CN115737720A - Antibacterial paste composition and preparation method and application thereof - Google Patents
Antibacterial paste composition and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses an antibacterial paste composition and a preparation method and application thereof, wherein the antibacterial paste composition comprises the following components in parts by weight: 30-50 parts of honeysuckle, 5-10 parts of phyllanthus urinaria, 8-10 parts of dried orange peel, 10-20 parts of raw liquorice, 10-30 parts of angelica dahurica, 10-20 parts of golden cypress, 5-10 parts of myrrh and 5-8 parts of borneol, and can promote early healing of diabetic foot wounds.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, and in particular relates to a bacteriostatic cream composition and a preparation method and application thereof.
Background
Organic footage is a complex target organ for diabetes, a multi-system disease. Diabetic patients can cause damage and malformation of foot soft tissues and bone joint systems due to excessive mechanical pressure caused by peripheral neuropathy and peripheral vascular disease, and further cause a series of foot problems from mild neurological symptoms to severe ulcers, infections, vascular diseases and neuropathic fractures, and if active treatment cannot sufficiently solve symptoms and complications of lower limbs, catastrophic consequences can be caused.
According to 6 grades of diabetic foot injuries, a 0-grade wound can be treated by adopting modified shoes, mold type inner pads or deepened shoes if the foot is at ulcer risk, and patients can be educated and regularly follow up. Once skin cracks develop, active intervention is necessary to avoid further development of the lesion. Methods to relieve level 1 wounds from external pressure include wearing post-operative shoes, using ankle braces, wearing prefabricated walkable braces, or using full contact plaster. In addition to proper reduced pressure and compression sites, proper ulcer wound care is needed to avoid necrosis of tissue dehydrating cells and accelerate wound healing. The surgical indication is failure of improvement in local pressure or a higher grade wound. Wounds of grade 2 and 3 require surgical intervention, and wounds of grade 3 require the application of antibiotics and may also require amputation. In contrast to other parts of the body, hindfoot ulcers are more in need of surgical intervention because local tissue is difficult to decompress and blood transport is also poor. The surgical methods include ulcer debridement, apophyseal resection, correction of foot and ankle deformities, and the like. Correcting the paw or hammer toe may reduce the incidence or recurrence of the forefoot dorsal ulcer. Additionally, prolongation of the calcaneus is also contemplated to relieve pressure on the plantar side of the forefoot or midfoot. In the prior art, except for operations, the treatment method of the diabetic foot mainly adopts antibiotics to control infection, other medicines are not reliable and can be selected, and toe amputation or limb amputation treatment is required when the obvious infection to ulcer and gangrene occurs.
However, long-term use of antibiotics can cause drug resistance and reduce the curative effect.
Disclosure of Invention
In view of this, the application provides a bacteriostatic cream composition, a preparation method and an application thereof, which can promote early healing of diabetic foot wounds.
In order to achieve the technical purpose, the following technical scheme is adopted in the application:
in a first aspect, the application provides an antibacterial cream composition, which comprises the following components in parts by mass: 30-50 parts of honeysuckle, 5-10 parts of common leafflower herb, 8-10 parts of tangerine peel, 10-20 parts of raw liquorice, 10-30 parts of dahurian angelica root, 10-20 parts of amur corktree bark, 5-10 parts of myrrh and 5-8 parts of borneol.
Preferably, the composition comprises the following components in parts by mass: 30-40 parts of honeysuckle, 8-10 parts of common leafflower herb, 8-10 parts of tangerine peel, 10-15 parts of raw liquorice, 10-20 parts of dahurian angelica root, 10-15 parts of amur corktree bark, 5-8 parts of myrrh and 5-8 parts of borneol.
Preferably, the composition comprises the following components in parts by weight: 30 parts of honeysuckle, 10 parts of common leafflower herb, 10 parts of tangerine peel, 10 parts of raw liquorice, 10 parts of dahurian angelica root, 10 parts of amur corktree bark, 5 parts of myrrh and 5 parts of borneol.
In a second aspect, the present application provides a method for preparing a bacteriostatic cream composition, comprising the steps of: mixing flos Lonicerae, cacumen Securinegae Suffruticosae, pericarpium Citri Tangerinae, glycyrrhrizae radix, radix Angelicae Dahuricae, cortex Phellodendri, and Myrrha, grinding, sieving, adding Borneolum Syntheticum, and mixing to obtain mixture; adding oleum Sesami into the mixture, stirring, and sterilizing to obtain antibacterial paste composition.
Preferably, the sterilization is ultraviolet irradiation sterilization or ethylene oxide sterilization.
Preferably, after concentration, the mass ratio of the mixture to the sesame oil is 3-5:8.
preferably, the screened particle size is 100-120 mesh.
