CN105079215A - Medicine composition for treating diabetic foot ulcer - Google Patents
Medicine composition for treating diabetic foot ulcer Download PDFInfo
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- CN105079215A CN105079215A CN201510645783.3A CN201510645783A CN105079215A CN 105079215 A CN105079215 A CN 105079215A CN 201510645783 A CN201510645783 A CN 201510645783A CN 105079215 A CN105079215 A CN 105079215A
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Abstract
The invention belongs to the technical field of medicines, and particularly relates to a medicine composition for treating diabetic foot ulcer. The medicine composition comprises the following components: honeysuckle, Chinese angelica, radix platycodonis, polygonum multiflorum, radix bupleuri, mint, herba schizonepetae, radix paeoniae alba, cortex phellodendri and radix glycyrrhizae. The medicine composition is reasonable in prescription, simple in preparation process, convenient to use, obvious in curative effect and free of toxic and side effects, and is an effective medicine for treating diabetic foot ulcer.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of pharmaceutical composition for the treatment of diabetic foot ulcer.
Background technology
Diabetic foot ulcer is that the lower limb caused due to the blood capillary of diabetics and Peripheral neuropathy and the various pathological changes of peripheral vessel in various degree infect, the destruction of ulcer and/or deep tissue, and severe patient acra can gangrene, even may amputation.
According to the principle of classification of Wagner, the clinical scale of diabetic foot is 6 grades.0 grade has the foot that ulcer of foot risk factor occurs, at present without ulcer.1 grade of superficial ulcer, clinically without infection.2 grades of darker ulcer, often merge soft tissue inflammation (cellulitis), without the infection of abscess or bone.3 grades of degree of depth infect, with osseous tissue pathological changes or abscess.4 grades of circumscribed gangrenes (toe, heel or front instep).5 grades all gangrenous.
Diabetic foot drafts typing standard mesh according to " tcm syndrome Differential Diagnosis " " new Chinese medicine guideline of clinical investigations " (trying), be divided into blood stasis to hinder network type, the wet stasis of blood makes malicious type, body exogenous pathogen love type, wherein the wet stasis of blood makes malicious type: foot ulceration, wound surface has a large amount of yellow pus or pus tongue, and slough does not take off, all rednesses of skin ulcer or dark red tenderness, bitter taste, xerostomia is wish drink not, red tongue or dark red, yellow and greasy fur. slippery and rapid pulse or stringy and rapid pulse.
Along with the theoretical level of Chinese medicine in recent years improves constantly, clinical experience is enriched constantly, more and more demonstrates the advantage of its uniqueness, has the effect that Western medicine is incomparable.Chinese traditional treatment can reach treating both the principal and secondary aspects of a disease and the little therapeutic effect of side effect, is worth research further also to be applied in clinical.
Summary of the invention
The invention provides one, to have prescription rigorous, and compatibility science is evident in efficacy, can play curative effect of medication to greatest extent, and easy to prepare, and patient compliance is good, the pharmaceutical composition of the treatment diabetic foot ulcer had no side effect.
For achieving the above object, technical scheme provided by the invention is the pharmaceutical composition of described treatment diabetic foot ulcer, it is characterized in that the weight portion of described pharmaceutical composition primary raw material medicine consists of: Flos Lonicerae 10-14 part, Radix Angelicae Sinensis 8-10 part, Radix Platycodonis 10-12 part, Radix Polygoni Multiflori 8-10 part, Radix Bupleuri 10-12 part, Herba Menthae 6-8 part, Herba Schizonepetae 10-12 part, Radix Paeoniae Alba 10-12 part, Cortex Phellodendri 8-10 part, Radix Glycyrrhizae 3-5 part.
Most preferred technique scheme of the present invention is that pharmaceutical composition of the present invention is obtained by the material medicine of following weight portion: Flos Lonicerae 12 parts, Radix Angelicae Sinensis 9 parts, Radix Platycodonis 11 parts, Radix Polygoni Multiflori 9 parts, Radix Bupleuri 11 parts, Herba Menthae 7 parts, Herba Schizonepetae 11 parts, the Radix Paeoniae Alba 11 parts, Cortex Phellodendri 9 parts, 4 parts, Radix Glycyrrhizae.
