CN1943721A - A Chinese traditional externally use medicinal composition for treatment of diabetic feet - Google Patents
A Chinese traditional externally use medicinal composition for treatment of diabetic feet Download PDFInfo
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Abstract
This invention relates to a Chinese traditional externally use medicinal composition for treatment of diabetic feet which belongs to the field of the Chinese traditional medicine. Its character is that it is prepared by using the following Chinese medical ingredients: common bletolla tiber, honeysuckle, Chinese angelica root, frankincense, licorice root, densegruit pittany bark, Dahurian angelica root, kuhseng, myrrh, coptis rhizome, Chinese corktree bark.Composition of this invention is an externally used washing liquid. It has the curative effects of restraining the platelet aggregation so to reduce the formation of thrombus, restraining the nucleic acid of the bacterium's cell, promoting protein synthetic, sterilizing and anti-inflammation. It can improve partial microcirculation, dispel toxin, astringing and promoting the tissue regeneration, and effectively clear up the obstacle of microcirculation of the diabetic feet. This invention also reveals preparing method.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly a kind of external medicine composition for the treatment of diabetic foot.
Background technology
Diabetes are diseases of a kind of serious harm human body health, and diabetic foot is one of its major complications.Few to effective treatment of diabetic foot both at home and abroad at present, mainly be control protopathy.But when peripheral vascular disease appears in diabetics, when particularly diabetic foot occurring, modern medicine is also had difficulty in taking a step to the treatment of this disease, and therapeutic process not only side effect is bigger, and curative effect is also imprecise, the relapse rate height; And pathological changes is carried out the method for local excision, and not only have unnecessarily damage, because the relapse rate height, the patient also is difficult for accepting.
Chinese medicine is having its distinctive feature aspect the research treatment diabetic foot, in recent years, and at aspects such as clinical researches, a large amount of clinical efficacy reports is arranged, important function has been played in the treatment of this disease, compare the Chinese medicine primary disease with doctor trained in Western medicine with a long history, method is more, curative effect is reliable, and no wound and misery have no side effect, the patient easily accepts, thereby, use extensively, be worthy of popularization.
Summary of the invention
The objective of the invention is to, for patient with diabetic feet provides a kind of effective, convenient and swift, Chinese medicine composition of having no side effect, not influencing internal metabolism.And utilize the technology of preparing of modern Chinese medicine technology and external agent, and be prepared as external-use lotion, make every effort to accomplish the medicine sick institute that goes directly, directly remove the illness in affected part, reduce recurrence, eliminate mental maladjustment, pleasant mental and body.
The present invention adopts following technical scheme to realize:
A kind of external medicine composition for the treatment of diabetic foot is characterized in that being made by following Chinese medicine: Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Lonicerae, Radix Angelicae Sinensis, Olibanum, Radix Glycyrrhizae, Cortex Dictamni, the Radix Angelicae Dahuricae, Radix Sophorae Flavescentis, Myrrha, Rhizoma Coptidis, Cortex Phellodendri.
The Chinese medicine of the preferred following weight percentage ratio of medicine of the present invention is made: Pseudobulbus Bletillae (Rhizoma Bletillae) 35～41%, Flos Lonicerae 7～11%, Radix Angelicae Sinensis 7～11%, Olibanum 7～11%, Radix Glycyrrhizae 5～9%, Cortex Dictamni 5～9%, the Radix Angelicae Dahuricae 5～9%, Radix Sophorae Flavescentis 3～7%, Myrrha 3～7%, Rhizoma Coptidis 2～6%, Cortex Phellodendri 1～5%.
The proportioning that is more preferably is: Pseudobulbus Bletillae (Rhizoma Bletillae) 38～40%, Flos Lonicerae 8～10%, Radix Angelicae Sinensis 8～10%, Olibanum 8～10%, Radix Glycyrrhizae 6～8%, Cortex Dictamni 6～8%, the Radix Angelicae Dahuricae 6～8%, Radix Sophorae Flavescentis 4～6%, Myrrha 4～6%, Rhizoma Coptidis 3～5%, Cortex Phellodendri 2～4%.
A kind of application of external medicine composition in the preparation external-use lotion for the treatment of diabetic foot.Chinese medicine composition of the present invention is prepared into external-use lotion according to routine techniques in use.
Preferred using method is: according to formula proportion of the present invention, take by weighing the Chinese medicinal granule of gross weight 45.5 grams, add warm water 2500～3000ml dissolved substance, the water temperature of foot bath generally is no more than 40 degree, every day 1～2 time, each 20～25 minutes, 30 days was a course of treatment.
