CN103735630A - Traditional Chinese medicine for treating gout - Google Patents
Traditional Chinese medicine for treating gout Download PDFInfo
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- CN103735630A CN103735630A CN201310723192.4A CN201310723192A CN103735630A CN 103735630 A CN103735630 A CN 103735630A CN 201310723192 A CN201310723192 A CN 201310723192A CN 103735630 A CN103735630 A CN 103735630A
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Abstract
The invention discloses a traditional Chinese medicine for treating gout. The traditional Chinese medicine consists of the medicinal materials of semen plantaginis and perilla stems. The traditional Chinese medicine for treating the gout provided by the invention is safe, effective, low in production cost, simple in taking method and low in cost, can be taken for a long time, and does not have a toxic or side effect.
Description
Technical field
The present invention relates to Chinese medicine technical field, be specifically related to a kind of Chinese medicine for the treatment of gout and preparation method thereof.
Background technology
Gout is that in human body, the metabolism of purine substance gets muddled, cause the synthetic increase of Uric Acid or discharge and reduce, cause hyperuricemia, when human body serum Uric Acid Concentration is too high, uric acid is deposited in joint, cartilage and kidney with the form of sodium salt, cause and organize foreign body inflammatory reaction, i.e. gout.Gout develops into present commonly encountered diseases by rare disease previously, closely related with people's dietary habit, lifestyle change.Its clinical characters is acute gouty arthritis and the hyperuricemia repeatedly showing effect.Acute stage most of patients in midnight or early morning onset, from the beginning of mostly being the inflammation of single joint, about half is the first metatarsophalangeal joints, instep, secondly often involve heel, toe articulations digitorum manus and other medium and small joints, the redness and swelling of joints burning pain of getting involved, and with heating, leucocytosis, erythrocyte sedimentation rate accelerates, night often severe pain not able person sleep, after about several weeks, symptom disappears gradually, after several months or several years, send out again, proceed to chronic phase, cause arthroncus deformity, stiff.During most of patient with gout outbreak, just treatment, does not pay attention at ordinary times, because its medical history is long, outbreak repeatedly, presents a kind of lifelong participation disease form.Blood uric acid raises in fact, not only can cause the outbreak of acute arthritis, also can cause the important organ infringements such as heart, kidney, therefore not only will pay attention to the active treatment of acute attack stage, also to pay attention to paracmastic treatment, carry out well and can greatly reduce gouty arthritis outbreak, delay disease progression, prevent complication.
The treatment of gout at present be take anti-inflammatory analgetic, uric acid resisting as main, and conventional anti-gout drugs side effect is many, and a lot of patients can not tolerate.Patient with gout is after acute stage, and the drug administration of being often unwilling is again treated.Chinese medicine acute gouty arthritis clinical efficacy is good and side effect is less, easily by patient, accepted, but Chinese medicine for oral administration decocts trouble, has affected the clinical application of Chinese medicine.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine for the treatment of gout;
Another object of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine of gout.
The object of the invention is to realize by following technical scheme:
The Chinese medicine for the treatment of gout of the present invention, its parts by weight of raw materials is:
Semen Plantaginis 5-15 part, Caulis Perillae 10-30 part.
Preferably:
10 parts of Semen Plantaginiss, 20 parts of Caulis Perillaes.
Below crude drug source of the present invention:
Semen Plantaginis is the dry mature seed of Plantaginaceae plant Herba Plantaginis Plantago asiatica L. or Plantago depressa Willd Plantago depressa Willd..Sweet, be slightly cold.Return liver, kidney, lung, small intestine meridian.Clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, and improving eyesight is eliminated the phlegm.For edema distension, the puckery pain of pyretic stranguria, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain, phlegm-heat cough.
Caulis Perillae is the dry stem of labiate Folium Perillae Perilla frutescens (L.) Britt..Pungent, temperature.Return lung, spleen channel.Regulating the flow of QI to ease the stomach, pain relieving, antiabortive.Vexed for chest and diaphragm painful abdominal mass, gastralgia, belch vomiting, frequent fetal movement.
Another aspect of the present invention has been to provide the preparation method of Chinese medicine of the present invention, and concrete preparation method is as follows:
Scheme one: after two kinds of medical materials are cleaned respectively, are dried, are pulverized, excessively after 10-20 mesh sieve, mix, production process of bagged tea routinely, bagged medicine tea is made in pack.
Scheme two: get 2 taste medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, and merge extractive liquid, filters, the clear paste that when filtrate is concentrated into 70-80 ℃, relative density is 1.10-1.25, obtains described active component.
