CN1628770A - Cough stopping and asthma relieving medicine and its preparation - Google Patents

Cough stopping and asthma relieving medicine and its preparation Download PDF

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Publication number
CN1628770A
CN1628770A CN 200410040561 CN200410040561A CN1628770A CN 1628770 A CN1628770 A CN 1628770A CN 200410040561 CN200410040561 CN 200410040561 CN 200410040561 A CN200410040561 A CN 200410040561A CN 1628770 A CN1628770 A CN 1628770A
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medicine
stopping
cough
asthma
relieving
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CN 200410040561
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CN1270762C (en )
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唐秋海
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唐秋海
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Abstract

The invention provides a cough stopping and asthma relieving medicine and its preparation, wherein the medicine is prepared from the following traditional Chinese medicinal herbs (by weight portion), dried orange peel 150-170, grassleaved sweetflag rhizome 80-110, polygonum cuspidatum 300-320, polygonum cuspidatum 180-200, Boenninghausenia sessilicarpa 370-380, roor of sessile stemona 90-105, Marsdenia tenacissima 740-760, almond 90-105, cordate houttuynia 370-380, mulberry bark 180-195.

Description

一种止咳平喘的药物及其制备方法 Cough and asthma, and one kind of pharmaceutical preparation

技术领域 FIELD

本发明涉及止咳平喘的药剂,具体地说是以中草药为原料制成的中成药剂。 The present invention relates to pharmaceutical cough and asthma, in particular for the Chinese herbal medicine agent is made of a raw material. 本发明还涉及它的制备方法。 The present invention further relates to a method for its preparation.

背景技术 Background technique

咳喘疾病是人类的一种常见病,目前治疗此类疾病的药物较多,如急支糖浆、止咳喘、蜜炼川贝枇杷膏等。 Cough is a common human diseases, the current drug treatment of such diseases more, such as acute bronchitis syrup, only cough, honey refining Loquat ointment. 但未见用本发明的组方和制备方法制成的该类药剂。 However, such an agent with no side groups and methods of preparation of the present invention is made.

发明内容 SUMMARY

本发明的目的是提供一种对于肺热引起的咳嗽痰稠,口干咽痒以及急慢性支气管炎引起的痰温咳喘具有较好疗效的止咳平喘药物其及制备方法。 Object of the present invention is to provide a temperature for cough phlegm cough phlegm thick, dry mouth and throat itching caused by acute and chronic bronchitis Hyperactivity induced cough and asthma drugs having a good effect and its preparation method.

本发明的止咳平喘药物是根据彝医长期实践的经验研制出的一种中成药制剂。 Cough and asthma medicament of the present invention is to develop long-term practical experience of the medical Yi out a proprietary formulation. 具有清热化痰、止咳平喘的功能,特别对于肺燥、痰热、痰湿等症具有较好的疗效。 Function has phlegm, cough and asthma, especially for Dryness, phlegm, phlegm embolism have a good effect. 本发明的止咳平喘药物是含以下重量配比原料制成的药剂:陈皮150~170,石菖薄80~110,虎仗300~320,天冬180~200,石椒草370~380,百部90~105,通关藤740~760,臭灵丹370~380,苦杏仁90~105,鱼腥草370~380,桑白皮180~195。 Cough and asthma medicament of the present invention is prepared containing the following ingredients agent weight ratio: Citrus 150 to 170, 80 to 110 thin Shi Chang, tiger battle 300 to 320, 180 to asparagine 200, 370 to 380 Peperomia stone, one hundred 90 to 105, Marsdenia 740 ~ 760, 370 ~ 380 panacea smell, bitter almond 90 to 105, Houttuynia 370 to 380, 180 to 195 Morus alba.

