CN1907358A - Pharmaceutical composition for preventing and treating avian coccidiosis and its preparing method - Google Patents
Pharmaceutical composition for preventing and treating avian coccidiosis and its preparing method Download PDFInfo
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Abstract
The invention relates to a pharmaceutical composition for the prevention and treatment of avian coccidiosis and process for preparation, wherein the composition comprises the following raw materials (by weight ratio): dichroa root 10-40 parts, bupleurum root 7-20 parts, flavescent sophora root 15-30 parts, sweet wormwood 7-20 parts, carbonized sanguisorba root 7-20 parts, cogongrass rhizome 7-20 parts. The preparing process comprises steps of ultramicro disintegrating, passing through 100-300 mesh sieves, proportioning and mixing homogeneously.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, in particular, relate to Chinese medicine composition of a kind of prevention and treatment avian coccidiosis and preparation method thereof.
Background technology
The chicken chicken coccidiosis is a kind of modal disease.Cause of disease is a kind of unicellular protozoon, parasitizes in the intestinal mucosa epithelial cell, is one of serious disease of harm poultry husbandry.The easy repeated infection of chicken coccidiosis be difficult for to be eliminated, and coccidiosis causes that easily body growth is slow, and easily dead chicken is quickened, increased to his disease of secondary.Parasitize coccidiosis in the epithelial cell by in parasitic intestinal submucosa tissue, drawing the nutrient growth and breeding, cause disease chicken anemia, become thin, poor growth and death.The Excreta that coccidiosis produces in metabolic process is to the toxic effect of chicken.Coccidiosis is at the intestinal submucosa tissue endoparasitism of chicken, intestinal submucosa tissue is damaged and is vulnerable to the invasion and attack of pathogenic bacterium in the intestinal and the secondary bacterial enteritis quickens the disease chicken death and increases mortality rate.
At present, the aviculture of China is raised scattered based on peasant household mostly, and it is uneven that the raiser cultures level, lack relevant feeding and management and epidemic prevention and control knowledge, cause the sickness rate and the relapse rate of some diseases to significantly improve, especially the coccidiosis that causes because of feeding and management is improper, at present, it is the widest to treat this disease range of application, what effect was the most outstanding is sulfa drugs, and the sulfa drugs toxic and side effects is big, is easy to generate drug residue and the laying rate that influences egg fowl, is under an embargo in the outlet poultry production, thereby it is low to seek a kind of toxicity, the good medicine of therapeutic effect is aspect treatment and prevention avian coccidiosis, and is significant.At present, there is a lot of veterinary drug producer to be devoted to the research and the production of Chinese medicine, but commercially available general Chinese powder medicine crude fiber content height at present, and the digestive tract of poultry is short, a little less than coarse-fibred digestion power, makes the effective ingredient stripping difficulty in the medicine, effect is uncertain, causes waste.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, a kind of effective prevention and treatment avian coccidiosis are provided, the Chinese medicine composition of medicine noresidue and effective ingredient is fully contacted and fast stripping with the gastrointestinal mucosal of sick fowl is given full play to the preparation method of Chinese medicine composition of diseases prevention, the resistant effect of medicine.
The present invention is achieved through the following technical solutions:
The pharmaceutical composition of a kind of prevention and treatment avian coccidiosis is characterized in that the raw material of making the active composition by weight consists of: 10～40 parts of Radix Dichroaes, 7～20 parts of Radix Bupleuri, 15～30 parts of Radix Sophorae Flavescentiss, 7～20 parts of Herba Artemisiae Annuaes, 7～20 parts of charred Radix Sanguisorbae, 7～20 parts of goldenseals.
The raw material composition of making the active composition by weight preferably contains: 32 parts of Radix Dichroaes, 10 parts of Radix Bupleuri, 22 parts of Radix Sophorae Flavescentiss, 10 parts of Herba Artemisiae Annuaes, 10 parts of charred Radix Sanguisorbae, 10 parts of goldenseals.
