CN108785214A - A kind of anti-blue light damage compound and its application in cosmetics - Google Patents
A kind of anti-blue light damage compound and its application in cosmetics Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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Abstract
The invention discloses a kind of compound of anti-blue light damage, the active constituent of the compound is by the Chinese medicine leaf of bamboo, Cortex Phellodendri, sophora flower, grape pip, giant knotweed, Radix Glycyrrhizae and centella is compound is prepared.The present invention also provides a kind of above-mentioned preparation methods of anti-blue light damage compound, weigh each Chinese medicine material ingredient, by extraction, filtering, sedimentation, centrifugation, medicinal extract is made in micro-filtration film process, concentration technology stage；Medicinal extract is dissolved into the liquid that mass fraction is 0.1~10%, as anti-blue light damages compound.The anti-blue light damage compound has strong absorption within the scope of the 400~480nm of wave band of blue light region, and has effects that anti-oxidant, reparation.Anti- blue light compound significant effect provided by the invention, it is safe in conjunction with traditional Chinese medicine technology, it can be applied in cosmetics use.
Description
Technical field
The invention belongs to Chinese medicine and daily chemicals fields, are related to a kind of cosmetics, and specifically a kind of anti-blue light damage is compound
Object and its application in cosmetics.
Background technology
Being exposed to for a long time under sunlight can cause light injury, previous consumer to be primarily upon the purple in sunlight skin
Damage of the outside line to human skin, and have ignored the effect of visible light.At present in daily life, in addition in sunlight
Outside blue light, mobile phone, computer, TV and other artificial light sources such as LED light can also generate blue light, increase people in blue light
Exposure duration.Xia Aiting and Tian Yan damages research caused by blue light and has carried out research summary（Xia Aiting, field swallow blue lights pair
Skin damage and its protection and progress [J] illuminating engineering journals, 2017,28 (6):20-23）.
In recent years, find can be light-exposed for research, especially blue light（400~480nm of wavelength）It is brighter to the damage of skin
It is aobvious.Blue light is that visible spectrum medium wavelength is most short, and the highest wave band of energy, penetration capacity is stronger compared with ultraviolet light, to the skin of people
Also the damage of similar ultraviolet light can be generated.
Research report blue light can penetrate skin histology, so that cell is generated oxidative stress and cytotoxicity, reduce into fiber finer
The oxidation resistance of born of the same parents inhibits fibroblast proliferation, reduces extracellular matrix, leads to light aging；It can additionally influence
The growth of chrotoplast, metabolism, DNA damage even can lead to cell dysfunction and have Apoptosis.
The cosmetics and Effect raw material product of anti-blue light damage currently on the market are few, and concern and type are also less.So
Developing a kind of product of anti-blue light damage is very important.
Invention content
For above-mentioned technical problem in the prior art, the present invention provides a kind of anti-blue light damage compound and its changing
Application in cosmetic, this anti-blue light damage compound and its application in cosmetics will solve in the prior art
The ineffective technical problem of blue light in cosmetics anti-visible-light.
The present invention provides a kind of anti-blue lights to damage compound, and the active constituent of the compound is by the Chinese medicine leaf of bamboo, Cortex Phellodendri, Chinese scholartree
Flower, grape pip, giant knotweed, Radix Glycyrrhizae and centella is compound is prepared.
Further, the compound is prepared by the raw material of following parts by weight：1-20 parts of the leaf of bamboo, Cortex Phellodendri 1-20
Part, 1-20 parts of sophora flower, 1-20 parts of grape pip, 1-20 parts of giant knotweed, 0.5-10 parts of Radix Glycyrrhizae, 0.5-10 parts of centella.
Further, the compound is prepared by the raw material of following parts by weight：15 parts of the leaf of bamboo, 12 parts of Cortex Phellodendri, Chinese scholartree
Spend 12 parts, 8 parts of grape pip, 8 parts of giant knotweed, 8 parts of Radix Glycyrrhizae, 6 parts of centella.
