CN103142736A - Compound urinary calculus removing oral liquid and preparation method thereof - Google Patents
Compound urinary calculus removing oral liquid and preparation method thereof Download PDFInfo
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- CN103142736A CN103142736A CN2013100805468A CN201310080546A CN103142736A CN 103142736 A CN103142736 A CN 103142736A CN 2013100805468 A CN2013100805468 A CN 2013100805468A CN 201310080546 A CN201310080546 A CN 201310080546A CN 103142736 A CN103142736 A CN 103142736A
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Abstract
The invention discloses compound urinary calculus removing oral liquid. The oral liquid consists of longhairy antenoron herb, plantain seed, spina gleditsiae, chicken gizzard-membrane, fried bitter orange, prepared Chinese rhubarb, giant knot weed, raw cape jasmine fruit and sodium benzoate. The compound urinary calculus removing oral liquid is reasonable in prescription and has a good effect.
Description
Technical field
The present invention relates to a kind of calculus oral liquid and preparation method thereof.
Background technology
" all source of disease marquis's opinions " says " therefore all pouring persons are by suffering from a deficiency of the kidney bladder heat also ", " medical secrets of official. five types of stranguria " record " cause of disease stranguria caused by urinary stone person, drench stone also--suffering from a deficiency of the kidney, hot institute takes advantage of; heat becomes to drench ", the traditional Chinese medical science thinks, lithangiuria belongs to the categories such as sand Stranguria, stranguria caused by urinary stone, stranguria with blood, and mostly being damp and hot heresy pents up the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, urine pulls the devil by the tail, accumulate over a long period, in urine, impurity is become sandstone, and calculus with the passing of time, just can cause qi depression to blood stasis, phlegm and blood stasis again; Therefore clinically on the Chinese medicine calculus spininess to the damp-heat in lower-JIAO determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, as calculus with the passing of time not under, many 5 short expectorant blood stasis dispellings are processed.Existing calculus medicine complicated component, effect is undesirable.
Summary of the invention
The object of the present invention is to provide a kind of formula reasonable, effective compound recipe calculus oral liquid and preparation method thereof.
Technical solution of the present invention is:
A kind of compound recipe calculus oral liquid, it is characterized in that: the medicine material by following weight portion forms:
120 parts of Herba Lysimachiaes; 100 parts of Semen Plantaginiss; 80 parts of Spina Gleditsiaes; 80 parts of Endothelium Corneum Gigeriae Galli; 60 parts of Fructus Aurantii (parched); 40 parts of Radix et Rhizoma Rhei (processed); 40 parts of Rhizoma Polygoni Cuspidati; 40 parts of Gardenias; 3.0 parts of sodium benzoate.
A kind of preparation method of compound recipe calculus oral liquid, it is characterized in that: Herba Lysimachiae, Semen Plantaginis, Spina Gleditsiae, Endothelium Corneum Gigeriae Galli, Fructus Aurantii (parched), Radix et Rhizoma Rhei (processed), Rhizoma Polygoni Cuspidati, Gardenia eight flavor medicines were soaked 2 hours, solid-liquid ratio 1:15, g/ml, decoct 2 times, each 1 hour, merge extractive liquid,, filter after staticly settling 24 hours, discard filtering residue; Filtrate is concentrated, adds sodium benzoate to stir, filter, and adding distil water, packing, sterilization, and get final product.
Compound recipe calculus oral liquid is take Herba Lysimachiae as monarch drug, and is sweet, bitter, enters kidney, urinary bladder channel, clearing away heat-damp and promoting diuresis, treating stranguria fossil; The Semen Plantaginis eliminating dampness by diuresis is treating stranguria helps both heresies of clearing away damp-heat of Herba Lysimachiae, and tonneau urine, increase the urine amount again, and knot stone glides with urine and discharges; Radix et Rhizoma Rhei (processed), Rhizoma Polygoni Cuspidati, Gardenia 5 Herba Lysimachiae clearing away heat-damp and promoting diuresis; Fructus Aurantii (parched) is apt to away alter, and property specially row is loose, promoting flow of QI and blood, and both the spasmolytic emergency was stopped acute angor, and short ureteral peristalsis helps calculus descending again; Phlegm and blood stasis easily becomes calculus, calculus with the passing of time, easily the expectorant stasis of blood is cementing again, therefore add Spina Gleditsiae, short expectorant blood stasis dispelling is with calculus; Endothelium Corneum Gigeriae Galli enters urinary bladder channel, the merit of the hard Sal Nitri of having, lithodialysis fossil.The perfect square preparation can impel the calculus skeleton to loosen, and the cracking calculus is effectively controlled the mucous membrane of urethra inflammation, reduces the adhesive force of calculus, reduces calculus and discharges resistance, promotes ureteral peristalsis, strengthens calculus and discharges power, thereby obviously improve the calculus effective percentage.