The raw material composition of making the active composition by weight preferably contains: 32 parts of Radix Dichroaes, 10 parts of Radix Bupleuri, 22 parts of Radix Sophorae Flavescentiss, 12 parts of Herba Artemisiae Annuaes, 12 parts of charred Radix Sanguisorbae, 12 parts of goldenseals.
The preparation of drug combination method of prevention of the present invention and treatment avian coccidiosis is characterized in that comprising the steps:
(1) get respectively the distinguish the flavor of effective site of medical material of Radix Dichroae, Radix Bupleuri, Radix Sophorae Flavescentis, Herba Artemisiae Annuae, charred Radix Sanguisorbae, goldenseal, through micronizing after the assay was approved, the 100-300 order sieves;
(2) take by weighing 10～40 parts of Radix Dichroaes by weight, 7～20 parts of Radix Bupleuri, 15～30 parts of Radix Sophorae Flavescentiss, 7～20 parts of Herba Artemisiae Annuaes, 7～20 parts of charred Radix Sanguisorbae, 7～20 parts of goldenseals, mix homogeneously is promptly made the pharmaceutical composition that prevents and treat avian coccidiosis step by step.
The present invention has following technique effect:
The present invention is a pure Chinese medicinal preparation, is raw material owing to adopt Chinese medicine, and is nontoxic, harmless, the medicine noresidue.Radix Dichroae in the side and Herba Artemisiae Annuae all have inhibitory action to multiple protozoon, cooperate Radix Bupleuri simultaneously, Radix Sophorae Flavescentis, charred Radix Sanguisorbae coccidiosis are considered to wet disease in the traditional Chinese medical science, Radix Dichroae and Herba Artemisiae Annuae are inhibited to the growth of coccidiosis, Radix Sophorae Flavescentis, Radix Bupleuri are then effective to the wet disease that multiple reason causes, coccidiosis can cause intestinal bleeding simultaneously, and charred Radix Sanguisorbae has good anastalsis, prescription has demonstrated fully the characteristics of Chinese medicine and pharmacy treating both the principal and secondary aspects of a disease, and coccidiosis is had better curative effect.And, Chinese medicine source, side is wide, cheap, easy to use, can directly be added in the animal feed, play prevention and therapeutical effect to avian coccidiosis, the while drug residue free, but Secure Application can improve said composition in the occupation rate in market and raiser's compliance in outlet poultry and egg fowl, meets the developing direction of green veterinary drug.
Said composition adopts the effective site of the medical material of respectively distinguishing the flavor of, Chinese crude drug is carried out micronizing, make it pass through the 100-300 mesh sieve, destroy plant cell wall to greatest extent, solved Chinese medicine powder crude fiber content height, effective ingredient is difficult to the deficiency of stripping, and effective ingredient can fully be contacted with the gastrointestinal mucosal of sick fowl and also stripping fast, gives full play to diseases prevention, the resistant effect of medicine.Clinical trial shows that this product can reach more than 90% the control rate of avian coccidiosis.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Choose the effective site of Radix Dichroae, Radix Bupleuri, Radix Sophorae Flavescentis, Herba Artemisiae Annuae, charred Radix Sanguisorbae, goldenseal, the above-mentioned medical material of respectively distinguishing the flavor of is through micronizing after the assay was approved, and the 100-300 order sieves, and is standby afterwards.
Embodiment 1
Take by weighing standby 10 parts of 10 parts of 22 parts of 10 parts of 32 parts of 100 purpose Radix Dichroaes, Radix Bupleuri, Radix Sophorae Flavescentiss, Herba Artemisiae Annuaes, charred Radix Sanguisorbae, 10 parts of goldenseals by weight, mix homogeneously step by step, promptly get 1/5th of each prescription element earlier, add to full dose behind the mix homogeneously again and mix, promptly make the Chinese medicine composition of a kind of prevention and treatment avian coccidiosis.
Embodiment 2
Take by weighing standby 20 parts of 15 parts of 18 parts of 10 parts of 20 parts of 200 purpose Radix Dichroaes, Radix Bupleuri, Radix Sophorae Flavescentiss, Herba Artemisiae Annuaes, charred Radix Sanguisorbae, 8 parts of goldenseals by weight, mix homogeneously step by step, promptly get 1/5th of each prescription element earlier, add to full dose behind the mix homogeneously again and mix, promptly make the Chinese medicine composition of a kind of prevention and treatment avian coccidiosis.
