CN106540153B

CN106540153B - Traditional Chinese medicine composition containing mulberry leaves and application thereof

Info

Publication number: CN106540153B
Application number: CN201510593769.3A
Authority: CN
Inventors: 郭刚
Original assignee: HEBEI YILING HOSPITAL
Current assignee: HEBEI YILING HOSPITAL
Priority date: 2015-09-17
Filing date: 2015-09-17
Publication date: 2021-03-30
Anticipated expiration: 2035-09-17
Also published as: CN106540153A

Abstract

The invention discloses a mulberry leaf-containing traditional Chinese medicine composition and application thereof, belonging to the field of traditional Chinese medicines, wherein the traditional Chinese medicine composition comprises the following raw materials: mulberry leaf, asiatic pennywort herb, giant knotweed rhizome, weeping forsythia capsule, dittany bark, Indian iphigenia bulb and glabrous greenbrier rhizome. The medicines are reasonably compatible, and can effectively treat scleroderma.

Description

Traditional Chinese medicine composition containing mulberry leaves and application thereof

Technical Field

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a pharmaceutical composition and application thereof.

Background

Scleroderma is a connective tissue disease characterized by inflammation, degeneration, thickening and fibrosis of the skin, which in turn hardens and shrinks, which can cause multiple system damage. In addition to degenerative changes in the skin, synovium, and digital (toe) artery, systemic sclerosis may also involve organs such as digestive tract, lung, heart, and kidney.

For scleroderma, early diagnosis and early treatment are favorable for preventing disease progression, and the principle is blood vessel expansion, fibrosis resistance, immunosuppression and immunoregulation, but no specific medicine is available. (1) Medicine for blood vessel and improving microcirculation. Including aspirin, dipyridamole, etc., which alters platelet function, ketanzenin is a histamine antagonist that reduces the frequency and severity of the onset of raynaud's phenomenon and improves the prognosis of toe ulcers, but is ineffective in improving skin thickening or visceral organ damage. Nitrendipine, a calcium channel blocker, is a potent vasodilator. Angiotensin converting enzyme inhibitors such as Thiopropyl acid and enalapril are effective in controlling hypertension and early renal insufficiency. (2) Glucocorticoids and immunosuppression. The dose of prednisone is decreased after one month for maintenance. Methotrexate and cyclosporin a (csa) have been used in a few human trials, and penicillamine is an immunomodulator and has a certain effect in inhibiting skin sclerosis and visceral damage. For patients with pulmonary interstitial disease, glucocorticoid and CTX can be used to change the disease condition, and tripterygium glycosides and macrolides can relieve symptoms.

Various ointments are also available on the market for external use for scleroderma, but the same ointments as those of the present invention have not been found.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition containing mulberry leaves and application of the traditional Chinese medicine composition in a medicine for treating scleroderma. The formula is reasonable in matching, and can effectively treat scleroderma.

The mulberry leaf-containing traditional Chinese medicine composition comprises the following raw materials in parts by weight: 5-10 parts of mulberry leaf, 15-30 parts of centella, 9-15 parts of giant knotweed, 6-15 parts of weeping forsythia, 5-10 parts of cortex dictamni, 3-9 parts of Indian iphigenia bulb and 15-60 parts of glabrous greenbrier rhizome. Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight:

5 parts of mulberry leaf, 30 parts of asiatic pennywort herb, 15 parts of giant knotweed rhizome, 6 parts of weeping forsythia capsule, 5 parts of dittany bark, 9 parts of Indian iphigenia bulb and 60 parts of glabrous greenbrier rhizome.

Or

10 parts of mulberry leaf, 15 parts of centella, 9 parts of giant knotweed, 15 parts of weeping forsythia, 10 parts of cortex dictamni, 3 parts of Indian iphigenia bulb and 15 parts of glabrous greenbrier rhizome.

Or

8 parts of mulberry leaf, 20 parts of centella, 12 parts of giant knotweed, 10 parts of weeping forsythia, 8 parts of cortex dictamni, 6 parts of Indian iphigenia bulb and 25 parts of glabrous greenbrier rhizome.

Or

6 parts of mulberry leaf, 25 parts of asiatic pennywort herb, 10 parts of giant knotweed rhizome, 12 parts of weeping forsythia capsule, 6 parts of dittany bark, 5 parts of Indian iphigenia bulb and 40 parts of glabrous greenbrier rhizome.

The Chinese medicinal composition is ointment, cream or liniment.

To clarify the effect of the Chinese medicinal composition of the present invention in treating scleroderma, the following tests were carried out using the medicaments prepared in example 1 (hereinafter referred to as the medicaments of the present invention).