In a third aspect, the application provides a use of a bacteriostatic cream composition in the preparation of an antibacterial medicament.
Preferably, the bacteria comprise one or more of escherichia coli, staphylococcus aureus and staphylococcus epidermidis.
In a fourth aspect, the use of a bacteriostatic cream composition in the manufacture of an adjuvant medicament for the treatment of diabetic foot infection.
The beneficial effect of this application is as follows:
1. the formula has the effects of detoxifying and removing necrotic tissue, promoting blood circulation and promoting tissue regeneration, treats both principal and secondary aspects of diseases, and is obviously superior to western medicines, and the characteristics of easy drug resistance, temporary treatment and non-permanent treatment are achieved.
2. The formula is based on the traditional Chinese medicine macroscopic theory legislation, has wide action targets, and fundamentally overcomes the characteristic of single target of western medicines.
3. The formula has good curative effect on diabetic foot, short treatment course and low cost, and western medicines have uncertain application curative effect, long treatment course and high cost.
4. All the components are natural components, and no hormone component exists, so that the composition is easy to absorb by a human body, and the curative effect is obvious.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The application provides an antibacterial paste composition, which comprises the following components in parts by mass: 30-50 parts of honeysuckle, 5-10 parts of common leafflower herb, 8-10 parts of tangerine peel, 10-20 parts of raw liquorice, 10-30 parts of dahurian angelica root, 10-20 parts of amur corktree bark, 5-10 parts of myrrh and 5-8 parts of borneol.
In the scheme, the action mechanism of each component is as follows:
honeysuckle flower and phyllanthus urinaria have the functions of detoxifying, removing putrefaction, inducing diuresis and relieving swelling.
Chen Pi has the action of moving qi and can move qi and dissipate nodulation.
The raw licorice root has the effect of detoxifying.
Huang Bai is bitter in taste and cold in nature. Has effects of clearing heat, eliminating dampness, purging pathogenic fire, removing heat, removing toxic substance, and treating sore. Can be used for treating damp-heat dysentery, jaundice urine red, leukorrhagia pudendal pruritus, heat stranguria pain, tinea pedis flaccidity cramped, hectic fever due to yin deficiency, night sweat, nocturnal emission, pyocutaneous disease, toxic swelling, eczema, and eczema. Salted cortex phellodendri is used for nourishing yin and reducing internal heat. Can be used for treating hyperactivity of fire due to yin deficiency, night sweat and steaming bone.
Mo Yao is pungent and bitter in flavor and neutral in nature. Dispel stasis, relieve pain, resolve swelling and promote tissue regeneration. Can be used for treating thoracic obstruction, cardialgia, gastralgia, dysmenorrhea, amenorrhea, puerperal stagnation, abdominal mass, abdominal pain, rheumatalgia, traumatic injury, carbuncle, swelling, and skin and external diseases.
Borneol is pungent, bitter and slightly cold in property, pungent and fragrant in flavor, moves and flees, enters bones and muscles to relieve pain, can be used for treating traumatic injury and bone and muscle pain, can also be used for clearing heat and relieving pain, promoting granulation and healing sore after external application, and can be used for treating sore and ulcer swelling pain, unhealed ulcer, ear purulence and the like.
Preferably, the composition comprises the following components in parts by weight: 30-40 parts of honeysuckle, 8-10 parts of common leafflower herb, 8-10 parts of dried orange peel, 10-15 parts of raw liquorice, 10-20 parts of angelica dahurica, 10-15 parts of golden cypress, 5-8 parts of myrrh and 5-8 parts of borneol, and more preferably comprises the following components in parts by mass: 30 parts of honeysuckle, 10 parts of common leafflower herb, 10 parts of tangerine peel, 10 parts of raw liquorice, 10 parts of dahurian angelica root, 10 parts of amur corktree bark, 5 parts of myrrh and 5 parts of borneol.
Meanwhile, the application provides a preparation method of the antibacterial cream composition, which comprises the following steps: mixing flos Lonicerae, cacumen Securinegae Suffruticosae, pericarpium Citri Tangerinae, glycyrrhrizae radix, radix Angelicae Dahuricae, cortex Phellodendri, and Myrrha, grinding, sieving, adding Borneolum Syntheticum, and mixing to obtain mixture; adding oleum Sesami into the mixture, stirring, and sterilizing to obtain antibacterial paste composition, wherein the final product is paste convenient for application.
The sterilization mode is ultraviolet irradiation sterilization or ethylene oxide sterilization, and infection caused by mixed bacteria is avoided.
After concentration, the mass ratio of the mixture to the sesame oil is 3-5:8, the paste formed was homogeneous in texture.
In order to uniformly disperse the components in the paste, the particle size of the sieved particles is 100-120 meshes.
