CN107115236A - One kind is dispelled scar Essence - Google Patents
One kind is dispelled scar Essence Download PDFInfo
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- CN107115236A CN107115236A CN201710331747.9A CN201710331747A CN107115236A CN 107115236 A CN107115236 A CN 107115236A CN 201710331747 A CN201710331747 A CN 201710331747A CN 107115236 A CN107115236 A CN 107115236A
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- essence
- scar
- extract
- dispelled
- rhizoma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Dispelled scar Essence the invention discloses one kind, Essence of the present invention includes shark chondroitin 0.4~1.2%, Rhizoma of Japanse Galangal extract 0.2~0.8%, Herba Duchesneae Indicae extract 0.2~0.8%, glycerine 5~10%, butanediol 2~6%, allantoin 0.5~1.5%, glycine betaine 0.4~0.8%, carbomer 0.1~0.5%, EDETATE SODIUM 0.02~0.05%, Sodium Hyaluronate 0.5~1%, deionized water, the present invention dispels scar Essence with more safely and effectively inhibiting bacteria and diminishing inflammation and scar effect of dispelling.
Description
Technical field
The present invention relates to cosmetic field, and in particular to one kind is dispelled scar Essence.
Background technology
Skin care item at present on the market are various in style, and species is complicated, and many skin care item all be unable to do without chemical composition, lead to
Chang Douhui adds mineral oil, preservative and stabilizer etc. in skin care item, skin care item is turned into the hodgepodge of chemical raw material, skin care
These chemical compositions in product directly or indirectly can produce injury to our skin, if be used for a long time containing it is irritant into
Point or chemical composition skin care item, it is easy to skin is done and pounded, will be occurred ahead of time the problems such as microgroove, color spot.With people couple
The demand of whitening and skin-protecting and the understanding to health, people increasingly pay attention to pure natural non-stimulated natural production when selecting skin care item
Product, so some pure natural plant products are increasingly favored by people seeking beauty.
Skin care item enterprise fast development of the China in Recent Years using pure plant skin care item as characteristic, it is added into vegetable active
It is divided into feature, has adhered to plant safety, natural, health beauty and skin care marrow and mixed active plant elite and modern biotechnology section
The achievement of skill.Machine composition of wherein living turns into the new lover of current skin care item circle, and machine component product living is matched somebody with somebody by unique vigor
Side is developed, and all the components are derived from living the herbaceous plant and flowers that machine farm is planted, and precious herbal ingredients are ground
The work machine formula of beauty is made, helps all kinds of skin to reply balance in most natural mode, the same of skin health balance is being ensured
When, make skin feel more comfortable.
Scar refers to after various wounds the mode of appearance of caused normal skin tissue and the change of histopathology
It is referred to as.After it is human body wound, a kind of normal, inevitable physiological reaction during wound or surface of a wound normal healing,
It is the inevitable outcome of wound healing process.The essence of scar be it is a kind of do not possess normal skin tissue's structure and physiological function,
Lose normal structure vigor, abnormal, unsound tissue.It is beautiful that scar has not only broken up body surface, also hinder linked groups or
The physiological function of organ, or even deformity.People in actual life often due to it is different the reason for local skin cause damage, some
The scar influence that scar is caused is attractive in appearance, but lacks one kind now and can be good at removing scar, and to skin fanout free region
Cosmetics.
The content of the invention
According to the deficiencies in the prior art, the technical problems to be solved by the invention are to provide one kind and dispelled scar Essence, with up to
To the purpose for scar beauty of dispelling.
The Essence includes the component of following mass percent：Shark chondroitin 0.4~1.2%, Rhizoma of Japanse Galangal extract 0.2
~0.8%, Herba Duchesneae Indicae extract 0.2~0.8%, shark chondroitin, the weight part ratio of Rhizoma of Japanse Galangal extract and Herba Duchesneae Indicae extract is (2
~6)：(1~4)：(1~4).
