CN105213818A - A kind of Chinese medicine composition being used for the treatment of apoplexy sequela and preparation method thereof - Google Patents
A kind of Chinese medicine composition being used for the treatment of apoplexy sequela and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine composition being used for the treatment of apoplexy sequela and preparation method thereof, belong to medical art, this Chinese medicine composition is prepared from by following raw material: Hirudo, Squama Manis, artificial Calculus Bovis; Borneolum Syntheticum, Radix Polygoni Multiflori, Radix Achyranthis Bidentatae, Scorpio, Styrax; Radix Clematidis, Pheretima, Herba Asari, Radix Et Rhizoma Rhei, Radix Notoginseng; Radix Salviae Miltiorrhizae, Moschus, Rhizoma Gastrodiae, Eupolyphaga Seu Steleophaga, Arisaema Cum Bile; the Radix Astragali, Radix Ginseng Rubra, Semen Persicae, Zaocys; Flos Carthami, Radix Glycyrrhizae, Rhizoma Polygonati, Radix Scrophulariae.Chinese medicine composition provided by the invention has promoting blood circulation to remove obstruction in the collateral, and spasmolytic such as to relieve dizziness, high fever, infantile convulsions, epilepsy, etc. at the effect, and easy to use, instant effect, toxic and side effects is little.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition being used for the treatment of apoplexy sequela and preparation method thereof, belong to medical art.
Background technology
Apoplexy is the disease general name of Chinese medicine, is also that people are to the general designation of acute cerebrovascular disease be commonly called as.Apoplexy is the commonly encountered diseases of person in middle and old age, and be that the world today endangers one of three kinds of maximum diseases to the mankind, mortality rate and disability rate are all high.Apoplexy sequela comprises cerebral hemorrhage, cerebral thrombosis, and main manifestations is quadriplegia, appetite, facial hemiparalysis, the symptoms such as bradyphrenia.In recent years, along with the raising for the treatment of level, mortality rate decreases, but disability rate still remains high.
In prior art, Western medicine long-term taking injures the organs such as Liver and kidney, makes the matter worse undoubtedly to the state of an illness.Therefore, research and development one can fast effectively and lasting medicine, and the Chinese medicine composition of the treatment apoplexy sequela that toxic and side effects is little has very important clinical meaning.
Summary of the invention
For prior art Problems existing, the invention provides a kind of Chinese medicine composition being used for the treatment of apoplexy sequela, said composition has promoting blood circulation to remove obstruction in the collateral, and spasmolytic such as to relieve dizziness, high fever, infantile convulsions, epilepsy, etc. at the effect, and easy to use, instant effect, toxic and side effects is little.
Present invention also offers a kind of preparation method being used for the treatment of the Chinese medicine composition of apoplexy sequela, the method, by carrying out classification process to different material, farthest can utilize the effective ingredient in medicine, and reduce toxic and side effects, meanwhile, medicament ratio of briquetting is high.
The technical scheme that the present invention is adopted to achieve these goals is:
The invention provides a kind of Chinese medicine composition being used for the treatment of apoplexy sequela, is be prepared from by the crude drug of following weight: Hirudo 126g, Squama Manis 28g, artificial Calculus Bovis 28g, Borneolum Syntheticum 6g, Radix Polygoni Multiflori 288g, Radix Achyranthis Bidentatae 126g, Scorpio 9g, Styrax 6g, Radix Clematidis 126g, Pheretima 126g, Herba Asari 126g, Radix Et Rhizoma Rhei 126g, Radix Notoginseng 320g, Radix Salviae Miltiorrhizae 520g, Moschus 1.9g, Rhizoma Gastrodiae 6g, Eupolyphaga Seu Steleophaga 126g, Arisaema Cum Bile 126g, Radix Astragali 520g, Radix Ginseng Rubra 62g, Semen Persicae 126g, Zaocys 62g, Flos Carthami 126g, Radix Glycyrrhizae 126g, Rhizoma Polygonati 126g, Radix Scrophulariae 288g;
Described crude drug is dry weight.
