CN108785401A - External medicine composition for treating a variety of psoriasis and preparation method - Google Patents
External medicine composition for treating a variety of psoriasis and preparation method Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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Abstract
A kind of external medicine composition for treating a variety of psoriasis, it is made of medicine materials such as aconiti preparata,radix, wild aconite root, stir-baked SQUAMA MANITIS, scorpio, centipede, Moschus.Ointment can be made.It is suitable for being adapted to psoriasis vulgaris, psoriasis pustulosa, erythrodermic psoriasis using drug of the present invention, permeability is strong, quick, curative effect is stablized, toxic side effect is small, 30% for the treatment of cost less than conventional therapy, and treatment is easy to operate, convenient for nursing, medication one week takes effect, and the general course for the treatment of one is January to a year and a half, and total effective rate is up to 100%, cure rate 99.07% realizes radical cure effect after recovery from illness.
Description
Technical field
It is especially a kind of for treating a variety of silver bits the present invention relates to composition and preparation method that a kind of Chinese medicine is raw material
The external medicine composition and preparation method of disease.
Background technology
Psoriasis is commonly called as psoriasis, is a kind of chronic inflammatory skin, and the course of disease is longer, there is easy tendency of recurrence.With epidermis
It is proliferated the erythroderma desquamativum being characterized, divides homeliness type, pustule type, erythrodermic, four kinds of arthropathica, clinically again
It is the most common with homeliness type.Think that its morbidity may be related with heredity, infection, allergy, dysbolism and autoimmunity.It should
The course of disease is long, recurrent exerbation, is not easy to effect a radical cure.Clinical manifestation is with erythema, and based on the scales of skin that peel off, whole body can fall ill, and with scalp, four limbs are stretched
Side is relatively conventional, mostly aggravates in winter.
The current therapeutic effect of doctor trained in Western medicine is simultaneously unsatisfactory, be primarily due to it is many treatment psoriasis drugs have it is serious
Toxic side effect, and drug resistance is also easy to produce after long-term treatment.Once have and report the case that proposition Keyin pills cause serious liver damage, and skin
Though it is effective that matter steroid hormone and immunosuppressor are applied to treatment psoriasis, serious hormone dependant and immune system
The side effect of aspect also needs to seek improved method.
Chinese medicine psoriasis is referred to as white lump,《Yizong Jinjian sunset section's heart method》Described in：" white arrange shaped like rash scabies, Se Bai and
How unhappy itch, Gu by ailment said due to cold or exposure visitor's skin, it is also dry hard to tolerate outer by blood ".《Surgery card controls pandect》Day：" to lump (a lump wind), skin
Skin is dry to itch, and plays such as rash scabies and color is white, bits scratched, is gradually splited open to limbs are uninteresting, blood goes out pain ".Traditional Chinese medicine thinks the shape of the disease
Flourishing at polyphyly noxious heat in the blood system, life is dry humorously, caused by failure of skin and muscle to be nourished.Blood-deficiency and wind-dry is the Important cause of disease interpretation of the cause, onset and process of an illness of psoriasis.It is existing
There are many psoriasis external application Chinese medicine formula is treated in document, there is different therapeutic effects, but have no can and Zhiduo County's kind psoriasis
Report, easily the problem of recurrence do not solve yet.Be badly in need of at present it is a kind of can and Zhiduo County kind psoriasis and reach radical cure effect external application in
Drug composition.
Invention content
The purpose of the present invention is to provide a kind of external medicine compositions for treating a variety of psoriasis.
Idicatio：It is adapted to psoriasis vulgaris, psoriasis pustulosa, erythrodermic psoriasis.
Diagnostic criteria：
（1）Psoriasis vulgaris：Occur the erythema that the clear, shape size of boundary differs at skin lesion, around has inflammatory blush, slightly
Infiltration thickens, and surface covers the multilayer silvery white scales of skin that peel off, and the scales of skin that peel off is easy to scrape de-, and light red shinny semitransparent thin film, scratches after scraping
The visible small blutpunkte of film.
（2）Psoriasis pustulosa：This type is fallen ill drastically, has general malaise and with constitutional symptoms such as tension and relaxation high fevers and in vain
Cytosis.Initial skin lesion is acute inflammation erythema, and surface has most intensive syringe needles to the grain grain sterile superficial of size yellow-white
Pimple, Chang Kekuo prolong whole body.
