CN108883133A - 使用红细胞的治疗方法 - Google Patents
使用红细胞的治疗方法 Download PDFInfo
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- CN108883133A CN108883133A CN201680082308.2A CN201680082308A CN108883133A CN 108883133 A CN108883133 A CN 108883133A CN 201680082308 A CN201680082308 A CN 201680082308A CN 108883133 A CN108883133 A CN 108883133A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/18—Erythrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0641—Erythrocytes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/35—Polyols, e.g. glycerin, inositol
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
- C12N2502/1114—T cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1323—Adult fibroblasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1352—Mesenchymal stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/25—Urinary tract cells, renal cells
- C12N2502/256—Renal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/28—Vascular endothelial cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/30—Coculture with; Conditioned medium produced by tumour cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2015905309 | 2015-12-22 | ||
| AU2015905309A AU2015905309A0 (en) | 2015-12-22 | Therapeutic methods using erythrocytes | |
| PCT/AU2016/000404 WO2017106899A2 (en) | 2015-12-22 | 2016-12-22 | Therapeutic methods using erythrocytes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108883133A true CN108883133A (zh) | 2018-11-23 |
Family
ID=59088638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680082308.2A Pending CN108883133A (zh) | 2015-12-22 | 2016-12-22 | 使用红细胞的治疗方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11564948B2 (enExample) |
| EP (1) | EP3393482A4 (enExample) |
| JP (2) | JP2018538343A (enExample) |
| KR (1) | KR20180102096A (enExample) |
| CN (1) | CN108883133A (enExample) |
| AU (1) | AU2016374643B2 (enExample) |
| CA (1) | CA3009369A1 (enExample) |
| SG (1) | SG11201805052YA (enExample) |
| WO (1) | WO2017106899A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113337402B (zh) | 2011-10-17 | 2024-11-29 | 麻省理工学院 | 细胞内传递 |
| EP3848695A1 (en) | 2013-08-16 | 2021-07-14 | Massachusetts Institute Of Technology | Selective delivery of material to cells |
| KR20170074235A (ko) | 2014-10-31 | 2017-06-29 | 메사추세츠 인스티튜트 오브 테크놀로지 | 면역 세포로의 생체분자의 전달 |
| CA2964138C (en) | 2014-11-14 | 2023-11-14 | Massachusetts Institute Of Technology | Disruption and field enabled delivery of compounds and compositions into cells |
| US11125739B2 (en) | 2015-01-12 | 2021-09-21 | Massachusetts Institute Of Technology | Gene editing through microfluidic delivery |
| SG10201912910PA (en) | 2015-07-09 | 2020-02-27 | Massachusetts Inst Technology | Delivery of materials to anucleate cells |
| WO2017041051A1 (en) | 2015-09-04 | 2017-03-09 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to cells comprising a cell wall |
| CN114019171A (zh) | 2015-10-07 | 2022-02-08 | 善威生物私人有限公司 | 血液制备和图谱分析 |
| WO2018112500A1 (en) * | 2016-12-20 | 2018-06-28 | Sangui Bio Pty. Ltd | Blood profiling with protease inhibitors |
| WO2022192446A1 (en) * | 2021-03-10 | 2022-09-15 | Terasaki Institute For Biomedical Innovation | Production of heme for cell-based meat products |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5858358A (en) * | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| FR2778851A1 (fr) * | 1998-05-19 | 1999-11-26 | Aetsrn | Composition a base d'inhibiteurs de cysteine-proteases pour retarder la senescence, l'autodestruction et l'hemolyse des erythrocytes |
