CN108685788A - Blue anti-oxidant face cream of one bulb and preparation method thereof - Google Patents

Blue anti-oxidant face cream of one bulb and preparation method thereof Download PDF

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Publication number
CN108685788A
CN108685788A CN201810767289.8A CN201810767289A CN108685788A CN 108685788 A CN108685788 A CN 108685788A CN 201810767289 A CN201810767289 A CN 201810767289A CN 108685788 A CN108685788 A CN 108685788A
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parts
extract
skin
face cream
bulb
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不公告发明人
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Foshan Huili Cosmetics Science And Technology Co Ltd
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Foshan Huili Cosmetics Science And Technology Co Ltd
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Publication of CN108685788A publication Critical patent/CN108685788A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)

Abstract

The invention belongs to technical field of skin care, disclose blue anti-oxidant face cream of a bulb and preparation method thereof, it is acted on by the antibacterial anti-inflammatory of the extracts such as Rhizoma Polygonati extract, dandelion extract, bamboo extractive and ball orchid extract, anti-oxidant and other effects, it is prepared into the free radical that can be removed in skin, avoid damage of the free radical to cell, promote the metabolism of skin, improve the elasticity of skin, the generation of delaying skin wrinkle, reduce the calmness of pigment, and the face cream with notable skin whitening, moisturizing effect.

