CN108686044A - A kind of Eriocheir sinensis liver protectant and preparation method thereof - Google Patents

A kind of Eriocheir sinensis liver protectant and preparation method thereof Download PDF

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Publication number
CN108686044A
CN108686044A CN201810720316.6A CN201810720316A CN108686044A CN 108686044 A CN108686044 A CN 108686044A CN 201810720316 A CN201810720316 A CN 201810720316A CN 108686044 A CN108686044 A CN 108686044A
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parts
eriocheir sinensis
liver
seed
component
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CN108686044B (en
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王美垚
徐钢春
徐跑
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Freshwater Fisheries Research Center of Chinese Academy of Fishery Sciences
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Freshwater Fisheries Research Center of Chinese Academy of Fishery Sciences
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482Cassia, e.g. golden shower tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13Coniferophyta (gymnosperms)
    • A61K36/14Cupressaceae (Cypress family), e.g. juniper or cypress
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/46Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/84Valerianaceae (Valerian family), e.g. valerian
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The present invention relates to a kind of Eriocheir sinensis liver agent and preparation methods, belong to aquatic feeds production technical field.It includes mainly cassia seed, Sculellaria barbata, moutan bark, cortex albiziae, the seed of Oriental arborvitae, Cortex Eucommiae, Poria cocos, fragrant pine, radix paeoniae rubra, Radix Rehmanniae.By crushing, immersion, decoction, filtering, concentration, packaging then obtains a kind of liver protectant used for aquiculture.The present invention is inserted in feed in aquiculture animal hypoimmunity and is used.Each component is herbal component, has many advantages, such as small toxicity, Small side effects, the functions such as each component has both protect liver cholagogic, calmness is allayed excitement, strengthen immunity, resisting stress, is a kind of efficient, environment-friendly type Eriocheir sinensis liver protectant.

