CN108743667A - A kind of Chinese medicine for treating rhinitis composition, preparation method and pharmaceutical preparation - Google Patents
A kind of Chinese medicine for treating rhinitis composition, preparation method and pharmaceutical preparation Download PDFInfo
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Abstract
The Chinese medicine composition of the treatment rhinitis of the present invention can effectively eliminate nasal cavity inflammation, concha enlargement, nasal decongestion by the mutual compatible of each component, improve symptom caused by congestion, therapeutic effect is good, controls difficulty in relapse after healing, and drug resistance is not generated, it is suitable for adult and children.The pharmaceutical preparation of the treatment rhinitis of the present invention, the Chinese medicine composition is mixed in suitable physiological saline, is used for nasal irrigation, can be played good therapeutic effect.The preparation method of the Chinese medicine composition of the treatment rhinitis of the present invention formulates the extracting method of adaptability according to the difference of each component active ingredient, and active ingredient is effectively extracted, the drug effect of the Chinese medicine composition can be made to be played to the greatest extent.
Description
Technical field
The invention belongs to lunar physics technique fields, and in particular to a kind of Chinese medicine for treating rhinitis composition, preparation method and
Pharmaceutical preparation.
Background technology
It is virus, bacterium, allergen, various physical and chemical factors and certain systemic diseases even if the inflammation in rhinitis nasal cavity
The inflammation of caused nasal membrane, main pathological change are nasal membrane hyperemia, swelling, exudation, hyperplasia, atrophy or necrosis
Deng.
There are many symptoms of rhinitis：Nasal obstruction, more tears, smell decline, dizziness headache, loss of appetite, easily tired, memory subtract
It moves back and has a sleepless night, morbidity is frequent, serious to affect the work, life and health of people, therefore should cause to treatment of rhinitis
Enough attention.
Currently, treat rhinitis both at home and abroad, generally using decongestant such as 1% ephedrine, Xylometazoline nose-spray,
Oxymetazoline Hydrochloride, hydrochloric acid naphthalene man oxazoline nasal drops etc.；Steroids preparation it is more common as Triamcinolone acetonide nasal spray,
Beclomeasone propionate nasal aerosol, fluticasone propionate nasal spray etc., long-time service easy to produce Drug-resistant row, are also easy
Cause rhinitis medicamentosa, cannot fundamentally change the symptom of patients with rhinitis, have the shortcomings that recurrent exerbation, it is final that operation is needed to control
It treats.
Invention content
Based on problem above, one purpose of the invention is to provide a kind of Chinese medicine for treating rhinitis composition, can be effective
Nasal cavity inflammation, concha enlargement, nasal decongestion are eliminated, improves symptom caused by congestion, therapeutic effect is good, is not easy after healing
Recurrence, and do not generate drug resistance.
Another object of the present invention is to provide a kind of preparation method of the Chinese medicine composition of the treatment rhinitis.
The technical scheme is that：
The present invention provides a kind of Chinese medicine for treating rhinitis composition, is composed of the following raw materials by weight：25-30 parts of gold and silver
Flower, 10-15 parts of radix scutellariaes, 5-10 parts of Fructus Forsythiaes, 3-8 parts of radix bupleuri and 10-15 parts of Radix Isatidis.
The Chinese medicine composition for the treatment of rhinitis according to the present invention, is composed of the following raw materials by weight：28 portions of honeysuckles, 12 parts
8 parts of Fructus Forsythiaes of radix scutellariae, 6 parts of radix bupleuri and 12 parts of Radix Isatidis.
In the above Chinese medicine composition each component have it is pure and fresh have one's ideas straightened out, dampness removing is except dry and other effects, think through actual clinical verification,
For various nasal obstructions, nasal cavity is unsmooth and the nursing of other Rhinitis Symptoms has obvious curative effects.
Honeysuckle：Clearing heat and detoxicating, wind-heat dissipating can strengthen immunity, anti-inflammatory etc.；
Fructus Forsythiae：Clearing heat and detoxicating, dispersing swelling and dissipating binds have the effects that antibacterial, anti-inflammatory, anti-liver damage, analgesia；
Radix Isatidis：It is clearing heat and detoxicating, cool blood relieving sore-throat；
Radix bupleuri：It is soothing the liver in inducing diaphoresis, rising Yang, it is antipyretic, anti-inflammatory, improve immunity the effects that；
Radix scutellariae：Heat-clearing and damp-drying drug, purging intense heat and detonicating, antibacterial, it is antiviral the effects that.
In above each composition, using Fructus Forsythiae as monarch drug in a prescription, dispersing accumulation of pathogen and clearing away heat, honeysuckle and radix scutellariae are ministerial drug, and clearing heat and detoxicating, plate is blue
Root is adjutant, and cool blood of detoxifying, radix bupleuri is to make medicine, antibacterial inducing diaphoresis.
The present invention also provides a kind of pharmaceutical preparation for treating rhinitis, including the Chinese medicine composition and physiological saline, institutes
The amount ratio for stating Chinese medicine composition and physiological saline is 1.5-2g:250-500mL.Using the pharmaceutical preparation as spray, nose is rinsed
Chamber, you can play good therapeutic effect.
The pharmaceutical preparation for the treatment of rhinitis according to the present invention is given 12 one full year of life above crowd and is used, the Chinese medicine composition
Amount ratio with physiological saline is 2g:500mL.