Scheme three: get 2 taste medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, merge extractive liquid,, filters the clear paste that when filtrate is concentrated into 70-80 ℃, relative density is 1.05-1.20, add ethanol, making containing alcohol amount is 40-70%, and standing 12-24 hour filters, the extractum that when filtrate is concentrated into 70-80 ℃, relative density is 1.10-1.25, obtains described active component.
Scheme four: get 2 taste medical materials, use 40-80% alcohol reflux 2-3 time, the 4-10 that each ethanol consumption is medical material total amount doubly, extraction time is 1-3 hour, and merge extractive liquid, filters, the extractum that when filtrate is concentrated into 60-80 ℃, relative density is 1.10-1.25, obtains described active component.
Get scheme two to the prepared active component of scheme four, add starch, dextrin, granulate, dry, granulate makes granule.
The Chinese medicine for the treatment of gout of the present invention, can also coordinate with pharmaceutically acceptable carrier, makes various oral formulations, tablet, capsule, oral liquid, syrup, mixture etc.
Method 1: tablet
Get scheme two to one of scheme four gained active component, add tablet to commonly use adjuvant, production method is prepared into tablet of the present invention routinely.
The conventional adjuvant of above-mentioned tablet comprises one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 2: capsule
Get scheme two to one of scheme four gained active component, add capsule to commonly use adjuvant, production method is prepared into capsule of the present invention routinely.
The conventional adjuvant of above-mentioned capsule comprises one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 3: syrup
Get scheme two to one of scheme four gained active component, add syrup to commonly use adjuvant, production method is prepared into syrup of the present invention routinely.
The conventional adjuvant of above-mentioned syrup comprises one of correctives, antiseptic, cosolvent or whole.
Method 4: mixture
Get scheme two to one of scheme four gained active component, add mixture to commonly use adjuvant, production method is prepared into mixture of the present invention routinely.
The conventional adjuvant of above-mentioned mixture comprises one of correctives, antiseptic or whole.
Method 5: oral liquid
Get scheme two to one of scheme four gained active component, dissolve after-purification, concentrated, add oral liquid to commonly use adjuvant, production method is prepared into oral liquid of the present invention routinely.
The conventional adjuvant of above-mentioned oral liquid comprises one of correctives, antiseptic, cosolvent or whole.
Gout is affluenza, closely related with people's thick greasy product of delicious food of taking food, the Caulis Perillae energy alleviating distention in middle-JIAO therapeutic method to keep the adverse QI flowing downwards, and solving toxin of fish and crab, promotes metabolism, specially controls " food and drink are sick ", " wine disease of muscle "; Gout outbreak raises inseparable with blood uric acid, be mainly renal metabolism uric acid function variation, and Semen Plantaginis energy diuresis promotes uric acid metabolism.Two medicines share and suit gout pathogenesis, and effective uric acid resisting reduces gout recurrence, and only need soaked Instant Drinks or for tea-drinking, instructions of taking is simple, cheap, can long-term taking, have no side effect.
A kind of Chinese medicine for the treatment of gout provided by the invention has the following advantages:
1, the medicated tea for the treatment of gout provided by the invention is safe and effective, particularly adds Caulis Perillae promoting the circulation of QI to alleviate the stagnation in middle-JIAO, and its property of medicine is than Folium Perillae milder, be applicable to long-term taking, and the medicinal tea of preparation and granule only need soaked generation tea-drinking, instructions of taking is simple, cheap, energy long-term taking, has no side effect.
2, clinical test results shows, treats March, adopts medicated tea of the present invention to reach 100% to the effective percentage of patient with gout, and recovery from illness+obvious effective rate reaches 90%, can improve the clinical syndrome of patient with gout, and curative effect is better than matched group allopurinol tablet.
3, medicated tea formula of the present invention is rationally innovated, production cost is low, technique is simple.
The specific embodiment
Below by embodiment, further illustrate the present invention.It should be understood that embodiments of the invention are for the present invention rather than limitation of the present invention are described.The simple modifications that essence according to the present invention is carried out the present invention all belongs to the scope of protection of present invention.
Embodiment 1
Semen Plantaginis 0.5kg, Caulis Perillae 1kg, after two kinds of medical materials be dry, pulverize respectively, mixes after 10 mesh sieves excessively, production process of bagged tea routinely, bagged medicine tea is made in pack.