用上述组方按以下步骤制取颗粒剂:1)先将石菖蒲、臭灵丹、石椒草、鱼腥草粉碎,置入蒸馏器中加适量水加热蒸馏1~2小时,收集挥发油,备用;将蒸馏后的水溶液滤过,另器收集;2)将其余七味药材陈皮、天冬、虎仗、百部、通关藤、苦杏仁、桑白皮粉碎与上述蒸馏后的药渣与加水煎煮二次,第一次加8~10倍量的水煎煮2~3小时,放液,滤过,另器收集滤液;第二次再加4~5倍量的水煎煮1~1.5小时,放液,滤过,合并二次滤液及蒸馏过后的水溶液,真空低温浓缩至适量加等量70%的乙醇萃取三次,吸取上清液,真空低温60~68℃浓缩至相对密度为1.32~1.35的清膏;3)按1份清膏,4.5~5份蔗糖,1~1.5份糊精的比例配料,搅拌,使充分混匀,然后用70%的乙醇调整干湿度,过筛,制粒,低温干燥后喷加上述石菖薄等药材的挥发油,密闭约2~3小时后,迅速 Preparation of the above prescription granules according to the following steps: 1) First Shichangpu, smelly panacea, stone pepper grass, Houttuynia pulverized, into the distillation vessel was heated distilled water q.s. 1 to 2 hours, collecting volatile oil, alternate; aqueous solution after distillation was filtered, collected another; 2) the remaining ingredients shichimi Citrus, asparagine, tiger battle, one hundred, Marsdenia, mandelic, Morus alba pulverized with the dregs with distilled water was added secondary boiling, add the first 8 to 10 times the amount of boiling water for 2 to 3 hours, and filtrate discharge, filtration, and the other collected; plus a second amount of a 4 to 5-fold boiling water 1 1.5 hours discharge, filtration, and after the combined filtrate was distilled aqueous secondary, and concentrated in vacuo to a low amount equal amount of 70% ethanol and extracted three times, the supernatant, 60 ~ 68 ℃ low-temperature vacuum concentrated to a relative density 1.32 to 1.35 clear paste; 3) 1 part clear paste, 4.5 to 5 parts of sucrose, 1 to 1.5 parts of dextrin ratio of ingredients, stirring to mix well, then adjust the humidity with 70% ethanol, sieved , granulation, spray-adding the above-mentioned low temperature and dried herbs such as thin Shi Chang volatile oil, closed about 2 to 3 hours, rapidly 搅拌使均匀,分装成袋,密封,即得颗粒剂。 Stirring uniformly, distributed into the bag, seal, i.e., to obtain granules.

本发明的药物还可按现有技术制成其它剂型。 Medicament according to the present invention may also be made from other prior art dosage forms.

本发明的药物具有清热化痰、止咳平喘的功能,对于由肺热引起的咳嗽痰稠,口干咽痒以及急慢性支气管炎引起的痰温咳喘具有较好疗效。 Medicament of the present invention has phlegm, cough and asthma functions for temperature cough phlegm cough phlegm thick, dry mouth, and itchy throat Hyperactivity caused by the acute and chronic bronchitis due to having a better effect. 本发明的制剂经过充分论证,选用疗效可靠、装量准确、稳定性好、携带方便、容易掌握剂量,成本比较低廉、人们容易接受的颗粒剂(冲剂)。 Formulations of the invention after full argument, the choice of effective and reliable, accurate loading capacity, good stability, easy to carry, easy to grasp dose, relatively low cost, it is easy to accept granules (granules). 本制备方法按照处方中各药材所具有的理化性质,采用了部份药材先提取挥发油再和其它一些药材进行煎煮提取其中的水溶性成份,最后进行醇沉除去煎煮液中诸如淀粉、粘液质、蛋白质、树脂鞣质等水溶性杂质的制备工艺,充分得到药材的有效成份,确保制剂的有效性和稳定性。 The present production method according to the physicochemical properties of each formulation has ingredients, herbs to extraction using a volatile oil portion then boiling for herbs and other ingredients wherein the water-soluble extract, finally to remove heavy alcohols such as starch decoction, mucus preparation of water-soluble impurities, proteins, tannin resins and the like, to obtain the full medicinal active ingredient, to ensure the effectiveness and stability of the formulation.