Function: heat-clearing and toxic substances removing, reducing swelling and alleviating pain restores menstrual flow and invigorates blood circulation, and granulation promoting is treated wound.
Cure mainly: diabetic foot
Points for attention: avoid the peppery thing of raw meat.The child, pregnant, through the careful usefulness of women in term.Under doctor's guidance, use.
The Chinese medicinal granule that the present invention adopts is commercial goods commonly used, simultaneously, also can adopt the conventional prepared slices of Chinese crude drugs to make washing liquid of the present invention.
The present invention is during clinical verification, and the commodity during use are called the diabetic foot washing liquid.
The Chinese crude drug Latin title that is adopted among the present invention is as follows:
Pseudobulbus Bletillae (Rhizoma Bletillae) (Rhizoma Bletillae), Flos Lonicerae (Flos Lonicerae), Radix Angelicae Sinensis (Radix Angelicae Sinensis), Olibanum (Frankincense), Radix Glycyrrhizae (Radix Glycyrrhizae), Cortex Dictamni (Cortex Dictamni), the Radix Angelicae Dahuricae (RadixAngelicae Dahuricae), Radix Sophorae Flavescentis (Radix Sophorae Flavescentis), Myrrha (Myrrh), Rhizoma Coptidis (RhizomaCoptidis), Cortex Phellodendri (Cortex Phellodendri).
Below further set forth beneficial effect of the present invention by clinical observation on the therapeutic effect, concrete case.
One, clinical observation on the therapeutic effect test
Diabetics is because of the peripheral nerve pathological changes, and multiple factors such as artery of lower extremity blood supply insufficiency and bacterial infection cause pathological changes such as foot pain, the dark ulcer of skin, acromelic gangrene, are referred to as diabetic foot.At present symptomatic treatments such as blood sugar lowering, debridement, infection, about 60% the patient's poor prognosis of adopting of diabetic foot more.For exploring the new method of effective treatment diabetic foot, the author uses traditional treatment and adds the Chinese medicine external curing, and patient with diabetic feet is treated and compared with conventional treatments.
1. clinical data
1.1 physical data: select patient with diabetic feet 108 examples of diagnosis and treatment in 2002～2005, be made as the treatment group, wherein male 50 examples, women 58 examples, 52～67 years old age, average 59.2 years old, the course of disease 7～15 months in the court's department of endocrinology application external therapy of tcm; Randomly draw diabetic foot conventional therapy patient 110 examples, be made as matched group, wherein male 53 examples, women 57 examples, 51～68 years old age, average 59.1 years old, the course of disease 6～15 months.
1.2 the standard of including in: 1. the diabetes medical history is more than 10 years; 2. clinical symptoms be the cool fiber crops of foot, swell and ache, downright bad, dorsal artery of foot weakens or disappear; 3. Doppler shows that the foot lumen of vessels is narrow or inaccessible, and tube wall thickens, and 4. blood flow rate slows down has other complication persons of diabetes also can be selected in.
1.3 exclusion standard: 1. promoting the circulation of blood pipe bypass graft and amputation patient 2. uncooperative maybe can not adhere to continuous therapist 3. blood pressure can not be controlled at the following person of 160/100mmHg 4. active hemorrhage person is arranged.
2 treatment and methods
2.1 Chinese medicine external bubble is washed the treatment prescription: Radix Sophorae Flavescentis, Cortex Dictamni, the Radix Angelicae Dahuricae, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Lonicerae, Radix Glycyrrhizae, Olibanum, Myrrha, Cortex Phellodendri, Radix Angelicae Sinensis, Rhizoma Coptidis.(above medicine is Chinese medicinal granule, is provided by Tianjiang Pharmaceutical Industry Co., Ltd., Jiangyin).
2.2 method
Treatment group and matched group are all used Primary Care: blood sugar control is had a dinner in strict accordance with the diabetes recipe in plateau range, conventional intravenous drip broad ectrum antibiotic.1 grade of patient selects for use asepsis injector that content is extracted out to diabetic foot; use 2.5% iodine tincture prevention infection, 2 grades of diabetic foots, 3 grades of patients are cut the evacuation of pus drain, keep drain unobstructed; take the method for nibbling to remove gradually to slough, note protection tendon and ligament.Matched group: use furacillin solution, the local clear skin ulcer of diabetic foot is handled the back soak; Treatment group: suffer from the local bubble of foot with the Chinese medicine top and wash treatment.Usage: get in the above magistral medicines, add warm water 2500～3000ml dissolved substance, the water temperature of foot bath generally is no more than 40 degree, and every day 1～2 time, each 20～25 minutes, 30 days was a course of treatment.After one course of treatment with the matched group comparative analysis.