Further, the compound is prepared by the raw material of following parts by weight：16 parts of the leaf of bamboo, 12 parts of Cortex Phellodendri, Chinese scholartree
Spend 12 parts, 8 parts of grape pip, 8 parts of giant knotweed, 6 parts of Radix Glycyrrhizae, 6 parts of centella.
Further, the compound is prepared by the raw material of following parts by weight：10 parts of the leaf of bamboo, 15 parts of Cortex Phellodendri, Chinese scholartree
Spend 15 parts, 6 parts of grape pip, 6 parts of giant knotweed, 8 parts of Radix Glycyrrhizae, 5 parts of centella.
Further, the compound is prepared by the raw material of following parts by weight：8 parts of the leaf of bamboo, 16 parts of Cortex Phellodendri, sophora flower
16 parts, 8 parts of grape pip, 8 parts of giant knotweed, 3 parts of Radix Glycyrrhizae, 7 parts of centella.
The present invention also provides a kind of above-mentioned preparation methods of anti-blue light damage compound, include the following steps：
1) each Chinese medicine material ingredient is weighed, by feed liquid mass ratio 1:5~1:30, addition 30~80% alcohols solvent of mass fraction, 70
DEG C atmospheric extraction 2h, filtering, 10 DEG C settle 1~7 day, 2800r/min 20min centrifugal filtrations, micro-filtration film process, vacuum distillation,
50 DEG C of heat treatment of concentrate, obtain medicinal extract, spare；
2) step 1 is taken out）Alcohols solvent is added in the medicinal extract of preparation, and it is 0.1~10% content liquid to be prepared into mass percent concentration
Body, as anti-blue light damage compound.
Further, the alcohols solvent is in ethyl alcohol, butanediol, propylene glycol, glycerine, Isopropanediol, dipropylene glycol
One or more kinds of mixing.
The present invention also provides a kind of anti-blue lights to damage cosmetics, and compound is damaged containing above-mentioned anti-blue light.
Further, in the cosmetics, the mass percent concentration of the anti-blue light compound is 0.1 ~ 20%.
Further, in above-mentioned anti-blue light damage cosmetics, the mass percent containing anti-blue light compound is 0.1 ~
10%。
Specifically, a kind of anti-blue light damage cosmetics are to damage compound and common cosmetic additive by anti-blue light
It is formed with carrier.
In raw material selected by the anti-blue light damage compound of the present invention, the leaf of bamboo has clearing heat and relieving fidgetness, promotes the production of body fluid, the work(of diuresis
Effect；Cortex Phellodendri has the effect of heat-clearing and damp-drying drug, purging intense heat, except steaming, detoxification sore treatment；Sophora flower has the effect of heat-clearing, cool blood, hemostasis；Grape pip has
There are anti-oxidant, removing free radical, antiphlogistic effects；Giant knotweed is clearing heat and detoxicating, the effect of removing blood stasis and analgesics；Radix Glycyrrhizae have it is clearing heat and detoxicating, dispel
The effect of phlegm and relieving cough；Centella has clearing heat and promoting diuresis, the effect of subdhing swelling and detoxicating.
The present invention is compared with prior art, and technological progress is significant.A kind of anti-blue light damage provided by the invention is multiple
Object is closed, there is stronger assimilation effect within the scope of the 400~480nm of wavelength of blue light region, and the compound has anti-oxidant, reparation
Effect.Anti- blue light damage compound combination China's traditional Chinese medicine ingredients and theory, it is safe, it is easy to use, it is applied and is being changed
In cosmetic, there is preferable foreground.
With reference to specific embodiment, the invention will be further described.
Description of the drawings
Fig. 1 is that 1% anti-blue light damages compound-propylene glycol liquid in 400-500nm transmittance graphs.
Fig. 2 shows clearance rate of the anti-blue light damage compound to DPPH free radicals of different quality containing.