以下是本发明的药物临床疗效观察结果:按照1993年卫生部制订发布的《中药新药临床研究指导原则》的内容,主要对肺燥、痰热、痰湿三个证型进行了临床疗效观察,结果肺燥型有效率为100%,痰热型有效率为97.5%;痰湿型有效率为86.6%;总有效率为95.28%。 The following is a drug clinical efficacy results of the invention: According to the content of the 1993 Ministry of Health to develop "guiding principles of traditional Chinese medicine clinical research of new drugs," published mainly on Dryness, phlegm, phlegm three syndromes were observed clinical efficacy, results Dryness type was 100% effective, phlegm heat rate was 97.5%; phlegm rate was 86.6%; total effective rate was 95.28%.

一、临床诊断标准及疗效判定标准(一)临床诊断标准1.中医辩证分型(1)肺燥型:咳嗽,少痰,质粘如丝,咯之不爽,或痰中带血,咽痒,便干溲赤,舌质红,苔薄黄,脉细或数。 A clinical diagnostic criteria and clinical criteria (a) clinical diagnostic criteria 1. Chinese Medicine of the type (1) Dryness type: cough, sputum less sticky substance such as silk, the slightly uncomfortable, blood or sputum, itchy , then dry urinate red, red tongue thin yellow, pulse or number.

(2)痰热型:咳嗽,痰黄稠,咯血或痰中带血,口渴喜饮或胸闷气喘,小便黄,大便干结,发热或不发热,舌红苔黄,脉弦滑或数。 (2) Type phlegm: cough, thick yellow sputum, hemoptysis, blood or sputum, thirst drink or chest tightness, wheezing, yellow urine, dry stool, fever or without fever, red tongue yellow, slippery pulse or number.

(3)痰湿型:咳嗽,痰多色白,质稠,或胸闷气短,舌质淡,苔白腻,脉濡或滑。 (3) phlegm: cough, phlegm, white, thick, or shortness of breath, pale, greasy moss, pulse or slippery.

2.主要症状程度的划分:(1)咳嗽轻度(+):白天间断咳嗽,不影响正常生活和工作。 2. The main symptoms of the degree of division: (1) mild cough (+): intermittent cough during the day, does not affect the normal life and work.

中度(++):症状界于轻度(+)与重度(+++)之间重度(+++):昼夜咳嗽频繁或阵咳,影响工作和睡眠。 Moderate (++): for mild symptoms sector (+) and severe (+++) and severe (+++) between: day and night, frequent coughing or array cough, affecting work and sleep.

(2)气喘轻度(+):气喘偶有发作,程度轻,不影响睡眠或活动。 (2) mild asthma (+): occasional asthma attack, to a lesser degree, does not affect sleep or activity.

中度(++):界于轻度(+)与重度(+++)之间。 Moderate (++): bound to mild (+) and severe (+++) between.

重度(+++):气喘明显,不能平卧,影响工作和睡眠。 Severe (+++): asthma obviously, not supine, affecting work and sleep.

(二)纳入病例标准符合肺燥、痰热、痰湿型中医临床诊断标准者,可纳入临床观察病例。 (B) meet the inclusion criteria of cases Dryness, phlegm, phlegm TCM clinical diagnostic criteria, can be incorporated into clinical observation of patients.

(三)排除病例标准1、中医辩证分型属风寒及寒饮伏肺者。 (C) the exclusion criteria patients 1, TCM dialectical type is a cold and cold drinks volts the lung.

2、证实由结核、真菌、肿瘤、刺激性气体过敏等因素所致的慢性咳嗽气喘患者。 2, it was confirmed in patients with chronic cough, asthma caused by tuberculosis, fungal, tumor, allergic irritant gases and other factors.

3、合并有心血管、肾肝和造血系统等原发性疾病者,精神病患者。 3, associated with cardiovascular, renal and hepatic primary hematopoietic system diseases, mental illness.

4、妊娠期妇女。 4, pregnant women.

(四)疗效判断标准1、单项症状疗效判断标准(1)咳显效:症状明显好转(+++→+或++→-)。 (D) an efficacy criterion, individual symptoms efficacy criterion (1) cough markedly: significant improvement in symptoms (+++ → + or ++ → -).

有效:症状好转(+++→++或++→+)。 Effective: symptoms improved (+++ → ++ or ++ → +).

无效:症状无改变或姨转不明显。 Invalid: no change in symptoms or aunt turn obvious.