Description

Blue anti-oxidant face cream of one bulb and preparation method thereof
Technical field
The present invention relates to technical field of skin care, and in particular to blue anti-oxidant face cream of a bulb and preparation method thereof.
Background technology
With the progress of society and economic development, people's lives level is continuously improved, for beauty and skin care cosmetics Requirement it is also higher and higher, with advancing age, the collagen of skin is slowly lost in, can cause skin occur water shortage, wrinkle The skin problems such as the coarse, freckle of line, pore, it can be the sufficient moisture of skin supplement that face cream, which is a kind of, moisturize the skin, and energy The skin care item of phenomena such as smooth skin pattern, improvement wrinkle of skin.Chinese patent"A kind of composition being used to prepare face cream, Include the face cream and preparation method thereof of the composition"(patent publication No.:CN105640793A a kind of folic acid, panthenol) are disclosed It with the composition of tocopherol acetate, and is prepared into and can effectively moisturize the skin using the composition, reduce skin lines, increase skin The face cream of skin elasticity, but be continuously increased currently with the skin care item of natural prodcuts development, natural prodcuts, which have to be free of, to be harmful into Point, safe, the features such as mildness is good is the trend of current cosmetics research, and China's Chinese herbal medicine resource is abundant, to medium-height grass The studies and clinical application of medicine is with a long history, and abundant data is had accumulated in the extraction etc. of pharmacological property, effect, toxicity, active ingredient And experience, therefore, using Chinese herbal medicine research and develop it is a have anti-oxidant, anti-aging effects cosmetics meet the big of cosmetic industry Trend.
Invention content
To solve the above-mentioned problems, the present invention provides blue anti-oxidant face cream of a bulb and preparation method thereof, pass through Huang The antibacterial anti-inflammatory of extracts, anti-oxidant and other effects such as essence, dandelion, the leaf of bamboo and ball orchid act on, and skin can be promoted by being prepared into Metabolism improves the elasticity of skin, the face cream that delaying skin wrinkle generates.
The present invention can be achieved through the following technical solutions:
The blue anti-oxidant face cream of one bulb, it is composed of the following components:5-8 parts of cetostearyl alcohol, glycerin monostearate 2-4 Part, 3-5 parts of shea butter, 3-5 parts of saualane, 3-5 parts of isopropyl palmitate, 5-8 parts of Trivent OCG, bisabolol 0.1- 0.5 part, 0.5-1 parts of Seabuckthorn Oil, 0.1-0.2 parts of methyl hydroxybenzoate, 0.1-0.5 parts of allantoin, 5-8 parts of glycerine, trehalose 1-2 Part, 0.1-0.3 parts of Sodium Hyaluronate, 0.5-1 parts of Rhizoma Polygonati extract, 0.5-1 parts of dandelion extract, bamboo extractive 0.6- 0.8 part, 0.4-0.8 parts of ball orchid extract, water is to 100 parts.
Preferably, the blue anti-oxidant face cream of a bulb is composed of the following components:6-7 parts of cetostearyl alcohol, single tristearin It is 2.5-3.5 parts of acid glyceride, 3.5-4.5 parts of shea butter, 3.5-4.5 parts of saualane, 3.5-4.5 parts of isopropyl palmitate, pungent 6-7 parts of acid glycerol three ester, 0.2-0.4 parts of bisabolol, 0.6-0.9 parts of Seabuckthorn Oil, 0.12-0.18 parts of methyl hydroxybenzoate, allantois 0.2-0.4 parts plain, 6-7 parts of glycerine, 1.2-1.8 parts of trehalose, 0.15-0.25 parts of Sodium Hyaluronate, Rhizoma Polygonati extract 0.6-0.9 Part, 0.6-0.9 parts of dandelion extract, 0.65-0.75 parts of bamboo extractive, 0.5-0.7 parts of ball orchid extract, water are to 100 parts.
Preferably, the blue anti-oxidant face cream of a bulb is composed of the following components:6.5 parts of cetostearyl alcohol, single tristearin 3 parts of acid glyceride, 4 parts of shea butter, 4 parts of saualane, 4 parts of isopropyl palmitate, 6.5 parts of Trivent OCG, bisabolol 0.3 part, 0.7 part of Seabuckthorn Oil, 0.15 part of methyl hydroxybenzoate, 0.3 part of allantoin, 6.5 parts of glycerine, 1.5 parts of trehalose, hyaluronic acid 0.2 part of sodium, 0.8 part of Rhizoma Polygonati extract, 0.7 part of dandelion extract, 0.7 part of bamboo extractive, 0.6 part of ball orchid extract, water To 100 parts.
Preferably, the preparation method of the dandelion extract is:Dandelion herb gauze wrapped is taken, 10 times of amounts are put into Soaked overnight in distilled water, heating decoct 1h, filter to take filter residue and 8 times of amount distilled water decoction 1h are added, filter to take filter residue and be added 6 times It measures distilled water and decocts 1h, filtering merges 3 filtrates, is concentrated by evaporation to 1g/ml to get dandelion extract.
Preferably, the preparation method of the ball orchid extract is:It takes ball orchid stem to crushed 60 mesh sieve, is 1 by solid-liquid ratio:8 Distilled water, heating and refluxing extraction 3 times at 80 DEG C is added, each 1h is filtered while hot, merges 3 filtrates, and rotary evaporation concentrates, To filter liquor concentration be 1g/ml to get ball orchid extract.