The application provides an application of a bacteriostatic paste composition in preparation of antibacterial drugs, wherein the bacteria comprise one or more of escherichia coli, staphylococcus aureus and staphylococcus epidermidis.
Meanwhile, the application of the antibacterial ointment composition in preparing an auxiliary medicine for treating diabetic foot infection is further provided, the development of diabetic feet can be effectively controlled, the early healing of the wound surfaces of the diabetic feet is promoted, and the defects that western medicines are easy to resist medicines, treat symptoms and root causes but not root causes, have single action target points, uncertain curative effect, long treatment course and high cost are overcome.
The present application is further illustrated by the following specific examples.
Example 1
An antibacterial cream composition comprises the following components in parts by weight: 50 parts of honeysuckle, 5 parts of common leafflower herb, 8 parts of tangerine peel, 20 parts of raw liquorice, 30 parts of dahurian angelica root, 20 parts of amur corktree bark, 5 parts of myrrh and 8 parts of borneol.
A preparation method of a bacteriostatic cream composition comprises the following steps: mixing and grinding honeysuckle, phyllanthus urinaria, dried orange peel, raw liquorice, angelica dahurica, phellodendron and myrrh according to the mass parts, then sieving the mixture, adding borneol and mixing the mixture uniformly to obtain a mixture, wherein the particle size of the sieved mixture is 100 meshes; adding the sesame oil into the mixture and stirring, wherein the mass ratio of the mixture to the sesame oil is 3: and 8, then, irradiating and disinfecting by ultraviolet rays to obtain the antibacterial paste composition.
Example 2
The bacteriostatic paste composition comprises the following components in parts by weight: 40 parts of honeysuckle, 9 parts of common leafflower herb, 9 parts of tangerine peel, 12 parts of raw liquorice, 15 parts of dahurian angelica root, 12 parts of amur corktree bark, 5 parts of myrrh and 5 parts of borneol.
A preparation method of a bacteriostatic paste composition comprises the following steps: mixing and grinding honeysuckle, phyllanthus urinaria, dried orange peel, raw liquorice, angelica dahurica, phellodendron and myrrh according to the mass parts, then sieving the mixture, adding borneol and mixing the mixture to obtain a mixture, wherein the particle size of the sieved mixture is 110 meshes; adding sesame oil into the mixture and stirring, wherein the mass ratio of the mixture to the sesame oil is 5: and 8, then, irradiating and disinfecting by ultraviolet rays to obtain the antibacterial paste composition.
Example 3
An antibacterial cream composition comprises the following components in parts by weight: 30 parts of honeysuckle, 10 parts of common leafflower herb, 10 parts of tangerine peel, 10 parts of raw liquorice, 10 parts of dahurian angelica root, 10 parts of amur corktree bark, 5 parts of myrrh and 5 parts of borneol.
A preparation method of a bacteriostatic paste composition comprises the following steps: mixing and grinding honeysuckle, phyllanthus urinaria, dried orange peel, raw liquorice, angelica dahurica, phellodendron and myrrh according to the mass parts, then sieving the mixture, adding borneol and mixing the mixture to obtain a mixture, wherein the particle size of the sieved mixture is 120 meshes; adding sesame oil into the mixture, and stirring, wherein the mass ratio of the mixture to the sesame oil is 5: and 8, then placing the mixture in a closed ethylene oxide sterilizer for sterilization and disinfection to obtain the antibacterial paste composition.
Testing and evaluation
100 diabetic patients were selected as evaluation subjects to evaluate the wound repair effect.
The patient receives basic treatment, including oral hypoglycemic agent or insulin injection to control blood sugar to be close to normal level (6.6-8.3 mmol/l), strictly according to diabetes diet, selecting antibiotics according to the bacterial culture and drug sensitivity test results of wound surface wound secretion, and taking the selected antibiotics as a control group.
Meanwhile, the wound surface is washed by 3 percent hydrogen peroxide solution, then the wound surface is cleaned by normal saline, the silkworm food sore-cleaning method is used for cleaning peripheral necrotic tissues until the wound surface is hemorrhagic, if closed gangrene is required to be cleaned to an open wound, the antibacterial ointment composition of the embodiment 1-3 and the selected antibiotics are respectively and uniformly coated on the affected part, then a TDP lamp is used for irradiating for 15 minutes, a piece of sterilized gauze is externally coated, then a TDP lamp is used for irradiating for 15 minutes, an adhesive plaster is used for fixing, the secretion is treated by the method for 1 time or more every day, 21 days are taken as a treatment course, and 3 treatment courses are continuously observed.
The evaluation criteria were:
the method has the following advantages: after one treatment course, the secretion of the wound surface is obviously reduced, and the wound surface shrinkage rate is more than or equal to 50 percent;
and (4) invalidation: after one treatment course, the secretion of the wound surface is slightly reduced, and the wound surface shrinkage rate is less than 50%.