Embodiment 3
Take by weighing standby 20 parts of 20 parts of 30 parts of 20 parts of 40 parts of 300 purpose Radix Dichroaes, Radix Bupleuri, Radix Sophorae Flavescentiss, Herba Artemisiae Annuaes, charred Radix Sanguisorbae, 20 parts of goldenseals by weight, mix homogeneously step by step, promptly get 1/5th of each prescription element earlier, add to full dose behind the mix homogeneously again and mix, promptly make the Chinese medicine composition of a kind of prevention and treatment avian coccidiosis.
Embodiment 4
Take by weighing 10 parts of 100 standby purpose Radix Dichroaes by weight, 7 parts of Radix Bupleuri, 15 parts of Radix Sophorae Flavescentiss, 7 parts of Herba Artemisiae Annuaes, 7 parts of charred Radix Sanguisorbae, 7 parts of goldenseals, mix homogeneously step by step, promptly get 1/5th of each prescription element earlier, add to full dose behind the mix homogeneously again and mix, promptly make the Chinese medicine composition of a kind of prevention and treatment avian coccidiosis.
Embodiment 5
Take by weighing 28 parts of 200 standby purpose Radix Dichroaes by weight, 15 parts of Radix Bupleuri, 22 parts of Radix Sophorae Flavescentiss, 12 parts of Herba Artemisiae Annuaes, 12 parts of charred Radix Sanguisorbae, 12 parts of goldenseals, mix homogeneously step by step, promptly get 1/5th of each prescription element earlier, add to full dose behind the mix homogeneously again and mix, promptly make the Chinese medicine composition of a kind of prevention and treatment avian coccidiosis.
Embodiment 6
Take by weighing standby 10 parts of 8 parts of 27 parts of 18 parts of 30 parts of 300 purpose Radix Dichroaes, Radix Bupleuri, Radix Sophorae Flavescentiss, Herba Artemisiae Annuaes, charred Radix Sanguisorbae, 15 parts of goldenseals by weight, mix homogeneously step by step, promptly get 1/5th of each prescription element earlier, add to full dose behind the mix homogeneously again and mix, promptly make the Chinese medicine composition of a kind of prevention and treatment avian coccidiosis.
Embodiment 7
Take by weighing standby 17 parts of 13 parts of 24 parts of 18 parts of 20 parts of 200 purpose Radix Dichroaes, Radix Bupleuri, Radix Sophorae Flavescentiss, Herba Artemisiae Annuaes, charred Radix Sanguisorbae, 17 parts of goldenseals by weight, mix homogeneously step by step, promptly get 1/5th of each prescription element earlier, add to full dose behind the mix homogeneously again and mix, promptly make the Chinese medicine composition of a kind of prevention and treatment avian coccidiosis.
Embodiment 8
Take by weighing standby 12 parts of 12 parts of 22 parts of 10 parts of 32 parts of 200 purpose Radix Dichroaes, Radix Bupleuri, Radix Sophorae Flavescentiss, Herba Artemisiae Annuaes, charred Radix Sanguisorbae, 12 parts of goldenseals by weight, mix homogeneously step by step, promptly get 1/5th of each prescription element earlier, add to full dose behind the mix homogeneously again and mix, promptly make the Chinese medicine composition of a kind of prevention and treatment avian coccidiosis.
Clinical trial:
1. application example:
The address: the Xiao Wang village, Jinghai County, Tianjin honest and just certain
Kind: AA broiler chicken
Age in days: 17 ages in days
Incidence: chicken group spirit is depressed, and the feather pine disorderly closes one's eyes to stay and stands, draw Fructus Lycopersici esculenti sample loose stool, be with blood in the excrement, the chicken that has even draw hemafecia, feed intake descends, mortality rate 7%, and cuing open visible mucous membrane of small intestine of inspection and serosal surface has the petechial hemorrhage that differs in size, intestinal mucosa thickens, and takes pathological material of disease to diagnose through test chamber, is judged to avian coccidiosis, in feedstuff, only add said composition by 0.5g/d, logotype 3 days, mortality rate reduces, feed intake obviously rises, and it is normal that feces recovers, and obtains good result.