（3）Erythrodermic psoriasis：There is flush at original psoriatic lesion position in this disease early stage, a large amount of furfurs, rapidly
Sheet is prolonged into expansion, and whole body, which is finally presented, diffuses sexflush infiltration, often there is that sheet is normal " skin island ", the heat that often occurs together, chilly, headache,
General malaise etc..
A kind of external medicine composition for treating a variety of psoriasis, it is by active ingredient or active ingredient and pharmacy
Upper acceptable carrier composition, it is characterised in that the active ingredient is made of the raw material of following weight proportion：Aconiti preparata,radix 40-
60 parts, 40-60 parts of wild aconite root, 30 parts of stir-baked SQUAMA MANITIS 15-, 15-30 parts of scorpio, 15-30 parts of centipede, 15-25 parts of Moschus.
The pathogensis of psoriasis is more complicated, and industry is it is generally accepted that inherent cause and environmental factor are coefficient at present
As a result.Traditional Chinese medicine thinks that the formation polyphyly noxious heat in the blood system of the disease is flourishing, and life is dry humorously, caused by failure of skin and muscle to be nourished.The present invention is to pass through
Detoxification, cool blood moisturize and reach therapeutic purposes.
Aconiti preparata,radix：Major function:Dispelling wind and eliminating dampness, antalgic.For wind-cold-dampness arthralgia, arthralgia, trusted subordinate's crymodynia, cold hernia
Have a pain, narcotic analgesic.There is anti-inflammatory efficacy.
Wild aconite root：With dispelling wind and eliminating dampness, the effect of antalgic, for treating wind-cold-dampness arthralgia, arthralgia, Xin Fuling
Bitterly, cold hernia relieves pain.Mostly external application, for example apply, wash, steep.《Compendium of Materia Medica》It records：Control intermittent headache larynx numbness, carbuncle swells serious case of furuncle.
Stir-baked SQUAMA MANITIS：Cold nature.Effect：Detumescence suppuration, scattered silt dredging collateral, promoting menstruation, lower breast, invigorating blood circulation analgesia.It cures mainly：Ulcer sore
Swollen, wind-cold-dampness arthralgia, Amenorrhea, alactation, hemostasis, the accumulation of disease scab.It can external application.There is anti-inflammatory effect.
Scorpio：Nature and flavor are pungent flat, return liver warp.Ceases wind antispastic, removes obstruction in channels to relieve pain, dispersing pathogen accumulation.It cures mainly：Liver wind agitation, spasm are taken out
It jerks, child convulsion, middle air port, hemiplegia, lockjaw, rheumatoid arthritis stubborn, migraine and general headache, sore, scrofula.
Centipede：Property and flavor of peppery and warm, return liver warp.Effect：Ceases wind antispastic, removes obstruction in channels to relieve pain, dispersing pathogen accumulation.It cures mainly：Liver wind agitation, convulsion
Contraction is twitched, child convulsion, hemiplegia, lockjaw, rheumatoid arthritis stubborn, migraine and general headache, sore, scrofula, snakebite and bugbite.
Moschus：It cures mainly：Have one's ideas straightened out, ward off dirty, dredging collateral, dissipates the stasis of blood.Control apoplexy, coma due to blocking of the respiratory system, frightened epilepsy, middle evil unhappiness, trusted subordinate sudden and violent pain, abdominal mass
The hypochondriac lump, traumatic injury, swollen ulcer drug.There is antimicrobial antiphlogistic effect.
Fang Zhong：Aconiti preparata,radix has detoxification, windproof exsiccation；Wild aconite root promoting blood circulation, cold dispelling, promoting menstruation；Stir-baked SQUAMA MANITIS promoting menstruation；Scorpio helps
Toxin expelling；Centipede toxin expelling is subsided a swelling；Moschus heat dissipation cooling blood, expelling wind.6 taste medicines of full side, all medicines share search the heresy for picking channels and collaterals, and the detoxification that gathers altogether removes
Wet, cooling blood, expelling wind, enriching the blood to restore normal menstruation work(.Modern pharmacological research shows that aconiti preparata,radix, stir-baked SQUAMA MANITIS, centipede, Moschus have antimicrobial antiphlogistic town
Pain acts on, and has different degrees of inhibiting effect to multiple pathogenic microorganisms, therefore has repair to skin.