The dosage form of aforementioned pharmaceutical compositions is Chinese medicine for external application.
Above-mentioned external preparation is unguentum or water preparation.
Containing white vaseline, glyceryl monostearate and stearic acid in above-mentioned unguentum.
The preparation method step of above-mentioned unguentum is as follows: first, extracting honeysuckle, Radix Angelicae Sinensis, Radix Platycodonis, Radix Polygoni Multiflori, Radix Bupleuri, Herba Menthae, Herba Schizonepetae, the Radix Paeoniae Alba, Cortex Phellodendri, Radix Glycyrrhizae powder are broken into coarse powder, the alcoholic solution that volumetric concentration is 75% is added according to 6 times of coarse powder gross weight, reflux, extract, three times, return time is 3h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Next adds white vaseline, glyceryl monostearate, stearic acid and distilled water and makes unguentum.
The present invention, relative to prior art, has following clear superiority:
First, pharmaceutical composition prescription of the present invention mainly develops according to the pathogenic characteristic of diabetic foot ulcer patient, there is clearing heat and expelling damp, enrich blood invigorate blood circulation, the remarkable efficacy of removing toxic substances and promoting pus discharge, putrefaction removing and tissue regeneration promoting.Pharmaceutical composition reasonable recipe of the present invention, has extremely strong specific aim curative effect to diabetic foot ulcer.Through clinical practice checking, its determined curative effect, mild in medicine property and, have no side effect and untoward reaction, safety coefficient is high.Chinese medicine preparation of the present invention adopts advanced extraction equipment and technique, abundant effective component extracting, can be made into Chinese medicine preparation easy to use.
Further, in pharmaceutical composition of the present invention, the function of each crude drug cures mainly:
Flos Lonicerae, sweet, cold.Return lung, the heart, stomach warp.Heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.
Radix Angelicae Sinensis, sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Radix Platycodonis, bitter, pungent, flat.Return lung meridian.Lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
Radix Polygoni Multiflori, bitter, sweet, puckery, temperature.Return liver, the heart, kidney channel.Removing toxic substances, eliminating carbuncle, loosening bowel to relieve constipation.For scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; Hyperlipidemia.
Radix Bupleuri, bitter, be slightly cold.Return liver, gallbladder meridian.Reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.
Herba Menthae, pungent, cool.Return lung, Liver Channel.Dispelling wind-heat.Refresh oneself, rash.For anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, breast the side of body feeling of distension and oppression.
Herba Schizonepetae, pungent, tepor.Return lung, Liver Channel.Induce sweat loose wind, rash.For flu, headache, measles, rubella, skin infection from the beginning of.Parch to black treating hematochezia, metrorrhagia, puerperal blood faints.
The Radix Paeoniae Alba, bitter, sour, be slightly cold.Return liver, spleen channel.Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Cortex Phellodendri, bitter, cold.Return kidney, urinary bladder channel.Heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity { is warded off }, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.
Radix Glycyrrhizae, sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
The present invention also asks the purposes protecting aforementioned pharmaceutical compositions in the medicine of preparation treatment diabetic foot ulcer.In clinical observation process, 150 routine diabetic foot ulcer patients use medicine composite for curing of the present invention, and symptom can significantly improve in a short time, total effective rate 94%.And body weight, heart rate, blood pressure, hepatic and renal function are showed no obvious change before and after treatment, in whole therapeutic process, do not find allergy and obvious adverse events.Clinical effectiveness shows that the clinical application of we is safely and effectively, is worth studying and applying further.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but the present invention is not limited only to following specific embodiment.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1 unguentum
The each raw material of the present invention is taken: Flos Lonicerae 12 parts, Radix Angelicae Sinensis 9 parts, Radix Platycodonis 11 parts, Radix Polygoni Multiflori 9 parts, Radix Bupleuri 11 parts, Herba Menthae 7 parts, Herba Schizonepetae 11 parts, the Radix Paeoniae Alba 11 parts, Cortex Phellodendri 9 parts, 4 parts, Radix Glycyrrhizae by following weight.