3 observation of curative effect
3.1 criterion of therapeutical effect is cured: normal under the skin color temperature, no numb pain, sense of touch is normal, and open wound surface heals fully; Take a turn for the better: suffer from the cacesthenic scope of skin of foot and before dwindle, the more preceding minimizing of gangrenous merocrine secretion thing, wound surface significantly reduces; Invalid: suffering from the cacesthenic scope of skin of foot does not have and changes or enlarge, and gangrenous wound surface does not have and dwindles, and secretions does not have minimizing.
3.2 result
The treatment group is cured 77 examples (accounting for 71.3%); 22 examples that take a turn for the better (accounting for 20.4%); Invalid 9 examples (accounting for 8.3%); Total effective rate 91.7%.Matched group is cured 47 examples (accounting for 42.7%); 31 examples that take a turn for the better (accounting for 28.2%); Invalid 32 examples (accounting for 29.1%); Total effective rate 70.9%.Learn to handle by statistics, X2=21.672, group there is significant difference P＜0.001, two.
4 know from experience
The traditional Chinese medical science is thought: " necrosis " category of the diabetes spp traditional Chinese medical science, its pathological characteristic is to merge on the diabetes deficiency of YIN basis in malicious Sheng, the deficiency of vital energy, yang deficiency, the process in pathological changes, because yang deficiency and bringing about the spread of body fluid's deficiency, blood operation is not smooth, stasis of blood resistance venation, so the pathological changes of yin deficiency and blood stasis runs through whole process all the time, this hinders resistance consistent with the modern medicine microcirculation.The basic pathogenesis of diabetes is that deficiency of vital energy the moon is thanks to scorching, the then scorching for a long time bright blood of disease and the hyperamization stasis of blood, but the capable also hyperamization stasis of blood of the unable promotion blood of the deficiency of vital energy, and the stagnation of blood stasis venation, it is diabetic foot that yang-energy can not reach that Yu Simo then sends out with warm muscle, muscle arteries and veins.Modern medicine is thought diabetics, and in blood sugar increasing, blood fat raises, and blood viscosity obviously increases and microcirculation disturbance, and the obstruction of collaterals by blood stasis of this and the traditional Chinese medical science matches.Obstruction of collaterals by blood stasis, yang-energy can not replenishing vital QI with drugs of warm nature four ends be that mark is real; The blood stasis stagnation adds overabundant yin again loses and the deficiency of vital energy, and this is a deficiency in origin.The specimen deficiency and excess transforms state of an illness complexity mutually.Primary disease foot pain, or rest pain or hypnalgia are due to stagnation of blood stasis and the yang-energy stasis, stagnation of QI and blood may bring about pain; Deficiency of qi and yin, muscle arteries and veins skin lose in moistening and support then numb limbs and tense tendons, even intermittent claudication; Stagnation of blood stasis, the yang-energy acra of can not leading to, then skin cool, pale, purple dark.
We are according to the major lesions mechanism of diabetic foot, and with the yin nourishing of invigorating blood circulation, QI invigorating is activated yang on method of treatment, promote blood circulation and separate the stasis of blood, heat clearing and damp drying.In the washout side: Radix Sophorae Flavescentis, Flos Lonicerae, Radix Glycyrrhizae, Cortex Phellodendri, Rhizoma Coptidis, Cortex Dictamni heat-clearing and toxic substances removing, dampness spasmolytic, Chinese Angelica blood replonishing, Radix Angelicae Dahuricae pain relieving, Olibanum, Myrrha promoting blood circulation to remove obstruction in the collateral, Pseudobulbus Bletillae (Rhizoma Bletillae) convergence granulation promoting.Perfect square has the platelet aggregation of inhibition and reduces thrombosis, the nucleic acid, the protein synthesis that suppress bacterial cell, bactericidal antiphlogistic, can improve local microcirculation, toxin expelling is restrained granulation promoting, has solved the microcirculation disturbance of diabetic foot effectively, given full play to tcm characteristic, for the treatment diabetic foot provides a kind of effective method.
Two, medical record for example
1. Zou, man, 66 years old, first visit in January, 2005.Suffered from diabetes 11 years, it is basicly stable to obey blood sugar lowering blood glucose for a long time.The first quarter moon cause is worn and is newly bought the left sufficient little toe postoperative infection of the crowded wound of leather shoes, causes instep ulcer, pain, comes the court's treatment through certain hospitalize DeGrain.Examine and see: the about 4.8cm * 3.2cm of instep ulcer surface ulcer, purulent secretion is arranged, the ulcer surface surrounding skin has erythra, little water scar, the rash pain of itching.With ulcer surface cleaning and sterilizing repeatedly, the aseptic blister of breaking is washed with the Chinese medicine bubble, treat 28 days every day 2 times, and wound heals fully, the sufferings disappearance.Follow up a case by regular visits to and do not recur half a year.