Description

A kind of Eriocheir sinensis liver protectant and preparation method thereof
Technical field
The invention belongs to animal feed production technical field more particularly to a kind of Eriocheir sinensis liver protectant and its Preparation method.
Background technology
Eriocheir sinensis (Eriocheir sinensis), it is commonly called as river crab, is under the jurisdiction of Arthropoda (Arthropoda), Crustachia (Crustacea), Eriocheir (Eriocheir).Its fine and tender taste, delicious flavour, are considered as Aquatic products treasure, it is deep to be favored by consumers in general.The artificial breeding of Eriocheir sinensis is explored since the 70's of 20th century, it is existing Modern Eriocheir sinensis has become that China's fresh water new, special products of famous brands, of extra fine quality is leading and pillar kind, and freshwater aquiculture production in China's is being pushed to hold It plays an important role in continuous sound development.
Liver pancreas is river crab vital tissue, participate in internal digestion, storage, secrete growth promoting substance, removing toxic substances and be immunized, The multiple functions such as absorption of nutrient ingredients are of great significance to the normal growth and development of river crab.In recent years, due to environment dirt Dye, aquaculture management be improper etc. to cause river crab hepatopancrease impaired or even dead.Therefore, in culture of Chinese mitten crab, the protection of hepatopancrease is It is extremely important.The researchs such as current related river crab protect liver preparation are few, while each component drug effect is relatively single, cannot achieve complete River crab hepatopancrease function is protected and is improved in face, thus it is foster to be badly in need of a kind of potent, comprehensive, environmentally friendly, simple and practical Eriocheir sinensis It grows and uses liver protectant and preparation method.
Invention content
For the deficiency of existing river crab liver-protecting preparation research, the present invention is directed to develop one kind to protect comprehensively and enhance river crab A kind of hepatopancrease function, efficient, environmental protection Eriocheir sinensis liver protectant and preparation method.Now take following technology Scheme:
A kind of Eriocheir sinensis liver protectant and preparation method, it is characterised in that including 5-11 parts of cassia seed, Sculellaria barbata 4- 10 parts, 3-8 parts of moutan bark, 2-7 parts of cortex albiziae, 2-6 parts of the seed of Oriental arborvitae, 3-8 parts of Cortex Eucommiae, 2-9 parts of Poria cocos, fragrant 2-6 parts of pine, radix paeoniae rubra 3- 8 parts, 2-11 parts of Radix Rehmanniae, 48-55 parts of water.
A kind of Eriocheir sinensis liver protectant of the present invention, preparation method comprise the technical steps that:
A. cassia seed, Sculellaria barbata, moutan bark, cortex albiziae, the seed of Oriental arborvitae, Cortex Eucommiae, Poria cocos, fragrant pine, radix paeoniae rubra, Radix Rehmanniae are mixed laggard Row is primary to be crushed, and makes it 95% by 10 mesh screens;
B. it by mixture obtained by step A, soaks 50-80 minutes;
C. said mixture use is cooked by slow fire 1-1.5 hours, filtering obtains filtrate;
D. by filtrate heating concentration 1-1.5 hours, until volume is 1/2 before concentration;
E. it after solution to be concentrated cooling, packs, sealing, as a kind of Eriocheir sinensis liver protectant.
The device have the advantages that as follows:
Preferably each herbal component of the present invention, nontoxic, Small side effects, each component scientific compatibility have both protect liver cholagogic, calmness It allays excitement, the functions such as strengthen immunity, resisting stress, full protection is carried out to river crab hepatopancrease.It is also added with food calling component simultaneously, increases Preference of the strong river crab to feed.It is a kind of full effect, green, eating, prepares a kind of simple Eriocheir sinensis guarantor Liver agent.
Specific implementation mode
The present invention will be further described in conjunction with specific embodiments below:
Embodiment 1
A kind of Eriocheir sinensis liver protectant and preparation method, including following raw materials by weight:Cassia seed 8 Part, 7 parts of Sculellaria barbata, 5 parts of moutan bark, 5 parts of cortex albiziae, 3 parts of the seed of Oriental arborvitae, 4 parts of Cortex Eucommiae, 5 parts of Poria cocos, fragrant 4 parts of pine, 5 parts of radix paeoniae rubra, life 4 parts of ground, 50 parts of water.
A kind of Eriocheir sinensis liver protectant, preparation method includes the following steps:
A. cassia seed, Sculellaria barbata, moutan bark, cortex albiziae, the seed of Oriental arborvitae, Cortex Eucommiae, Poria cocos, fragrant pine, radix paeoniae rubra, Radix Rehmanniae are mixed laggard Row is primary to be crushed, and makes it 95% by 10 mesh screens;
B. it by mixture obtained by step A, soaks 55 minutes;
C. said mixture use is cooked by slow fire 1 hour, filtering obtains filtrate;
D. by filtrate heating concentration 1 hour, until volume is 1/2 before concentration;
E. it after solution to be concentrated cooling, packs, sealing, as a kind of Eriocheir sinensis liver protectant.
Currently preferred component has the beneficial effect that:
Cassia seed:Also known as Cassia occidentalis, go back pupil etc., it is leguminous herbaceous plant's Cassia or the mature seed of little Cassia tora.With clearing liver The functions such as purging intense heat, tonifying kidney and improving eyesight.Its in the present invention as clearing away the liver-fire, protect liver component and use.
Sculellaria barbata:Also known as Tian Jicao, Herba hyperici attenuati etc., it is horse lamiaceae labiatae scutellaria herbaceos perennial.With heat-clearing solution The functions such as malicious, antibacterial, immunological regulation.Its in the present invention as clearing heat and cooling blood, protect liver cholagogic, strengthen immunity component and use.
Moutan bark:For ranunculaceae peony dry root skin.The ground such as Anhui, Sichuan, Henan, Shandong are originated in, there is heat-clearing Cool blood, activate blood circulation and disperse blood clots, reducing the asthenic fever, nourishing heart and other effects.Its in the present invention is used as protect liver nourishing heart component.
Cortex albiziae:For the bark of legume silk tree, have and blood, calming heart, five viscera settling and other effects.Its conduct in the present invention Tranquilizing and allaying excitement component and use.
The seed of Oriental arborvitae:For the dry mature kernal of cupressaceae plant arbor-vitae.Be distributed in THE SOUTH OF NORTHEAST CHINA, through North China it is to the south cross Guangdong, In Northern Guangxi, west to Shaanxi, Gansu, southwest to the ground such as Sichuan, Yunnan, Guizhou.With mental-tranquilization, protect liver and other effects.This hair Its in bright is used as nourishing heart protect liver component.
Cortex Eucommiae:Also known as bakelite, it is Eucommiaceae plant.Tonify the liver and kidney, strengthen muscles and bones effect, have remove internal rubbish, Reinforce body cell metabolism, broad-spectrum antiseptic improves white blood cell pharmacological action etc..Its in the present invention is as strengthen immunity group Divide and adds.
Poria cocos:For the dry sclerotia of On Polyporaceae Poria cocos.Be distributed Hebei, Henan, Shandong, Anhui, Zhejiang, Fujian, The ground such as Guangdong, Guangxi, Hunan, Hubei, Sichuan, Guizhou, Yunnan, Shanxi.The effect of with invigorating the spleen, strong body.Its in the present invention is made It is used for invigorating the spleen, strengthen immunity component.
Fragrant pine:Also known as rhizoma nardostachyos, it is born in alpine steppe area or the sparse woods of 3000m or more, is distributed in Gansu, Qinghai, four The ground such as river, northwestern Yunnan Province.Fragrant pine is patrinia herb.Pharmacological action is mainly calmness, resisting stress etc..It has strong simultaneously Rosin sample fragrance, the effect that can be improved and extend the food calling factor play range.Its in the present invention is as resisting stress, food calling component And it uses.
Radix paeoniae rubra:For the dry root of ranunculaceae plant radix paeoniae rubra or river radix paeoniae rubra.It is distributed in Shaanxi, Gansu, Qinghai, Sichuan and Tibet Etc. ground.Have effects that clearing heat and cooling blood, resisting stress to.Its in the present invention is used as resisting stress component.
Radix Rehmanniae:Alias radix rehmanniae recen, wild country Huang, mountain cigarette root etc. are the root tuber of scrophulariaceae rehmannia glutinosa plant.Perennial herb is planted Object has the effect of clearing heat and cooling blood, beneficial Yin and promoting production of body liquid, resisting stress.Its in the present invention is used as resisting stress component.
The using effect of the present invention is as follows:
It is used in one aquatic feeds factory of Zhenjiang, Jiangsu.In Feed Manufacturing, every 1 ton of feed using 30kg, support by this Eriocheir sinensis It grows and uses liver protectant.Then it is used in a local river crab culture pond.Time be July summer, before using this feed river crab ingest compared with Difference, vigor is poor, and liver color is shallow.The feed containing this liver protectant is fed, after a week, in order, vigor enhances river crab hepatopancrease, The lower water of happiness is ingested, and food ration significantly increases, constitution enhancing.
Embodiment 2
A kind of Eriocheir sinensis liver protectant and preparation method, including following raw materials by weight:Cassia seed 7 Part, 6 parts of Sculellaria barbata, 7 parts of moutan bark, 3.5 parts of cortex albiziae, 4.5 parts of the seed of Oriental arborvitae, 4 parts of Cortex Eucommiae, 5 parts of Poria cocos, fragrant loose 4 parts, radix paeoniae rubra 4.5 parts, 5.5 parts of Radix Rehmanniae, 49 parts of water.
A kind of liver protectant used for aquiculture, preparation method includes the following steps:
A. cassia seed, Sculellaria barbata, moutan bark, cortex albiziae, the seed of Oriental arborvitae, Cortex Eucommiae, Poria cocos, fragrant pine, radix paeoniae rubra, Radix Rehmanniae are mixed laggard Row is primary to be crushed, and makes it 95% by 10 mesh screens;
B. it by mixture obtained by step A, soaks 65 minutes;
C. said mixture use is cooked by slow fire 1.2 hours, filtering obtains filtrate;
D. filtrate is heated into 1 hour of concentration, until volume is 1/2 before concentration;
E. it after solution to be concentrated cooling, packs, sealing, as a kind of Eriocheir sinensis liver protectant.
The using effect of the present invention is as follows:
It is used in one Feed Manufacturing factory of Nanjing.In Feed Manufacturing, every 1 ton of feed using 30kg, use by this Eriocheir sinensis Liver protectant.Then it is used in a local river crab culture pond.Time is summer August, and river crab ingests poor before using this feed, living Force difference, hepatopancrease atrophy easily occur dead.The feed containing this liver protectant is fed, after a week, river crab hepatopancrease situation significantly changes Kind, color is vivid, and vigor enhancing, Xi Xiashui ingests, and food ration significantly increases, constitution enhancing.