The pharmaceutical preparation for the treatment of rhinitis according to the present invention, gives 12 one full year of life or less crowd use, the Chinese medicine composition
Amount ratio with physiological saline is 1.5g:250mL.
The present invention provides the preparation method of the Chinese medicine composition of the treatment rhinitis, includes the following steps：
(1) Honegsukle flower P.E is produced：
A, it is decocted after soaking honeysuckle, filters, obtain the first filtrate；Concentrate the filtrate to 70-80 DEG C relatively
Density is the clear cream of 1.20-1.25；
B, ethyl alcohol is added after the cooling clear cream and is sufficiently stirred, obtain alcohol mixeding liquid, filtered after standing 12 hours
To supernatant and residue, the pH value of the supernatant is adjusted to 6.0-8.0 with sodium hydroxide solution；
C, the ethanol water that mass fraction is 75% is added to the residue obtained after filter, stirs evenly, stand 12 hours
After filter, obtain ethanol, recycle the ethyl alcohol in the ethanol to no alcohol taste, obtain remove alcohol extract；
D, by the supernatant and except alcohol extract merges, the heavy mixed liquor of water is obtained, adds water water in sinking mixed liquor to the water
It after heavy, is filtered again, obtains the heavy filtrate of water, the heavy filtrate of the water is concentrated and dried, Honegsukle flower P.E is obtained；
(2) forsythia suspense extraction is produced：
A, it is decocted after soaking Fructus Forsythiae, filters, obtain the first filtrate；Concentrate the filtrate to 70-80 DEG C it is relatively close
Degree is the clear cream of 1.20-1.25；
B, ethyl alcohol is added after the cooling clear cream and is sufficiently stirred, obtain alcohol mixeding liquid, filtered after standing 12 hours
To supernatant and residue, sodium hydroxide solution adjusts the pH value of supernatant to 6.0-8.0；
C, the ethanol water that mass fraction is 75% is added in the residue obtained after filter, stirred evenly, stand 12 hours
After filter, obtain ethanol, recycle the ethyl alcohol in the ethanol to no alcohol taste, obtain remove alcohol extract；
D, by the supernatant and except alcohol extract merges, the heavy mixed liquor of water is obtained, adds water water in sinking mixed liquor to the water
It after heavy, is filtered again, obtains the heavy filtrate of water, the heavy filtrate of the water is concentrated and dried, forsythia suspense extraction is obtained；
(3) Baical Skullcap root P.E is produced：
A, after crushing radix scutellariae plus water decocts, and filters, obtains the first filtrate；Concentrate the filtrate to 70-80 DEG C it is relatively close
Degree is the clear cream of 1.15-1.25, at 70-80 DEG C with salt acid for adjusting pH to 1.0-3.0, keeps the temperature 1 hour, after standing 12 hours,
Filtering, obtains the second filtrate and filter residue；
B, the water of 8-10 times of quality of filter residue is added in the filter residue, and pH to 6.0-8.0 is adjusted with sodium hydroxide solution,
It adds ethyl alcohol and is sufficiently stirred, obtain alcohol mixeding liquid；The alcohol mixeding liquid is filtered, third filtrate is obtained；
C, the third filtrate pH to 1.0-2.0 is adjusted with hydrochloric acid, stands 10 hours after keeping the temperature 1 hour at 45-55 DEG C, mistake
Filter, must sieve down sediment；
D, it is 6.0-8.0 the sediment to be washed till pH with ethyl alcohol, after recycling ethyl alcohol, obtains Baical Skullcap root P.E；
(4) bupleurum extract is produced：
A, the sodium chloride solution of mass fraction 8-12% will be added after radix bupleuri drying and crushing, impregnate 24 hours, boil, collect
Distillate adjusts pH to 4.0-7.0 with sodium hydroxide solution, and filtering obtains filtrate；
B, after drying filtrate, bupleurum extract is obtained；
(5) isatis root extract is produced：
A, Radix Isatidis is added water to cook, is filtered, the first filtrate and the first filter residue；
B, first filtrate is concentrated into the clear cream that 50-60 DEG C of relative density is 1.15-1.20, mass fraction, which is added, is
After 75% ethanol water, alcohol mixeding liquid is obtained, after the alcohol mixeding liquid is staticly settled, leaching supernatant；
C, the ethyl alcohol in the supernatant is recycled to no alcohol taste, obtains removing alcohol extract, is added to described remove in alcohol extract
Water water is heavy, and the second filtrate is obtained after filtering；
D, isatis root extract is made after being concentrated and dried second filtrate；
(6) after each drug extract co-grinding for obtaining step (1)-(5), the Chinese medicine composition is obtained.
The preparation method of the Chinese medicine composition of the above treatment rhinitis, can have the active principle in each drug component
Effect extraction, keeps excellent drug effect.Wherein, the restriction for concentrating relative density is based on the sedimentation effect and ethyl alcohol in precipitation process
Utilization rate determine.The parameter that pH is adjusted, which determines, to be determined to the recovery rate of each drug extract based on pH value.
The preparation method of the Chinese medicine composition for the treatment of rhinitis according to the present invention, in step (1) B and (2) B, the second
The mass fraction of ethyl alcohol is 60-80% in alcohol mixed liquor；The mass fraction of ethyl alcohol is 40- in alcohol mixeding liquid described in step (3) B
60%；The mass fraction of ethyl alcohol is 55-65% in alcohol mixeding liquid described in step (5) B.