Modern experimental pharmacology studies show that: (1) compound recipe calculus oral liquid can reduce gallstone formation rate, and the cholesterol and lecithin content decline, the bile acid that raise because of high caloric diet in bile are raise, prompting compound recipe calculus oral liquid can be reduced to stone trend, suppresses the formation of experimental rat cholesterol calculus; (2) compound recipe calculus oral liquid can obviously increase experimental cholesterol calculus rat urine amount, and reduces its serum flesh liver and urea nitrogen content, increases its total serum protein, and prompting compound recipe calculus oral liquid has the effect of anti-biliary tract urinary system infection inflammation-inhibiting; (3) effect of compound recipe calculus oral liquid " clearing away heat-damp and promoting diuresis, treating stranguria fossil ", its calculus effect may be the curative effect that produces by diuresis mechanism.
Experiment research:
1. the feedstuff preparation causes the preparation reference literature of stone feedstuff, and sucrose-cheese (1:2) is basis, separately adds cholesterol 0.2%, Sal 3%, VB120.1%, Concentrated Cod-liver Oil 0.4%.First sucrose and Sal are added appropriate water temperature fire and boil to dissolving fully, add the cheese of powdery.Become to stick with paste (80000r/min, 30s) on high speed disperser, then add cholesterol, VB12 and Concentrated Cod-liver Oil, mix thoroughly, 4 ° of C preserve, and are standby.
2. model preparation is respectively organized every of rat and is all taken food by 7g/d.The Normal group feedstuff is fed normal diet, and all the other are respectively organized equal ig2g and cause stone feedstuff paste, every day 3 times. and the administration group is also distinguished the medicine of ig corresponding dosage every day, and each is organized the rat male and female and divides cage.(20 ± 5) ° C, 30d is fed in light bath on every Sundays 1 time continuously.After last administration, rat fasting 12h plucks eyeball and gets blood 2ml, cuts open at once and gets gallbladder, and capillary tube is drawn bile.
Experimental studies results:
The comparison (n=10) of table 1. compound recipe calculus oral liquid to each group suslik gallstone formation rate
Annotate: compare * P＜0.05 with model control group; * P＜0.01; Compare with Normal group,
▲ ▲P＜0.01.
Table 2. compound recipe calculus oral liquid on the impact of rat bile Ch, Bs, PL content (
N=10)
Annotate: compare * P＜0.05 with model control group; * P＜0.01; Compare with Normal group,
▲P＜0.05.
Table 3. compound recipe calculus oral liquid on the impact of rat urine amount (ml/24h,
N=10)
Annotate: compare * P＜0.05 with model control group; * P＜0.01; Compare with Normal group,
▲P＜0.05.
Table 4. compound recipe calculus oral liquid on the impact of rat blood serum BUN, Cr and total protein (
N=10)
Annotate: compare * P＜0.05 with model control group; * P＜0.01; Compare with Normal group,
▲P＜0.05.
The invention will be further described below in conjunction with embodiment.
The specific embodiment
Herba Lysimachiae 120g, Semen Plantaginis 100g, Spina Gleditsiae 80g, Endothelium Corneum Gigeriae Galli 80g, Fructus Aurantii (parched) 60g, Radix et Rhizoma Rhei (processed) 40g, Rhizoma Polygoni Cuspidati 40g, Gardenia 40g eight flavor medicines are soaked (solid-liquid ratio 1:15, g/ml) 2 hours, decoct 2 times, each 1 hour, merge extractive liquid,, filter after staticly settling 24 hours, discard filtering residue.Filtrate is concentrated into 900-950ml, adds sodium benzoate 3.0g to stir, and filters, and adding distil water is to 1000ml, and packing is sterilized, and be get final product.
Quality standard:
Specification: 50ml * 10/ bottle
Character: this product is brown liquid, and a small amount of precipitation is arranged.
Check: relative density: should be not less than 1.03; PH value: 7.0-7.5.
The consumption usage: every day three times, each 50ml, shaking before taking.
Storage: the airtight storage in shady and cool place.