(2)喘显效:症状明显好转(+++→+或++→-)。 (2) markedly asthma: significant improvement in symptoms (+++ → + or ++ → -).

有效:症状好转(+++→++或++→+)。 Effective: symptoms improved (+++ → ++ or ++ → +).

无效:症状无改变。 Invalid: no change in symptoms.

2、总疗效判断标准显效:咳、喘症状明显好转(+++→或++→-)。 2, the overall efficacy criteria markedly: cough, dyspnea symptoms improved significantly (+++ → or ++ → -).

有效:咳、喘症状好转(+++→++或++→+)。 Effective: cough, dyspnea symptoms improved (+++ → ++ or ++ → +).

无效:咳、喘症状无改变。 Invalid: cough, dyspnea, no change in symptoms.

二、治疗方法(一)观察用药物--本发明的药物,塑料袋装,每包8克。 Second, the method of treatment (a) was observed with the drug - drug of the present invention, a plastic bag, 8 grams per packet.

(二)治疗方法凡来门诊的病人,只要符合纳入病例标准即作为观察对象:询问症状,检查体证,按观察记录相关内容后,即处方给药,口服止咳平喘冲剂,每次1包,一日4次,6天为一疗程,进行追踪观察,将获得的症状、体征状况记录入观察表。 (B) Where the treatment of patients to the clinic, patients met the inclusion criteria as long as the observation target that is: inquiry symptoms specimen card, press observed and recorded content, i.e. formulation, oral granules cough and asthma, each package 1 4 times a day, six days for a course, a follow-up observation, the symptoms will get the signs observed condition record into the table.

三、观察结果(一)一般情况本组供临床观察106例,一般情况见表1:表1例性别年龄(岁)职业数 男 女 <10 11~20 21~30 31~40 41~50 51~60 60> 职员 工人 农民 居民肺燥型 36 14 22 3 6 10 9 6 2 0 8 1 18 9痰热型 40 18 22 1 3 11 8 2 8 7 13 0 20 7痰湿型 30 13 17 0 1 3 9 2 4 11 10 4 13 3n 106 45 61 4 10 24 26 10 14 13 31 5 51 19本组各证型病状的发生率及治疗后的消失率、总有效率见表2、表3:表2分 例治疗前阳性治疗后有效症 状型 数 n 占例数百分率(%) n 有效率(%)肺 咳 嗽 36 100.00 36 100.00少痰质粘 34 94.44 34 100.00燥 36 痰中带血 Third, the observation result of (a) for this group of general clinical observation of 106 cases, typically in Table 1: Table 1 Example Sex Age (years) male and female occupation number <10 11 to 20 21 to 30 31 to 40 41 to 50 51 to 60 60> staff workers resident farmers Dryness type 3,614,223,610,962,081,189 phlegm heat 4,018,221,311,828,713,020 phlegm. 7 301317013 9 2 4 11 10 4 13 3n 106 45 61 4 10 24 26 10 14 13 31 5 51 19 the group of incidence of the syndrome and post-treatment conditions disappearance rate, the total efficiency in table 2, table 3: table 2 after treatment before a positive therapeutic effective symptomatic cases division number n representing the number of percentage of cases (%) n rate (%) 36 100.00 36 100.00 lung cough phlegm less sticky substance 34 94.44 34 100.00 36 dry sputum 4 11.11 4 100.00咽 痒 23 63.88 23 100.00型 便 干 28 77.77 28 100.00溲 赤 25 69.44 25 100.00痰 咳 嗽 39 97.50 38 97.43痰黄稠 39 97.50 38 97.43热 40 咯血或痰中带血 2 5.00 2 100.00口 渴 31 77.50 31 100.00型 胸闷气短 36 90.00 35 97.22大 便 干 39 97.50 39 100.00痰 咳 嗽 30 100.00 27 90.00湿 30 痰多色白质稠 30 100.00 15 50.00型 胸闷气短 18 60.00 13 72.22 4 4 100.00 11.11 63.88 23 100.00 23 itchy then dry type 28 77.77 25 69.44 28 100.00 25 100.00 urinate productive cough phlegm 39 97.50 38 97.43 39 97.50 38 97.43 yellow thick heat hemoptysis or sputum 2 40 5.00 100.00 2 thirst 31 77.50 31 36 90.00 100.00 shortness of breath type dry stool 35 97.22 39 97.50 39 100.00 30 100.00 27 90.00 productive cough phlegm, white matter wet fused 30 100.00 15 50.00 30 18 60.00 13 type shortness of breath 72.22