The results are shown in Table 1.
TABLE 1 test results
From the results, it can be seen that the effect of the antibiotic is equivalent to that of the bacteriostatic cream composition of the scheme in the first course of treatment, but the treatment effect is inferior to that of the application due to the drug resistance generated by the antibiotic along with the prolongation of the course of treatment.
The bacteriostatic cream composition can effectively control the development of diabetic feet, promote the early healing of the wound surfaces of the diabetic feet, and overcome the defects that western medicines are easy to resist medicines, treat symptoms and root causes but not root causes, have single action target points, uncertain curative effect, long course of treatment and high cost.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are also included in the scope of the present invention.
Claims (10)
1. The antibacterial paste composition is characterized by comprising the following components in parts by weight: 30-50 parts of honeysuckle, 5-10 parts of common leafflower herb, 8-10 parts of tangerine peel, 10-20 parts of raw liquorice, 10-30 parts of dahurian angelica root, 10-20 parts of amur corktree bark, 5-10 parts of myrrh and 5-8 parts of borneol.
2. The bacteriostatic paste composition according to claim 1, which comprises the following components in parts by mass: 30-40 parts of honeysuckle, 8-10 parts of common leafflower herb, 8-10 parts of tangerine peel, 10-15 parts of raw liquorice, 10-20 parts of dahurian angelica root, 10-15 parts of amur corktree bark, 5-8 parts of myrrh and 5-8 parts of borneol.
3. A bacteriostatic cream composition according to claim 1, which is characterized by comprising the following components in parts by weight: 30 parts of honeysuckle, 10 parts of common leafflower herb, 10 parts of tangerine peel, 10 parts of raw liquorice, 10 parts of dahurian angelica root, 10 parts of amur corktree bark, 5 parts of myrrh and 5 parts of borneol.
4. A method of preparing a bacteriostatic cream composition according to any one of claims 1-3, comprising the steps of: mixing flos Lonicerae, cacumen Securinegae Suffruticosae, pericarpium Citri Tangerinae, glycyrrhrizae radix, radix Angelicae Dahuricae, cortex Phellodendri and Myrrha, grinding, sieving, adding Borneolum Syntheticum, and mixing to obtain mixture; adding oleum Sesami into the mixture, stirring, and sterilizing to obtain antibacterial paste composition.
5. A method for preparing a bacteriostatic cream composition according to claim 4, wherein the sterilization mode is ultraviolet irradiation sterilization or ethylene oxide sterilization.
6. A preparation method of a bacteriostatic cream composition according to claim 4, wherein after concentration, the mass ratio of the mixture to the sesame oil is 3-5:8.
7. a method of preparing a bacteriostatic cream composition according to claim 4 wherein the screened particle size is 100-120 mesh.
8. Use of a bacteriostatic cream composition according to claims 1-3 in the preparation of an antibacterial medicament.
9. The use of claim 8, wherein the bacteria comprise one or more of Escherichia coli, staphylococcus aureus, and Staphylococcus epidermidis.
10. An application of antibacterial ointment composition in preparing adjuvant medicine for treating diabetic foot infection is provided.
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| CN202211523636.5A CN115737720A (en) | 2022-11-25 | 2022-11-25 | Antibacterial paste composition and preparation method and application thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943721A (en) * | 2006-10-20 | 2007-04-11 | 青岛市市立医院 | A Chinese traditional externally use medicinal composition for treatment of diabetic feet |
| CN102429976A (en) * | 2011-12-07 | 2012-05-02 | 尚如湖铁医院 | Traditional Chinese medicinal ointment preparation for treating burns and scalds and preparation method thereof |
| CN110638892A (en) * | 2018-11-02 | 2020-01-03 | 顺德职业技术学院 | Preparation for preventing and treating diabetic foot and preparation method thereof |
| CN114470055A (en) * | 2022-02-28 | 2022-05-13 | 中国中医科学院西苑医院 | External medicine formula for treating diabetic foot ulcer wound |
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- 2022-11-25 CN CN202211523636.5A patent/CN115737720A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943721A (en) * | 2006-10-20 | 2007-04-11 | 青岛市市立医院 | A Chinese traditional externally use medicinal composition for treatment of diabetic feet |
| CN102429976A (en) * | 2011-12-07 | 2012-05-02 | 尚如湖铁医院 | Traditional Chinese medicinal ointment preparation for treating burns and scalds and preparation method thereof |
| CN110638892A (en) * | 2018-11-02 | 2020-01-03 | 顺德职业技术学院 | Preparation for preventing and treating diabetic foot and preparation method thereof |
| CN114470055A (en) * | 2022-02-28 | 2022-05-13 | 中国中医科学院西苑医院 | External medicine formula for treating diabetic foot ulcer wound |
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