Claims (2)

1. a kind of Eriocheir sinensis liver protectant and preparation method, it is characterised in that including 5-11 parts of cassia seed, Sculellaria barbata 4-10 parts, 3-8 parts of moutan bark, 2-7 parts of cortex albiziae, 2-6 parts of the seed of Oriental arborvitae, 3-8 parts of Cortex Eucommiae, 2-9 parts of Poria cocos, fragrant 2-6 parts of pine, radix paeoniae rubra 3-8 parts, 2-11 parts of Radix Rehmanniae, 48-55 parts of water.
2. a kind of Eriocheir sinensis liver protectant as described in claim 1, preparation method includes the following steps:
A. cassia seed, Sculellaria barbata, moutan bark, cortex albiziae, the seed of Oriental arborvitae, Cortex Eucommiae, Poria cocos, fragrant pine, radix paeoniae rubra, Radix Rehmanniae are mixed laggard Row is primary to be crushed, and makes it 95% by 10 mesh screens;
B. it by mixture obtained by step A, soaks 50-80 minutes;
C. said mixture use is cooked by slow fire 1-1.5 hours, filtering obtains filtrate;
D. by filtrate heating concentration 1-1.5 hours, until volume is 1/2 before concentration;
E. it after solution to be concentrated cooling, packs, sealing, as a kind of Eriocheir sinensis liver protectant.
CN201810720316.6A 2018-07-03 2018-07-03 Liver-protecting agent for cultivating eriocheir sinensis and preparation method thereof Active CN108686044B (en)

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