Embodiment 2
Semen Plantaginis 1.5kg, Caulis Perillae 3kg, after two kinds of medical materials be dry, pulverize respectively, mixes after 20 mesh sieves excessively, production process of bagged tea routinely, bagged medicine tea is made in pack.
Embodiment 3
Semen Plantaginis 1kg, Caulis Perillae 2kg, after two kinds of medical materials be dry, pulverize respectively, mixes after 20 mesh sieves excessively, production process of bagged tea routinely, bagged medicine tea is made in pack.
Embodiment 4 granules
Semen Plantaginis 5kg, Caulis Perillae 10kg, get 2 taste medical materials, extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid,, filters the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.10, add starch, dextrin, granulate, dry, granulate and get final product.
Embodiment 5 granules
Semen Plantaginis 15kg, Caulis Perillae 30kg, get 2 taste medical materials, with 40% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, 3 hours, 2 hours, 1 hour respectively extraction time, merge extractive liquid,, filters, the extractum that when filtrate concentrates 60 ℃, relative density is 1.25, add starch, dextrin, granulate, dry, granulate and get final product.
Embodiment 6 granules
Semen Plantaginis 10kg, Caulis Perillae 20kg, get 2 taste medical materials, extracting in water 3 times, three amount of water are equivalent to respectively 12 times, 8 times, 6 times of medical material gross weight, 3 hours, 2 hours, 1 hour respectively each extraction time, merge extractive liquid,, filters, the clear paste that when filtrate is concentrated into 70 ℃, relative density is 1.20, add ethanol, making containing alcohol amount is 40%, standing 24 hours, filter, the extractum that when filtrate is concentrated into filtrate and is concentrated into 70 ℃, relative density is 1.10, adds starch, dextrin, granulates, dry, granulate and get final product.
Embodiment 7 granules
Semen Plantaginis 9kg, Caulis Perillae 25kg, gets 2 taste medical materials, uses alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, each ethanol consumption is respectively 10 times, 8 times of medical material total amount, and extraction time is respectively 4 hours, 3 hours, merge extractive liquid,, filter, the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.10, adds starch, dextrin, granulates, dry, granulate and get final product.
Embodiment 8 granules
Semen Plantaginis 11kg, Caulis Perillae 23kg, get 2 taste medical materials, extracting in water 3 times, three amount of water are respectively 12 times, 8 times, 6 times of medical material gross weight, three extraction times are respectively 3 hours, 2 hours, 1 hour, merge extractive liquid,, filters the clear paste that when filtrate is concentrated into 70 ℃, relative density is 1.25, add starch, dextrin, granulate, dry, granulate and get final product.
Embodiment 9 granules
Semen Plantaginis 12kg, Caulis Perillae 24kg, gets 2 taste medical materials, extracting in water 2 times, each amount of water is equivalent to respectively 12 times, 10 times of medical material gross weight, and each extraction time is respectively 3 hours, 2 hours, merge extractive liquid,, filters, and filtrate is concentrated into the clear paste that at 80 ℃, relative density is 1.05, add ethanol, making containing alcohol amount is 70%, standing 12 hours, filter, the extractum that when filtrate is concentrated into 70 ℃, relative density is 1.25, adds starch, dextrin, granulates, dry, granulate and get final product.
Embodiment 10 syrups
Semen Plantaginis 6kg, Caulis Perillae 12kg, gets 2 taste medical materials, extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, and the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid,, filters the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.10.In extractum, add syrup adjuvant sucrose, sorbic acid, water to stir, make syrup.
Embodiment 11 mixture
Semen Plantaginis 12kg, Caulis Perillae 15kg, gets 2 taste medical materials, extracting in water 3 times, three amount of water are equivalent to respectively 12 times, 8 times, 6 times of medical material gross weight, 3 hours, 2 hours, 1 hour respectively each extraction time, merge extractive liquid,, filters, it is 3 times of medical material gross weight that filtrate is concentrated into gross weight, fill, adds mixture adjuvant sucrose, ethyl ester, water, sorbic acid to stir, and makes mixture.
Embodiment 12 oral liquids
Semen Plantaginis 7kg, Caulis Perillae 22kg, gets 2 taste medical materials, extracting in water 2 times, 2 amount of water are equivalent to respectively 10 times, 8 times of medical material gross weight, 2 hours respectively each extraction time, merge extractive liquid,, filter, filtrate is concentrated into 2 times of medical material gross weight, adds adjuvant Mel, monoglycosides, benzoic acid, stir evenly after fine straining, subpackage, sterilizing, makes oral liquid.
