CN1939521A - Medicine for treating gout - Google Patents
Medicine for treating gout Download PDFInfo
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- CN1939521A CN1939521A CN 200510021790 CN200510021790A CN1939521A CN 1939521 A CN1939521 A CN 1939521A CN 200510021790 CN200510021790 CN 200510021790 CN 200510021790 A CN200510021790 A CN 200510021790A CN 1939521 A CN1939521 A CN 1939521A
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Abstract
A Chinese medicine for treating gout is prepared from 12 Chinese-medicinal materials including areca seed, epimedium, coix seed, tangerine peel, etc.
Description
Technical field
The present invention relates to medical technical field, relate to the pharmaceutical composition for the treatment of gout or rather.
Background technology
Gout be one group since purine metabolic disturbance due to disease.Its clinical characters is that hyperuricemia and the gouty acute arthritis that causes are therefrom shown effect repeatedly, tophus deposition, tophus chronic arthritis and joint deformity etc.Often involve kidney and cause that chronic interstitial nephritis and uric acid renal calculus form.Increase reason according to uric acid in the blood and can be divided into constitutional and Secondary cases two big classes.The cause of disease of primary gout is owing to due to the congenital purine metabolic disturbance, belong to heritability.The cause of disease of secondary gout can be caused by multiple reasons such as nephropathy, leukemia, medicine, foods, good send out in the male and menopause the women, the male is more than the women, M-F is 20 to 1.Primary disease with redness and swelling of joints, burning pain, outbreak repeatedly, joint motion is dumb is main clinical manifestation, belongs to Chinese medicine " arthromyodynia " category." treatise on blood trouble ": " gout, general numbness and hypoesthesia, limbs pain, modern name gout, Gu are said arthromyodynia ".
Gout sickness rate height, difficult, the outbreak repeatedly of healing, various difficulties and disease make the patient suffering can't bear, and this disease is classified as one of human ten big pertinacious diseases of 20th century by the United Nations's health organization.It also is the human second largest metabolism class disease that is only second to diabetes.The gout pilosity is born in middle-aged and elderly people, overweight people and brain worker.Along with the raising of people's living standard and the change of dietary structure, the sickness rate of gout rises just year by year, and China hyperuricemia value disease patient number has reached 1.2 hundred million, nearly 1,500 ten thousand people of patient with gout wherein at present according to statistics.Simultaneously, the sickness rate of gout also has the trend that becomes younger when increasing, and former gout is common in male more than 40 years old, and now, because dietary habit and living condition's change, the male about 30 years old suffers from the also very of sore wind more and sees.
The Western medicine that is used for the treatment of gout at present mainly contains: colchicine, Phenylbutazone or crovaril, indometacin, ibuprofen (ibvprofen, ibuprofen), piroxicam (piroxicanum), naproxen (naproxen congex), ACTH and prednisone etc.But said medicine can only be stablized the state of an illness mostly, can not effect a radical cure gout; Can cause that also serious adverse causes the infringement of hepatic and renal function; Even treatment in the recent period effectively can not disease controlling be recurred, and can produce drug resistance and repellence, even the patient more or less can occur inevitably: leukopenia, cardiac function is impaired, hepatic and renal function is impaired, stimulating intestine and stomach system, aplastic anemia, cause complication such as diabetes.Increasing expert thinks: from the organic conception of the traditional Chinese medical science, with the whole determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs of Chinese medicine, can yet be regarded as and treat another good footpath of gout; Not only the toxic and side effects of Chinese medicine itself significantly reduces, and can reduce the Western medicine dose, overcomes the huge toxic and side effects of for a long time taking Western medicine merely and being brought.But the Chinese patent medicine for the treatment of gout in the market is few, and curative effect lacks preferably especially, and the patient still can only stablize the state of an illness by taking the bigger Western medicine of toxic and side effects in a large number.
Summary of the invention
Purpose of the present invention just provides a kind of new Chinese medicine preparation for the treatment of gout, and this Drug therapy gout curative effect is better, and side effect is little, and safety is good.
The technical solution adopted for the present invention to solve the technical problems is: a kind of medicine for the treatment of gout, it is made up of following crude drug: Semen Arecae, Herba Epimedii, Rhizoma Atractylodis, Semen Coicis, silkworm excrement, Pericarpium Citri Reticulatae, Radix Platycodonis, Rhizoma Curcumae Longae, Folium Perillae, Fructus Evodiae, Fructus Chaenomelis, Rhizoma Zingiberis Recens.