The preparation method of the Chinese medicine composition for the treatment of rhinitis according to the present invention decocts 2 times in step (1) A, and every time 2
Hour, collecting decoction is the first filtrate；It in step (2) A, decocts 3 times, first and second time 2 hours each, and third time 1 hour is closed
And decocting liquid is the first filtrate three times；It in step (3) A, decocts 2 times, 2 hours for the first time, second 1 hour, merging was decocted twice
Liquid is the first filtrate；In step (4) A, the first distillate after single flash is distilled again, it is first to collect re-distilled liquid
0.7-0.8 times of quality of distillate, as final distillate；It in step (5) A, decocts 2 times, adds 5 times of Radix Isatidis for the first time
Quality water decocts 1 hour, and 3 times of quality water, which are added, into the dregs of a decoction after filtering carries out second of decoction 0.5 hour, merges decocting liquid twice
For the first filtrate.In actual drug extraction process, decocts or the time of distillation and times influence are to final drug effect and economy
Benefit, above decoction, distillation technique feature obtain in actual drug preparation process heuristic process, i.e., are decocted above-mentioned
Under the cooperation for boiling time, number and distillation technique, obtained final drug extract drug effect is notable.
The preparation method of the Chinese medicine composition for the treatment of rhinitis according to the present invention carries out in step (1) D, step (2) D
When water sinks, the additive amount of water is 5-10 times of the heavy mixed liquor quality of the water；In step (5) C, when progress water is heavy, water adds
Dosage is remove alcohol extract quality 5-10 times.The additive amount of water determines final active principle extraction efficiency, adds above
Dosage is enough fully fully to extract the active ingredient in drug, avoids the waste of active principle.
The preparation method of the Chinese medicine composition for the treatment of rhinitis according to the present invention, in step (6), in described after crushing
The granularity of drug composition is 180-220 mesh.Granularity after the Chinese medicine composition crushes also directly affects controlling for nasal irrigation
Therapeutic effect, granularity is excessive, drug effect can not fast reaction, therapeutic effect is poor；Undersized is more influenced it will cause nasal cavity sensitivity
Therapeutic effect.
Beneficial effects of the present invention are：
The Chinese medicine composition of the treatment rhinitis of the present invention can effectively eliminate nasal cavity inflammation by the mutual compatible of each component
Disease, concha enlargement, nasal decongestion improve symptom caused by congestion, and therapeutic effect is good, controls difficulty in relapse after healing, and not
Drug resistance is generated, adult and children are suitable for.
The pharmaceutical preparation of the treatment rhinitis of the present invention, the Chinese medicine composition is mixed in suitable physiological saline, is used for
Nasal irrigation can play good therapeutic effect.
The preparation method of the Chinese medicine composition of the treatment rhinitis of the present invention is formulated according to the difference of each component active ingredient
Active ingredient is effectively extracted, the drug effect of the Chinese medicine composition can be made to obtain maximum journey by the extracting method of adaptability
The performance of degree.
Specific implementation mode
To make the object, technical solutions and advantages of the present invention clearer, technical scheme of the present invention will be carried out below
Detailed description.Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Base
Embodiment in the present invention, those of ordinary skill in the art are obtained all without making creative work
Other embodiment belongs to the range that the present invention is protected.
Embodiment 1
The present invention provides a kind of Chinese medicine for treating rhinitis composition, is composed of the following raw materials by weight：25 parts of honeysuckles, 15
Part radix scutellariae, 5 parts of Fructus Forsythiaes, 8 parts of radix bupleuri and 10 parts of Radix Isatidis.
The present invention also provides a kind of pharmaceutical preparation for treating rhinitis, including above-mentioned Chinese medicine composition and physiological saline, institutes
The amount ratio for stating Chinese medicine composition and physiological saline is 2g:500mL.