Specific implementation mode
It can be with the present invention will be further elaborated by the following examples, it is clear that the scope of the present invention not office
It is limited to following embodiments.Based on the embodiments of the present invention, relevant technical staff in the field is not departing from the content of present invention, essence
Method described herein and application are modified or are suitably changed and combined in god and range, belongs to the protection model of the present invention
It encloses.
The present invention carries out general and/or concrete description to the raw material and experimental method that are arrived used in experiment, uses
To many materials and operating method be known in the art, be described in detail as far as possible in the present invention；Used Chinese medicine material
It is provided for our company and/or market product purchasing.
Embodiment 1：Anti- blue light damages compound
A kind of active constituent of anti-blue light damage compound is prepared by the raw material of following mass parts：16 parts of the leaf of bamboo, Cortex Phellodendri 12
Part, 12 parts of sophora flower, 8 parts of grape pip, 8 parts of giant knotweed, 6 parts of Radix Glycyrrhizae, 6 parts of centella.
Anti- blue light damages compound preparation method, as follows：
1）Each Chinese medicine material ingredient is accurately weighed, by feed liquid mass ratio 1:5,80% alcohols solvent of mass fraction is added, often at 70 DEG C
Pressure extraction 2h, filter cloth, 10 DEG C settle 5 days, 2800r/min 20min centrifugal filtrations, and micro-filtration film process is evaporated under reduced pressure, concentration
50 DEG C of heat treatment of liquid, obtain medicinal extract, spare.
2）Take out step 1）Alcohols solvent is added in the medicinal extract of preparation, is prepared into 2% and contains quantity of fluid, and as anti-blue light damage is multiple
Close object.
Embodiment 2：Anti- blue light damages compound
A kind of active constituent of anti-blue light damage compound is prepared by the raw material of following mass parts：10 parts of the leaf of bamboo, Cortex Phellodendri 15
Part, 15 parts of sophora flower, 6 parts of grape pip, 6 parts of giant knotweed, 8 parts of Radix Glycyrrhizae, 5 parts of centella.
Anti- blue light damages compound preparation method, as follows：
1）Each Chinese medicine material ingredient is accurately weighed, by feed liquid mass ratio 1:15,70% alcohols solvent of mass fraction is added, at 70 DEG C
Atmospheric extraction 2h, filter cloth, 10 DEG C settle 3 days, 2800r/min 20min centrifugal filtrations, micro-filtration film process, and vacuum distillation is dense
The 50 DEG C of heat treatment of contracting liquid, obtain medicinal extract, spare.
2）Take out step 1）Alcohols solvent is added in the medicinal extract of preparation, is prepared into 5% and contains quantity of fluid, and as anti-blue light damage is multiple
Close object.
Embodiment 3：Anti- blue light damages compound
A kind of active constituent of anti-blue light damage compound is prepared by the raw material of following mass parts：8 parts of the leaf of bamboo, Cortex Phellodendri 16
Part, 16 parts of sophora flower, 8 parts of grape pip, 8 parts of giant knotweed, 3 parts of Radix Glycyrrhizae, 7 parts of centella.
Anti- blue light damages compound preparation method, as follows：
1）Each Chinese medicine material ingredient is accurately weighed, by feed liquid mass ratio 1:25,55% alcohols solvent of mass fraction is added, at 70 DEG C
Atmospheric extraction 2h, filter cloth, 10 DEG C settle 1 day, 2800r/min 20min centrifugal filtrations, micro-filtration film process, and vacuum distillation is dense
The 50 DEG C of heat treatment of contracting liquid, obtain medicinal extract, spare.
2）Take out step 1）Alcohols solvent is added in the medicinal extract of preparation, is prepared into 10% and contains quantity of fluid, as anti-blue light damage
Compound.
Embodiment 4：Blue light absorption is tested
The research product of compound is damaged with anti-blue light prepared by experimental example 2.The anti-blue light of precise damages compound, using third
Glycol makees solvent and prepares scanning within the scope of liquid progress 400~480nm of blue light region of mass fraction 1%.The results are shown in Figure 1.