The weight proportion of each crude drug can be selected from the said medicine:
Semen Arecae 10-60 part Herba Epimedii 5-50 part Rhizoma Atractylodis 1-30 part Semen Coicis 1-40 part
Silkworm excrement 5-40 part Pericarpium Citri Reticulatae 1-30 part Radix Platycodonis 1-30 part Rhizoma Curcumae Longae 1-30 part
Folium Perillae 1-30 part Fructus Evodiae 1-20 part Fructus Chaenomelis 1-30 part Rhizoma Zingiberis Recens 1-30 part
The weight proportion of each crude drug is preferably in the said medicine:
Semen Arecae 20-50 part Herba Epimedii 10-40 part Rhizoma Atractylodis 1-20 part Semen Coicis 5-30 part
Silkworm excrement 10-30 part Pericarpium Citri Reticulatae 1-20 part Radix Platycodonis 1-20 part Rhizoma Curcumae Longae 1-20 part
Folium Perillae 1-20 part Fructus Evodiae 1-15 part Fructus Chaenomelis 1-20 part Rhizoma Zingiberis Recens 1-20 part
The weight proportion of each crude drug is more preferably in the said medicine:
Semen Arecae 25-40 part Herba Epimedii 15-30 part Rhizoma Atractylodis 5-15 part Semen Coicis 10-20 part
Silkworm excrement 15-25 part Pericarpium Citri Reticulatae 5-15 part Radix Platycodonis 3-15 part Rhizoma Curcumae Longae 5-15 part
Folium Perillae 5-15 part Fructus Evodiae 2-8 part Fructus Chaenomelis 5-15 part Rhizoma Zingiberis Recens 5-15 part
The weight proportion of each crude drug is more preferably in the said medicine:
Semen Arecae 28-32 part Herba Epimedii 18-22 part Rhizoma Atractylodis 8-12 part Semen Coicis 12-18 part
Silkworm excrement 18-22 part Pericarpium Citri Reticulatae 8-12 part Radix Platycodonis 5-10 part Rhizoma Curcumae Longae 5-10 part
Folium Perillae 5-10 part Fructus Evodiae 2-5 part Fructus Chaenomelis 5-10 part Rhizoma Zingiberis Recens 5-10 part
The better weight proportion of each crude drug is in the said medicine:
15 parts of 10 parts of Semen Coiciss of 20 parts of Rhizoma Atractylodis of 30 parts of Herba Epimedii of Semen Arecae
6 parts in 8 portions of Rhizoma Curcumae Longaes of 10 parts of Radix Platycodoniss of 20 parts of Pericarpium Citri Reticulataes of silkworm excrement
8 parts in 6 portions of Rhizoma Zingiberis Recenss of 4 portions of Fructus Chaenomeliss of 8 parts of Fructus Evodiaes of Folium Perillae
Perhaps be:
16 parts of 10 parts of Semen Coiciss of 22 parts of Rhizoma Atractylodis of 28 parts of Herba Epimedii of Semen Arecae
8 parts in 6 portions of Rhizoma Curcumae Longaes of 8 parts of Radix Platycodoniss of 18 parts of Pericarpium Citri Reticulataes of silkworm excrement
10 parts in 8 portions of Rhizoma Zingiberis Recenss of 3 portions of Fructus Chaenomeliss of 5 parts of Fructus Evodiaes of Folium Perillae
The medicine of above-mentioned treatment gout can be made the medicine of any one suitable on pharmaceutics dosage form with each crude drug after treatment according to the formulation method of routine, preferably makes granule, tablet, hard capsule, oral liquid, soft capsule, drop pill etc.
According to the needs of the various drug forms of preparation, medicine of the present invention also can add suitable pharmaceutic adjuvant such as filler, disintegrating agent, binding agent, lubricant, antiseptic etc. in preparation process.
The used various raw medicinal materials of the present invention are the Chinese crude drug that meets country or provincial standard regulation.
Compared with prior art, the invention has the beneficial effects as follows: above 12 flavor Chinese medicine composition are not used for the treatment of together the technical scheme of gout in (1) prior art, medicine of the present invention provides another new selection for the gout patient; Show through pharmacodynamics test and toxicological test that (2) it is better that medicine of the present invention is used for the treatment of the gout curative effect, and toxic and side effects is little, safety is good.