2. Zhang, the man, 59 years old, first visit in November, 2003 was suffered from diabetes 10 years, and it is basicly stable to obey blood sugar lowering blood glucose for a long time.Because of foot pressurized in the right side right vola strip hematoma occurs with ulceration, the about 18cm * 1.2cm of ulcer surface ulcer has purulent secretion, and with ulcer surface cleaning and sterilizing repeatedly, reuse Chinese medicine bubble is washed, and treats 25 days every day 2 times earlier, and ulcer surface heals fully, the hematoma disappearance.Follow up a case by regular visits to and do not recur half a year.
Pan so-and-so, the man, 67 years old, first visit in January, 2005 was suffered from diabetes 12 years, it is basicly stable to obey blood sugar lowering blood glucose for a long time.Because of left side foot middle toe onychoptosis first quarter moon, toe-end is blue, and suppurate sexual secretion and one week of pus go to a doctor.Once failed to respond to any medical treatment with YUNNAN BAIYAO and gentian voiet.Earlier to wound surface cleaning and sterilizing repeatedly, reuse Chinese medicine bubble is washed, and treat 30 days wound healing, new first sprouting every day 2 times.
The specific embodiment
Embodiment 1
Adopt the Chinese medicinal granule of following weight to make: Pseudobulbus Bletillae (Rhizoma Bletillae) 17.3g (38%), Flos Lonicerae 4.1g (9%), Radix Angelicae Sinensis 4.1g (9%), Olibanum 3.6g (8%), Radix Glycyrrhizae 3.1 (7%), Cortex Dictamni 2.7g (6%), Radix Angelicae Dahuricae 2.7g (6%), Radix Sophorae Flavescentis 2.3g (5%), Myrrha 2.3g (5%), Rhizoma Coptidis 1.8g (4%), Cortex Phellodendri 1.5g (3%).
With above-mentioned Chinese medicinal granule, add warm water 2500～3000ml dissolved substance, promptly make external-use lotion of the present invention.
Embodiment 2
Adopt the Chinese medicinal granule of following weight to make: Pseudobulbus Bletillae (Rhizoma Bletillae) 18.2g (40%), Flos Lonicerae 3.6g (8%), Radix Angelicae Sinensis 3.6g (8%), Olibanum 4.5g (10%), Radix Glycyrrhizae 2.7 (6%), Cortex Dictamni 3.1g (7%), Radix Angelicae Dahuricae 3.1g (7%), Radix Sophorae Flavescentis 2.3g (5%), Myrrha 1.8g (4%), Rhizoma Coptidis 1.5g (3%), Cortex Phellodendri 1.5g (3%).Method for making is with embodiment 1.
Embodiment 3
Adopt the Chinese medicinal granule of following weight to make: Pseudobulbus Bletillae (Rhizoma Bletillae) 17.7g (39%), Flos Lonicerae 4.6 (10%), with return 4.1g (9%), Olibanum 3.6g (8%), Radix Glycyrrhizae 3.6 (8%), Cortex Dictamni 3.6g (8%), Radix Angelicae Dahuricae 2.7g (6%), Radix Sophorae Flavescentis 1.8g (4%), Myrrha 1.8g (4%), Rhizoma Coptidis 1.5g (3%), Cortex Phellodendri 0.9g (2%).Method for making is with embodiment 1
Embodiment 4
Adopt the Chinese medicinal granule of following weight to make: Pseudobulbus Bletillae (Rhizoma Bletillae) 15.9g (35%), Flos Lonicerae 3.6g (8%), Radix Angelicae Sinensis 3.6g (8%), Olibanum 3.6g (8%), Radix Glycyrrhizae 2.7g (6%), Cortex Dictamni 2.7g (6%), Radix Angelicae Dahuricae 3.6g (8%), Radix Sophorae Flavescentis 2.7g (6%), Myrrha 2.7g (6%), Rhizoma Coptidis 2.3g (5%), Cortex Phellodendri 1.8g (4%).Method for making is with embodiment 1
Embodiment 5
Adopt the prepared slices of Chinese crude drugs of following weight to make: Pseudobulbus Bletillae (Rhizoma Bletillae) 69.3g (41%), Flos Lonicerae 11.8g (7%), Radix Angelicae Sinensis 11.8g (7%), Olibanum 11.8g (7%), Radix Glycyrrhizae 8.4g (5%), Cortex Dictamni 8.4g (5%), Radix Angelicae Dahuricae 15.2g (9%), Radix Sophorae Flavescentis 11.8g (7%), Myrrha 11.8g (7%), Rhizoma Coptidis 6.8g (4%), Cortex Phellodendri 1.7g (1%).Method for making is with embodiment 1
Embodiment 6
Adopt the prepared slices of Chinese crude drugs of following weight to make: Pseudobulbus Bletillae (Rhizoma Bletillae) 59.2g (35%), Flos Lonicerae 18.6g (11%), Radix Angelicae Sinensis 18.6g (11%), Olibanum 16.9g (10%), Radix Glycyrrhizae 11.8g (7%), Cortex Dictamni 13.5g (8%), Radix Angelicae Dahuricae 8.4g (5%), Radix Sophorae Flavescentis 5.1g (3%), Myrrha 5.1g (3%), Rhizoma Coptidis 3.4g (2%), Cortex Phellodendri 8.4g (5%).Method for making is with embodiment 1.