Preparation technology is as follows:
First, extracting honeysuckle, Radix Angelicae Sinensis, Radix Platycodonis, Radix Polygoni Multiflori, Radix Bupleuri, Herba Menthae, Herba Schizonepetae, the Radix Paeoniae Alba, Cortex Phellodendri, Radix Glycyrrhizae powder are broken into coarse powder, the alcoholic solution that volumetric concentration is 75% is added according to 6 times of coarse powder gross weight, reflux, extract, three times, return time is 3h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Next adds white vaseline, glyceryl monostearate, stearic acid and distilled water and makes unguentum.
When using medicine composite for curing diabetic foot ulcer of the present invention, use prepared unguentum, often prop up 10g containing crude drug amount 5g, every day 3 times, dispenser thickness 0.1-0.2cm.
Embodiment 2 unguentum
The each raw material of the present invention is taken: Flos Lonicerae 12 parts, Radix Angelicae Sinensis 9 parts, Radix Polygoni Multiflori 9 parts, Radix Bupleuri 11 parts, Herba Menthae 7 parts, Herba Schizonepetae 11 parts, Cortex Phellodendri 9 parts, 4 parts, Radix Glycyrrhizae by following weight proportion.
Preparation technology is as such as embodiment 1.
Embodiment 3 unguentum
The each raw material of the present invention is taken: Flos Lonicerae 10 parts, Radix Angelicae Sinensis 8 parts, Radix Platycodonis 10 parts, Radix Polygoni Multiflori 8 parts, Radix Bupleuri 10 parts, Herba Menthae 6 parts, Herba Schizonepetae 10 parts, the Radix Paeoniae Alba 10 parts, Cortex Phellodendri 8 parts, 3 parts, Radix Glycyrrhizae by following weight proportion.
Preparation technology is as such as embodiment 1.
Embodiment 4 unguentum
The each raw material of the present invention is taken: Flos Lonicerae 14 parts, Radix Angelicae Sinensis 10 parts, Radix Platycodonis 12 parts, Radix Polygoni Multiflori 10 parts, Radix Bupleuri 12 parts, Herba Menthae 8 parts, Herba Schizonepetae 12 parts, the Radix Paeoniae Alba 12 parts, Cortex Phellodendri 10 parts, 5 parts, Radix Glycyrrhizae by following weight proportion.
Preparation technology is as embodiment 1.
The clinical observation of embodiment 5 medicine composite for curing diabetic foot ulcer of the present invention
1, case selection:
Select hospital and the outpatient service stasis of blood that wets to make malicious patients with type Ⅰ DM ulcer of foot patient 150 example, be divided into observation group and contrast a, b group at random, often organize 50 examples.
Wherein observation group male 28 example, women 22 example, 42.6 ~ 78.2 years old age, 54.8 years old mean age; The diabetic foot ulcer course of disease: 8d-10w, average 6.5 ± 1.8w; Wherein 2 grade of 16 example, 3 grade of 19 example, 4 grade of 15 example.Contrast a group male 27 example, women 23 example, 43.8 ~ 76.4 years old age, 55.8 years old mean age; The diabetic foot ulcer course of disease: 9d-10w, average 6.2 ± 1.5w; Wherein 2 grade of 17 example, 3 grade of 18 example, 4 grade of 15 example.Contrast b group male 27 example, women 23 example, 46.8 ~ 76.2 years old age, 55.2 years old mean age; The diabetic foot ulcer course of disease: 8d-10w, average 6.4 ± 1.6w; Wherein 2 grade of 16 example, 3 grade of 18 example, 4 grade of 16 example.Three groups of basic datas are compared, three groups in sex, age, the state of an illness, the course of disease etc. through statistical procedures there are no significant difference (P>0.05), there is comparability.