Further, the dosage form of described Chinese medicine composition is pill.
Present invention also offers a kind of preparation method being used for the treatment of the Chinese medicine composition of apoplexy sequela, comprise the following steps:
(1) by Hirudo, Squama Manis, Scorpio, Pheretima, Eupolyphaga Seu Steleophaga, Zaocys grinds to form mixed powder, then adds yellow wine, and triethanolamine soaks 25-30min after stirring, and then adds citric acid, and jolting extracts 3 times, merging filtrate after sucking filtration;
(2) by Radix Clematidis, Herba Asari, Radix Et Rhizoma Rhei, Flos Carthami, adds medical stone powder and carries out parch 15-20min, then spray vinegar, utilizes waste heat to continue stewing 8-10min, screens out medical stone powder, dried in the air by raw material cool;
(3) by the same surplus stock of step (2) raw material, (described surplus stock is artificial Calculus Bovis, Borneolum Syntheticum, Radix Polygoni Multiflori, Radix Achyranthis Bidentatae; Styrax, Radix Notoginseng, Radix Salviae Miltiorrhizae; Moschus, Rhizoma Gastrodiae, Arisaema Cum Bile; the Radix Astragali, Radix Ginseng Rubra, Semen Persicae; Radix Glycyrrhizae, Rhizoma Polygonati, Radix Scrophulariae) grind to form 160 order fine powders; then add above-mentioned filtrate, stir, be prepared into pill.
Further, in step (1), described mixed powder is 1g:8-10mL with the solid-liquid ratio of yellow wine.
Further, the alcohol content of above-mentioned yellow wine is 16-20%.
Further, in step (1), the addition of described triethanolamine accounts for mixed powder gross weight 0.03-0.05%.
Further, in step (1), the addition of described citric acid accounts for the 0.5-0.8% of mixed powder gross weight.
Further, in step (1), the condition that described jolting is extracted is: temperature is 30-35 DEG C, extracts 1.5h at every turn.
Further, in step (2), the addition of described medical stone powder is Radix Clematidis, Herba Asari, Radix Et Rhizoma Rhei and Flos Carthami gross weight 3 times; Described vinegar fountain height accounts for Radix Clematidis, Herba Asari, and the 0.5-0.8 of Radix Et Rhizoma Rhei and Flos Carthami gross weight doubly.
Usage and dosage: pill (be prepared into the watered pill, after filtrate stirs with fine powder, can temper, be adjusted to soft or hard and be suitable for, the toughness held, unclamps, and slightly disperses) the heavy 1g of every 10 balls prepared by the present invention, an oral 3g, three times on the one.
The each medical material of the present invention by the compatibility of science, reinforcement and elimination in combination, each medical material synergism, enhancing human body immunity function, thus reach promoting blood circulation to remove obstruction in the collateral, effect that spasmolytic relieves dizziness, high fever, infantile convulsions, epilepsy, etc.The present invention, according to different raw materials, carries out different processing methods to it, can improve the utilization rate of medical material, meanwhile, reduces the toxic component in raw material, reduces toxic and side effects.The present invention is in extracts active ingredients process, add triethanolamine in right amount, the stripping of Lac in raw material can be improved, meanwhile, increase the surface activity of each raw material, coordinate the yellow wine of certain alcohol content, improve the dissolution rate of effective ingredient, simultaneously the abundant stripping of Lac, containing a certain amount of sugar in yellow wine, Lac with the glucide synergism in yellow wine, thus improves ratio of briquetting and the resting period of pill; Citric acid add can in and the fishy smell such as methanthiol in medicine, reduce the fishy smell of medicine, improve palatability.Maifanitum can adsorb toxic component and the harmful heavy metal elements such as the ethers volatilized in parch process, reduces material toxicity.
Advantage of the present invention is:
(1) each raw material scientific compatibility, reinforcement and elimination in combination, has promoting blood circulation to remove obstruction in the collateral, effect that spasmolytic relieves dizziness, high fever, infantile convulsions, epilepsy, etc., easy to use, instant effect, and little to the intestines and stomach burden, toxic and side effects is little, reaches the object of radical cure.