表3显 效 有 效 无 效 有效率分型 例数n % n % n % %肺燥型 36 20 55.55 16 44.44 0 0 100.00痰热型 40 26 65.00 13 32.50 1 2.50 97.50痰湿型 30 0 0 26 86.60 4 13.33 88.66n 106 46 43.39 55 51.88 5 4.70 95.28以上肺燥型、痰热型、痰湿型106例病人中除5例无效者外,其余病例舌质、舌苔、脉象6天后均基本恢复正常,分别统计意义已没有实际意义。 Table 3 Effective Ineffective markedly efficient classification number of cases n% n% n%% Dryness type 16 44.44 36 20 55.55 00 100.00 13 of phlegm heat 65.00 32.50 4026 2.50 97.50 phlegm 1 300 026 4 13.33 86.60 88.66n 106 46 43.39 55 51.88 5 4.70 95.28 Dryness above type, phlegm heat, phlegm 106 cases of patients except 5 cases ineffective, the remaining cases tongue, tongue, pulse were returned to normal after 6 days, respectively statistics meaning has no practical significance.

四、不良反应观察结果:本组106例病人,经服用本制剂6天,总量达24包,无一例出现不良反应。 Fourth, the observation of adverse reactions: The group 106 patients, six days after taking the formulation, the total amount of the package 24, with no adverse reactions. 说明本制剂临床用药十分安全。 Illustrate the preparation of clinical medicine is very safe.

五、结论(一)根据临床观察的目的,对106例现症咳喘人按照中医辩证分型进行了6天的治疗观察,结果说明止咳平喘冲剂对肺燥型、痰热型咳喘效果较好,有效率分别为100%和97.5%,对于肺燥型、痰热型的疗效是可以肯定的。 V. Conclusions (a) according to the purpose of the clinical observation of 106 cases are symptoms of cough who were treated for 6 days according to Chinese Medicine of the type described results Dryness type Granule on cough and asthma, cough and phlegm heat effect good, efficient 100% and 97.5%, respectively, for the type Dryness, phlegm heat effect is certain. 本制剂适应于肺燥型和痰热型病人,与此同时,从病例统计分析中也可以得知对于年龄偏大(老年),病程长的患者,服用6天药是不可能有多大效果的,如果较长时间的服用,效果是会比现在好一些的。 The preparation adapted to the type and phlegm Dryness type of patient, at the same time, from the statistical analysis of cases that can be for older, longer duration of patients (elderly), taking six days the drug is impossible to have much effect If taking a long time, the effect will be better than now some. 无效5例中除1例是82岁的男性(农民),患慢性支气管炎已达30余年,1例是75岁的男性(职员)患者,另一例是71岁的男性(农民)患者,患慢性支气管炎也有30余年,这部分病例支气管、细支气管和肺实质难免已造成组织的病理性改变,单纯服用本制剂一时难以奏效也是理所当然的。 Invalid 5 cases except one case is 82-year-old man (farmer), has reached 30 years suffering from chronic bronchitis, 1 case of 75-year-old male (staff) patients, is another example of 71-year-old male (farmers) in patients suffering from chronic bronchitis also has more than 30 years, which in some cases bronchi, bronchioles and lung parenchyma inevitably have resulted in pathological changes in the organization, making it difficult to simply taking this preparation work is taken for granted.

(二)经过临床观察,本制剂经不同年龄、不同性别、不同职业、不同病程的各证病服用,未发现1例不良反应。 (B) After clinical observation, the present formulations of different age, gender, occupation, each card different courses of disease taking, not one case of adverse effects found.