1. Clinical data

1.1 case enrollment

60 patients are treated in Bigeling hospital in Hebei, and are randomly divided into a control group and a treatment group, wherein 30 patients in the control group: 15 male patients, 15 female patients, age 13-68 years, average age 40 years, 10 patients with affection of upper limbs, 5 patients with affection of neck, back, waist and abdomen, 9 patients with affection of lower limbs, and 6 patients with Raynaud's phenomenon; the treatment groups consisted of 30 cases: 15 male patients, 15 female patients, 12-67 years old, 41 years old, 9 patients with lesions affected on both upper limbs, 6 patients with affected on the back, waist and abdomen, 7 patients with affected on the lower limbs, 8 patients with Raynaud's phenomenon, and no difference between the two groups of patients.

1.2 diagnostic criteria:

refer to the standard of the Ministry of health, clinical research guidelines for treating systemic scleroderma with new Chinese medicines.

2. Method of producing a composite material

2.1 methods of treatment:

control group: the Hepialin ointment is used for hot compress for 15 minutes, and then the Hepialin ointment is smeared, and the massage is carried out for 15 minutes, three times a day and the use is carried out for one month.

Treatment groups: the medicine of the invention is used for scrubbing the skin and directly applying the skin, three times a day and one month of use.

2.2 therapeutic efficacy assessment criteria

And (3) curing: the symptoms disappear, the skin becomes soft, the pathological changes are basically controlled, and all indexes in a laboratory are detected and recovered to be normal; the effect is shown: the main symptoms disappear, the skin basically becomes soft, most pathological changes are controlled, and most experimental indexes are recovered to be normal;

the method has the following advantages: part of symptoms and signs disappear, the skin basically becomes soft, the pathological change part is controlled, and the experimental index part returns to normal;

and (4) invalidation: all symptoms are not obviously improved.

3. Results

Table 1 comparison of therapeutic effects between groups (example,%)

Compared with the control group, # P < 0.05

As can be seen from the comparison of the curative effect results of the two groups in the table 1, the treatment group and the control group have significant difference in the aspect of total effective rate, wherein P is less than 0.05. The curative effect of the treatment group is obviously better than that of the control group.

The experiments show that the medicine can effectively treat scleroderma, because the mulberry leaves have the effects of dispelling wind and heat, resisting bacteria and diminishing inflammation, and clearing away heat and toxic materials; the asiaticoside can be used for treating skin ulcer, and has good therapeutic effect on dermatoses; giant knotweed can treat rheumatism, arthralgia, carbuncle, swelling and sore; fructus forsythiae has effects of clearing away heat and toxic materials, dispersing pathogenic accumulation, and relieving swelling; cortex Dictamni Radicis has effects of clearing heat, eliminating dampness, dispelling pathogenic wind, relieving itching, and removing toxic substance; pseudobulbus Cremastrae Seu pleiones can be used for treating carbuncle, furuncle, scrofula, subcutaneous nodule, snake and insect bite, and cripple; the glabrous greenbrier rhizome has the effects of detoxifying, dehumidifying and joint movement smoothing, and the medicines are reasonable in compatibility and can effectively treat scleroderma.

Detailed Description

Example 1:

50g of mulberry leaf, 300g of centella, 150g of giant knotweed, 60g of weeping forsythia, 50g of cortex dictamni, 90g of Indian iphigenia bulb and 600g of glabrous greenbrier rhizome.

Making into ointment according to conventional method.

Example 2:

100g of mulberry leaf, 150g of centella, 90g of giant knotweed, 150g of weeping forsythia, 100g of cortex dictamni, 30g of Indian iphigenia bulb and 150g of glabrous greenbrier rhizome.

Making into cream according to conventional method.

Example 3:

80g of mulberry leaf, 200g of centella asiatica, 120g of giant knotweed rhizome, 100g of weeping forsythia, 80g of cortex dictamni, 60g of Indian iphigenia bulb and 250g of glabrous greenbrier rhizome.

Making into liniment by conventional method.

Example 4:

60g of mulberry leaf, 250g of asiatic centella, 100g of giant knotweed, 120g of weeping forsythia, 60g of cortex dictamni, 50g of Indian iphigenia bulb and 400g of glabrous greenbrier rhizome.

Making into ointment according to conventional method.

Claims

1. A traditional Chinese medicine composition containing mulberry leaves is characterized in that the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 5-10 parts of mulberry leaf, 15-30 parts of centella, 9-15 parts of giant knotweed, 6-15 parts of weeping forsythia, 5-10 parts of cortex dictamni, 3-9 parts of Indian iphigenia bulb and 15-60 parts of glabrous greenbrier rhizome.

2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight:

3. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight:

4. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight:

5. The traditional Chinese medicine composition according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight:

6. The Chinese medicinal composition according to any one of claims 1 to 5, wherein the Chinese medicinal composition is an ointment, a cream or a liniment.

7. The Chinese medicinal composition according to any one of claims 1 to 5, wherein the Chinese medicinal composition is used for preparing a medicament for treating scleroderma.