2.1 experiment clinical trial data
1.1 summary adopts pharmaceutical composition of the present invention by high dose (1.0g/d only), middle dosage (0.5g/d only), three dosage spices treatments of low dosage (0.2g/d only) to the fast large-scale broiler chicken of AA of artificial challenge's coccidiosis, organizing, fall ill with sulfaclozine soluble powder of sodium (medicine contrast), not medication (positive control) is organized, the not medication (negative control) of not falling ill is organized in contrast.The result shows: high, medium and low dosage group of pharmaceutical composition of the present invention and sulfaclozine soluble powder of sodium all have higher curative effect to avian coccidium infection, the effect of drug regimen object height wherein of the present invention, middle dosage group and sulfaclozine soluble powder of sodium is best, but three's difference not significantly (P＞0.05); Each group of pharmaceutical composition of the present invention is significantly higher than the not medication group of falling ill (P＜0.01) with the relative weight gain rate utmost point of sulfaclozine soluble powder of sodium.Studies show that symptom obviously alleviates and gradually recovery after drug regimen object height of the present invention, the medication of middle dosage group chick, body weight increases, and its curative effect is suitable with the sulfaclozine soluble powder of sodium.
1.2 test report
Attached experiment clinical trial data sees Table 2
1.3 test objective
At present, aquaculture is low because of the intensification degree, the rural culture is many supports in the majority with ground flat, the feeding and management level is generally low, the contact probability of chicken and feces is increased, each stage morbidity that causes coccidiosis to culture at broiler, and sickness rate and mixed infection rate improve is for the prevention and the treatment of primary disease brings difficulty.Suffer from fowl and mainly show the feather pine disorderly, inappetence or useless exhausted, spirit is depressed, blood stool even be hemafecia fully, have draw feedstuff just or the Fructus Lycopersici esculenti sample just, if treatment is untimely or wrong treatment is arranged, often cause the death of disease fowl.Driving ball looses as a kind of antiprotozoal drug.Be mainly used in the control avian coccidiosis.In order further to estimate its prevention effect, carried out the treatment experiment of artificial challenge's avian coccidiosis, for the clinical practice of pharmaceutical composition of the present invention provides scientific basis to coccidiosis.
1.4 content of the test
1.4.1 experimental animal
1.4.1.1 the fast large-scale broiler chicken of kind AA
1.4.1.2 the source is available from Tianjin City Livestock Raising and Veterinary Inst.'s experimental animal room.
1.4.1.3 weight average body weight 1.62kg
1.4.1.4 age in days 30 ages in days
1.4.1.5 the physical examination test chicken adopts online flat mode of supporting, and manages by normal feeding and management, does not make any immunity inoculation, raises to 30 ages in days, experimentizes through physical examination.
1.4.1.6 every treated animal number is divided into A, B, C, D, E, F group, 110 every group at random with the chicken group.The grouping situation sees Table 1
Table 1
| Numbering | Group | Quantity/only | Average weight/kg | Usage and consumption | Drug treatment |
| A | Normal healthy controls (not infecting) | 300 | 1.63 | 0 | |
| B | Infect contrast | 300 | 1.62 | 0 | |
| C | Pharmaceutical composition high dose group of the present invention | 300 | 1.60 | 1.0g/d spice only | 3 days |
| D | Dosage group in the pharmaceutical composition of the present invention | 300 | 1.64 | 0.5g/d spice only | 3 days |
| E | Pharmaceutical composition low dose group of the present invention | 300 | 1.61 | 0.2g/d spice only | 3 days |
| F | Sulfaclozine soluble powder of sodium matched group | 300 | 1.62 | 1g/L | 3 days |
Adopt online flat mode of supporting, 28/meter of density 1.4.1.7 raise the condition test chicken
2, 28 ℃ of temperature, illumination 16 hours/day, daily ration is produced the complete granular material for Tianjin Zhengda Group, and main nutrient composition meets in the index regulation feedstuff and does not contain any antibacterials.Adopt and freely drink water.