2, case selection and exclusion standard:
All patients entering to organize all meet following standard:
1. the diagnostic criteria about type Ⅱdiabetes mellitus in diabetology branch of Chinese Medical Association (version in 2007) Chinese type Ⅱdiabetes mellitus guideline of prevention and treatment is met, be diagnosed as the patient of type Ⅱdiabetes mellitus, and diabetic foot ulcers diagnosis is divided into the patient of 2-4 level by Wagner staging;
2. age≤80 years old.
3. meeting tcm diagnosis disease is that the wet stasis of blood makes malicious type: foot ulceration, and wound surface has a large amount of yellow pus or pus tongue, and slough does not take off, all rednesses of skin ulcer or dark red tenderness, bitter taste, and xerostomia is wish drink not, red tongue or dark red, yellow and greasy fur. slippery and rapid pulse or stringy and rapid pulse.
3, exclusion standard:
1. the foot ulcers patient that non-diabetic disease of having clarified a diagnosis causes;
2. complete with severe cardiac, Liver and kidney function and there is the patient of severe infections;
3. the patient of severe psychiatric, dysnoesia is had.
4, Therapeutic Method:
Observation group: on basis of conventional therapy, be coated with the unguentum prepared by the embodiment of the present invention 1, smearing ointment 0.1-0.2cm is thick, changes a medicine every day.
Contrast a group: on basis of conventional therapy, be coated with the unguentum prepared by the embodiment of the present invention 2, smearing ointment 0.1-0.2cm is thick, changes a medicine every day.
Contrast b group: conventional therapy simultaneously, is selected antibiotic according to the secretions Bacteria culturing at foot disease position and drug sensitive test result, carried out in time while namely taking insulin or oral antidiabetic drug to control blood glucose according to the state of an illness, effective debridement treatment.
January is a course for the treatment of, evaluates curative effect after two courses for the treatment of.
5, the standard of curative effect evaluation:
1. cure: gangrene or ulcer heal completely.
2. effective: ulcer oozes out basic disappearance, fresh granulation tissue growth, ulcer area reduces former more than 2/3.
3. effective: wound surface oozes out comparatively and reduces, and have a little granulation tissue to grow, ulcer area comparatively before reduces former more than 1/3.
4. invalid: wound surface further develops without significant change or gangrene.
6, therapeutic outcome
1) statistical analysis
The data obtained application SPSS14.0 software carries out statistical analysis, and measurement data is with mean ± standard deviation
represent, adopt t inspection, enumeration data adopts x
2inspection, P>0.05 is no significant difference, and P<0.05 is that difference has statistical significance, and P<0.01 is that difference has significance statistical significance.
2) clinical observation concrete outcome is as follows:
The routine patient of observation group 50, wherein 18 cure, and 17 examples are effective, and effectively, 3 examples are invalid, total effective rate 94% for 12 examples; The routine patient of contrast a group 50, wherein 11 cure, and 13 examples are effective, and effectively, 11 examples are invalid, total effective rate 78% for 15 examples; The routine patient of contrast b group 50, wherein 9 cure, and 12 examples are effective, and effectively, 13 examples are invalid, total effective rate 74% for 16 examples.Observation group with contrast a, b group comparing difference and have statistical significance, P < 0.05, though contrast a, b group compares have certain difference, no significant difference, P > 0.05.
The above results shows, after diabetic foot ulcer disease patient the application of the invention medicine composite for curing of observation group, symptom can significantly improve, a group is more known with contrasting, prescription of the present invention changes flavour of a drug and will not reach therapeutic effect of the present invention, and body weight, heart rate, blood pressure, hepatic and renal function are showed no obvious change before and after observation group's treatment, in whole therapeutic process, do not find allergy and obvious adverse events.Clinical effectiveness shows that the clinical application of we is safely and effectively, is worth studying and applying further.