The preparation method of the blue anti-oxidant face cream of one bulb, includes the following steps:
(1) cetostearyl alcohol, glycerin monostearate, isopropyl palmitate, Trivent OCG, bisabolol, breast are taken The wooden fruit oil, Seabuckthorn Oil, saualane and methyl hydroxybenzoate mixing, are heated to 80-90 DEG C of stirring and dissolving, obtain oil phase;
(2) it takes glycerine, trehalose and allantoin to be heated to 85 DEG C of stirring and dissolvings, obtains water phase;
(3) oil phase is poured into water phase under high velocity agitation and is emulsified, and continue to stir, obtain emulsification lotion;
(4) when lotion to be emulsified is cooled to 50 DEG C, it is blue that Rhizoma Polygonati extract, dandelion extract, bamboo extractive, ball is added The Sodium Hyaluronate of extract and dissolving, stirs evenly, the blue anti-oxidant face cream of the cooling ball up to the present invention.
Each main composition mechanism of action of the present invention is as follows:
Dandelion is the drying herb of feverfew, and bitter is cold in nature, with clearing heat and detoxicating, dispersing swelling and dissipating binds, inducing diuresis for treating strangurtia Effect has the function of stronger Scavenger of ROS and certain anti-aging effects, in addition, Pu containing flavone compound Public English extract has significant inhibiting effect to gold-coloured staphylococci, staphylococcus epidermis etc., has antimicrobial antiphlogistic, antimycotic anti- The effects that viral.
Ball orchid is Asclepiadaceae ball Cymbidium perennial evergreen liana, contains saponin(e, flavones, organic acid, cumarin, steroidal Isoreactivity ingredient also has very strong antioxidant activity in vitro and to de- other than having more significant bacteriostasis antibiosis effect The inhibiting effect of oxygen ribose oxidation damage has significant scavenging effect, and energy to the active oxygen radical of chemical reaction production It improves under oxidative stress status to the protective effect of body.
Sealwort is a kind of dietotherapeutic herbaceous plant, rich in bioactivity such as flavonoids, polysaccharide, saponins and amino acid Ingredient has antiviral, anti-oxidant, antibacterial bacteriostatic and moisturizing and other effects;In the leaf of bamboo containing there are many beneficial to human body activity at Point, including flavonoids, phenolic acid class, alkaloid, polysaccharide, amino acid peptides and Anthraquinones etc., wherein bamboo-leaves flavones are important work Property ingredient, have the function of restraining and sterilizing bacteria, anti-inflammatory, scavenging activated oxygen etc., to skin have anti-aging, radioresistance, skin whitening, moisturizing And other effects.
The present invention has following advantageous effect:
(1) present invention in dandelion extract, contained by active constituent have very high antioxidant activity, Neng Gouxun Speed is purged free radical, effectively blocks damaging action of the free radical to skin, to have anti-aging wrinkle-proof effect, together When can also reduce pigmented occurrence and development, and dandelion extract also has stronger antibacterial and anti-inflammation functions, can repair Damaged skin mitigates stimulation and damage of the free radical to skin;
(2) ball orchid extract of the invention has significant bacteriostasis antibiosis effect and stronger oxidation resistance, can be to more Remaining free radical carries out strong removing, keeps the steady of skin histology free radical, improves generation of the free radical in skin histology It thanks to situation, mitigates the stimulation to skin histology and inflammation damnification, to have the function that protect skin;
(3) it is added to Rhizoma Polygonati extract and bamboo extractive in the present invention, by the flavones ingredient in sealwort and the leaf of bamboo, The antioxidant activity of product is improved, the extra free radical of skin is removed, inhibits the growth of skin surface bacterium, and beautiful with moisturizing White effect is additionally highly resistant to damage of the ultraviolet light to skin;
(4) present invention by Rhizoma Polygonati extract, bamboo extractive, dandelion extract and ball orchid extract compounding together with, The free radical in skin can be removed, damage of the free radical to cell is avoided, promotes the metabolism of skin, improves the bullet of skin Property, the generation of delaying skin wrinkle reduces the calmness of pigment, and has significant skin whitening, moisturizing effect.
Specific implementation mode
In order to make the technical means, the creative features, the aims and the efficiencies achieved by the present invention be easy to understand, tie below Specific embodiment is closed, the present invention is further explained.
The blue anti-oxidant face cream embodiment 1-5 formulas of a bulb of the invention are as shown in table 1:
Table 1