Embodiment 7
Adopt the prepared slices of Chinese crude drugs of following weight to make: Pseudobulbus Bletillae (Rhizoma Bletillae) 60.8g (36%), Flos Lonicerae 15.2g (9%), Radix Angelicae Sinensis 15.2g (9%), Olibanum 16.9g (11%), Radix Glycyrrhizae 15.2g (9%), Cortex Dictamni 15.2g (9%), Radix Angelicae Dahuricae 8.4g (5%), Radix Sophorae Flavescentis 5.1g (3%), Myrrha 5.1g (3%), Rhizoma Coptidis 3.4g (2%), Cortex Phellodendri 6.8g (4%).Method for making is with embodiment 1.
Claims (4)
1. an external medicine composition for the treatment of diabetic foot is characterized in that being made by following Chinese medicine: Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Lonicerae, Radix Angelicae Sinensis, Olibanum, Radix Glycyrrhizae, Cortex Dictamni, the Radix Angelicae Dahuricae, Radix Sophorae Flavescentis, Myrrha, Rhizoma Coptidis, Cortex Phellodendri.
2. the external medicine composition of treatment diabetic foot according to claim 1, it is characterized in that making: Pseudobulbus Bletillae (Rhizoma Bletillae) 35～41%, Flos Lonicerae 7～11%, Radix Angelicae Sinensis 7～11% by the Chinese medicine of following weight percentage ratio, Olibanum 7～11%, Radix Glycyrrhizae 5～9%, Cortex Dictamni 5～9%, the Radix Angelicae Dahuricae 5～9%, Radix Sophorae Flavescentis 3～7%, Myrrha 3～7%, Rhizoma Coptidis 2～6%, Cortex Phellodendri 1～5%.
3. the external medicine composition of treatment diabetic foot according to claim 1, it is characterized in that making: Pseudobulbus Bletillae (Rhizoma Bletillae) 38～40%, Flos Lonicerae 8～10%, Radix Angelicae Sinensis 8～10% by the Chinese medicine of following weight percentage ratio, Olibanum 8～10%, Radix Glycyrrhizae 6～8%, Cortex Dictamni 6～8%, the Radix Angelicae Dahuricae 6～8%, Radix Sophorae Flavescentis 4～6%, Myrrha 4～6%, Rhizoma Coptidis 3～5%, Cortex Phellodendri 2～4%.
4. the application of external medicine composition in the preparation external-use lotion for the treatment of diabetic foot.
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| CN104800425A (en) * | 2015-04-23 | 2015-07-29 | 杨孝良 | External Chinese herbal compound applying liquid for treating diabetic foot ulcer |
| CN105079215A (en) * | 2015-10-07 | 2015-11-25 | 青岛辰达生物科技有限公司 | Medicine composition for treating diabetic foot ulcer |
| CN105250525A (en) * | 2015-10-14 | 2016-01-20 | 蒋庆耀 | Traditional Chinese medicine lotion for treating diabetic foot and preparation method thereof |
| CN112807381A (en) * | 2021-02-22 | 2021-05-18 | 荆培佩 | External medicament for treating diabetic foot disease and preparation thereof |
| CN115737720A (en) * | 2022-11-25 | 2023-03-07 | 麦莩医疗器械(武汉)有限公司 | Antibacterial paste composition and preparation method and application thereof |
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| CN100448473C (en) | 2009-01-07 |
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