Embodiment 5：Anti- blue light damage compound removes free radical test
The anti-blue light damage compound prepared with embodiment 2 makees research product.The anti-blue light of precise damages compound, using third
Glycol makees the liquid that solvent preparation different quality containing is 0.1%, 0.2%, 0.5%, 1%, 2% and carries out removing energy to free radical DPPH
Power is tested.
Experimental method：It takes the polysaccharide solution of 3mL various concentrations to be placed in test tube, 1mL DPPH is added（1.0×10-4 mol/
L, 50% ethyl alcohol）Solution is uniformly mixed, reacts 30min in the dark, and it is As to survey absorbance in 517nm, and 50% ethyl alcohol of 1mL replaces
The absorbance of DPPH is Ac, and it is Ao that 50% ethyl alcohol of 3mL, which replaces the absorbance of anti-blue light damage compound,.Each sample is put down three times
Row, takes its average value.Clearance rate calculates as follows：
) ×100
The results are shown in Figure 2：
From Fig. 1 and Fig. 2 can be seen that addition 1% mass fraction anti-blue light damage compound blue light region range transmissivity compared with
It is low, i.e., it is stronger to the absorption of blue light；And 0.2% mass fraction anti-blue light damage compound the clearance rate of free radical DPPH is reached
91.6%；With stronger blue light absorption and oxidation resistant effect.
Embodiment 6：Anti- blue light damages gel
The anti-blue light damage compound prepared with embodiment 2 makees research product.Formula is with reference to following table：
Preparation method is as follows：
1. first Carbopol, Sodium Hyaluronate are dispersed in glycerine, add in water and raise simultaneously temperature to 85 DEG C；
2. cooling to 50-55 DEG C；
3. B phases are added, C phases are stirring evenly and then adding into, stir evenly discharging, pH value is controlled in 5.5-6.5.
Embodiment 7：Anti- blue light damages cream
The anti-blue light damage compound prepared with embodiment 2 makees research product.Formula is with reference to following table：
Note：Expression is not added with.
Preparation method is as follows：
1. first Carbopol is dispersed in butanediol, adds in water and raise simultaneously temperature to 85 DEG C；
2. remaining component of addition B phases, stirs evenly；
3. A phases is complete in 85 DEG C of dissolvings, it stirs evenly；
4. A is added in B phases and stirs homogeneous, defoaming is cooled to 50 DEG C；
5. C phases are added, D phases are stirring evenly and then adding into, are stirred evenly, pH value is controlled in 5.5-6.5.
Embodiment 8：Anti- blue light injury experiment test
Cream is damaged using the anti-blue light that above-described embodiment 7 is prepared（Formula one, formula two, formula four）For testing research.
Method one：
Test 10 people of volunteer is chosen, 4 3*3cm test zones of test is chosen at tester back, chooses a region and oppose
According to 3mL creams are uniformly smeared in remaining 3 regions respectively；1h is irradiated using LED light, contains blue light（Wavelengths centered 450nm）, 150J/
m2, pigment deposition amount is detected using CK Company, Instrument MDD4-Mexameter MX18（MPD）（Including melanin and ferroheme）,
As a result it see the table below 1.
Method two：
Test 10 people of volunteer is chosen, 4 3*3cm test zones of test is chosen at tester back, 1h is irradiated using LED light,
Containing blue light（Wavelengths centered 450nm）, 150J/m2, choose a region and compare, 3mL's uniformly smeared in remaining 3 regions respectively
Formula one, is formulated four creams 28 days at formula two, 2 times a day, color is detected using CK Company, Instrument MDD4-Mexameter MX18
Plain deposition（MPD）（Including melanin and ferroheme）, as a result see the table below 2.
