CN104398774A - Traditional Chinese drug for treating diabetic peripheral neuropathy - Google Patents

Traditional Chinese drug for treating diabetic peripheral neuropathy Download PDF

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CN104398774A
CN104398774A CN201410692097.7A CN201410692097A CN104398774A CN 104398774 A CN104398774 A CN 104398774A CN 201410692097 A CN201410692097 A CN 201410692097A CN 104398774 A CN104398774 A CN 104398774A
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peripheral neuropathy
radix
diabetic peripheral
traditional chinese
treating diabetic
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夏美娜
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Abstract

The invention relates to the field of drug formulas, in particular to a traditional Chinese drug for treating diabetic peripheral neuropathy. The traditional Chinese drug is characterized by being prepared from the following raw material herbs by weight percentage: 7-9% of caulis spatholobi, 4-7% of phryma leptostachya, 5-8% of hematoxylon, 4-6% of smallfruit fig aerial root, 6-8% of radices lithospermi, 4-7% of herba leonuri, 4-7% of short-pedicel aconite root, 2-5% of asarum, 4-6% of silvervine tea, 3-6% of folium artemisiae argyi, 5-8% of Eclipta prostrata, 4-8% of multiflora rose fruit, 3-6% of Commelina diffusa, 6-10% of spina gleditsiae, 4-7% of gorgon fruit, 3-5% of radix asparagi and 3-6% of rhizoma pinelliae preparata. The raw material herbs are soaked in water and decocted, and residues are removed to obtain a filter liquor. The traditional Chinese drug is high in curative effect of treating diabetic peripheral neuropathy, free of toxic and side effects and suitable of treating diabetic peripheral neuropathy in the early stage or in the advanced stage.