The preparation method of above-mentioned dandelion extract is:Dandelion herb gauze wrapped is taken, 10 times of amount distilled water are put into Middle soaked overnight, heating decoct 1h, filter to take filter residue and 8 times of amount distilled water decoction 1h are added, filter to take filter residue and 6 times of amount distillations are added Water decocts 1h, and filtering merges 3 filtrates, is concentrated by evaporation to 1g/ml to get dandelion extract.
The preparation method of above-mentioned ball orchid extract is:It takes ball orchid stem to crushed 60 mesh sieve, is 1 by solid-liquid ratio:8 are added distillation Water, heating and refluxing extraction 3 times at 80 DEG C, each 1h are filtered while hot, merge 3 filtrates, rotary evaporation concentration, until filtrate is dense Degree is 1g/ml to get ball orchid extract.
The preparation method of the blue anti-oxidant face cream of an above-mentioned bulb, includes the following steps:
(1) cetostearyl alcohol, glycerin monostearate, isopropyl palmitate, Trivent OCG, bisabolol, breast are taken The wooden fruit oil, Seabuckthorn Oil, saualane and methyl hydroxybenzoate mixing, are heated to 80-90 DEG C of stirring and dissolving, obtain oil phase;
(2) it takes glycerine, trehalose and allantoin to be heated to 85 DEG C of stirring and dissolvings, obtains water phase;
(3) oil phase is poured into water phase under high velocity agitation and is emulsified, and continue to stir, obtain emulsification lotion;
(4) when lotion to be emulsified is cooled to 50 DEG C, it is blue that Rhizoma Polygonati extract, dandelion extract, bamboo extractive, ball is added The Sodium Hyaluronate of extract and dissolving, stirs evenly, the blue anti-oxidant face cream of the cooling ball up to the present invention.
Comparative example 1
Difference lies in without addition ball orchid extract in composition of raw materials with embodiment 1.
Comparative example 2
Difference lies in without addition dandelion extract in composition of raw materials with embodiment 1.
Comparative example 3
Difference lies in without addition Rhizoma Polygonati extract and bamboo extractive in composition of raw materials with embodiment 1.
Efficacy validation
Antioxidative Activity Determination:
The sample solution of above-described embodiment 1-5 and comparative example 1-3 are taken, uses DPPH solution, salicylic acid solution and sulphur respectively Sour ferrous solution, Tris-HCL buffer solutions carry out the clearance rate to DPPH free radicals, to the clearance rates of OH free radicals and To O2 -The test of the clearance rate of free radical measures its absorbance, and calculates its clearance rate P1,P2,P3, result such as 2 institute of table Show:
2 each group face cream of table is to DPPH, OH and O2 -Clearance rate
As shown in Table 2, to DPPH, OH and O in embodiment 1-5 groups2 -Clearance rate highest be respectively 59.2%, 82.5% and 68.7%, compared with comparative example 1-3 groups, the difference with conspicuousness illustrates that ball orchid prepared by the present invention is anti-oxidant Face cream is used in compounding by the plant extracts such as ball orchid, sealwort, dandelion and the leaf of bamboo, has stronger oxidation resistance, Interior free yl can be effectively removed, damage of the free radical to skin is reduced, to protect the skin from the injury of free radical.
Skin proof test:
160 subjects are selected, are randomly divided into 8 groups, every group of 20 people, average age was 35 one full year of life, was mostly dry water shortage Property skin quality, it is early daily to be later than the face cream for respectively using embodiment 1-5 and comparative example 1-3 to prepare after face cleaning, continuous 3 months, to by Examination person carries out the questionnaire survey of the skin problems such as skin oil, moisture, collagen, elasticity and pigment, result such as 3 institute of table Show:
3 each group Analyses Methods for Sensory Evaluation Results of table
As shown in Table 3, in embodiment 3,18 people feel that skin of face moisture, collagen content increase, skin Skin becomes to compact flexible, and skin oil and melanin continuously decrease, and only have 11 people in comparative example 1-3, illustrate to compare Face cream effect prepared by example 1-3 is not so good as embodiment, and the blue anti-oxidant face cream of ball prepared by the present invention can improve skin face Moisture increases collagen content, and can reduce skin oil and pigment, to keep skin elasticity and gloss.
In conclusion the clearance rate that the blue anti-oxidant face cream of ball prepared by the present invention can improve skin to free radical, is reduced Damage of the free radical to skin, moreover it is possible to which the activity for inhibiting intracellular tyrosine enzyme prevents the formation of melanin, reduces skin oil Content, and improve moisture of skin, collagen content makes skin become soft, smooth, water profit, flexible.
Several embodiments of the invention above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously Cannot the limitation to the scope of the claims of the present invention therefore be interpreted as.It should be pointed out that for those of ordinary skill in the art For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention Protect range.