The preparation method of the Chinese medicine composition of the treatment rhinitis, includes the following steps：
(1) Honegsukle flower P.E is produced：
A, it carries out decocting 2 times after soaking honeysuckle, 2 hours every time, collecting decoction was the first filtrate；Filtrate is dense
It is reduced to the clear cream that 70 DEG C of relative densities are 1.25；
B, ethyl alcohol is added after the cooling clear cream and is sufficiently stirred, obtain alcohol mixeding liquid, second in the alcohol mixeding liquid
The mass fraction of alcohol is 60%, supernatant and residue is obtained by filtration after the alcohol mixeding liquid is stood 12 hours, with hydroxide
Sodium solution adjusts the pH value of the supernatant to 8.0；
C, the ethanol water that mass fraction is 75% is added to the residue obtained after filter, stirs evenly, stand 12 hours
After filter, obtain ethanol, recycle the ethyl alcohol in the ethanol to no alcohol taste, obtain remove alcohol extract；
D, by the supernatant and except alcohol extract merges, the heavy mixed liquor of water is obtained, it is in sinking mixed liquor to the water plus described
It after the water progress water of water 5 times of quality of heavy mixed liquor sinks, is filtered again, obtains the heavy filtrate of water, the heavy filtrate of the water is concentrated
It is dry, obtain Honegsukle flower P.E；
(2) forsythia suspense extraction is produced：
A, it carries out decocting 3 times after soaking Fructus Forsythiae, first and second time 2 hours each, and third time 1 hour merges three
Secondary decocting liquid is the first filtrate；Concentrate the filtrate to the clear cream that 80 DEG C of relative densities are 1.20；
B, ethyl alcohol is added after the cooling clear cream and is sufficiently stirred, obtain alcohol mixeding liquid, second in the alcohol mixeding liquid
The mass fraction of alcohol is 80%, and supernatant and residue, sodium hydroxide is obtained by filtration after the alcohol mixeding liquid is stood 12 hours
Solution adjusts the pH value of supernatant to 6.0；
C, the ethanol water that mass fraction is 75% is added in the residue obtained after filter, stirred evenly, stand 12 hours
After filter, obtain ethanol, recycle the ethyl alcohol in the ethanol to no alcohol taste, obtain remove alcohol extract；
D, by the supernatant and except alcohol extract merges, the heavy mixed liquor of water is obtained, it is in sinking mixed liquor to the water plus described
It after the water progress water of water 10 times of quality of heavy mixed liquor sinks, is filtered again, obtains the heavy filtrate of water, the heavy filtrate of the water is concentrated
It is dry, obtain forsythia suspense extraction；
(3) Baical Skullcap root P.E is produced：
A, after crushing radix scutellariae plus water decoct 2 times, 2 hours for the first time, second 1 hour, merges decocting liquid twice and is
First filtrate；The clear cream that 70 DEG C of relative densities are 1.25 is concentrated the filtrate to, at 70 DEG C with salt acid for adjusting pH to 3.0, heat preservation 1
Hour, after standing 12 hours, filtering obtains the second filtrate and filter residue；
B, the water of 8 times of quality of filter residue is added in the filter residue, and pH to 8.0 is adjusted with sodium hydroxide solution, is added
Ethyl alcohol is simultaneously sufficiently stirred, and the mass fraction for obtaining ethyl alcohol in alcohol mixeding liquid described in alcohol mixeding liquid is 40%；By the ethyl alcohol
Mixed liquor filters, and obtains third filtrate；
C, the third filtrate pH to 2.0 is adjusted with hydrochloric acid, 10 hours is stood after keeping the temperature 1 hour at 45 DEG C, filtered, must sieve
Lower sediment；
D, it is 8.0 the sediment to be washed till pH with ethyl alcohol, after recycling ethyl alcohol, obtains Baical Skullcap root P.E；
(4) bupleurum extract is produced：
A, the sodium chloride solution of mass fraction 8% will be added after radix bupleuri drying and crushing, impregnate 24 hours, boil, distill, it will
First distillate after single flash is distilled again, collects 0.8 times of quality that re-distilled liquid is first distillate, as final
Distillate adjusts pH to 4.0 with sodium hydroxide solution, and filtering obtains filtrate；
B, after drying filtrate, bupleurum extract is obtained；
(5) isatis root extract is produced：
A, Radix Isatidis is added water to cook, is decocted 2 times, for the first time plus 5 times of quality water of Radix Isatidis decoct 1 hour, and filtering is backward
The water that 3 times of quality of the dregs of a decoction are added in the dregs of a decoction carries out second of decoction 0.5 hour, and it is the first filtrate to merge decocting liquid twice；
B, first filtrate is concentrated into the clear cream that 60 DEG C of relative densities are 1.15, the second that mass fraction is 75% is added
After alcohol solution, alcohol mixeding liquid is obtained, the mass fraction of ethyl alcohol is 65% in the alcohol mixeding liquid, and the ethyl alcohol is mixed
After liquid staticly settles, leaching supernatant；
C, the ethyl alcohol in the supernatant is recycled to no alcohol taste, obtains removing alcohol extract, is added to described remove in alcohol extract
After the water progress water except 5 times of quality of alcohol extract sinks, the second filtrate is obtained after filtering；
D, isatis root extract is made after being concentrated and dried second filtrate；
(6) after each drug extract co-grinding to 220 mesh for obtaining step (1)-(5), the Chinese traditional medicine composition is obtained
Object.
Embodiment 2
The present invention provides a kind of Chinese medicine for treating rhinitis composition, is composed of the following raw materials by weight：30 parts of honeysuckles, 10
Part radix scutellariae, 10 parts of Fructus Forsythiaes, 3 parts of radix bupleuri and 15 parts of Radix Isatidis.
The present invention also provides a kind of pharmaceutical preparation for treating rhinitis, including above-mentioned Chinese medicine composition and physiological saline, institutes
The amount ratio for stating Chinese medicine composition and physiological saline is 1.5g:250mL.