(2) by diverse ways process raw material, effective rate of utilization is high, and reduces the toxic and side effects of raw material.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail.
Vinegar used in the present invention is that the permanent suitable group in Jiangsu produces 3 years mature vinegar.
Embodiment 1
Be used for the treatment of a Chinese medicine pill for apoplexy sequela, raw material is: Hirudo 126g, Squama Manis 28g, artificial Calculus Bovis 28g, Borneolum Syntheticum 6g; Radix Polygoni Multiflori 288g, Radix Achyranthis Bidentatae 126g, Scorpio 9g, Styrax 6g, Radix Clematidis 126g; Pheretima 126g, Herba Asari 126g, Radix Et Rhizoma Rhei 126g, Radix Notoginseng 320g, Radix Salviae Miltiorrhizae 520g; Moschus 1.9g, Rhizoma Gastrodiae 6g, Eupolyphaga Seu Steleophaga 126g, Arisaema Cum Bile 126g; Radix Astragali 520g, Radix Ginseng Rubra 62g, Semen Persicae 126g, Zaocys 62g; Flos Carthami 126g, Radix Glycyrrhizae 126g, Rhizoma Polygonati 126g, Radix Scrophulariae 288g.
The preparation method of above-mentioned Chinese medicine pill, comprises the following steps:
(1) by Hirudo, Squama Manis, Scorpio, Pheretima, Eupolyphaga Seu Steleophaga, Zaocys grinds to form mixed powder, then adds yellow wine (alcohol content is 16%) according to solid-liquid ratio 1g:10mL, add the triethanolamine accounting for mixed powder gross weight 0.03%, soak 30min after stirring, then add the citric acid accounting for mixed powder gross weight 0.5%, at temperature 35 DEG C, jolting extracts 3 times, each 1.5h, merging filtrate after sucking filtration;
(2) by Radix Clematidis, Herba Asari, Radix Et Rhizoma Rhei, Flos Carthami, adds the medical stone powder accounting for its gross weight 3 times and carries out parch 15min, then sprays the vinegar accounting for gross weight 0.5 times, utilizes waste heat to continue stewing 8min, screens out medical stone powder, dried in the air by raw material cool;
(3) step (2) raw material is ground to form 160 order fine powders with surplus stock, then add above-mentioned filtrate, stir, be prepared into pill; The heavy 1g of every 10 balls.
Embodiment 2
Be used for the treatment of a Chinese medicine pill for apoplexy sequela, raw material composition is with embodiment 1.
Preparation method comprises the following steps:
(1) by Hirudo, Squama Manis, Scorpio, Pheretima, Eupolyphaga Seu Steleophaga, Zaocys grinds to form mixed powder, then adds yellow wine (alcohol content is 20%) according to solid-liquid ratio 1g:8mL, add the triethanolamine accounting for mixed powder gross weight 0.05%, soak 25min after stirring, then add the citric acid accounting for mixed powder gross weight 0.6%, at temperature 30 DEG C, jolting extracts 3 times, each 1.5h, merging filtrate after sucking filtration;
(2) by Radix Clematidis, Herba Asari, Radix Et Rhizoma Rhei, Flos Carthami, adds the medical stone powder accounting for its gross weight 3 times and carries out parch 15min, then sprays the vinegar accounting for gross weight 0.7 times, utilizes waste heat to continue stewing 9min, screens out medical stone powder, dried in the air by raw material cool;
(3) step (2) raw material is ground to form 160 order fine powders with surplus stock, then add above-mentioned filtrate, stir, be prepared into pill; The heavy 1g of every 10 balls.
Embodiment 3
Be used for the treatment of a Chinese medicine pill for apoplexy sequela, raw material composition is with embodiment 1.