For curative effect and the safety that confirms medicine of the present invention, the inventor has carried out pharmacodynamics and toxicity test is investigated.The research method and the result of the test that are adopted are as follows:
(1) pharmacodynamics test research
1, test material
(1), medicine and reagent:
The medicinal dropping ball of medicine of the present invention for making according to embodiment one described crude drug weight proportion.
Colchicine is Yunnan Plant Pharmaceutical Industry Co., Ltd.'s product.
(2), animal: Kunming mouse, SD rat are provided by institute of antibiotics, Sichuan Experimental Animal Center.
2, test method and result
(1) to the influence of hyperuricemia mice serum uric acid level
Get 60 of Kunming mouses, male and female are all used, body weight 18～22g, be divided into normal saline group, medicine low dose group of the present invention (dosage group in 4g raw medicinal herbs/kg), the medicine of the present invention (8g raw medicinal herbs/kg), medicine high dose group of the present invention (16g raw medicinal herbs/kg), positive controls at random, gavage normal saline, medicine of the present invention and colchicine respectively, every day 1 time, 4d continuously.Behind the last administration 1h, except that the normal saline group, all the other each treated animal Intraperitoneal injection of hypoxanthine 1mg/kg cause the mice hyperuricemia, capacity blank liquid such as normal saline group injection.Injection back 0.5h, each treated animal is plucked eyeball and is got blood, and the centrifugal 15min of 3000r/min gets serum and surveys the hematuria acid number.
The influence of table 1 pair hyperuricemia mice serum uric acid level (X ± SD)
| Group | Quantity (only) | Dosage (the g raw medicinal herbs/kg) | Hematuria acid number (umol/l) |
| Dosage group medicine low dose group of the present invention in the normal saline group model group positive controls medicine high dose group of the present invention medicine of the present invention | 10 10 10 10 10 10 | -- -- 0.1mg/kg 16 8 4 | 136±29** 735±122 165±15** 170±13** 194±19** 215±23** |
Annotate: compare with model group: * * P＜0.01
As can be seen from the table, each group of the high, medium and low dosage of medicine of the present invention all can reduce the mice serum uric acid level, with model group significant difference is arranged relatively.
(2) antiinflammatory test (mice auricle swelling method)
Get 50 of Kunming mouses, male, body weight 18～22g, be divided into normal saline group, medicine low dose group of the present invention (dosage group in 4g raw medicinal herbs/kg), the medicine of the present invention (8g raw medicinal herbs/kg), medicine high dose group of the present invention (16g raw medicinal herbs/kg), positive controls at random, gavage normal saline, medicine of the present invention and colchicine respectively, every day 1 time, 3d continuously.Behind the last administration 1.5h, dimethylbenzene is applied to two sides, mouse right ear front and back, 20 μ L/ only take off vertebra with mice behind the 1h and put to death, and cut two ears along the auricle baseline, lay round auricle at same position respectively with the 9mm card punch, weigh, and calculate the swelling rate.
Table 2 xylol causes the influence (X ± SD) of mice ear degree
| Group | Quantity (only) | Dosage (the g raw medicinal herbs/kg) | Swelling degree (mg) | Inhibitory rate of intumesce (%) |
| Dosage group medicine low dose group of the present invention in the normal saline group positive control alkali medicine high dose group of the present invention medicine of the present invention | 10 10 10 10 10 | --- 0.1mg/kg 16 8 4 | 18.83±4.17 14.92±2.84** 12.33±4.41** 13.92±3.62** 14.62±1.24** | 20.76 34.51 26.11 22.75 |
Annotate: compare * * P＜0.01 with the normal saline group
Experimental result shows that each dosage of medicine of the present invention all can obviously be suppressed the mice ear degree, compares with the normal saline group, and significant difference (seeing Table 2) is arranged.
(3) analgesic experiment: (glacial acetic acid causes mouse writhing method)
Get 60 of Kunming mouses, male and female half and half, be divided into normal saline group, medicine low dose group of the present invention (dosage group in 4g raw medicinal herbs/kg), the medicine of the present invention (8g raw medicinal herbs/kg), medicine high dose group of the present invention (16g raw medicinal herbs/kg), positive controls at random, gavage normal saline, medicine of the present invention and colchicine respectively, 1 time/d, continuous 3d.Behind the last administration 1.5h, mouse peritoneal is injected 0.9% acetic acid 0.2mL/ only, observe and record 20min in mice turn round the body number of times.The result is as shown in table 3 below.