The preparation method of the Chinese medicine composition of the treatment rhinitis, includes the following steps：
(1) Honegsukle flower P.E is produced：
A, it carries out decocting 2 times after soaking honeysuckle, 2 hours every time, collecting decoction was the first filtrate；Filtrate is dense
It is reduced to the clear cream that 80 DEG C of relative densities are 1.20；
B, ethyl alcohol is added after the cooling clear cream and is sufficiently stirred, obtain alcohol mixeding liquid, second in the alcohol mixeding liquid
The mass fraction of alcohol is 80%, supernatant and residue is obtained by filtration after the alcohol mixeding liquid is stood 12 hours, with hydroxide
Sodium solution adjusts the pH value of the supernatant to 6.0；
C, the ethanol water that mass fraction is 75% is added to the residue obtained after filter, stirs evenly, stand 12 hours
After filter, obtain ethanol, recycle the ethyl alcohol in the ethanol to no alcohol taste, obtain remove alcohol extract；
D, by the supernatant and except alcohol extract merges, the heavy mixed liquor of water is obtained, it is in sinking mixed liquor to the water plus described
It after the water progress water of water 10 times of quality of heavy mixed liquor sinks, is filtered again, obtains the heavy filtrate of water, the heavy filtrate of the water is concentrated
It is dry, obtain Honegsukle flower P.E；
(2) forsythia suspense extraction is produced：
A, it carries out decocting 3 times after soaking Fructus Forsythiae, first and second time 2 hours each, and third time 1 hour merges three
Secondary decocting liquid is the first filtrate；Concentrate the filtrate to the clear cream that 70 DEG C of relative densities are 1.25；
B, ethyl alcohol is added after the cooling clear cream and is sufficiently stirred, obtain alcohol mixeding liquid, second in the alcohol mixeding liquid
The mass fraction of alcohol is 60%, and supernatant and residue, sodium hydroxide is obtained by filtration after the alcohol mixeding liquid is stood 12 hours
Solution adjusts the pH value of supernatant to 8.0；
C, the ethanol water that mass fraction is 75% is added in the residue obtained after filter, stirred evenly, stand 12 hours
After filter, obtain ethanol, recycle the ethyl alcohol in the ethanol to no alcohol taste, obtain remove alcohol extract；
D, by the supernatant and except alcohol extract merges, the heavy mixed liquor of water is obtained, it is in sinking mixed liquor to the water plus described
It after the water progress water of water 5 times of quality of heavy mixed liquor sinks, is filtered again, obtains the heavy filtrate of water, the heavy filtrate of the water is concentrated
It is dry, obtain forsythia suspense extraction；
(3) Baical Skullcap root P.E is produced：
A, after crushing radix scutellariae plus water decoct 2 times, 2 hours for the first time, second 1 hour, merges decocting liquid twice and is
First filtrate；The clear cream that 80 DEG C of relative densities are 1.15 is concentrated the filtrate to, at 80 DEG C with salt acid for adjusting pH to 1.0, heat preservation 1
Hour, after standing 12 hours, filtering obtains the second filtrate and filter residue；
B, the water of 10 times of quality of filter residue is added in the filter residue, and pH to 6.0 is adjusted with sodium hydroxide solution, is added
Ethyl alcohol is simultaneously sufficiently stirred, and the mass fraction for obtaining ethyl alcohol in alcohol mixeding liquid described in alcohol mixeding liquid is 60%；By the ethyl alcohol
Mixed liquor filters, and obtains third filtrate；
C, the third filtrate pH to 1.0 is adjusted with hydrochloric acid, 10 hours is stood after keeping the temperature 1 hour at 55 DEG C, filtered, must sieve
Lower sediment；
D, it is 6.0 the sediment to be washed till pH with ethyl alcohol, after recycling ethyl alcohol, obtains Baical Skullcap root P.E；
(4) bupleurum extract is produced：
A, the sodium chloride solution of mass fraction 12% will be added after radix bupleuri drying and crushing, impregnate 24 hours, boil, distill,
First distillate after single flash is distilled again, collects 0.7 times of quality that re-distilled liquid is first distillate, as finally
Distillate, with sodium hydroxide solution adjust pH to 7.0, filtering, obtain filtrate；
B, after drying filtrate, bupleurum extract is obtained；
(5) isatis root extract is produced：
A, Radix Isatidis is added water to cook, is decocted 2 times, for the first time plus 5 times of quality water of Radix Isatidis decoct 1 hour, and filtering is backward
The water that 3 times of quality of the dregs of a decoction are added in the dregs of a decoction carries out second of decoction 0.5 hour, and it is the first filtrate to merge decocting liquid twice；
B, first filtrate is concentrated into the clear cream that 50 DEG C of relative densities are 1.20, the second that mass fraction is 75% is added
After alcohol solution, alcohol mixeding liquid is obtained, the mass fraction of ethyl alcohol is 55% in the alcohol mixeding liquid, and the ethyl alcohol is mixed
After liquid staticly settles, leaching supernatant；
C, the ethyl alcohol in the supernatant is recycled to no alcohol taste, obtains removing alcohol extract, is added to described remove in alcohol extract
After the water progress water except 10 times of quality of alcohol extract sinks, the second filtrate is obtained after filtering；
D, isatis root extract is made after being concentrated and dried second filtrate；
(6) after each drug extract co-grinding to 180 mesh for obtaining step (1)-(5), the Chinese traditional medicine composition is obtained
Object.
Embodiment 3
The present invention provides a kind of Chinese medicine for treating rhinitis composition, is composed of the following raw materials by weight：28 parts of honeysuckles, 12
8 parts of Fructus Forsythiaes of part radix scutellariae, 6 parts of radix bupleuri and 12 parts of Radix Isatidis.
The present invention also provides a kind of pharmaceutical preparation for treating rhinitis, including above-mentioned Chinese medicine composition and physiological saline, institutes
The amount ratio for stating Chinese medicine composition and physiological saline is 1.8g:300mL.