The preparation method of the shark chondroitin comprises the following steps：
(1) Shark cartilage water is boiled into ultramicro grinding after wash away grease and S-layer proteins, drying, adds highly basic, water-bath is degraded,
Filter centrifugation, takes supernatant to adjust PH to neutrality；
(2) toward sodium chloride is added in supernatant of the step (1) after alkaline degradation, water-bath degraded takes supernatant after centrifugation；
(3) pancreatin is added in the supernatant after being degraded toward step (2) through sodium chloride, water-bath degraded adds extract solution water-bath
Heat makes pancreatin be centrifuged after inactivating, and takes supernatant.
The preparation method of the Rhizoma of Japanse Galangal extract is：Crushed after Alpinia japonica is dried in the shade, be heated to reflux carrying with 75~95% ethanol
4~5h is taken, is filtered, the rotated evaporimeter concentration of filtrate.
The preparation method of the Herba Duchesneae Indicae extract is：Mock-strawberry is dried, 40~60 mesh sieves were crushed, with 70~90% ethanol
1~2h of heating and refluxing extraction, filtering, the rotated evaporimeter concentration of filtrate.
The Essence is made up of the raw material of following mass percent：Shark chondroitin 0.4~1.2%, Rhizoma of Japanse Galangal extract
0.2~0.8%, Herba Duchesneae Indicae extract 0.2~0.8%, glycerine 5~10%, butanediol 2~6%, allantoin 0.5~1.5%, sweet tea
Dish alkali 0.4~0.8%, carbomer 0.1~0.5%, EDETATE SODIUM 0.02~0.05%, Sodium Hyaluronate 0.5~1%, the third two
Alcohol 2~8%, beta glucan 0.2~0.4%, menthanol lactic acid ester 0.1~0.2%, triethanolamine 0.1~0.5%, benzene oxygen second
Alcohol 0.3~0.7%, Sensiva SC50 0.02~0.08%, methyl hydroxybenzoate 0.01~0.02%, ethyl hydroxy benzoate 0.01~
0.02%, deionized water surplus.
The preparation method of the Essence comprises the following steps：
(1) by glycerine, butanediol, allantoin, glycine betaine, carbomer, EDETATE SODIUM, Sodium Hyaluronate, propane diols, β-Portugal
Glycan, menthanol lactic acid ester, Phenoxyethanol, Sensiva SC50, methyl hydroxybenzoate, ethyl hydroxy benzoate and deionized water are added together to be stirred
Mix in pot, be heated to 80-85 DEG C, stirring is complete to dissolving；
(2) 40-45 DEG C is cooled to, shark chondroitin, Rhizoma of Japanse Galangal extract, Herba Duchesneae Indicae extract and triethanolamine is sequentially added,
Stirring discharging completely.
Scar of being dispelled to present invention Essence part material makees following introduce：
Shark chondroitin：Shark chondroitin is the acid mucopolysaccharides that preparation is extracted from Shark cartilage tissue, is
White or off-white powder；Odorless；Have and draw moist.The aqueous solution tool toughness of this product, heating is non-condensing, readily soluble in water, no
It is dissolved in the organic solvents such as ethanol, acetone and ether, its esters is relatively stablized to heat, heated not also to be destroyed up to 80 DEG C.Shark is soft
Ossein has the ability of antioxidant and anti-aging, also with anti-inflammatory, accelerating wound healing, the effect that regulation or suppression are sticked, moisture absorption
Water conservation etc. improves the function of skin cell metabolism.Shark chondroitin can promote fibroblastic propagation, can change the generation of cell
Thank to environment, strengthen cell viability, accelerate mitosis.
Rhizoma of Japanse Galangal extract：Alpinia japonica, Classification system Atractylodes macrocephala.Also known as the bighead atractylodes rhizome, small wooden raft Ji, Yu Shu,
The winter bighead atractylodes rhizome, wash rice art, poplar small wooden raft, Wu Shu, piece art, rhizoma atractylodis etc., belong to composite family, [WTBX herbaceos perennial.The nice and cool weather of happiness, with
Rhizome is used as medicine, with multinomial medicinal function, and Rhizoma of Japanse Galangal extract contains Huang Tong Lei ﹑ Tie Lei ﹑ Diphenylheptanes classes and steroid etc.