The influence of table 3 pair glacial acetic acid induced mice writhing response (X ± SD)
| Group | Quantity (only) | Dosage (the g raw medicinal herbs/kg) | 20min turns round body number of times (inferior) |
| Dosage group medicine low dose group of the present invention in the normal saline group positive controls medicine high dose group of the present invention medicine of the present invention | 10 10 10 10 10 | --- 0.1mg/kg 16 8 4 | 76.00±11.56 48.90±7.84** 36.36±9.38** 39.54±7.35** 42.32±9.59** |
Annotate: compare P＜0.01 with the normal saline group
As can be seen, each dosage group of medicine of the present invention and normal saline group relatively all have significant analgesia role (P＜0.01) from above table.
(2) acute toxicity test research
The inventor has carried out the acute toxicity test investigation with mice to medicine of the present invention.The result: the maximum dosage-feeding of medicine mouse stomach of the present invention administration is 250g crude drug/kg/24h, and (312 times of 0.8g crude drug/kg), under this dosage, tangible toxic reaction does not appear in animal to be about 60kg body weight adult clinical oral administration consumption per day.The result shows that safety of medicine dosage range of the present invention is bigger, and safety is good.
The specific embodiment
The present invention is described in further detail below in conjunction with the specific embodiment.
Embodiment one
Medicine of the present invention is made by following materials of weight proportions medicine:
15 parts of 10 parts of Semen Coiciss of 20 parts of Rhizoma Atractylodis of 30 parts of Herba Epimedii of Semen Arecae
6 parts in 8 portions of Rhizoma Curcumae Longaes of 10 parts of Radix Platycodoniss of 20 parts of Pericarpium Citri Reticulataes of silkworm excrement
8 parts in 6 portions of Rhizoma Zingiberis Recenss of 4 portions of Fructus Chaenomeliss of 8 parts of Fructus Evodiaes of Folium Perillae
Embodiment two
Medicine of the present invention is made by following materials of weight proportions medicine:
16 parts of 10 parts of Semen Coiciss of 22 parts of Rhizoma Atractylodis of 28 parts of Herba Epimedii of Semen Arecae
8 parts in 6 portions of Rhizoma Curcumae Longaes of 8 parts of Radix Platycodoniss of 18 parts of Pericarpium Citri Reticulataes of silkworm excrement
10 parts in 8 portions of Rhizoma Zingiberis Recenss of 3 portions of Fructus Chaenomeliss of 5 parts of Fructus Evodiaes of Folium Perillae
Embodiment three
Medicine of the present invention is made by following materials of weight proportions medicine:
15 parts of 10 parts of Semen Coiciss of 22 parts of Rhizoma Atractylodis of 32 parts of Herba Epimedii of Semen Arecae
8 parts in 6 portions of Rhizoma Curcumae Longaes of 8 parts of Radix Platycodoniss of 20 parts of Pericarpium Citri Reticulataes of silkworm excrement
10 parts in 8 portions of Rhizoma Zingiberis Recenss of 3 portions of Fructus Chaenomeliss of 8 parts of Fructus Evodiaes of Folium Perillae
Embodiment four
Medicine of the present invention is made by following materials of weight proportions medicine:
12 parts of 12 parts of Semen Coiciss of 18 parts of Rhizoma Atractylodis of 28 parts of Herba Epimedii of Semen Arecae
5 parts in 10 portions of Rhizoma Curcumae Longaes of 12 parts of Radix Platycodoniss of 22 parts of Pericarpium Citri Reticulataes of silkworm excrement
5 parts in 10 portions of Rhizoma Zingiberis Recenss of 2 portions of Fructus Chaenomeliss of 5 parts of Fructus Evodiaes of Folium Perillae
Embodiment five
Medicine of the present invention is made by following materials of weight proportions medicine:
18 parts of 8 parts of Semen Coiciss of 22 parts of Rhizoma Atractylodis of 32 parts of Herba Epimedii of Semen Arecae
10 parts in 5 portions of Rhizoma Curcumae Longaes of 8 parts of Radix Platycodoniss of 18 parts of Pericarpium Citri Reticulataes of silkworm excrement
10 parts in 5 portions of Rhizoma Zingiberis Recenss of 5 portions of Fructus Chaenomeliss of 10 parts of Fructus Evodiaes of Folium Perillae
Embodiment six
Medicine of the present invention is made by following materials of weight proportions medicine:
10 parts of 20 parts of Semen Coiciss of 40 parts of Rhizoma Atractylodis of 10 parts of Herba Epimedii of Semen Arecae