| US20120195869A1 (en) * | 1999-08-30 | 2012-08-02 | Terman David S | Sickled Erythrocytes with Anti-tumor Agents Induce Tumor Vaso-occlusion and Tumoricidal Effects |
| WO2013045885A1 (en) * | 2011-09-28 | 2013-04-04 | St George's Hospital Medical School | Treatment for mitrochondrial neurogastrointestinal encephalomyopathy (mngie) |
| WO2013139906A1 (en) * | 2012-03-21 | 2013-09-26 | Erytech Pharma | Medicament for the treatment of acute myeloid leukemia (aml) |
| WO2014181309A1 (en) * | 2013-05-10 | 2014-11-13 | Erydel S.P.A. | Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes |
| WO2015156586A1 (ko) * | 2014-04-07 | 2015-10-15 | 한양대학교 산학협력단 | 적혈구계 세포의 인 비트로 확장 |
Family Cites Families (26)
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| US4931276A (en) | 1987-10-30 | 1990-06-05 | Franco Robert S | Method for introducing desired agents into red blood cells |
| WO1992005801A1 (en) | 1990-10-04 | 1992-04-16 | University Of Virginia Alumni Patents Foundation | Primate erythrocyte bound monoclonal antibody heteropolymers |
| MXPA03000765A (es) * | 2000-07-24 | 2004-05-21 | Gendel Ltd | Suministro de polipeptido il-2. |
| PT1495328E (pt) | 2002-04-16 | 2014-09-09 | Vlaams Interuniv Inst Biotech | Um marcador para medir cirrose hepática |
| GB0325483D0 (en) | 2003-10-31 | 2003-12-03 | Plasmacute As | Assay |
| US20080095749A1 (en) * | 2004-03-22 | 2008-04-24 | Sudeepta Aggarwal | Mesenchymal stem cells and uses therefor |
| US7378054B2 (en) | 2004-04-16 | 2008-05-27 | Savvipharm Inc | Specimen collecting, processing and analytical assembly |
| US20060166223A1 (en) | 2005-01-26 | 2006-07-27 | Reed Michael W | DNA purification and analysis on nanoengineered surfaces |
| WO2006123253A2 (en) | 2005-03-29 | 2006-11-23 | Inverness Medical Switzerland Gmbh | Device and method of monitoring a patient |
| US20100184049A1 (en) | 2007-04-27 | 2010-07-22 | Steve Goodison | Glycoprotein Profiling of Bladder Cancer |
| FR2919804B1 (fr) * | 2007-08-08 | 2010-08-27 | Erytech Pharma | Composition et vaccin therapeutique anti-tumoral |
| US20110245092A1 (en) | 2008-03-04 | 2011-10-06 | John Bilello | Diagnosing and monitoring depression disorders based on multiple serum biomarker panels |
| CA3150872A1 (en) * | 2008-05-06 | 2009-11-12 | Astellas Institute For Regenerative Medicine | Methods for producing enucleated erythroid cells derived from pluripotent stem cells |
| WO2010147621A1 (en) | 2009-06-16 | 2010-12-23 | The Trustees Of Columbia University In The City Of New York | Methods for ameliorating adverse effects associated with transfusion of aged red blood cells |
| CN102472744B (zh) | 2009-08-13 | 2015-11-25 | 巴斯夫欧洲公司 | 诊断甲状腺疾病的手段和方法 |
| WO2011091154A2 (en) * | 2010-01-21 | 2011-07-28 | The Regents Of The University Of California | Use of human erythrocytes for prevention and treatment of cancer dissemination and growth |
| WO2011127056A2 (en) | 2010-04-05 | 2011-10-13 | The Uab Research Foundation | Biomarkers for assessing exposure to ionizing radiation and absorbed dose |
| SG195180A1 (en) | 2011-05-31 | 2013-12-30 | Singapore Health Serv Pte Ltd | Method for detecting disease biomarkers |
| BR112013032659B1 (pt) * | 2011-07-06 | 2021-04-06 | Histocell S.L. | Método para o tratamento de células-tronco mesenquimais, que compreende a obtenção e o isolamento das células-tronco mesenquimais e a cultura das células em um meio de tratamento; e uso das células |