Our compatibility is comprehensive, promoting blood circulation and removing obstruction in channels, all medicines totally 5, treating both manifestation and root cause of disease, and blood wind of living is made to go, and skin must moisten, blood vessels circulation,
Dryness evil must be exempted from, and itch ceases certainly.The effect of fundamentally having reached healing psoriasis.We are to normal psoriasis pustulosa, pustule type simultaneously
A variety of psoriasis such as psoriasis, erythrodermic have therapeutic effect, can be used for a plurality of types of psoriasis.
Ointment can be made in drug of the present invention, and the ointment of drug of the present invention is that soybean oil, soybean oil is used to pass through baking
Roasting method is made.Baking prepares soybean oil, and oil yield about 20% can increase since soybean oil has detoxification to a variety of sore scabies poison stasis of bloods
The effect of strong drug of the present invention.
A kind of preparation method for treating the external medicine composition of a variety of psoriasis includes the following steps：
1, it stocks up：A, it takes the drug dry product of above-mentioned weight proportion to clean respectively, is ground into smalls, be uniformly mixed；B, legal system is toasted
Standby soybean oil：Soybean is set in silo, and small fire to moderate heat heated baking continues to can be prepared by within 4 to 5 hours black soybean oil；C, it takes
Appropriate soybean oil is spare；2, mixed preparing：Soybean oil is slowly added into the container for being equipped with drug, paste is stirred into, it is small
Bottle packing.
The ointment application method of drug of the present invention：Affected part is first cleaned, ointment is applied to affected part, applies once daily, makes oil
Cream acts on affected part epidermal tissue, and detoxification promoting blood circulation promotes local blood network unimpeded, promotes illing skin metabolism, promotes epidermis
Regeneration.Every 3-5 days, affected part is washed with warm water, epidermis is peeled one layer, after affected part aqueous vapor is dried, embrocates ointment again.Such as
This is operated repeatedly.
Course for the treatment of situation after the ointment use of drug of the present invention is January to 1 year and a half.Patients with mild, the medication 1-2 months can fully recover from an illness
More；Moderate patient is general, and the 5-6 months can fully recover, and severe patient can fully recover for 1 year or so.Skin at lesions of patients is by repeatedly decortication
Regeneration, skin are gradually repaired, and curative effect is finally reached.
Since 2006, inventor constantly explores, and to hundreds of Chinese medicine experiment screening repeatedly, develops the medicine of the present invention
Object is adapted to common, pustular, psoriatic exfoliative dermatitis.Synergistic effect, production are played between the 6 hyte medicines of this prescription
Unexpected original effect is given birth to, effect, which is not the simple superposition of the respective effect of 6 drugs, to be reached.Medicine of the present invention
Object shows its original effect, has permeability strong, quick, and curative effect is stablized, and toxic side effect is small, and medical expense is low, expense
No more than the 30% of conventional therapy, treatment is easy to operate, convenient for nursing.In August, 2006 in July, 2018 is total to admitted patient 215
People, course for the treatment of January to 1 year and a half, wherein：Fully recover 213 people, cure rate 99.07%, 100 % of total effective rate, and the patient of recovery from illness is so far not
See that an example recurs, radical cure effect is realized after recovery from illness.Inventor was through clinical practice in 11 years, in the patient in circumference nearly hundred
With very high reputation, at least tens of patients come to go to a doctor every year now.
Criterion of therapeutical effect and related treatment statistics are as follows：
Criterion of therapeutical effect
（1）Recovery from illness：Skin lesion is subsided completely, or 95% or more recession.
（2）Effectively：50% or more skin lesion recession.
（3）In vain：Skin lesion recession is less than 50%, and symptom is without significant change.
Therapeutic effect situation counts
Model case
Case one, female, 50 years old, liberal profession, firmly areas Sichuan Province's Guangyuan City Li Zhou.Patient feels scalp from June, 1986 is set forth in
It itches, is found after a few days on scalp and white scab successively occurs in right leg, oneself looked for a variety of medicines to smear, do not improved.1994
March in year is diagnosed as psoriasis vulgaris through Guangyuan City Hospital of Chinese Medicine, is treated using a variety of Chinese and western drugs, and medication improves, end-of-dose failure,
Lasting for years.It arrives the big West China Hospital diagnosis and treatment in Chengdu river within 2006, recurs shortly after.Go within 2008 association of China hospital therapy, takes silver
It considers to be worth doing capsule half a year, body surface major part scab disappears, but back has the scab of one piece of diameter about 5cm sizes to have no disappearance always.