1.4.2 EXPERIMENTAL DESIGN A group is the normal healthy controls group, the B group is for infecting matched group, and the C group is pharmaceutical composition high dose group of the present invention, and the D group is dosage group in the pharmaceutical composition of the present invention, the E group is pharmaceutical composition low dose group of the present invention, and the F group is the sulfaclozine soluble powder of sodium.
1.4.3 medicine and source
1.4.3.1 be subjected to the reagent thing
1.4.3.1.1 title pharmaceutical composition of the present invention
1.4.3.1.2 research institute Tianjin City Hynard Animal Pharmaceutical Co., Ltd
1.4.3.1.3 lot number 020321
1.4.3.1.4 the attached experiment clinical trial data of survey report sees Table 2.
1.4.3.1.5 specification prescription: Radix Dichroae 2500g, Radix Bupleuri 900g, Radix Sophorae Flavescentis 1850g, Herba Artemisiae Annuae 1000g, charred Radix Sanguisorbae 900g, goldenseal 900g.
1.4.4 contrast medicine sulfaclozine soluble powder of sodium
1.4.4.1 I technology department of company prepare research institute according to the relevant regulations of " Ministry of Agriculture's veterinary drug quality standard ".
1.4.4.2 lot number 020325
1.4.4.3 the attached experiment clinical trial data of survey report sees Table 2.
1.4.4.4 specification: 30% sulfaclozine sodium.
1.5 morbidity mode
1.5.1 artificial onset
1.5.1.1 source of infection collection: according to clinical classical symptom, cut open inspection pathological change and laboratory diagnosis, be diagnosed as the sick chicken of coccidium infection.Gather the source of infection of coccidian oocyst at its intestinal contents as test.
1.5.1.2 morbidity method: press the grouping of table 1, give chick in experimental group, medicine matched group, the positive controls with coccidium infection; Negative control group adopts and normally feeds, and does not infect.
1.5.1.3 result of infection: all occur the symptom (negative control group except) identical in 4 days with coccidiosis.5 that choose in the positive controls are cutd open inspection and laboratory diagnosis, and its result is the coccidium infection of chicken.
1.5.2 dosage
1.5.2.1 dosage is selected foundation
Above-mentioned dosage is with reference to usage and consumption in " drive ball loose " in Shanxi Province's veterinary drug quality standard and fixed.
1.5.2.2 high, medium and low dosage
High dose is only pressed 1.0g/d, and middle dosage is only pressed 0.5g/d, and low dosage is only pressed 0.2g/d.
1.5.3 route of administration spice.After the artificial challenge waits clinical symptoms to occur, immediately each group chicken is treated by design.
1.5。4 experimental results and analysis
1.5.4。1 test clinical experiment efficacy result sees Table 2
Table 2.
| Numbering | Group | Mortality rate/% | Inefficiency % | Effective percentage % | Cure rate % | Experiment has symptom chicken number when finishing |
| A | Normal healthy controls (not infecting) | 0(0/300) | - | - | - | - |
| B | Infect contrast | 17 (51/300) | 17 | 83 | 69 | 42 |
| C | Pharmaceutical composition high dose group of the present invention | 2(6/300) | 2 | 98 | 97 | 3 |
| D | Dosage group in the pharmaceutical composition of the present invention | 4(12/300) | 4 | 96 | 90 | 18 |
| E | Pharmaceutical composition low dose group of the present invention | 11 (33/300) | 11 | 89 | 81 | 24 |
| F | Sulphur is pressed chloropyrazine soluble powder of sodium matched group | 5(15/300) | 5 | 95 | 90 | 15 |
1.5.4.2 after the cure rate medication, the clinical symptoms complete obiteration; Search for food, drink water and physical signs such as spirit recovers normal for curing fully, curing number, to account for the total percentage ratio of this group test be cure rate.