Embodiment 13 granules
Semen Plantaginis 12kg, Caulis Perillae 25kg, get 2 taste medical materials, extracting in water 2 times, each amount of water is equivalent to respectively 12 times, 10 times of medical material gross weight, each extraction time is respectively 3 hours, 2 hours, merge extractive liquid,, filters, and filtrate is concentrated into the clear paste that at 80 ℃, relative density is 1.05, add adjuvant Icing Sugar, starch, dextrin, ethanol, make granule.
Embodiment 14 medicinal tea
Semen Plantaginis 13kg, Caulis Perillae 18kg, get 2 taste medical materials, extracting in water 2 times, each amount of water is equivalent to respectively 12 times, 10 times of medical material gross weight, each extraction time is respectively 3 hours, 2 hours, merge extractive liquid,, filters, and filtrate is concentrated into the clear paste that at 80 ℃, relative density is 1.05, add adjuvant Icing Sugar, starch, dextrin, make medicinal tea.
clinical efficacy
1, case selection
1) meet constitutional gouty arthritis criteria for classification, get rid of acute gout arthritis simultaneously;
2) age is in 18-70 person between year, male or female;
3) do not take other uric acid resisting medicines and affect uric acid metabolism and the medicine of excretion reaches more than 1 week.
2, diagnostic criteria
Adopt in the < < clinic diagnosis guide rheumatism fascicle > > that Chinese Medical Association in 2010 promulgates " Primary Gouty Arthritis criteria for classification ".
1. in joint fluid, there is specificity urate crystal, or
2. in the tophus confirming with chemical method or micropolariscope, contain urate crystal, or
3. possess 6 in following 12 (clinical, laboratory, the performances of x line): the outbreak of A. acute arthritis surpasses once; B. inflammatory reaction reached peak in one day; C. monarthritis outbreak; D. visible local joint is rubescent; E. the first hesitate toe joint pain or swelling; F. one-sided first open up toe joint and get involved; G. the one-sided osteoarthrosis of staggering is got involved; H. suspicious tophus; I. hyperuricemia; J. unsymmetry intraarticular swelling (confirmation of x line); K. under cortical bone cyst without bone erosion (confirmation of x line); When L. arthritis is shown effect, the culture of joint fluid is negative.
First with reference to above-mentioned diagnostic criteria, patient diagnosed has gout, and with blood uric acid rising (male and postmenopausal women >420umol/L, Pre-menopausal Women > 350umol/L).Get rid of acute gout arthritis, 1. carrying out property of pain increases the weight of, and reaches peak at 12 hours, is difficult to stand simultaneously: the redness and swelling of joints of 2. getting involved is scorching hot, function limitation, tenderness are all very obvious.
Note: the 7th edition < < internal medicine > > that Level of Serum Uric Acid is published with reference to people's health
3, curative effect determinate standard
Employing comprehensive therapeutic effect evaluation: (with reference to the < < new Chinese medicine guideline of clinical investigations > > of health ministry issue)
Clinical recovery: the total mark of arthralgia, tenderness, acute redness, limitation of activity declines 100%.
Effective: the total mark of arthralgia, tenderness, acute redness, limitation of activity declines >=66%.
Effective: total mark decline >=33% and the < 66% of arthralgia, tenderness, acute redness, limitation of activity.
Invalid: the total mark decline <33% of arthralgia, tenderness, acute redness, limitation of activity.
Note: computing formula (nimodipine method): integration reduces percentage ratio=(the rear integration of integration one treatment before treating) front integration * 100% of/treatment.
4, drug use method
Treatment group is taken the embodiment of the present invention 3 Tea containing traditional Chinese medicines, adds boiled water 500ml, soaked generation tea-drinking, 1 time on the 1st;
Matched group allopurinol tablet 0.1g, 2 times/day;
Treat March altogether.
5, clinical effectiveness
Curative effect comparison after two groups of treatments, in Table 1.
Curative effect comparison before and after table 1 liang group treatment
| Group | Number of cases | Recovery from illness | Effective | Effectively | Invalid | Effective percentage | Effective+cure rate |
| Treatment group | 30 | 8 | 19 | 3 | 0 | 100% | 90% |
| Matched group | 30 | 4 | 11 | 14 | 1 | 96.7% | 50% |
As shown in Table 1, use Tea containing traditional Chinese medicine treatment that the present invention treats gout after 3 months, total effective rate reaches 100%, and its obvious effective rate and cure rate are all better than allopurinol tablet group.