30 parts in 3 portions of Rhizoma Curcumae Longaes of 15 parts of Radix Platycodoniss of 40 parts of Pericarpium Citri Reticulataes of silkworm excrement
15 parts in 5 portions of Rhizoma Zingiberis Recenss of 2 portions of Fructus Chaenomeliss of 20 parts of Fructus Evodiaes of Folium Perillae
Embodiment seven
Medicine of the present invention is made by following materials of weight proportions medicine:
1 part of 15 parts of Semen Coicis of 50 parts of Rhizoma Atractylodis of 20 parts of Herba Epimedii of Semen Arecae
5 parts in 30 portions of Rhizoma Curcumae Longaes of 1 part of Radix Platycodonis of 15 parts of Pericarpium Citri Reticulataes of silkworm excrement
30 parts in 15 portions of Rhizoma Zingiberis Recenss of 15 portions of Fructus Chaenomeliss of 30 parts of Fructus Evodiaes of Folium Perillae
Embodiment eight
Medicine of the present invention is made by following materials of weight proportions medicine:
40 parts of 1 part of Semen Coiciss of 15 parts of Rhizoma Atractylodis of 60 parts of Herba Epimedii of Semen Arecae
1 part in 15 portions of Rhizoma Curcumae Longaes of 5 parts of Radix Platycodoniss of 10 parts of Pericarpium Citri Reticulataes of silkworm excrement
20 parts in 1 portion of Rhizoma Zingiberis Recens of 8 portions of Fructus Chaenomeliss of 15 parts of Fructus Evodiaes of Folium Perillae
Embodiment nine
Medicine of the present invention is made by following materials of weight proportions medicine:
20 parts of 30 parts of Semen Coiciss of 5 parts of Rhizoma Atractylodis of 50 parts of Herba Epimedii of Semen Arecae
15 parts in 1 portion of Rhizoma Curcumae Longae of 30 parts of Radix Platycodoniss of 25 parts of Pericarpium Citri Reticulataes of silkworm excrement
5 parts in 20 portions of Rhizoma Zingiberis Recenss of 20 portions of Fructus Chaenomeliss of 5 parts of Fructus Evodiaes of Folium Perillae
Embodiment ten
Medicine of the present invention is made by following materials of weight proportions medicine:
30 parts of 5 parts of Semen Coiciss of 10 parts of Rhizoma Atractylodis of 40 parts of Herba Epimedii of Semen Arecae
10 parts in 20 portions of Rhizoma Curcumae Longaes of 20 parts of Radix Platycodoniss of 5 parts of Pericarpium Citri Reticulataes of silkworm excrement
8 parts in 25 portions of Rhizoma Zingiberis Recenss of 1 portion of Fructus Chaenomelis of 1 part of Fructus Evodiae of Folium Perillae
Embodiment 11
Medicine of the present invention is made by following materials of weight proportions medicine:
5 parts of 12 parts of Semen Coiciss of 30 parts of Rhizoma Atractylodis of 25 parts of Herba Epimedii of Semen Arecae
20 parts in 10 portions of Rhizoma Curcumae Longaes of 18 parts of Radix Platycodoniss of 30 parts of Pericarpium Citri Reticulataes of silkworm excrement
1 part in 30 portions of Rhizoma Zingiberis Recenss of 6 portions of Fructus Chaenomeliss of 5 parts of Fructus Evodiaes of Folium Perillae
Embodiment 12
Medicine of the present invention is made by following materials of weight proportions medicine:
15 parts of 10 parts of Semen Coiciss of 60 parts of Rhizoma Atractylodis of 5 parts of Herba Epimedii of Semen Arecae
40 parts in 50 portions of Rhizoma Curcumae Longaes of 40 parts of Radix Platycodoniss of 2 parts of Pericarpium Citri Reticulataes of silkworm excrement
40 parts in 50 portions of Rhizoma Zingiberis Recenss of 30 portions of Fructus Chaenomeliss of 1 part of Fructus Evodiae of Folium Perillae
Embodiment 13
Medicine of the present invention is made by following materials of weight proportions medicine:
50 parts of 0.5 part of Semen Coiciss of 3 parts of Rhizoma Atractylodis of 100 parts of Herba Epimedii of Semen Arecae
45 parts in 1 portion of Rhizoma Curcumae Longae of 10 parts of Radix Platycodoniss of 50 parts of Pericarpium Citri Reticulataes of silkworm excrement
50 parts in 0.5 portion of Rhizoma Zingiberis Recens of 10 portions of Fructus Chaenomeliss of 40 parts of Fructus Evodiaes of Folium Perillae
The various embodiments described above medicine, all can be according to the formulation method of routine, with each crude drug of corresponding weight proportion after methods such as the extraction of routine and purification are handled, make the medicine of required dosage form again, as: granule, tablet, hard capsule, oral liquid, soft capsule, drop pill, water pill, honeyed pill etc.