Preparation method comprises the following steps:
(1) by Hirudo, Squama Manis, Scorpio, Pheretima, Eupolyphaga Seu Steleophaga, Zaocys grinds to form mixed powder, then adds yellow wine (alcohol content is 18%) according to solid-liquid ratio 1g:9mL, add the triethanolamine accounting for mixed powder gross weight 0.04%, soak 28min after stirring, then add the citric acid accounting for mixed powder gross weight 0.8%, at temperature 33 DEG C, jolting extracts 3 times, each 1.5h, merging filtrate after sucking filtration;
(2) by Radix Clematidis, Herba Asari, Radix Et Rhizoma Rhei, Flos Carthami, adds the medical stone powder accounting for its gross weight 3 times and carries out parch 15min, then sprays the vinegar accounting for gross weight 0.8 times, utilizes waste heat to continue stewing 10min, screens out medical stone powder, dried in the air by raw material cool;
(3) step (2) raw material is ground to form 160 order fine powders with surplus stock, then add above-mentioned filtrate, stir, be prepared into pill; The heavy 1g of every 10 balls.
Embodiment 4
Be used for the treatment of a Chinese medicine pill for apoplexy sequela, raw material composition is with embodiment 1.
Preparation method: be ground to 160 order powder after directly being mixed by each raw material, then make the watered pill, the heavy 1g of every 10 balls.
Effect test
1. toxicity test:
Test method: get SD rat 40, body weight 180 ~ 220g, male and female half and half, rat is equally divided into 4 groups, the crude drug that feeding embodiment of the present invention 1-4 provides respectively combines.Medicine feeding method is: by pill pulverize prepared by the present invention, be made into suspension with water.Often organize rat three gavage drug suspensions every day, every day, rat dosage was 1.5g/Kg, and Rat Fast can't help water, like this continuous gavage of method 15 days.
Result: during rat medication, the rat of embodiment 1-3, all without poisoning, the phenomena of mortality, is respectively organized activities in rats, appetite is normal.Have no significant change through dissection kidney, liver, adrenal cortex, genitals; After the pill perfusion that embodiment 4 is prepared by simple pill method, 3 rats occur irritated, blood pressure increasing state.
Conclusion: as can be seen from the above results, zoopery medication amount used exceeds the dose of adult's clinical application far away, but rat all occurs without dead or organ variation situation, therefore can show that medicine of the present invention has no side effect when human body uses.
2. the test of pesticide effectiveness
Test method: SD rat, body weight 250-300g, 40, male and female half and half; Set up rat brain apoplexy sequela model (modeling being carried out to the method that the drug effect of apoplexy sequela and study mechanism provide with reference to paper TL capsule), after rat revives, there is focus in various degree: contralateral hemiplegia, rotate and creep or the symptom of the dragging step neurologic impairment such as walking, pill prepared by embodiment 1 and 4 is utilized respectively after modeling, and NIAOXUEKANG group, blank group is set, 3 administrations every day, administration 4d and 7d carries out neural behavior scoring, mark is higher, show that animal behavior obstacle is more serious, concrete evaluation result is in table 1.
Table 1
Compared with blank group,
*p < 0.05,
*p < 0.01.
3. clinical laboratory data
Select hospital outpatient to be diagnosed as cerebral apoplexy sequela patient 85 example, wherein male 53 example, women 32 example, the age is 42-69 one full year of life, and sick time 3 months to 4 years is not etc.Taking medicine pill provided by the invention, an oral 3g, three times on the one, 35 days is a course for the treatment of.
Tcm syndrome:
Recovery from illness: clinical symptom disappearance, limb function obviously improves, and life can take care of oneself;
Effective: cardinal symptom alleviates, limb function improves;
Invalid: clinical symptoms is without significant change.
Add up after 45 days, concrete clinical laboratory data the results are shown in Table 2.
Table 2
4. model case
Model case 1: Cui, man, 63 years old, burst cerebral hemorrhage, left limb hemiplegia, water of easily choking when pulling at water, can not stand up, and take the Chinese medicine composition of the embodiment of the present invention 1 preparation after 23 days, recovery from illness, can walk alone, life can take care of oneself.