具体实施方式 detailed description

实施例1:按以下选取药材原料(重量单位:克):陈皮156,石菖薄96,虎仗312,天冬188,石椒草375,百部96,通关藤750,臭灵丹375,苦杏仁96,鱼腥草375,桑白皮188。 Example 1: 188, stone pepper grass 375, one hundred 96, Marsdenia 750, smelly panacea 375 Citrus 156, Shi Chang sheet 96, tiger battle 312, asparagine, bitter: the following selected medicinal material (basis weight: g) 96 almonds, Houttuynia 375, Morus alba 188.

制备方法:1)先将石菖蒲、臭灵丹、石椒草、鱼腥草粉碎,置入蒸馏器中加适量水加热蒸馏1小时,收集挥发油,备用;将蒸馏后的水溶液滤过,另器收集;2)将其余七味药材陈皮、天冬、虎仗、百部、通关藤、苦杏仁、桑白皮粉碎与上述蒸馏后的药渣与加水煎煮二次,第一次加8倍量的水煎煮2小时,放液,滤过,另器收集滤液;第二次再加4倍量的水煎煮1小时,放液,滤过,合并二次滤液及蒸馏过后的水溶液,真空低温浓缩至适量,加等量50~70%的乙醇萃取三次,吸取上清液,真空低温60~68℃浓缩至相对密度为1.32~1.35的清膏;3)按1份清膏,4.5份蔗糖,1份糊精的比例配料,搅拌,使充分混匀,然后用70%的乙醇调整干湿度,过筛,制粒,低温干燥后喷加上述石菖薄等药材的挥发油,密闭约2~3小时后,迅速搅拌使均匀,分装成袋,密封,即得颗粒剂 Preparation methods: 1) first Shichangpu, smelly panacea, stone pepper grass, Houttuynia pulverized, into the distillation vessel was heated distilled water q.s. 1 hour volatile oil was collected, the standby; the aqueous solution was filtered after distillation, other collected; 2) the remaining ingredients shichimi Citrus, asparagine, tiger battle, one hundred, Marsdenia, mandelic, Morus alba and dregs pulverized with addition of water after boiling the secondary distillation, first 8 times an amount of boiling water for 2 hours was put, filtered, the filtrate collected another; plus four times the second amount of boiling water for one hour, tapping, filtered, and the filtrate was combined second aqueous solution after the distillation, and concentrated in vacuo to a low amount, plus an equal amount of 50 to 70% ethanol and extracted three times, the supernatant was concentrated to a clear paste with a relative density of 1.32 to 1.35 cryogenic vacuum 60 ~ 68 ℃; 3) 1 part clear paste 4.5 parts of sucrose, 1 part dextrin proportioning, stirring to mix well, then adjusting humidity of 70% ethanol, sieved, granulated, spray dried low temperature volatile oil plus herbs like the above-described thin Shi Chang, sealed about 2 ~ after 3 hours, with rapid stirring uniformly, distributed into the bag, seal, i.e., to obtain granules

实施例2:按以下选取药材原料(重量单位:克):陈皮150,石菖薄80,虎仗300,天冬180,石椒草370,百部90,通关藤740,臭灵丹370,苦杏仁90,鱼腥草370,桑白皮180。 Example 2: The following selected medicinal material (basis weight: g): Citrus 150, Shi Chang sheet 80, tiger battle 300, asparagine 180, stone pepper grass 370, one hundred ninety, Marsdenia 740, smelly panacea 370, bitter 90 almonds, Houttuynia 370, 180 Morus alba.

按实施例1的方法制备。 Prepared according to Example 1 of the embodiment.

实施例3:按以下选取药材原料(重量单位:克):陈皮170,石菖薄110,虎仗320,天冬200,石椒草380,百部105,通关藤760,臭灵丹380,苦杏仁105,鱼腥草380,桑白皮195。 Example 3: The following selected medicinal material (basis weight: g): Citrus 170, Shi Chang sheet 110, tiger battle 320, asparagine 200, stone pepper grass 380, one hundred 105, Marsdenia 760, smelly panacea 380, bitter almond 105, 380 Houttuynia, Morus alba 195.