Tetra- recurrences of 2012-2015, whole body body surface is covered with scab when serious, arrives 410 Hospital of Guangyuan City and Guangyuan City Chinese medicine repeatedly
Institute is medical, makees light exposure treatment, applies plaster, and spray powder, does not cure, multiple relapse.Doctor informs that this disease can not effect a radical cure.At that time
There is the idea made light of one's life by commiting suicide.Until in April, 2017 is to this clinics, looks into and see that whole body body surface is covered with scab, scab color is greyish black, patient
It is apathetic, it is diagnosed as psoriasis vulgaris, it is primary that prescription with drug of the present invention embrocates affected part daily, and trouble is washed every 3-5 days warm water
Place, dries aqueous vapor and embrocates ointment again, operate repeatedly after washing.It is clearly better after two weeks, after four months, four limbs and thorax abdomen
Scab successively disappears, and continuous medication is after 1 year, body surface scab（Including back stubbornness scab）It completely disappears, when with carrying out here first visit
It becomes quite a different person, energetic, recovery from illness.Follow-up so far there are no recurrence.
Case two, man, 28 years old, liberal profession, firmly seven groups of the towns Bao Lun villages Hui Long of the areas Sichuan Province's Guangyuan City Li Zhou.Patient's readme
In in June, 2012 chest there is tinea spot, it is medical to arrive the towns Bao Lun central hospital immediately, is diagnosed as psoriasis, and medication two months is without good
Turn, scab spreads to four limbs.Treatment half a year had a surplus, did not took effect, sick to Guangyuan City West China dept. of dermatology hospital admission in January, 2013
Spot continues to spread to trunk and head, influences normal life.In April, 2015 carrys out this clinic first visit, sees that patient is several in addition to face
Whole body gathers scab, and scab is red.It is diagnosed as erythrodermic psoriasis.Prescription embrocates affected part one daily with drug of the present invention
It is secondary, it after 3-5 days warm water is washed affected part, washed dries aqueous vapor and embrocates ointment again, operate repeatedly.It is clearly better after two weeks.One
Further consultation after month, whole body tinea skin repeatedly fall off, and advise continuation medication.Continuous medication 5 months, body surface scab completely disappear, recovery from illness.Follow-up
Recurrence that so far there are no.
Case three, man, 28 years old, is engaged in agriculture, lives the areas Guangyuan City Li Zhou interwined dragon town.Patient's readme is beaten in March, 2016 in Zhejiang
Work finds that hickie occurs in calf, and itch checks in Jiaxing the People's Hospital and is diagnosed as psoriasis, treats several courses for the treatment of and do not get better
Turn.2 months 2017 to three courses for the treatment of of Shanghai Fudan University hospitalize, it is also of no avail.Scab is spread from leg to trunk.2017
July 7 in year goes to here first visit, sees that body surface is almost covered with scab, leg scab is slightly thick, is diagnosed as psoriasis vulgaris.Prescription is to locate
It is primary that affected part with drug of the present invention is embrocated daily by side, dries aqueous vapor after 3-5 days warm water is washed affected part, washed and embrocates ointment again, such as
This is operated repeatedly.Further consultation after January, patient tell medication after a week, and peeling at scab renews, and examines and sees that four limbs scab disappears substantially, advises
Continue medication.On October 14th, 2017, patient carry out clinic check, and body surface scab is without trace, recovery from illness.So far there are no for follow-up again
Hair.
Case four, female, 16 years old, student, firmly Shaanxi Province Ningqiang County county town.Patient's readme in May, 2016 is in the Hanzhong City people
Hospital is diagnosed as psoriasis, and treatment take a favorable turn January, short-term to recur.Successively Chengdu West China medical university and Shanghai large hospital is gone to seek medical advice,
Several courses for the treatment of are treated to improve, it is short-term to recur again.January in 2017,7 Nikkei people made referrals to here first visit, saw both legs and back almost cloth
Full scab, there is warts at scab center, is diagnosed as psoriasis pustulosa.It is primary that prescription with drug of the present invention embrocates affected part daily, every
Warm water washes affected part within 3-5 days, and aqueous vapor is dried after washing and embrocates ointment again, is operated repeatedly.Further consultation after January, patient tell medication one
Week sees warts atresia at scab, examines and sees that both legs scab declines, new skin shows, and advises continuation medication.On April 14th, 2017,
Patient carrys out clinic check, and body surface scab completely disappears, and fully recovers.Follow-up so far there are no recurrence.