In addition, according to the needs of the various drug forms of preparation, the various embodiments described above medicine also can add suitable pharmaceutic adjuvant such as magnesium stearate, starch, dextrin, sucrose, microcrystalline Cellulose, hydroxypropyl emthylcellulose, vegetable oil, lecithin, Polyethylene Glycol, propylene glycol, ethyl hydroxybenzoate or the like in preparation process.
Claims (8)
1. medicine for the treatment of gout, it is made up of following crude drug: Semen Arecae, Herba Epimedii, Rhizoma Atractylodis, Semen Coicis, silkworm excrement, Pericarpium Citri Reticulatae, Radix Platycodonis, Rhizoma Curcumae Longae, Folium Perillae, Fructus Evodiae, Fructus Chaenomelis, Rhizoma Zingiberis Recens.
2. according to the medicine of claim 1, it is characterized in that the weight proportion of each crude drug in the described medicine is:
Semen Arecae 10-60 part Herba Epimedii 5-50 part Rhizoma Atractylodis 1-30 part Semen Coicis 1-40 part
Silkworm excrement 5-40 part Pericarpium Citri Reticulatae 1-30 part Radix Platycodonis 1-30 part Rhizoma Curcumae Longae 1-30 part
Folium Perillae 1-30 part Fructus Evodiae 1-20 part Fructus Chaenomelis 1-30 part Rhizoma Zingiberis Recens 1-30 part
3. according to the medicine of claim 2, it is characterized in that the weight proportion of each crude drug in the described medicine is:
Semen Arecae 20-50 part Herba Epimedii 10-40 part Rhizoma Atractylodis 1-20 part Semen Coicis 5-30 part
Silkworm excrement 10-30 part Pericarpium Citri Reticulatae 1-20 part Radix Platycodonis 1-20 part Rhizoma Curcumae Longae 1-20 part
Folium Perillae 1-20 part Fructus Evodiae 1-15 part Fructus Chaenomelis 1-20 part Rhizoma Zingiberis Recens 1-20 part
4. according to the medicine of claim 3, it is characterized in that the weight proportion of each crude drug in the described medicine is:
Semen Arecae 25-40 part Herba Epimedii 15-30 part Rhizoma Atractylodis 5-15 part Semen Coicis 10-20 part
Silkworm excrement 15-25 part Pericarpium Citri Reticulatae 5-15 part Radix Platycodonis 3-15 part Rhizoma Curcumae Longae 5-15 part
Folium Perillae 5-15 part Fructus Evodiae 2-8 part Fructus Chaenomelis 5-15 part Rhizoma Zingiberis Recens 5-15 part
5. according to the medicine of claim 4, it is characterized in that the weight proportion of each crude drug in the described medicine is:
Semen Arecae 28-32 part Herba Epimedii 18-22 part Rhizoma Atractylodis 8-12 part Semen Coicis 12-18 part
Silkworm excrement 18-22 part Pericarpium Citri Reticulatae 8-12 part Radix Platycodonis 5-10 part Rhizoma Curcumae Longae 5-10 part
Folium Perillae 5-10 part Fructus Evodiae 2-5 part Fructus Chaenomelis 5-10 part Rhizoma Zingiberis Recens 5-10 part
6. according to the medicine of claim 5, it is characterized in that the weight proportion of each crude drug in the described medicine is:
15 parts of 10 parts of Semen Coiciss of 20 parts of Rhizoma Atractylodis of 30 parts of Herba Epimedii of Semen Arecae
6 parts in 8 portions of Rhizoma Curcumae Longaes of 10 parts of Radix Platycodoniss of 20 parts of Pericarpium Citri Reticulataes of silkworm excrement
8 parts in 6 portions of Rhizoma Zingiberis Recenss of 4 portions of Fructus Chaenomeliss of 8 parts of Fructus Evodiaes of Folium Perillae
7. according to the medicine of claim 5, it is characterized in that the weight proportion of each crude drug in the described medicine is:
16 parts of 10 parts of Semen Coiciss of 22 parts of Rhizoma Atractylodis of 28 parts of Herba Epimedii of Semen Arecae
8 parts in 6 portions of Rhizoma Curcumae Longaes of 8 parts of Radix Platycodoniss of 18 parts of Pericarpium Citri Reticulataes of silkworm excrement
10 parts in 8 portions of Rhizoma Zingiberis Recenss of 3 portions of Fructus Chaenomeliss of 5 parts of Fructus Evodiaes of Folium Perillae
8. according to each described medicine in the claim 1 to 7, it is characterized in that the dosage form of said medicine is selected from granule, tablet, hard capsule, oral liquid, soft capsule, drop pill.