Claims (8)
1. treat the pharmaceutical composition of diabetic foot ulcer for one kind, it is characterized in that, the weight portion of its crude drug consists of: Flos Lonicerae 10-14 part, Radix Angelicae Sinensis 8-10 part, Radix Platycodonis 10-12 part, Radix Polygoni Multiflori 8-10 part, Radix Bupleuri 10-12 part, Herba Menthae 6-8 part, Herba Schizonepetae 10-12 part, Radix Paeoniae Alba 10-12 part, Cortex Phellodendri 8-10 part, Radix Glycyrrhizae 3-5 part.
2. a kind of pharmaceutical composition for the treatment of diabetic foot ulcer as claimed in claim 1, it is characterized in that, the weight portion of its crude drug consists of: Flos Lonicerae 12 parts, Radix Angelicae Sinensis 9 parts, Radix Platycodonis 11 parts, Radix Polygoni Multiflori 9 parts, Radix Bupleuri 11 parts, Herba Menthae 7 parts, Herba Schizonepetae 11 parts, the Radix Paeoniae Alba 11 parts, Cortex Phellodendri 9 parts, 4 parts, Radix Glycyrrhizae.
3. a kind of pharmaceutical composition for the treatment of diabetic foot ulcer as described in claim 1,2, is characterized in that, described pharmaceutical composition is Chinese medicine for external application.
4. a kind of pharmaceutical composition for the treatment of diabetic foot ulcer as claimed in claim 3, it is characterized in that, described external preparation is unguentum or water preparation.
5. a kind of pharmaceutical composition for the treatment of diabetic foot ulcer as claimed in claim 4, is characterized in that, containing white vaseline, glyceryl monostearate and stearic acid in described unguentum.
6. a kind of pharmaceutical composition for the treatment of diabetic foot ulcer as claimed in claim 4, it is characterized in that, the preparation method of described Chinese medicine for external application has the following steps: first, extracting honeysuckle, Radix Angelicae Sinensis, Radix Platycodonis, Radix Polygoni Multiflori, Radix Bupleuri, Herba Menthae, Herba Schizonepetae, the Radix Paeoniae Alba, Cortex Phellodendri, Radix Glycyrrhizae powder are broken into coarse powder, the alcoholic solution that volumetric concentration is 75% is added according to 6 times of coarse powder gross weight, reflux, extract, three times, return time is 3h, filter, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Next adds white vaseline, glyceryl monostearate, stearic acid and distilled water and makes unguentum.
7. the purposes of the pharmaceutical composition as described in claim 1,2 in the pharmaceutical composition of preparation treatment diabetic foot ulcer.
8. the pharmaceutical composition as described in claim 1,2 makes the purposes in the pharmaceutical composition of malicious patients with type Ⅰ DM ulcer of foot in the wet stasis of blood of preparation treatment.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510645783.3A CN105079215A (en) | 2015-10-07 | 2015-10-07 | Medicine composition for treating diabetic foot ulcer |
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| CN201510645783.3A CN105079215A (en) | 2015-10-07 | 2015-10-07 | Medicine composition for treating diabetic foot ulcer |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022171096A1 (en) * | 2021-02-09 | 2022-08-18 | 鲁南制药集团股份有限公司 | Use of traditional chinese medicine composition in preparation of drugs for preventing or treating diabetes and/or diabetic complications |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943721A (en) * | 2006-10-20 | 2007-04-11 | 青岛市市立医院 | A Chinese traditional externally use medicinal composition for treatment of diabetic feet |
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2015
- 2015-10-07 CN CN201510645783.3A patent/CN105079215A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943721A (en) * | 2006-10-20 | 2007-04-11 | 青岛市市立医院 | A Chinese traditional externally use medicinal composition for treatment of diabetic feet |
Non-Patent Citations (2)
| Title |
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| 李景江等，: "顾步汤治疗糖尿病足28例", 《吉林中医药》 * |
| 谢炜等，: "《陈宝田教授经方临床应用》", 30 April 2014, 广东科技出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022171096A1 (en) * | 2021-02-09 | 2022-08-18 | 鲁南制药集团股份有限公司 | Use of traditional chinese medicine composition in preparation of drugs for preventing or treating diabetes and/or diabetic complications |
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