The preparation method of the Chinese medicine composition of the treatment rhinitis, includes the following steps：
(1) Honegsukle flower P.E is produced：
A, it carries out decocting 2 times after soaking honeysuckle, 2 hours every time, collecting decoction was the first filtrate；Filtrate is dense
It is reduced to the clear cream that 75 DEG C of relative densities are 1.23；
B, ethyl alcohol is added after the cooling clear cream and is sufficiently stirred, obtain alcohol mixeding liquid, second in the alcohol mixeding liquid
The mass fraction of alcohol is 70%, supernatant and residue is obtained by filtration after the alcohol mixeding liquid is stood 12 hours, with hydroxide
Sodium solution adjusts the pH value of the supernatant to 7.0；
C, the ethanol water that mass fraction is 75% is added to the residue obtained after filter, stirs evenly, stand 12 hours
After filter, obtain ethanol, recycle the ethyl alcohol in the ethanol to no alcohol taste, obtain remove alcohol extract；
D, by the supernatant and except alcohol extract merges, the heavy mixed liquor of water is obtained, it is in sinking mixed liquor to the water plus described
It after the water progress water of water 8 times of quality of heavy mixed liquor sinks, is filtered again, obtains the heavy filtrate of water, the heavy filtrate of the water is concentrated
It is dry, obtain Honegsukle flower P.E；
(2) forsythia suspense extraction is produced：
A, it carries out decocting 3 times after soaking Fructus Forsythiae, first and second time 2 hours each, and third time 1 hour merges three
Secondary decocting liquid is the first filtrate；Concentrate the filtrate to the clear cream that 75 DEG C of relative densities are 1.22；
B, ethyl alcohol is added after the cooling clear cream and is sufficiently stirred, obtain alcohol mixeding liquid, second in the alcohol mixeding liquid
The mass fraction of alcohol is 70%, and supernatant and residue, sodium hydroxide is obtained by filtration after the alcohol mixeding liquid is stood 12 hours
Solution adjusts the pH value of supernatant to 7.0；
C, the ethanol water that mass fraction is 75% is added in the residue obtained after filter, stirred evenly, stand 12 hours
After filter, obtain ethanol, recycle the ethyl alcohol in the ethanol to no alcohol taste, obtain remove alcohol extract；
D, by the supernatant and except alcohol extract merges, the heavy mixed liquor of water is obtained, it is in sinking mixed liquor to the water plus described
It after the water progress water of water 8 times of quality of heavy mixed liquor sinks, is filtered again, obtains the heavy filtrate of water, the heavy filtrate of the water is concentrated
It is dry, obtain forsythia suspense extraction；
(3) Baical Skullcap root P.E is produced：
A, after crushing radix scutellariae plus water decoct 2 times, 2 hours for the first time, second 1 hour, merges decocting liquid twice and is
First filtrate；The clear cream that 75 DEG C of relative densities are 1.20 is concentrated the filtrate to, at 75 DEG C with salt acid for adjusting pH to 2.0, heat preservation 1
Hour, after standing 12 hours, filtering obtains the second filtrate and filter residue；
B, the water of 9 times of quality of filter residue is added in the filter residue, and pH to 7.0 is adjusted with sodium hydroxide solution, is added
Ethyl alcohol is simultaneously sufficiently stirred, and the mass fraction for obtaining ethyl alcohol in alcohol mixeding liquid described in alcohol mixeding liquid is 40-60%；By the second
Alcohol mixed liquor filters, and obtains third filtrate；
C, the third filtrate pH to 1.0-2.0 is adjusted with hydrochloric acid, 10 hours is stood after keeping the temperature 1 hour at 50 DEG C, filtered,
Sediment must be sieved down；
D, it is 7.0 the sediment to be washed till pH with ethyl alcohol, after recycling ethyl alcohol, obtains Baical Skullcap root P.E；
(4) bupleurum extract is produced：
A, the sodium chloride solution of mass fraction 10% will be added after radix bupleuri drying and crushing, impregnate 24 hours, boil, distill,
First distillate after single flash is distilled again, collects 0.8 times of quality that re-distilled liquid is first distillate, as finally
Distillate, with sodium hydroxide solution adjust pH to 6.0, filtering, obtain filtrate；
B, after drying filtrate, bupleurum extract is obtained；
(5) isatis root extract is produced：
A, Radix Isatidis is added water to cook, is decocted 2 times, for the first time plus 5 times of quality water of Radix Isatidis decoct 1 hour, and filtering is backward
The water that 3 times of quality of the dregs of a decoction are added in the dregs of a decoction carries out second of decoction 0.5 hour, and it is the first filtrate to merge decocting liquid twice；
B, first filtrate is concentrated into the clear cream that 55 DEG C of relative densities are 1.18, the second that mass fraction is 75% is added
After alcohol solution, alcohol mixeding liquid is obtained, the mass fraction of ethyl alcohol is 60% in the alcohol mixeding liquid, and the ethyl alcohol is mixed
After liquid staticly settles, leaching supernatant；
C, the ethyl alcohol in the supernatant is recycled to no alcohol taste, obtains removing alcohol extract, is added to described remove in alcohol extract
After the water progress water except 7 times of quality of alcohol extract sinks, the second filtrate is obtained after filtering；
D, isatis root extract is made after being concentrated and dried second filtrate；
(6) after each drug extract co-grinding to 2000 mesh for obtaining step (1)-(5), the Chinese traditional medicine composition is obtained
Object.