制备方法: Preparation:

1)先将石菖蒲、臭灵丹、石椒草、鱼腥草粉碎,置入蒸馏器中加适量水加热蒸馏2小时,收集挥发油,备用;将蒸馏后的水溶液滤过,另器收集;2)将其余七味药材陈皮、天冬、虎仗、百部、通关藤、苦杏仁、桑白皮粉碎与上述蒸馏后的药渣与加水煎煮二次,第一次加10倍量的水煎煮3小时,放液,滤过,另器收集滤液;第二次再加5倍量的水煎煮1.5小时,放液,滤过,合并二次滤液及蒸馏过后的水溶液,真空低温浓缩至适量,加等量50~70%的乙醇萃取三次,吸取上清液,真空低温60~68℃浓缩至相对密度为1.32~1.35的清膏;3)按1份清膏,5份蔗糖,1.5份糊精的比例配料,搅拌,使充分混匀,然后用70%的乙醇调整干湿度,过筛,制粒,低温干燥后喷加上述石菖薄等药材的挥发油,密闭约2~3小时后,迅速搅拌使均匀,分装成袋,密封,即得颗粒剂。 1) First Shichangpu, smelly panacea, stone pepper grass, Houttuynia pulverized, into the distillation vessel was heated add water distilled for 2 hours, volatile oil was collected, the standby; the aqueous solution after distillation was filtered, collected another; 2) the remaining ingredients shichimi Citrus, asparagine, tiger battle, one hundred, Marsdenia, mandelic, Morus alba and dregs pulverized with addition of water after boiling the distillation twice, the first time plus 10 times the amount of water boiling for 3 hours was put, filtered, the filtrate collected another; plus 5 times the second amount of boiling water for 1.5 hours discharge, filtration, distillation and the combined filtrate after the second aqueous solution, and concentrated in vacuo low qs, add equal amount of 50 to 70% ethanol extracted three times, the supernatant, 60 ~ 68 ℃ low-temperature vacuum concentrated to a clear paste with a relative density of 1.32 to 1.35; and 3) the clear cream 1 part, 5 parts of sucrose, 1.5 parts of dextrin proportioning, stirring to mix well, then adjusting humidity of 70% ethanol, sieved, granulated, spray dried low temperature volatile oil plus herbs like the above-described thin Shi Chang, closed about 2 to 3 hours after rapidly stirring uniformly, distributed into the bag, seal, i.e., to obtain granules.

Claims (2)