Model case 2: Xue, female, 58 years old, apoplexy half a year, right lower extremity is numb, paralysis, can not flexion-extension motion, crooked mouth and tongue, babble Chu, took the Chinese medicine composition of the embodiment of the present invention 2 preparation after 2 months, patient's crooked mouth and tongue transference cure, speech is clear, and life is taken care of oneself substantially, and right lower extremity pain and numbness disappears.
Above-described embodiment is the present invention's preferably embodiment; but embodiments of the present invention are not by the restriction of embodiment; other is any do not deviate from spirit of the present invention and principle under make change, modification, combination, substitute, simplify and all should be equivalent substitute mode, be included within protection scope of the present invention.
Claims (9)
1. being used for the treatment of a Chinese medicine composition for apoplexy sequela, it is characterized in that, is be prepared from by the crude drug of following weight: Hirudo 126g, Squama Manis 28g, artificial Calculus Bovis 28g, Borneolum Syntheticum 6g, Radix Polygoni Multiflori 288g, Radix Achyranthis Bidentatae 126g, Scorpio 9g, Styrax 6g, Radix Clematidis 126g, Pheretima 126g, Herba Asari 126g, Radix Et Rhizoma Rhei 126g, Radix Notoginseng 320g, Radix Salviae Miltiorrhizae 520g, Moschus 1.9g, Rhizoma Gastrodiae 6g, Eupolyphaga Seu Steleophaga 126g, Arisaema Cum Bile 126g, Radix Astragali 520g, Radix Ginseng Rubra 62g, Semen Persicae 126g, Zaocys 62g, Flos Carthami 126g, Radix Glycyrrhizae 126g, Rhizoma Polygonati 126g, Radix Scrophulariae 288g;
Described crude drug is dry weight.
2. Chinese medicine composition according to claim 1, is characterized in that, the dosage form of described Chinese medicine composition is pill.
3. a preparation method for Chinese medicine composition as claimed in claim 1 or 2, is characterized in that, comprises the following steps:
(1) by Hirudo, Squama Manis, Scorpio, Pheretima, Eupolyphaga Seu Steleophaga, Zaocys grinds to form mixed powder, then adds yellow wine, and triethanolamine soaks 25-30min after stirring, and then adds citric acid, and jolting extracts 3 times, merging filtrate after sucking filtration;
(2) by Radix Clematidis, Herba Asari, Radix Et Rhizoma Rhei, Flos Carthami, adds medical stone powder and carries out parch 15-20min, then spray vinegar, utilizes waste heat to continue stewing 8-10min, screens out medical stone powder, dried in the air by raw material cool;
(3) step (2) raw material is ground to form 160 order fine powders with surplus stock, then add above-mentioned filtrate, stir, be prepared into pill.
4. preparation method according to claim 3, is characterized in that: described mixed powder is 1g:8-10mL with the solid-liquid ratio of yellow wine.
5. preparation method according to claim 4, is characterized in that: the alcohol content of described yellow wine is 16-20%.
6. preparation method according to claim 3, is characterized in that, the addition of described triethanolamine accounts for mixed powder gross weight 0.03-0.05%.
7. preparation method according to claim 3, is characterized in that: the addition of described citric acid accounts for the 0.5-0.8% of mixed powder gross weight.
8. preparation method according to claim 3, is characterized in that, the condition that described jolting is extracted is: temperature is 30-35 DEG C, extracts 1.5h at every turn.
9. preparation method according to claim 3, is characterized in that: the addition of described medical stone powder is Radix Clematidis, Herba Asari, Radix Et Rhizoma Rhei and Flos Carthami gross weight 3 times; Described vinegar fountain height accounts for Radix Clematidis, Herba Asari, and the 0.5-0.8 of Radix Et Rhizoma Rhei and Flos Carthami gross weight doubly.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107281397A (en) * | 2017-06-11 | 2017-10-24 | 三穗县人民医院 | A kind of powder for treating apoplexy sequelae |
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| CN85106091A (en) * | 1985-04-01 | 1986-07-16 | 辽阳制药厂 | Produce the method for anti-embolism regenerative pill |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107281397A (en) * | 2017-06-11 | 2017-10-24 | 三穗县人民医院 | A kind of powder for treating apoplexy sequelae |
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