Conclusion: the Chinese medicine that the present invention treats gout is uric acid resisting effectively, reduces gout recurrence, and only needs soaked generation tea-drinking, than existing medicine, can alleviate more rapidly gout symptom.
Model case
Xiao, man, 64 years old, people from Liuzhou, in March, 2013 is medical, and repeated relapsing extremities joint swells and ache 8 years, and blood uric acid 634 μ mol/L treat March through the embodiment of the present invention 2 Tea containing traditional Chinese medicines, and blood uric acid is down to 336 μ mol/L, follows up a case by regular visits to so far and does not recur again.
Deep certain, man, 69 years old, people from Rong'an, in May, 2013 is medical, and repeated relapsing joint of the lower extremity swells and ache more than 9 years, recently monthly show effect approximately 2 times, and blood uric acid 696 μ mol/L, through 5 Granules in Treating March of the embodiment of the present invention, check blood uric acid 325 μ mol/L, do not follow up a case by regular visits to and do not recur.
Wei, man, 52 years old, people from Liuzhou, in February, 2013 is medical, and joint of the lower extremity swells and ache more than 10 years repeatedly, whole body many places tophus, blood uric acid 598 μ mol/L, through 12 oral liquid treatment March of the embodiment of the present invention, check blood uric acid 298 μ mol/L, tophus is partly dissolved, and follows up a case by regular visits to and has no recurrence.
Although, above used general explanation, the specific embodiment and test, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements, all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (9)
1. treat a Chinese medicine for gout, its feature in its parts by weight of raw materials is:
Semen Plantaginis 5-15 part, Caulis Perillae 10-30 part.
2. the Chinese medicine for the treatment of gout as claimed in claim 1, is characterized in that its parts by weight of raw materials is:
10 parts of Semen Plantaginiss, 20 parts of Caulis Perillaes.
3. Chinese medicine as claimed in claim 1 or 2, is characterized in that the preparation method of its medicinal tea is: after two kinds of medical materials are cleaned respectively, are dried, are pulverized, excessively after 10-20 mesh sieve, mix, production process of bagged tea routinely, packs and make bagged medicine tea.
4. Chinese medicine as claimed in claim 1 or 2, the active component that it is characterized in that it is to adopt the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.
5. Chinese medicine as claimed in claim 4, the active component that it is characterized in that it is prepared from by the following method: get 2 taste medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, and merge extractive liquid, filters, the clear paste that when filtrate is concentrated into 70-80 ℃, relative density is 1.10-1.25, obtains described active component.
6. Chinese medicine as claimed in claim 4, the active component that it is characterized in that it is prepared from by the following method: get 2 taste medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, merge extractive liquid,, filter, the clear paste that when filtrate is concentrated into 70-80 ℃, relative density is 1.05-1.20, adds ethanol, and making containing alcohol amount is 40-70%, standing 12-24 hour, filter, the extractum that when filtrate is concentrated into 70-80 ℃, relative density is 1.10-1.25, obtains described active component.
7. Chinese medicine as claimed in claim 4, the active component that it is characterized in that it is prepared from by the following method: get 2 taste medical materials, with 40-80% alcohol reflux 2-3 time, the 4-10 that each ethanol consumption is medical material total amount doubly, extraction time is 1-3 hour, and merge extractive liquid, filters, the extractum that when filtrate is concentrated into 60-80 ℃, relative density is 1.10-1.25, obtains described active component.
8. Chinese medicine as claimed in claim 4, is characterized in that its process for producing granula is: get the prepared active component of any one in claim 5-7, add starch, dextrin, granulate, dry, granulate and get final product.
9. treat a Chinese medicine for gout, comprise the Chinese medicine composition of the treatment gout of claim 1 or 2, with acceptable carrier in pharmaceuticals industry.
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| CN201310723192.4A CN103735630B (en) | 2013-12-25 | 2013-12-25 | A kind of Chinese medicine for the treatment of gout |
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| CN106139009A (en) * | 2016-08-03 | 2016-11-23 | 韩洁茹 | A kind of Chinese medicine composition purposes in the medicine of preparation treatment chronic gout |
| CN111939235A (en) * | 2020-08-24 | 2020-11-17 | 柳州市中医医院 | Forming process method of compound gout granules |
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| CN111939235A (en) * | 2020-08-24 | 2020-11-17 | 柳州市中医医院 | Forming process method of compound gout granules |
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| Publication number | Publication date |
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| CN103735630B (en) | 2016-03-30 |
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