Description

The Chinese medicine for the treatment of diabetic peripheral neuropathy
Technical field
The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of Chinese medicine for the treatment of diabetic peripheral neuropathy.
Background technology
As everyone knows, diabetic Multiple Peripheral neuropathy is modal Diabetic Complications of Nervous System, in the diabetics of more than 25 years old, prevalence is 40%, full name is the multiple Peripheral nerve disease of symmetry; pathological changes mainly involves bilateral peripheral nerve; to feel and autonomic nerve symptom, and nervus motorius symptom is lighter.The chronic onset of clinical manifestation, is in progress gradually.Sensory symptoms is usually from Lower Distal Extremities, and main manifestations is the burn feeling of far-end of limb pain.Prickling sensation and creeping chill, night is heavy, and sharp ache is difficult to stand and affects sleep sometimes, also can occur the sensory disturbances such as symmetry is numb, ant walks, burn feeling.Simultaneously due to neural malnutrition there is pachylosis, chap, finger/toenail is fragile, uneven, there is intractable toe-end ulcer in severe patient, and gangrene is difficult to healing, and the symptom of some patient can develop into opposite side from side, and tendon reflex disappears or weakens.Clinical treatment major control blood glucose, improve microcirculation, but therapeutic effect is not good, and some patient can develop into anorexia, weight loss, depression and anxiety.Even cachectic states, there is intractable acra ulcer in some patients, downright bad and repeated infection causes septicemia, drastically influence patient's physical and mental health.
Summary of the invention
Technical problem to be solved by this invention is to overcome the deficiencies in the prior art, there is provided a kind of Chinese medicine for the treatment of diabetic peripheral neuropathy, cost is low, and treatment diabetic Multiple Peripheral neuropathy curative effect is high, have no side effect, have the liver and the kidney tonifying, spleen invigorating lung heat clearing, moisturizes dampness removing, QI invigorating cold expelling, blood circulation and channel invigorating, promoting the circulation of blood such as to be dispeled the wind at the effect, is applicable to the morning of diabetic Multiple Peripheral neuropathy, late period.
The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of Chinese medicine for the treatment of diabetic peripheral neuropathy, it is characterized in that being made up of the crude drug of following percentage by weight, Caulis Spatholobi 7 ~ 9%, Herba speranskiae tuberculatae 4 ~ 7%, Lignum Sappan 5 ~ 8%, Radix Aerio Fici Microcarpae 4 ~ 6%, Radix Arnebiae (Radix Lithospermi) 6 ~ 8%, Herba Leonuri 4 ~ 7%, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 4 ~ 7%, Herba Asari 2 ~ 5%, silvernine tea 4 ~ 6%, Folium Artemisiae Argyi 3 ~ 6%, Eclipta prostrata 5 ~ 8%, Fructus rosae multiflorae 4 ~ 8%, Herba Commelinae Diffusae 3 ~ 6%, Spina Gleditsiae 6 ~ 10%, Semen Euryales 4 ~ 7%, Radix Asparagi 3 ~ 5%, Rhizoma Pinelliae 3 ~ 6%, to remove slag to obtain after above-mentioned raw materials medicine is decocted filtrate.
The invention has the beneficial effects as follows, treatment diabetic peripheral neuropathy curative effect is high, has no side effect, have the liver and the kidney tonifying, spleen invigorating lung heat clearing, moisturizes dampness removing, the effects such as QI invigorating cold expelling, blood circulation and channel invigorating, promoting the circulation of blood dispel the wind, are applicable to the morning of diabetes Multiple Peripheral neuropathy, late period.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1:
Caulis Spatholobi, Herba speranskiae tuberculatae, Lignum Sappan, Radix Aerio Fici Microcarpae, Radix Arnebiae (Radix Lithospermi), Herba Leonuri, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Herba Asari, silvernine tea, Folium Artemisiae Argyi, Eclipta prostrata, Fructus rosae multiflorae, Herba Commelinae Diffusae, Spina Gleditsiae, Semen Euryales, Radix Asparagi, Rhizoma Pinelliae is adopted to be that raw material is prepared from.Its component (% by weight) is often paid as Caulis Spatholobi 9, Herba speranskiae tuberculatae 5, Lignum Sappan 7, Radix Aerio Fici Microcarpae 6, Radix Arnebiae (Radix Lithospermi) 7, Herba Leonuri 5, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 5, Herba Asari 4, silvernine tea 5, Folium Artemisiae Argyi 6, Eclipta prostrata 7, Fructus rosae multiflorae 5, Herba Commelinae Diffusae 5, Spina Gleditsiae 9, Semen Euryales 6, Radix Asparagi 5, Rhizoma Pinelliae 4.Getting above-mentioned 17 taste Chinese herbal medicine total amounts is 170 grams, at room temperature 17 taste Chinese herbal medicine is added water to 900 ~ 1100ml, soaks 4 ~ 6 hours, then boil slow fire with high heat to decoct to 80 ~ 90 minutes, remove slag to obtain filtrate about 150ml, and medicinal residues add water 200 ~ 300ml again, decoct 30 ~ 40 minutes, remove slag to obtain filtrate about 150ml, is total to obtain about 300ml medicine juice, i.e. obtained decoction of the present invention, load in sterile glass vials, seal bottle cap is for subsequent use, and every day, potion was oral at twice, each (medicine) being taken before meal 150ml.
Caulis Spatholobi of the present invention is enriched blood promoting the circulation of blood, and dredge the meridian passage, cures mainly rheumatic arthralgia, numb hand and foot, quadriplegia; Herba speranskiae tuberculatae wind-damp dispelling, invigorates blood circulation, and pain relieving is used for rheumatic arthralgia, joint stuffiness; Lignum Sappan main asthenia blood addiction gas is stopped up stagnant, and lochia is uneasy, and stir pain and blockage of main and collateral channels in abdomen, men and women's apoplexy, trismus and inability to speak, three tastes are monarch drug altogether; The heat clearing away of Radix Aerio Fici Microcarpae wind, promoting blood circulation and detoxication.Control influenza, pertussis, measles without adequate eruption, tonsillitis, eye conjunctivitis, eruptive disease is suffered from abdominal pain, rheumatic ostalgia, epistaxis, stranguria with blood, traumatic injury; Radix Arnebiae (Radix Lithospermi) removing heat from blood, invigorates blood circulation, heat clearing away, removing toxic substances.Control warm macule, jaundice due to damp-heat, purpura, tell, be defeated in battle, hematuria, stranguria with turbid discharge, constipation with heat retention, burn, eczema, erysipelas, carbuncle and ulcer; Herba Leonuri is invigorated blood circulation, silt of dispelling, regulating menstruation, disappear water, treatment menoxenia, and vaginal bleeding during pregnancy is had difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection, and it is ministerial drug that three tastes help monarch altogether; Assistant is with Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) energy wind-damp dispelling, and arteries and veins of invigorating blood circulation, arrogates to oneself pain relieving especially, for treating the good medicine of multiple pain.Be usually used in rheumatic arthralgia, neuralgia, toothache, traumatic pain, postoperative pain and cancerous protuberance pain etc.; Herba Asari dispels the wind, cold expelling, and row water, has one's ideas straightened out.Control air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia; Silvernine tea set heat-clearing and toxic substances removing, anti-inflammation, expelling wind and removing dampness, bone and muscle strengthening, blood pressure lowering, blood fat reducing and the effect such as to protect the liver; Folium Artemisiae Argyi is regulated the flow of vital energy blood, by cold-damp, and warming the meridian, hemostasis, antiabortive; Eclipta prostrata nourishing the liver and kidney, cooling blood for hemostasis, can control various haematemesis, the diseases such as enterorrhagia; The main carbuncle of Fructus rosae multiflorae, malignant boil knot meat, falls muscle and loses skin ulcer, steam, the erosion of the vulva not recover, sharp joint; The amenorrhea of Herba Commelinae Diffusae heat in blood stasis blocking or menoxenia, inducing diuresis for treating stranguria syndrome, damp-heat gonorrhoea; Spina Gleditsiae swollen ulcer drug, scrofula, skin ulcer rash stubborn dermatitis, puerperal hypogalactia, placenta retention, leprosy; Semen Euryales main arthralgia chiefly caused by damp pathogen spinal column gonalgia, invigorating middle warmer removes sudden and violent disease, beneficial vital essence, and Qiang Zhi, makes normal hearing and eyesight; Radix Asparagi YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, cough due to consumptive disease, Tianjin wound is thirsty, vexed insomnia, and interior-heat is quenched one's thirst; Rhizoma Pinelliae drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Control damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm is had a headache, and dizzy sleeplessness, altogether for making medicine.The ingenious prescription of 17 taste Chinese herbal medicine, reasonable compatibility, to strengthen the identical or close curative effect of medication of function.
The each raw material of the present invention also can the embodiment that mixes of ratio (percentage by weight) listed by according to the form below realize.Its processing technique is identical with embodiment 1.
The clinical trial carried out below in conjunction with my institute is done further the present invention, is described in detail:
1. case selection: selected case is diabetic Multiple Peripheral neuropathy patient, 62 examples, wherein man 28 example, female 34 example; Age, have between diabetic history 9--25,62 routine patients all had numb limbs and tense tendons, pain in 27--59 year, and superficial sensory disturbance and tendon reflex such as to weaken at clinical symptoms and the sign.Its diagnosis all meets " neurological " the 6th edition diagnostic criteria of Jia Jianping chief editor.
2. Therapeutic Method: every day 1 dose of decoction of the present invention, each (medicine) being taken before meal 150ml, every day sooner or later twice, takes 90 days altogether.
3. the standard of curative effect evaluation:
Effective: the subjective symptoms such as limbs pain, numbness, superficial sensory disturbance disappears, and tendon, quadriceps reflex recover substantially, electromyogram (increasing NCV > 5m/s) or recover normal.
Effective: the subjective symptomss such as limbs pain, numbness, superficial sensory disturbance obviously alleviate, tendon, quadriceps reflex do not recover normal completely, and electromyogram (increasing NCV < 5m/s) is clearly better.
Invalid: the subjective symptomss such as limbs pain, numbness, superficial sensory disturbance are without improvement, and tendon, quadriceps reflex, electromyogram are without significant change.
4. therapeutic effect: evaluate 62 routine diabetic, Multiple Peripheral neuropathy patient outcomes according to the standard of curative effect evaluation: effective 25 examples, effective 28 examples, no effect 9, total effective rate is 85.5%.