Compound, with significant Kang Jun ﹑ are anti-oxidant and the pharmacological activity effect such as anti-inflammatory and antalgic, Rhizoma of Japanse Galangal extract has relatively extensive
Antibacterial activity, inhibitory activity is all shown to bacillus subtilis, staphylococcus aureus, Escherichia coli respectively, its extract
The compound contained in thing all shows inhibitory activity to tetrads, and MIC value is 10 μ g/mL.Escherichia coli are all shown
Bacteriostatic activity, MIC value is 5 μ g/mL.Inhibitory activity MIC value to staphylococcus aureus and bacillus subtilis is 10 μ g/
mL。
Herba Duchesneae Indicae extract：Mock-strawberry, Chinese medicine name.For rose family mock-strawberry platymiscium mock-strawberry Duchesnea indica (Andr.)
Focke herb.Herba Duchesneae Indicae extract has good antibiotic property and inoxidizability.
Compared with prior art, the method have the advantages that：
(1) scar elite liquid energy of the invention of dispelling safeguards normal physiological metabolism and the function of skin, by promoting fibroblast
Propagation, change the metabolism environment of cell, strengthen cell viability, accelerate mitosis to reach safe scar effect of dispelling.
(2) present invention dispel scar Essence by natural shark chondroitin, Rhizoma of Japanse Galangal extract and Herba Duchesneae Indicae extract activity into
Packet is combined together, and is served aforesaid active principles in combination in the way of collaboration, inhibiting bacteria and diminishing inflammation and scar effect of dispelling；Namely this hair
Bright described scar Essence of dispelling is compounding Rhizoma of Japanse Galangal extract and Herba Duchesneae Indicae extract using shark chondroitin as primary raw material, is not letter
Single composition is added, but inhibiting bacteria and diminishing inflammation is played in the way of collaboration and scar effect of dispelling, and is metabolized in the normal physiological for safeguarding skin
On the premise of function, using various composition reasonable combination, cooperate with shared, by number of ways inhibiting bacteria and diminishing inflammation, improve skin thin
The function of born of the same parents' metabolism, promotes fibroblastic propagation, changes the metabolism environment of cell, strengthens cell viability, and acceleration has silk point
Split, with more safely and effectively inhibiting bacteria and diminishing inflammation and scar effect of dispelling, in the case where lacking one composition of any of which, can lead
Made Essence inhibiting bacteria and diminishing inflammation is caused to be died down with scar effect of dispelling.
Embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.The present invention of embodiment 1~5 dispels scar elite formula of liquid
It is shown in Table one
Table one
The preparation method of shark chondroitin comprises the following steps described in embodiment 1~5：
(3) Shark cartilage water is boiled into ultramicro grinding after wash away grease and S-layer proteins, drying, adds highly basic, water-bath is degraded,
Filter centrifugation, takes supernatant to adjust PH to neutrality；
(4) toward sodium chloride is added in supernatant of the step (1) after alkaline degradation, water-bath degraded takes supernatant after centrifugation；
(3) pancreatin is added in the supernatant after being degraded toward step (2) through sodium chloride, water-bath degraded adds extract solution water-bath
Heat makes pancreatin be centrifuged after inactivating, and takes supernatant.
The preparation method of Rhizoma of Japanse Galangal extract is described in embodiment 1：Crush, be heated to reflux with 95% ethanol after Alpinia japonica is dried in the shade
Extract 5h, filtering, the rotated evaporimeter concentration of filtrate.
The preparation method of Herba Duchesneae Indicae extract is described in embodiment 1：Mock-strawberry is dried, 60 mesh sieves were crushed, 90% ethanol is used
Heating and refluxing extraction 2h, filtering, the rotated evaporimeter concentration of filtrate.