Do not alleviate 1.5.4.3 the inefficiency clinical symptoms is seen, even appearance worsens or death is invalid, respectively organizes inefficiency according to invalid computation.
1.5.4.4 untoward reaction: press 1.0g/d and only mix drink.Test chicken is not observed any untoward reaction.
1.6 conclusion
1.6.1 this result of the test shows that pharmaceutical composition of the present invention is used for coccidium infection obvious effects.Curative effect statistics and X
2Assay shows, the therapeutic effect of drug regimen object height of the present invention, middle dosage group and sulfaclozine soluble powder of sodium is best, but three's difference is remarkable (P＞0.05) not, and the relative weight gain rate utmost point that drives diffusing each group of ball and sulfaclozine soluble powder of sodium group is significantly higher than and infects not medication group (P＜0.01).
Although the disclosed pharmaceutical composition that relates to a kind of prevention and treatment avian coccidiosis has been carried out special description with reference to embodiment, embodiment described above is illustrative and not restrictive, under the situation that does not break away from the spirit and scope of the present invention, all variations and modification are all within the scope of the present invention.
Claims (4)
1, the pharmaceutical composition of a kind of prevention and treatment avian coccidiosis is characterized in that the raw material of making the active composition by weight consists of: 10～40 parts of Radix Dichroaes, 7～20 parts of Radix Bupleuri, 15～30 parts of Radix Sophorae Flavescentiss, 7～20 parts of Herba Artemisiae Annuaes, 7～20 parts of charred Radix Sanguisorbae, 7～20 parts of goldenseals.
2, the pharmaceutical composition of prevention according to claim 1 and treatment avian coccidiosis is characterized in that the raw material of making the active composition by weight consists of: 32 parts of Radix Dichroaes, 10 parts of Radix Bupleuri, 22 parts of Radix Sophorae Flavescentiss, 10 parts of Herba Artemisiae Annuaes, 10 parts of charred Radix Sanguisorbae, 10 parts of goldenseals.
3, the pharmaceutical composition of prevention according to claim 1 and treatment avian coccidiosis, it is characterized in that the raw material of making the active composition by weight consists of: 32 parts of Radix Dichroaes, 10 parts of Radix Bupleuri, 22 parts of Radix Sophorae Flavescentiss, 12 parts of Herba Artemisiae Annuaes, 12 parts of charred Radix Sanguisorbae, 12 parts of goldenseals.
4, the preparation of drug combination method of described prevention of a kind of claim 1 and treatment avian coccidiosis is characterized in that comprising the steps:
(1) choose respectively the distinguish the flavor of effective site of medical material of Radix Dichroae, Radix Bupleuri, Radix Sophorae Flavescentis, Herba Artemisiae Annuae, charred Radix Sanguisorbae, goldenseal, through micronizing after the assay was approved, the 100-300 order sieves;
(2) take by weighing 10～40 parts of Radix Dichroaes by weight, 7～20 parts of Radix Bupleuri, 15～30 parts of Radix Sophorae Flavescentiss, 7～20 parts of Herba Artemisiae Annuaes, 7～20 parts of charred Radix Sanguisorbae, 7～20 parts of goldenseals, mix homogeneously is promptly made the pharmaceutical composition that prevents and treat avian coccidiosis step by step.
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| CN105362736A (en) * | 2015-11-09 | 2016-03-02 | 河南黑马动物药业有限公司 | Medicine for treating chicken coccidiosis and preparation method of medicine |
| CN108126119A (en) * | 2016-12-01 | 2018-06-08 | 黎凯华 | A kind of Chinese medicine preparation for preventing coccidiosis of domestic fowls |
| CN106517962A (en) * | 2016-12-16 | 2017-03-22 | 福建正大食品有限公司 | Mixture for preventing coccidiosis of indoor floor rearing meat chicken and application thereof |
| CN108567925A (en) * | 2018-07-16 | 2018-09-25 | 资兴市泰坤农林生态产业有限公司 | A kind of Chinese medicine composition, preparation method and application for treating chicken coccidiasis |
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