Specific implementation mode
Embodiment 1
It is a kind of for treating bald external medicine composition, it be by active ingredient or active ingredient with it is pharmaceutically acceptable
Carrier forms, it is characterised in that the active ingredient is made of the raw material of following weight proportion：
40 parts of aconiti preparata,radix, 40 parts of wild aconite root, 15 parts of stir-baked SQUAMA MANITIS, 15 parts of scorpio, 15 parts of centipede, 15 parts of Moschus.
Ointment is made as follows, includes the following steps：
1, it stocks up：A, it takes the drug dry product of above-mentioned weight proportion to clean respectively, is ground into smalls, be uniformly mixed；B, legal system is toasted
Standby soybean oil：2.5 kilograms of soybean is set in silo, and small fire to moderate heat heated baking continues to can be prepared by within 4 to 5 hours black soybean
0.5 kilogram of oil；C, take appropriate soybean oil spare；
2, mixed preparing：Soybean oil is slowly added into and is equipped in the container of hybrid medicine obtained by step a, paste is stirred into,
Bottle dispenses.
Embodiment 2
It is a kind of for treating bald external medicine composition, it be by active ingredient or active ingredient with it is pharmaceutically acceptable
Carrier forms, it is characterised in that the active ingredient is made of the raw material of following weight proportion：50 parts of aconiti preparata,radix, wild aconite root
50 parts, 20 parts of stir-baked SQUAMA MANITIS, 20 parts of scorpio, 20 parts of centipede, 20 parts of Moschus；The preparation method is the same as that of Example 1 for ointment.
Claims (3)
1. a kind of for treating the external medicine compositions of a variety of psoriasis, it be by active ingredient or active ingredient with pharmaceutically
Acceptable carrier composition, it is characterised in that the active ingredient is made of the raw material of following weight proportion：Aconiti preparata,radix 40-60
Part, 40-60 parts of wild aconite root, 30 parts of stir-baked SQUAMA MANITIS 15-, 15-30 parts of scorpio,
15-30 parts of centipede, 15-25 parts of Moschus.
2. a kind of external medicine composition for treating a variety of psoriasis according to claim 1, it is characterised in that：It
It is ointment, the ointment is prepared using soybean oil.
3. a kind of preparation method for treating the external medicine composition of a variety of psoriasis includes the following steps：
1）Stock：A, it takes the drug dry product of above-mentioned weight proportion to clean respectively, is ground into smalls, be uniformly mixed；B, legal system is toasted
Standby soybean oil：Soybean is set in silo, and small fire to moderate heat heated baking continues to can be prepared by within 4 to 5 hours black soybean oil；C, it takes
Appropriate soybean oil is spare；
2）Mixed preparing：Soybean oil is slowly added into and is equipped in the container of hybrid medicine obtained by step a, paste is stirred into,
Bottle dispenses.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811016008.1A CN108785401A (en) | 2018-09-01 | 2018-09-01 | External medicine composition for treating a variety of psoriasis and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811016008.1A CN108785401A (en) | 2018-09-01 | 2018-09-01 | External medicine composition for treating a variety of psoriasis and preparation method |
Publications (1)
| Publication Number | Publication Date |
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| CN108785401A true CN108785401A (en) | 2018-11-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201811016008.1A Pending CN108785401A (en) | 2018-09-01 | 2018-09-01 | External medicine composition for treating a variety of psoriasis and preparation method |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101057896A (en) * | 2007-02-08 | 2007-10-24 | 郑秀琴 | Traditional Chinese medicinal embrocation for treating psoriasis |
-
2018
- 2018-09-01 CN CN201811016008.1A patent/CN108785401A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101057896A (en) * | 2007-02-08 | 2007-10-24 | 郑秀琴 | Traditional Chinese medicinal embrocation for treating psoriasis |
Non-Patent Citations (2)
| Title |
|---|
| 单书健: "《重订古今名医临证金鉴.皮肤病卷》", 31 August 2017, 中国医药科技出版社 * |
| 彭胜权: "《中医生手册（修订版）》", 31 December 1995, 广东科技出版社 * |
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Application publication date: 20181113 |