The preparation method of Essence comprises the following steps described in embodiment 1~5：
(2) by glycerine, butanediol, allantoin, glycine betaine, carbomer, EDETATE SODIUM, Sodium Hyaluronate, propane diols, β-Portugal
Glycan, menthanol lactic acid ester, Phenoxyethanol, Sensiva SC50, methyl hydroxybenzoate, ethyl hydroxy benzoate and deionized water are added together to be stirred
Mix in pot, be heated to 85 DEG C, stirring is complete to dissolving；
(3) 45 DEG C are cooled to, shark chondroitin, Rhizoma of Japanse Galangal extract, Herba Duchesneae Indicae extract and triethanolamine is sequentially added, stirred
Discharging completely.
Comparative example 1
Difference with embodiment 1 is not add shark chondroitin, and other preparation conditions and method are same as Example 1.
Comparative example 2
Difference with embodiment 1 is not add Rhizoma of Japanse Galangal extract, and other preparation conditions and method are same as Example 1.
Comparative example 3
Difference with embodiment 1 is not add Herba Duchesneae Indicae extract, and other preparation conditions and method are same as Example 1.
Comparative example 4
Difference with embodiment 1 is not add shark chondroitin, Rhizoma of Japanse Galangal extract, Herba Duchesneae Indicae extract, other preparation conditions
It is same as Example 1 with method.
Scar of dispelling efficacy validation
The effect for scar Essence embodiment 1 of originally being dispelled below by operation instruction clinically：Clinical case 120 includes
There is the patient of different degrees of scar, daily using the present invention once, adhere to two months, obtain effective effect there are 110, effectively
Rate is 91.7%, and 102 are cured, and cure rate is 85%, and five patients are taken below using embodiment 1 three months and are periodically examined
Look into, obtain effect as shown in Table 2：
Table two
It is effective：Color and luster (red, flush or purple) shoals, and scar hardness (hard, moderate, soft) softens, with normal skin point
Boundary is clear (clear, fuzzy), and subjective symptoms is relieved.
Effectively：Color and luster (red, flush or purple) shoals, and scar hardness (hard, moderate, soft) softens, or and normal skin
Boundary is clear (clear, fuzzy), or subjective symptoms is relieved.
It is invalid：Without change.
Aggravate：Color and luster (red, flush or purple) is deepened, and scar hardness (hard, moderate, soft) is hardened, with normal skin point
Boundary is unintelligible (clear, fuzzy), and subjective symptoms is aggravated.
100 patients for including different degrees of scar of clinical case are divided into ten groups, daily using embodiment 1~5, control
Group 1~4, commercially available group (claiming the like product with scar effect of well dispelling on the market) once, adheres to two months, obtains effect such as
Shown in table three：
Table three
The above described is only a preferred embodiment of the present invention, being not the limitation for making other forms to the present invention, appoint
What those skilled in the art changed or be modified as possibly also with the technology contents of the disclosure above equivalent variations etc.
Imitate embodiment and be applied to other fields, but every without departing from technical solution of the present invention content, the technical spirit according to the present invention
Any simple modification, equivalent variations and the remodeling made to above example, still fall within the protection domain of technical solution of the present invention.
Claims (7)
- The scar Essence 1. one kind is dispelled, it is characterised in that the Essence includes the component of following mass percent：Shark chondroitin 0.4~1.2%, Rhizoma of Japanse Galangal extract 0.2~0.8%, Herba Duchesneae Indicae extract 0.2~0.8%.
- The scar Essence 2. one kind according to claim 1 is dispelled, it is characterised in that the shark chondroitin, Rhizoma of Japanse Galangal extract Weight part ratio with Herba Duchesneae Indicae extract is (2~6)：(1~4)：(1~4).
- The scar Essence 3. one kind according to claim 1 or 2 is dispelled, it is characterised in that the preparation side of the shark chondroitin Method comprises the following steps：(1) Shark cartilage water is boiled into ultramicro grinding after wash away grease and S-layer proteins, drying, adds highly basic, water-bath degraded, filtering Centrifugation, takes supernatant to adjust PH to neutrality；(2) toward sodium chloride is added in supernatant of the step (1) after alkaline degradation, water-bath degraded takes supernatant after centrifugation；(3) pancreatin is added in the supernatant after being degraded toward step (2) through sodium chloride, water-bath degraded makes extract solution heating water bath Centrifuged after pancreatin inactivation, take supernatant.