Experimental example
The clinical efficacy of the Chinese medicine composition of the treatment rhinitis of the present invention
1, diagnostic criteria and case selection
With reference to the rhinitis disease diagnostic criteria that Otolaryngology branch of Chinese Medical Association formulates, selection confirms there is manifest symptom
Or sign, meet diagnostic criteria rhinitis patient.Selected case is diagnosed as the patient of rhinitis disease, year by hals,Nasen und Ohrenheilkunde outpatient service
Age, situations such as state of an illness, clinical symptoms and age, was suitable between patient is randomly divided into two groups, each 40, two groups, has at 10-60 Sui
Comparativity.
2, therapy
Experimental group uses the Chinese medicine composition in the embodiment of the present invention 3 and nasal irrigation after suitable physiological saline mixing：
12 one full year of life above patient's dosage：It weighs 2g Chinese medicine compositions and mixes 0.9% sodium chloride solution 500ml；
Patient's dosage below 12 one full year of life：Weigh 1.5g Chinese medicine compositions mixing 0.9% sodium chloride solution 250ml, one day 2
It is secondary, a 20mL.
Control group uses Triamcinolone acetonide nose spray, is used according to drug specification.
The situation of change of each sign when recording 1 day, 3 days, one week and two weeks, counts onset time.
3, clinical criteria
Each case records daily illness situation of change in receiving therapeutic process, and it is swollen mainly to record sneeze, runny nose, concha
Greatly, the cardinal symptoms such as nasal decongestion.
It cures：Symptom completely disappears, and is not recurred in 6 months；
Effectively：The symptoms such as nasal obstruction, runny nose, concha enlargement mitigate；
In vain：Symptom is without substantially reduced, and sign is without significant change.
4, result
As can be seen from the above table, control group is rapid-action using Triamcinolone acetonide nose spray, and total effective rate at one week is higher than and makes
The total effective rate of irrigation made of Chinese medicine composition of the present invention, but in subsequent course for the treatment of, Triamcinolone acetonide nose spray works
Unobvious, at two weeks, the total effective rate of experimental group reaches 97.5%, and control group is only 80%, only than using one week when it is total
Effective percentage improves 5%.
It is recorded through clinical trail, using the experimental group case of the present invention, nasal obstruction, stream is relieved after nasal irrigation 3 times
Tears, concha enlargement symptom mitigate, and nasal decongestion symptom mitigates, rapid-action, good effect.And experimental group no matter age size, make
It is had no adverse reaction with rear.
Model case：
Mr. Wang, 26 years old, man, in more than 10 years of rhinitis, using sneeze, runny nose, concha enlargement as cardinal symptom, spring and autumn aggravated.Make
It being made pharmaceutical preparation with the Chinese medicine composition mixing physiological saline of the present invention, nasal irrigation is releive nasal obstruction and sneeze after primary,
Runny nose mitigates after 2 days, and concha enlargement is alleviated, and i.e. symptom completely disappears within one week.
Chen, 40 years old, female, rhinitis more than two decades, using runny nose, rhiocnesmus, nasal obstruction, concha enlargement as cardinal symptom.Use this
Pharmaceutical preparation is made in the Chinese medicine composition mixing physiological saline of invention, and nasal irrigation, once three times, 1 day is releive nasal obstruction and nose
Itch, runny nose mitigates after 3 days, and concha enlargement is alleviated, and i.e. symptom completely disappears within one week.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (10)
1. a kind of Chinese medicine for treating rhinitis composition, which is characterized in that be composed of the following raw materials by weight：25-30 portions of honeysuckles,
10-15 parts of radix scutellariaes, 5-10 parts of Fructus Forsythiaes, 3-8 parts of radix bupleuri and 10-15 parts of Radix Isatidis.
2. the Chinese medicine composition for the treatment of rhinitis according to claim 1, which is characterized in that by following raw material group
At：28 portions of honeysuckles, 12 parts of radix scutellariaes, 8 parts of Fructus Forsythiaes, 6 parts of radix bupleuri and 12 parts of Radix Isatidis.
3. a kind of pharmaceutical preparation for treating rhinitis, which is characterized in that including Chinese medicine composition as claimed in claim 1 or 2 and life
The amount ratio of reason brine, the Chinese medicine composition and physiological saline is 1.5-2g:250-500mL.
4. the pharmaceutical preparation for the treatment of rhinitis according to claim 3, which is characterized in that the Chinese medicine composition and physiology salt
The amount ratio of water is 2g:500mL.
5. the pharmaceutical preparation for the treatment of rhinitis according to claim 3, which is characterized in that the Chinese medicine composition and physiology salt
The amount ratio of water is 1.5g:250mL.