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| CN2005100217902A CN1939521B (en) | 2005-09-30 | 2005-09-30 | Medicine for treating gout |
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| CN2005100217902A CN1939521B (en) | 2005-09-30 | 2005-09-30 | Medicine for treating gout |
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| CN101810715A (en) * | 2009-02-24 | 2010-08-25 | 成都中医药大学附属医院 | New application of fructus evodiae and extracts and compounds thereof |
| CN101401888B (en) * | 2008-11-07 | 2011-02-02 | 张洪磊 | Chinese medicament preparation for treating gout |
| CN103735630A (en) * | 2013-12-25 | 2014-04-23 | 柳州市中医院 | Traditional Chinese medicine for treating gout |
| CN105169096A (en) * | 2014-08-06 | 2015-12-23 | 成都中医药大学附属医院 | Medicine composition for treating gout or/and hyperuricemia |
| CN113398232A (en) * | 2021-05-31 | 2021-09-17 | 四川升和药业股份有限公司 | Preparation method of pharmaceutical composition for treating gout and gouty arthritis |
| CN114652798A (en) * | 2022-03-22 | 2022-06-24 | 珠海市木棉网络科技有限公司 | Preparation method of tablet candy with gout treatment effect |
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| CN102940709B (en) * | 2012-10-31 | 2014-07-02 | 成都医路康医学技术服务有限公司 | Medicine composition for treating gout |
| CN110368428A (en) * | 2019-08-22 | 2019-10-25 | 黑龙江神志医院有限公司 | One kind being used for analgesic Chinese medicine composition, preparation method and applications |
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2005
- 2005-09-30 CN CN2005100217902A patent/CN1939521B/en not_active Expired - Fee Related
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101401888B (en) * | 2008-11-07 | 2011-02-02 | 张洪磊 | Chinese medicament preparation for treating gout |
| CN101810715A (en) * | 2009-02-24 | 2010-08-25 | 成都中医药大学附属医院 | New application of fructus evodiae and extracts and compounds thereof |
| CN101810715B (en) * | 2009-02-24 | 2013-04-17 | 成都中医药大学附属医院 | New application of fructus evodiae and extracts and compounds thereof |
| CN103735630A (en) * | 2013-12-25 | 2014-04-23 | 柳州市中医院 | Traditional Chinese medicine for treating gout |
| CN103735630B (en) * | 2013-12-25 | 2016-03-30 | 柳州市中医院 | A kind of Chinese medicine for the treatment of gout |
| CN105169096A (en) * | 2014-08-06 | 2015-12-23 | 成都中医药大学附属医院 | Medicine composition for treating gout or/and hyperuricemia |
| CN105169096B (en) * | 2014-08-06 | 2018-11-13 | 成都中医药大学附属医院 | A kind of pharmaceutical composition for treating gout or/and hyperuricemia |
| CN113398232A (en) * | 2021-05-31 | 2021-09-17 | 四川升和药业股份有限公司 | Preparation method of pharmaceutical composition for treating gout and gouty arthritis |
| CN114652798A (en) * | 2022-03-22 | 2022-06-24 | 珠海市木棉网络科技有限公司 | Preparation method of tablet candy with gout treatment effect |
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| CN1939521B (en) | 2010-10-06 |
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