Claims (6)

1. the blue anti-oxidant face cream of a bulb, which is characterized in that composed of the following components:5-8 parts of cetostearyl alcohol, monostearate It is 2-4 parts of glyceride, 3-5 parts of shea butter, 3-5 parts of saualane, 3-5 parts of isopropyl palmitate, 5-8 parts of Trivent OCG, red 0.1-0.5 parts of bisabol, 0.5-1 parts of Seabuckthorn Oil, 0.1-0.2 parts of methyl hydroxybenzoate, 0.1-0.5 parts of allantoin, 5-8 parts of glycerine, 1-2 parts of trehalose, 0.1-0.3 parts of Sodium Hyaluronate, 0.5-1 parts of Rhizoma Polygonati extract, 0.5-1 parts of dandelion extract, the leaf of bamboo carry Take 0.6-0.8 parts of object, 0.4-0.8 parts of ball orchid extract, water to 100 parts.
2. the blue anti-oxidant face cream of a bulb according to claim 1, which is characterized in that composed of the following components:Spermaceti 6-7 parts of stearyl alcohol, 2.5-3.5 parts of glycerin monostearate, 3.5-4.5 parts of shea butter, 3.5-4.5 parts of saualane, palmitic acid 3.5-4.5 parts of isopropyl ester, 6-7 parts of Trivent OCG, 0.2-0.4 parts of bisabolol, 0.6-0.9 parts of Seabuckthorn Oil, Metagin 0.12-0.18 parts of ester, 0.2-0.4 parts of allantoin, 6-7 parts of glycerine, 1.2-1.8 parts of trehalose, Sodium Hyaluronate 0.15-0.25 Part, 0.6-0.9 parts of Rhizoma Polygonati extract, 0.6-0.9 parts of dandelion extract, 0.65-0.75 parts of bamboo extractive, ball orchid extract 0.5-0.7 parts, water is to 100 parts.
3. the blue anti-oxidant face cream of a bulb according to claim 1 or 2, which is characterized in that composed of the following components:Whale 6.5 parts of wax stearyl alcohol, 3 parts of glycerin monostearate, 4 parts of shea butter, 4 parts of saualane, 4 parts of isopropyl palmitate, octanoic acid are sweet Oily 6.5 parts of three ester, 0.3 part of bisabolol, 0.7 part of Seabuckthorn Oil, 0.15 part of methyl hydroxybenzoate, 0.3 part of allantoin, 6.5 parts of glycerine, 1.5 parts of trehalose, 0.2 part of Sodium Hyaluronate, 0.8 part of Rhizoma Polygonati extract, 0.7 part of dandelion extract, bamboo extractive 0.7 Part, 0.6 part of ball orchid extract, water are to 100 parts.
4. according to the blue anti-oxidant face cream of one bulb of claim 1-3 any one of them, which is characterized in that the dandelion carries The preparation method of object is taken to be:Dandelion herb gauze wrapped is taken, soaked overnight in 10 times of amount distilled water is put into, heating decocts 1h filters to take filter residue and 8 times of amount distilled water decoction 1h is added, filters to take 6 times of amount distilled water of filter residue addition and decoct 1h, filtering, merging 3 Secondary filtrate is concentrated by evaporation to 1g/ml to get dandelion extract.
5. according to the blue anti-oxidant face cream of one bulb of claim 1-3 any one of them, which is characterized in that the ball orchid extraction The preparation method of object is:It takes ball orchid stem to crushed 60 mesh sieve, is 1 by solid-liquid ratio:8 are added distilled water, are heated to reflux at 80 DEG C Extraction 3 times, each 1h is filtered while hot, merges 3 filtrates, and rotary evaporation concentration carries until filter liquor concentration is 1g/ml to get ball orchid Take object.
6. the method for preparing the blue anti-oxidant face cream of a bulb as described in any one in claim 1-5, which is characterized in that including Following steps:
(1) the wooden fruit of cetostearyl alcohol, glycerin monostearate, isopropyl palmitate, Trivent OCG, bisabolol, breast is taken Oil, Seabuckthorn Oil, saualane and methyl hydroxybenzoate mixing, are heated to 80-90 DEG C of stirring and dissolving, obtain oil phase;
(2) it takes glycerine, trehalose and allantoin to be heated to 85 DEG C of stirring and dissolvings, obtains water phase;
(3) oil phase is poured into water phase under high velocity agitation and is emulsified, and continue to stir, obtain emulsification lotion;
(4) when lotion to be emulsified is cooled to 50 DEG C, Rhizoma Polygonati extract, dandelion extract, bamboo extractive, the extraction of ball orchid is added The Sodium Hyaluronate of object and dissolving, stirs evenly, the blue anti-oxidant face cream of the cooling ball up to the present invention.
CN201810767289.8A 2018-07-12 2018-07-12 Blue anti-oxidant face cream of one bulb and preparation method thereof Withdrawn CN108685788A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810767289.8A CN108685788A (en) 2018-07-12 2018-07-12 Blue anti-oxidant face cream of one bulb and preparation method thereof

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Application Number Priority Date Filing Date Title
CN201810767289.8A CN108685788A (en) 2018-07-12 2018-07-12 Blue anti-oxidant face cream of one bulb and preparation method thereof

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112353741A (en) * 2020-12-24 2021-02-12 瑞资兰(杭州)生物科技有限公司 Anti-wrinkle composition and anti-wrinkle cream

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112353741A (en) * 2020-12-24 2021-02-12 瑞资兰(杭州)生物科技有限公司 Anti-wrinkle composition and anti-wrinkle cream

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Application publication date: 20181023