Table 1
| Group | Control | Formula one | Formula two | Formula four |
| MPD | 7.49 | 6.82 | 5.31 | 3.89 |
Table 2
| Group | Control | Formula one | Formula two | Formula four |
| MPD reduced rates % | 6.92 | 9.34 | 21.46 | 54.72 |
From Tables 1 and 2 it is found that anti-blue light provided by the invention damages compound, have very well to the skin damage caused by blue light
Defence and reparation effect.
Claims (10)
1. a kind of anti-blue light damages compound, it is characterised in that：The active constituent of the compound be by the Chinese medicine leaf of bamboo, Cortex Phellodendri,
Sophora flower, grape pip, giant knotweed, Radix Glycyrrhizae and centella is compound is prepared.
2. a kind of anti-blue light damages compound according to claim 1, it is characterised in that：The compound is by following weight
The raw material of part is prepared：1-20 parts of the leaf of bamboo, 1-20 parts of Cortex Phellodendri, 1-20 parts of sophora flower, 1-20 parts of grape pip, 1-20 parts of giant knotweed,
0.5-10 parts of Radix Glycyrrhizae, 0.5-10 parts of centella.
3. a kind of anti-blue light damages compound according to claim 2, it is characterised in that：The compound is by following weight
The raw material of part is prepared：15 parts of the leaf of bamboo, 12 parts of Cortex Phellodendri, 12 parts of sophora flower, 8 parts of grape pip, 8 parts of giant knotweed, 8 parts of Radix Glycyrrhizae, centella 6
Part.
4. a kind of anti-blue light damages compound according to claim 2, it is characterised in that：The compound is by following weight
The raw material of part is prepared：16 parts of the leaf of bamboo, 12 parts of Cortex Phellodendri, 12 parts of sophora flower, 8 parts of grape pip, 8 parts of giant knotweed, 6 parts of Radix Glycyrrhizae, centella
6 parts.
5. a kind of anti-blue light damages compound according to claim 2, it is characterised in that：The compound is by following weight
The raw material of part is prepared：10 parts of the leaf of bamboo, 15 parts of Cortex Phellodendri, 15 parts of sophora flower, 6 parts of grape pip, 6 parts of giant knotweed, 8 parts of Radix Glycyrrhizae, centella
5 parts.
6. a kind of anti-blue light damages compound according to claim 2, it is characterised in that：The compound is by following weight
The raw material of part is prepared：8 parts of the leaf of bamboo, 16 parts of Cortex Phellodendri, 16 parts of sophora flower, 8 parts of grape pip, 8 parts of giant knotweed, 3 parts of Radix Glycyrrhizae, centella 7
Part.
7. a kind of preparation method of anti-blue light damage compound described in claim 1-6, it is characterised in that include the following steps：
Each Chinese medicine material ingredient is weighed, by feed liquid mass ratio 1:5~1:30, addition 30~80% alcohols solvent of mass fraction, 70 DEG C
Atmospheric extraction 2h, filtering, 10 DEG C settle 1~7 day, 2800r/min 20min centrifugal filtrations, micro-filtration film process, and vacuum distillation is dense
The 50 DEG C of heat treatment of contracting liquid, obtain medicinal extract, spare；
Take out step 1）Alcohols solvent is added in the medicinal extract of preparation, is prepared into mass percent concentration and contains quantity of fluid for 0.1~10%,
As anti-blue light damages compound.
8. a kind of preparation method of anti-blue light damage compound according to claim 7, it is characterised in that：The alcohols
Solvent is the mixing of one or more of ethyl alcohol, butanediol, propylene glycol, glycerine, Isopropanediol, dipropylene glycol.
9. a kind of anti-blue light damages cosmetics, it is characterised in that：Compound is damaged containing the anti-blue light described in claim 1-6.
10. a kind of anti-blue light according to claim 9 damages cosmetics, it is characterised in that：In the cosmetics, institute
The mass percent concentration for the anti-blue light damage compound stated is 0.1 ~ 20%.
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| CN108785214B (en) | 2021-06-04 |
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