  1. 1.一种止咳平喘的药物,其特征在于它是含以下重量配比原料制成的药剂:陈皮150~170,石菖薄80~110,虎仗300~320,天冬180~200,石椒草370~380,百部90~105,通关藤740~760,臭灵丹370~380,苦杏仁90~105,鱼腥草370~380,桑白皮180~195。 A pharmaceutical cough and asthma, characterized in that it is made of an agent comprising the following weight proportions of raw materials: Citrus 150 to 170, 80 to 110 thin Shi Chang, tiger battle 300 ~ 320, 180 ~ 200 asparagine, stone Peperomia 370 to 380, 90 to 105 one hundred, Marsdenia 740 ~ 760, 370 ~ 380 panacea smell, bitter almond 90 to 105, Houttuynia 370 to 380, 180 to 195 Morus alba.
  2. 2.如权利要求1所述的止咳平喘药物的制备方法,其特征在于按以下步骤制取颗粒剂:1)先将石菖蒲、臭灵丹、石椒草、鱼腥草粉碎,置入蒸馏器中加适量水加热蒸馏1~2小时,收集挥发油,备用;将蒸馏后的水溶液滤过,另器收集;2)将其余七味药材陈皮、天冬、虎仗、百部、通关藤、苦杏仁、桑白皮粉碎与上述蒸馏后的药渣与加水煎煮二次,第一次加8~10倍量的水煎煮2~3小时,放液,滤过,另器收集滤液;第二次再加4~5倍量的水煎煮1~1.5小时,放液,滤过,合并二次滤液及蒸馏过后的水溶液,真空低温浓缩至适量加等量70%的乙醇萃取三次,吸取上清液,真空低温60~68℃浓缩至相对密度为1.32~1.35的清膏;3)按1份清膏,4.5~5份蔗糖,1~1.5份糊精的比例配料,搅拌,使充分混匀,然后用70%的乙醇调整干湿度,过筛,制粒,低温干燥后喷加上述 2. The method as cough and asthma medicament according to claim 1, characterized in that the following steps take granules prepared: 1) first Shichangpu, smelly panacea, stone pepper grass, Houttuynia pulverized into distiller add water heated to distill 1 to 2 hours, collecting volatile oil, standby; the aqueous solution was filtered after distillation, other collected; 2) the remaining seven flavor ingredients orange peel, asparagine, tiger battle, one hundred, Marsdenia, bitter almond, Morus alba and dregs pulverized with the addition of water after boiling secondary distillation, add the first 8 to 10 times the amount of boiling water for 2-3 hours, subretinal fluid, filtrate collected another; the second plus 4 to 5 times the amount of 1 to 1.5 hours of boiling water, put, filtration, distillation and the combined filtrate after the second aqueous solution, and concentrated in vacuo to a low amount plus an equal amount of 70% ethanol extracted three times, the supernatant was aspirated, 60 ~ 68 ℃ low-temperature vacuum concentrated to a clear paste with a relative density of 1.32 to 1.35; and 3) 1 part clear paste, 4.5 to 5 parts of sucrose, 1 to 1.5 parts of dextrin proportioning, stirring, mix well, then with 70% ethanol to adjust humidity, sieving, granulation, spray-adding the above-mentioned low temperature drying 菖薄等药材的挥发油,密闭2~3小时后,迅速搅拌使均匀,分装成袋,密封,即得颗粒剂。 Chang thin volatile oils and other ingredients, sealed after 2 to 3 hours with rapid stirring uniformly, distributed into the bag, seal, i.e., to obtain granules.
CN 200410040561 2004-08-27 2004-08-27 Cough stopping and asthma relieving medicine and its preparation CN1270762C (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102133363A (en) * 2011-03-22 2011-07-27 唐秋海 Quality detection method for chinarue cough particle
CN102416093A (en) * 2010-09-28 2012-04-18 曲靖开发区格力康生物科技发展有限公司 Chinese herbal composition capable of diminishing inflammation and clearing throat
CN102793841A (en) * 2012-08-20 2012-11-28 孔庆玉 Traditional Chinese medicine composition for treating pediatric acute bronchitis
CN103735960A (en) * 2013-12-10 2014-04-23 济南新起点医药科技有限公司 Application of boenninghausenia sessilicarpa cough-asthma tablet to prepare medicaments for inhibiting lung cancer cell LLC proliferation
CN103735961A (en) * 2013-12-10 2014-04-23 济南新起点医药科技有限公司 Application of boenninghausenia sessilicarpa cough-asthma tablet to prepare medicaments for inhibiting lymphoma cell YAC-1 proliferation

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102416093A (en) * 2010-09-28 2012-04-18 曲靖开发区格力康生物科技发展有限公司 Chinese herbal composition capable of diminishing inflammation and clearing throat
CN102133363A (en) * 2011-03-22 2011-07-27 唐秋海 Quality detection method for chinarue cough particle
CN102133363B (en) 2011-03-22 2011-12-28 唐秋海 Quality detection method for chinarue cough particle
CN102793841A (en) * 2012-08-20 2012-11-28 孔庆玉 Traditional Chinese medicine composition for treating pediatric acute bronchitis
CN102793841B (en) 2012-08-20 2013-11-20 孔庆玉 Traditional Chinese medicine composition for treating pediatric acute bronchitis
CN103735960A (en) * 2013-12-10 2014-04-23 济南新起点医药科技有限公司 Application of boenninghausenia sessilicarpa cough-asthma tablet to prepare medicaments for inhibiting lung cancer cell LLC proliferation
CN103735961A (en) * 2013-12-10 2014-04-23 济南新起点医药科技有限公司 Application of boenninghausenia sessilicarpa cough-asthma tablet to prepare medicaments for inhibiting lymphoma cell YAC-1 proliferation
CN103735961B (en) * 2013-12-10 2016-08-17 代先慧 Application yac-1 lymphoma cells proliferating cells medicament stone Peperomia suppressing cough in the manufacture of sheet

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