- The scar Essence 4. one kind according to claim 1 or 2 is dispelled, it is characterised in that the preparation side of the Rhizoma of Japanse Galangal extract Method is：Crushed after Alpinia japonica is dried in the shade, with 75~95% ethanol 4~5h of heating and refluxing extraction, filtering, the rotated evaporimeter of filtrate is dense Contracting.
- The scar Essence 5. one kind according to claim 1 or 2 is dispelled, it is characterised in that the preparation side of the Herba Duchesneae Indicae extract Method is：Mock-strawberry is dried, 40~60 mesh sieves were crushed, with 70~90% ethanol 1~2h of heating and refluxing extraction, filtering, filtrate warp Rotary Evaporators are concentrated.
- The scar Essence 6. one kind according to claim 1 is dispelled, it is characterised in that the Essence is by following mass percent Raw material composition：Shark chondroitin 0.4~1.2%, Rhizoma of Japanse Galangal extract 0.2~0.8%, Herba Duchesneae Indicae extract 0.2~0.8% is sweet Oil 5~10%, butanediol 2~6%, allantoin 0.5~1.5%, glycine betaine 0.4~0.8%, carbomer 0.1~0.5%, EDETATE SODIUM 0.02~0.05%, Sodium Hyaluronate 0.5~1%, propane diols 2~8%, beta glucan 0.2~0.4%, peppermint Alcohol lactate 0.1~0.2%, triethanolamine 0.1~0.5%, Phenoxyethanol 0.3~0.7%, Sensiva SC50 0.02~ 0.08%, methyl hydroxybenzoate 0.01~0.02%, ethyl hydroxy benzoate 0.01~0.02%, deionized water surplus.
- The scar Essence 7. one kind according to any one of claim 1~6 is dispelled, it is characterised in that the preparation of the Essence Method comprises the following steps：(1) glycerine, butanediol, allantoin, glycine betaine, carbomer, EDETATE SODIUM, Sodium Hyaluronate, propane diols, β-Portugal are gathered Sugar, menthanol lactic acid ester, Phenoxyethanol, Sensiva SC50, methyl hydroxybenzoate, ethyl hydroxy benzoate and deionized water add stirring together In pot, 80-85 DEG C is heated to, stirring is complete to dissolving；(2) 40-45 DEG C is cooled to, shark chondroitin, Rhizoma of Japanse Galangal extract, Herba Duchesneae Indicae extract and triethanolamine is sequentially added, stirred Discharging completely.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710331747.9A CN107115236A (en) | 2017-05-11 | 2017-05-11 | One kind is dispelled scar Essence |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710331747.9A CN107115236A (en) | 2017-05-11 | 2017-05-11 | One kind is dispelled scar Essence |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107115236A true CN107115236A (en) | 2017-09-01 |
Family
ID=59726920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710331747.9A Withdrawn CN107115236A (en) | 2017-05-11 | 2017-05-11 | One kind is dispelled scar Essence |
Country Status (1)
| Country | Link |
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| CN (1) | CN107115236A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107496344A (en) * | 2017-10-23 | 2017-12-22 | 合肥卡迪尔化妆品有限公司 | Repair essence |
| CN113143814A (en) * | 2021-02-01 | 2021-07-23 | 中南大学湘雅医院 | Acid ester hydrophilic skin cream and preparation method thereof |
| CN113350212A (en) * | 2021-07-19 | 2021-09-07 | 广州新妆生物科技有限公司 | Natural brightening essence and preparation method thereof |
-
2017
- 2017-05-11 CN CN201710331747.9A patent/CN107115236A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107496344A (en) * | 2017-10-23 | 2017-12-22 | 合肥卡迪尔化妆品有限公司 | Repair essence |
| CN113143814A (en) * | 2021-02-01 | 2021-07-23 | 中南大学湘雅医院 | Acid ester hydrophilic skin cream and preparation method thereof |
| CN113350212A (en) * | 2021-07-19 | 2021-09-07 | 广州新妆生物科技有限公司 | Natural brightening essence and preparation method thereof |
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Application publication date: 20170901 |
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