6. the preparation method of the Chinese medicine composition for the treatment of rhinitis as claimed in claim 1 or 2, which is characterized in that including following step
Suddenly：
(1) Honegsukle flower P.E is produced：
A, it is decocted after soaking honeysuckle, filters, obtain the first filtrate；Concentrate the filtrate to 70-80 DEG C of relative density
For the clear cream of 1.20-1.25；
B, ethyl alcohol is added after the cooling clear cream and is sufficiently stirred, obtain alcohol mixeding liquid, be obtained by filtration after standing supernatant and
Residue adjusts the pH value of the supernatant to 6.0-8.0；
C, ethanol water is added to the residue obtained after filter, stirs evenly, is filtered after standing, obtain ethanol, described in recycling
Ethyl alcohol in ethanol obtains removing alcohol extract to no alcohol taste；
D, by the supernatant and except alcohol extract merges, the heavy mixed liquor of water is obtained, in sinking mixed liquor to the water plus after water water is heavy,
It is filtered again, obtains the heavy filtrate of water, the heavy filtrate of the water is concentrated and dried, Honegsukle flower P.E is obtained；
(2) forsythia suspense extraction is produced：
A, it is decocted after soaking Fructus Forsythiae, filters, obtain the first filtrate；Concentrating the filtrate to 70-80 DEG C of relative density is
1.20-1.25 clear cream；
B, ethyl alcohol is added after the cooling clear cream and is sufficiently stirred, obtain alcohol mixeding liquid, be obtained by filtration after standing supernatant and
Residue adjusts the pH value of supernatant to 6.0-8.0；
C, ethanol water is added in the residue obtained after filter, stirs evenly, is filtered after standing, obtain ethanol, described in recycling
Ethyl alcohol in ethanol obtains removing alcohol extract to no alcohol taste；
D, by the supernatant and except alcohol extract merges, the heavy mixed liquor of water is obtained, in sinking mixed liquor to the water plus after water water is heavy,
It is filtered again, obtains the heavy filtrate of water, the heavy filtrate of the water is concentrated and dried, forsythia suspense extraction is obtained；
(3) Baical Skullcap root P.E is produced：
A, after crushing radix scutellariae plus water decocts, and filters, obtains the first filtrate；Concentrating the filtrate to 70-80 DEG C of relative density is
The clear cream of 1.15-1.25 adjusts pH to 1.0-3.0 at 70-80 DEG C, and after heat preservation is stood, filtering obtains the second filtrate and filter
Slag；
B, the water of 8-10 times of quality of filter residue is added in the filter residue, and is adjusted pH to 6.0-8.0, add ethyl alcohol and fully stirred
It mixes, obtains alcohol mixeding liquid；It is filtered after the alcohol mixeding liquid is stood, obtains third filtrate；
C, the third filtrate pH to 1.0-2.0 is adjusted, is stood after being kept the temperature at 45-55 DEG C, is filtered, sediment must be sieved down；
D, it is 6.0-8.0 the sediment to be washed till pH with ethyl alcohol, after recycling ethyl alcohol, obtains Baical Skullcap root P.E；
(4) bupleurum extract is produced：
A, the sodium chloride solution of mass fraction 8-12% will be added after radix bupleuri drying and crushing, impregnate, boil, collect distillate, adjust
PH to 4.0-7.0 is saved, filtering obtains filtrate；
B, after drying filtrate, bupleurum extract is obtained；
(5) isatis root extract is produced：
A, Radix Isatidis is added water to cook, is filtered, the first filtrate and the first filter residue；
B, it is that 1.15-1.20 obtains second after ethanol water is added first filtrate to be concentrated into 50-60 DEG C of relative density
Alcohol mixed liquor, after the alcohol mixeding liquid is staticly settled, leaching supernatant；
C, the ethyl alcohol in the supernatant is recycled to no alcohol taste, obtains removing alcohol extract, adds water water in alcohol extract to described remove
It is heavy, the second filtrate is obtained after filtering；
D, isatis root extract is made after being concentrated and dried second filtrate；
(6) after each drug extract co-grinding for obtaining step (1)-(5), the Chinese medicine composition is obtained.
7. preparation method according to claim 6, which is characterized in that in step (1) B and (2) B, the ethyl alcohol mixing
The mass fraction of ethyl alcohol is 60-80% in liquid；The mass fraction of ethyl alcohol is 40-60% in alcohol mixeding liquid described in step (3) B；
The mass fraction of ethyl alcohol is 55-65% in alcohol mixeding liquid described in step (5) B.
8. preparation method according to claim 6, which is characterized in that in step (1) A, decoction 2 times, 2 hours every time,
Collecting decoction is the first filtrate；It in step (2) A, decocts 3 times, first and second time 2 hours each, and third time 1 hour merges three times
Decocting liquid is the first filtrate；It in step (3) A, decocts 2 times, 2 hours for the first time, second 1 hour, it is the to merge decocting liquid twice
One filtrate；In step (4) A, the first distillate after single flash is distilled again, collection re-distilled liquid is first distillate
0.7-0.8 times of quality, as final distillate；It in step (5) A, decocts 2 times, 1 hour for the first time, 0.5 is small for the second time
When, it is the first filtrate to merge decocting liquid twice.
9. preparation method according to claim 6, which is characterized in that in step (1) D, step (2) D, it is heavy to carry out water
When, the additive amount of water is 5-10 times of the heavy mixed liquor quality of the water；In step (5) C, when progress water is heavy, the additive amount of water
For 5-10 times except alcohol extract quality.
10. preparation method according to claim 6, which is characterized in that in step (6), the Chinese medicine group after crushing
The granularity for closing object is 180-220 mesh.
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| CN1739616A (en) * | 2005-08-26 | 2006-03-01 | 成都康奥药物研究所 | Skullcap root extract prepn for eye and its prepn process |
| CN103830323A (en) * | 2012-11-22 | 2014-06-04 | 青岛康地恩动物药业有限公司 | Preparation method of traditional Chinese preparation honeysuckle and radix scutellariae granules |
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| CN1739616A (en) * | 2005-08-26 | 2006-03-01 | 成都康奥药物研究所 | Skullcap root extract prepn for eye and its prepn process |
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| CN110946933A (en) * | 2020-01-29 | 2020-04-03 | 陈俭军 | Rhinitis medicine and its preparing process |
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