方法および組成物
US10272115B2 (en) * 2013-03-11 2019-04-30 Taiga Biotechnologies, Inc. Production and use of red blood cells
JP6383920B2 (ja) 2013-09-11 2018-09-05 有限会社ピコデバイス パーキンソン病の判定基準とする方法
CN107735095B (zh) * 2015-05-18 2022-06-14 希玛奈克斯特股份有限公司 储存全血的方法及其组合物
CN114019171A (zh) 2015-10-07 2022-02-08 善威生物私人有限公司 血液制备和图谱分析
WO2018112500A1 (en) 2016-12-20 2018-06-28 Sangui Bio Pty. Ltd Blood profiling with protease inhibitors

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858358A (en) * 1992-04-07 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Methods for selectively stimulating proliferation of T cells
FR2778851A1 (fr) * 1998-05-19 1999-11-26 Aetsrn Composition a base d'inhibiteurs de cysteine-proteases pour retarder la senescence, l'autodestruction et l'hemolyse des erythrocytes
US20120195869A1 (en) * 1999-08-30 2012-08-02 Terman David S Sickled Erythrocytes with Anti-tumor Agents Induce Tumor Vaso-occlusion and Tumoricidal Effects
WO2013045885A1 (en) * 2011-09-28 2013-04-04 St George's Hospital Medical School Treatment for mitrochondrial neurogastrointestinal encephalomyopathy (mngie)
WO2013139906A1 (en) * 2012-03-21 2013-09-26 Erytech Pharma Medicament for the treatment of acute myeloid leukemia (aml)
CN104394884A (zh) * 2012-03-21 2015-03-04 爱瑞泰克药物公司 用于治疗急性髓细胞白血病(aml)的药剂
WO2014181309A1 (en) * 2013-05-10 2014-11-13 Erydel S.P.A. Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes
WO2015156586A1 (ko) * 2014-04-07 2015-10-15 한양대학교 산학협력단 적혈구계 세포의 인 비트로 확장

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANA MAFALDA FONSECA等: "Red blood cells inhibit activation-induced cell death and oxidative stress in human peripheral blood T lymphocytes", 《BLOOD》 *
ANA MAFALDA FONSECA等: "Red blood cells inhibit activation-induced cell death and oxidative stress in human peripheral blood T lymphocytes", 《BLOOD》, vol. 97, no. 10, 15 May 2001 (2001-05-15), pages 3152 - 3160 *

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AU2016374643B2 (en) 2023-12-14
KR20180102096A (ko) 2018-09-14
JP2018538343A (ja) 2018-12-27
EP3393482A4 (en) 2019-08-21
SG11201805052YA (en) 2018-07-30
US20190000884A1 (en) 2019-01-03
JP2021155454A (ja) 2021-10-07
WO2017106899A2 (en) 2017-06-29
EP3393482A2 (en) 2018-10-31
US11564948B2 (en) 2023-01-31
AU2016374643A1 (en) 2018-07-05
WO2017106899A3 (en) 2017-09-28
CA3009369A1 (en) 2017-06-29

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