| HU230341B1 (hu) * | 2012-04-20 | 2016-02-29 | Advancell Diagnosztika Kft. | A vörösvérsejt-membrán kvantitatív biomarkerei |
| JP6329537B2 (ja) | 2012-07-11 | 2018-05-23 | サンガモ セラピューティクス, インコーポレイテッド | 生物学的薬剤の送達のための方法および組成物 |
| US10272115B2 (en) * | 2013-03-11 | 2019-04-30 | Taiga Biotechnologies, Inc. | Production and use of red blood cells |
| JP6383920B2 (ja) | 2013-09-11 | 2018-09-05 | 有限会社ピコデバイス | パーキンソン病の判定基準とする方法 |
| CN107735095B (zh) * | 2015-05-18 | 2022-06-14 | 希玛奈克斯特股份有限公司 | 储存全血的方法及其组合物 |
| CN114019171A (zh) | 2015-10-07 | 2022-02-08 | 善威生物私人有限公司 | 血液制备和图谱分析 |
| WO2018112500A1 (en) | 2016-12-20 | 2018-06-28 | Sangui Bio Pty. Ltd | Blood profiling with protease inhibitors |
-
2016
- 2016-12-22 CN CN201680082308.2A patent/CN108883133A/zh active Pending
- 2016-12-22 EP EP16876988.3A patent/EP3393482A4/en not_active Withdrawn
- 2016-12-22 KR KR1020187020347A patent/KR20180102096A/ko not_active Ceased
- 2016-12-22 CA CA3009369A patent/CA3009369A1/en active Pending
- 2016-12-22 WO PCT/AU2016/000404 patent/WO2017106899A2/en not_active Ceased
- 2016-12-22 AU AU2016374643A patent/AU2016374643B2/en active Active
- 2016-12-22 JP JP2018532777A patent/JP2018538343A/ja active Pending
- 2016-12-22 SG SG11201805052YA patent/SG11201805052YA/en unknown
- 2016-12-22 US US16/064,973 patent/US11564948B2/en active Active
-
2021
- 2021-07-01 JP JP2021109883A patent/JP2021155454A/ja active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5858358A (en) * | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| FR2778851A1 (fr) * | 1998-05-19 | 1999-11-26 | Aetsrn | Composition a base d'inhibiteurs de cysteine-proteases pour retarder la senescence, l'autodestruction et l'hemolyse des erythrocytes |
| US20120195869A1 (en) * | 1999-08-30 | 2012-08-02 | Terman David S | Sickled Erythrocytes with Anti-tumor Agents Induce Tumor Vaso-occlusion and Tumoricidal Effects |
| WO2013045885A1 (en) * | 2011-09-28 | 2013-04-04 | St George's Hospital Medical School | Treatment for mitrochondrial neurogastrointestinal encephalomyopathy (mngie) |
| WO2013139906A1 (en) * | 2012-03-21 | 2013-09-26 | Erytech Pharma | Medicament for the treatment of acute myeloid leukemia (aml) |
| CN104394884A (zh) * | 2012-03-21 | 2015-03-04 | 爱瑞泰克药物公司 | 用于治疗急性髓细胞白血病(aml)的药剂 |
| WO2014181309A1 (en) * | 2013-05-10 | 2014-11-13 | Erydel S.P.A. | Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes |
| WO2015156586A1 (ko) * | 2014-04-07 | 2015-10-15 | 한양대학교 산학협력단 | 적혈구계 세포의 인 비트로 확장 |
Non-Patent Citations (2)
| Title |
|---|
| ANA MAFALDA FONSECA等: "Red blood cells inhibit activation-induced cell death and oxidative stress in human peripheral blood T lymphocytes", 《BLOOD》 * |
| ANA MAFALDA FONSECA等: "Red blood cells inhibit activation-induced cell death and oxidative stress in human peripheral blood T lymphocytes", 《BLOOD》, vol. 97, no. 10, 15 May 2001 (2001-05-15), pages 3152 - 3160 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016374643B2 (en) | 2023-12-14 |
| KR20180102096A (ko) | 2018-09-14 |
| JP2018538343A (ja) | 2018-12-27 |
| EP3393482A4 (en) | 2019-08-21 |
| SG11201805052YA (en) | 2018-07-30 |
| US20190000884A1 (en) | 2019-01-03 |
| JP2021155454A (ja) | 2021-10-07 |
| WO2017106899A2 (en) | 2017-06-29 |
| EP3393482A2 (en) | 2018-10-31 |
| US11564948B2 (en) | 2023-01-31 |
| AU2016374643A1 (en) | 2018-07-05 |
| WO2017106899A3 (en) | 2017-09-28 |
| CA3009369A1 (en) | 2017-06-29 |
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