Effect duration: six months
High performance liquid chromatography (wavelength 360nm) is measured square rafter skin element (C in oral night
15H
10O
7) and kaempferide (C
15H
10O
6) content, every bottle must not be lower than 50mg.
Claims (2)
1. compound recipe calculus oral liquid, it is characterized in that: the medicine material by following weight portion forms:
120 parts of Herba Lysimachiaes; 100 parts of Semen Plantaginiss; 80 parts of Spina Gleditsiaes; 80 parts of Endothelium Corneum Gigeriae Galli; 60 parts of Fructus Aurantii (parched); 40 parts of Radix et Rhizoma Rhei (processed); 40 parts of Rhizoma Polygoni Cuspidati; 40 parts of Gardenias; 3.0 parts of sodium benzoate.
2. the preparation method of a compound recipe calculus oral liquid claimed in claim 1, it is characterized in that: Herba Lysimachiae, Semen Plantaginis, Spina Gleditsiae, Endothelium Corneum Gigeriae Galli, Fructus Aurantii (parched), Radix et Rhizoma Rhei (processed), Rhizoma Polygoni Cuspidati, Gardenia eight flavor medicines were soaked 2 hours, solid-liquid ratio 1:15, g/ml, decoct 2 times, each 1 hour, merge extractive liquid,, filter after staticly settling 24 hours, discard filtering residue; Filtrate is concentrated, adds sodium benzoate to stir, filter, and adding distil water, packing, sterilization, and get final product.
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| CN2013100805468A CN103142736A (en) | 2013-03-13 | 2013-03-13 | Compound urinary calculus removing oral liquid and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109288995A (en) * | 2018-11-26 | 2019-02-01 | 董明恒 | A kind of herbal composite and preparation method thereof for treating calculus |
| CN110025751A (en) * | 2019-01-29 | 2019-07-19 | 于荣光 | Repair the Chinese medicine composition of each internal organs metabolism of human body |
Citations (5)
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|---|---|---|---|---|
| JPH05961A (en) * | 1991-06-21 | 1993-01-08 | Tsumura & Co | Therapeulic agent for ectopic calcicosis |
| CN1363314A (en) * | 2001-01-10 | 2002-08-14 | 卿多舜 | Medicine for treating renal calculus and its preparing process |
| CN1927297A (en) * | 2005-09-05 | 2007-03-14 | 中国中医研究院中药研究所 | Compound recipe gallstone direct dissolution agent and its preparing process |
| CN102078561A (en) * | 2009-12-01 | 2011-06-01 | 赵莉 | Chinese traditional medicine composition for treating gallstone |
| CN102370950A (en) * | 2011-11-17 | 2012-03-14 | 中国中医科学院中医临床基础医学研究所 | Chinese medicinal compound preparation for treating gall-stone and preparation method thereof |
-
2013
- 2013-03-13 CN CN2013100805468A patent/CN103142736A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05961A (en) * | 1991-06-21 | 1993-01-08 | Tsumura & Co | Therapeulic agent for ectopic calcicosis |
| CN1363314A (en) * | 2001-01-10 | 2002-08-14 | 卿多舜 | Medicine for treating renal calculus and its preparing process |
| CN1927297A (en) * | 2005-09-05 | 2007-03-14 | 中国中医研究院中药研究所 | Compound recipe gallstone direct dissolution agent and its preparing process |
| CN102078561A (en) * | 2009-12-01 | 2011-06-01 | 赵莉 | Chinese traditional medicine composition for treating gallstone |
| CN102370950A (en) * | 2011-11-17 | 2012-03-14 | 中国中医科学院中医临床基础医学研究所 | Chinese medicinal compound preparation for treating gall-stone and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 《江苏中医药》 20121231 陈建华等 "排石合剂"改善输尿管支架管留置术后并发症及生活质量40例临床研究 第28-29页，第28页第2.1节，第29页第4节第2段 1-2 第44卷, 第7期 * |
| 陈建华等: ""排石合剂"改善输尿管支架管留置术后并发症及生活质量40例临床研究", 《江苏中医药》 * |
| 陈建华等: "排石合剂对比坦索罗辛治疗上尿路结石的疗效观察", 《亚太传统医药》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109288995A (en) * | 2018-11-26 | 2019-02-01 | 董明恒 | A kind of herbal composite and preparation method thereof for treating calculus |
| CN110025751A (en) * | 2019-01-29 | 2019-07-19 | 于荣光 | Repair the Chinese medicine composition of each internal organs metabolism of human body |
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Application publication date: 20130612 |