Claims (1)

1. treat the Chinese medicine of diabetic peripheral neuropathy for one kind, it is characterized in that: be made up of the crude drug of following percentage by weight, Caulis Spatholobi 7 ~ 9%, Herba speranskiae tuberculatae 4 ~ 7%, Lignum Sappan 5 ~ 8%, Radix Aerio Fici Microcarpae 4 ~ 6%, Radix Arnebiae (Radix Lithospermi) 6 ~ 8%, Herba Leonuri 4 ~ 7%, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 4 ~ 7%, Herba Asari 2 ~ 5%, silvernine tea 4 ~ 6%, Folium Artemisiae Argyi 3 ~ 6%, Eclipta prostrata 5 ~ 8%, Fructus rosae multiflorae 4 ~ 8%, Herba Commelinae Diffusae 3 ~ 6%, Spina Gleditsiae 6 ~ 10%, Semen Euryales 4 ~ 7%, Radix Asparagi 3 ~ 5%, Rhizoma Pinelliae 3 ~ 6%, filtrate of removing slag to obtain after above-mentioned raw materials medicine is decocted.
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105560640A (en) * 2015-09-09 2016-05-11 张苗 Traditional Chinese medicine for treating diabetic peripheral neuropathy
KR20160133347A (en) * 2015-05-12 2016-11-22 한국 한의학 연구원 Composition for prevention, improvement or treatment of peripheral neuropathy comprising Lithospermi Radix extract as effective component

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CN1562089A (en) * 2003-11-12 2005-01-12 任翠兰 Medicinal liquor

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高学敏主编: "《中药学（第二版）》", 31 January 2007 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160133347A (en) * 2015-05-12 2016-11-22 한국 한의학 연구원 Composition for prevention, improvement or treatment of peripheral neuropathy comprising Lithospermi Radix extract as effective component
KR101708165B1 (en) 2015-05-12 2017-02-21 한국 한의학 연구원 Composition for prevention, improvement or treatment of peripheral neuropathy comprising Lithospermi Radix extract as effective component
CN108348563A (en) * 2015-05-12 2018-07-31 韩国韩医学研究院 Contain composition for prevent, improve or treat peripheral neuropathy of the Asian puccoon root extract as active ingredient
US20180303889A1 (en) * 2015-05-12 2018-10-25 Korea Institute Of Oriental Medicine Composition for prevention, alleviation, or treatment of peripheral neuropathy comprising lithospermi radix extract as an effective component
US10517913B2 (en) * 2015-05-12 2019-12-31 Korea Institute Of Oriental Medicine Composition for prevention, alleviation, or treatment of peripheral neuropathy comprising Lithospermi Radix extract as an effective component
CN105560640A (en) * 2015-09-09 2016-05-11 张苗 Traditional Chinese medicine for treating diabetic peripheral neuropathy

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Application publication date: 20150311