CN108685716A - Streptococcus lactis dentifrice and preparation method - Google Patents
Streptococcus lactis dentifrice and preparation method Download PDFInfo
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- CN108685716A CN108685716A CN201810891834.4A CN201810891834A CN108685716A CN 108685716 A CN108685716 A CN 108685716A CN 201810891834 A CN201810891834 A CN 201810891834A CN 108685716 A CN108685716 A CN 108685716A
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- nisin
- surfactant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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Abstract
Streptococcus lactis dentifrice and preparation method are made of nisin, calcium carbonate, glycerine, caryophyllus oil, peppermint oil, xylitol, sodium fluoride, surfactant, chlorophyll and pure water, and the mass fraction that wherein each component uses is:0.1 ~ 0.25 part of nisin, 10 parts of calcium carbonate, 5 ~ 10 parts of glycerine, 0.5 part of caryophyllus oil, 0.5 part of peppermint oil, 8 parts of xylitol, 2 parts of sodium fluoride, 5 parts of surfactant, 2 parts of chlorophyll, 5 ~ 10 parts of pure water.The present invention adds nisin in toothpaste and substitutes chemical preservative; effectively oral cavity bacterium can be inhibited to grow; and nisin has no toxic and side effect to human body; it is natural sandy gravel; to protecting human health, the mouth diseases such as effective anti-treating dental ulcer, gingivitis, saprodontia, halitosis.
Description
Technical field
The present invention relates to oral care implement technical fields, and in particular to a kind of streptococcus lactis dentifrice and preparation side
Method.
Background technology
The reason of causing halitosis, saprodontia and gingival infection mainly people are easy residual between tooth in edible meat products
It stays, intraoral hygrothermal environment is easy to grow bacterium, and meat residuals then provide nutrition for bacterium, become Bacteria Culture
Base, general toothpaste to the rejection ability of oral bacteria, do not hold very much as long as it cannot completely remove bacterium and residual meat substance
Mouth infection is easily caused, so that endangering health, in field of toothpaste, preservative is necessary additive, but domestic at present
The preservative added in general toothpaste is mostly chemical preservative, is only capable of playing and prevents toothpaste putrefaction, and chemical preservative
There is certain destruction to mucous membrane of mouth.Nisin is a kind of bion preservative, non-toxic to humans, is entered
It can be absorbed by the body with breaks down into amino acids in human body.Effectively gram-positive bacteria can be inhibited to breed in oral cavity, to halitosis,
Saprodontia, gingivitis etc. have prevention effect, are not yet used in field of toothpaste at present.
Nisin, abbreviation Nisin are one generated by streptococcus lactis or Lactococcus lactis part strain fermentation
Micromolecular polypeptide compounds, it can effectively inhibit the growth of gram-positive bacterium and its spore, meanwhile, Nisin holds
It is easily degraded, will not be accumulated in human body by some protease in human body alimentary canal, be universally acknowledged safe natural anticorrosion
Agent.
There are many bacterial number in oral cavity, and type is quite complicated, at most most importantly streptococcus, staphylococcus and lactobacillus
The various bacteria type of equal categories, in close relations with the formation of saprodontia if there is a kind of Streptococcus mutans in oxygen streptococcus, which can divide
It solves the sucrose in food and generates the big insoluble glucan of high molecular weight, viscosity, so that other floras in oral cavity are adhered to tooth
Tooth surface and form bacterial plaque, lactobacillus energy fermentation polysaccharides class therein generates a large amount of acid, so that acid-base value is dropped to 4.5 or so, makes
Enamel and decalcification of dentine and cause saprodontia.
Invention content
The present invention provides a kind of streptococcus lactis dentifrice and preparation methods, anti-to solve chemistry of the existing technology
Rotten agent has the problem of certain destruction to mucous membrane of mouth.
The technical solution adopted by the present invention to solve the technical problems is:
A kind of streptococcus lactis dentifrice, by nisin, calcium carbonate, glycerine, caryophyllus oil, peppermint oil, xylitol, fluorination
Sodium, surfactant, chlorophyll and pure water composition, the mass fraction that wherein each component uses are:Nisin 0.1 ~
0.25 part, 10 parts of calcium carbonate, 5 ~ 10 parts of glycerine, 0.5 part of caryophyllus oil, 0.5 part of peppermint oil, 8 parts of xylitol, 2 parts of sodium fluoride, surface
5 parts of activating agent, 2 parts of chlorophyll, 5 ~ 10 parts of pure water.
Above-mentioned surfactant is anion surfactant.
The preparation method of above-mentioned streptococcus lactis dentifrice is that extracting lactic acid streptococcus is dissolved in pure water and stirs evenly shape
At nisin aqueous solution, then nisin aqueous solution will be formed and glycerine is uniformly mixed, then carbon is added thereto
Sour calcium and xylitol and surfactant are heated up to 70 DEG C ~ 80 DEG C and stir evenly, finally by caryophyllus oil, chlorophyll, peppermint oil and
Sodium fluoride be added thereto and go to de-airing mixer stir evenly, deaerate after pack.
In the Chinese medicine additive of the present invention:1, the effect of nisin:Most of gram-positive bacteriums are can inhibit,
And have strong inhibiting effect to the spore of bacillus, therefore it is widely used in food service industry as food preservative.Food
It is hydrolyzed into amino acid quickly under the effect of the physiological pH condition and alpha -chymotrypsin of human body after, human body intestinal canal will not be changed
Interior normal flora and the generation resistance problem that such as other antibiotic occur more will not occur intersecting anti-with other antibiotic
Property, it is a kind of efficient, nontoxic, safe, without side-effects antiseptics for natural food.2, the effect of caryophyllus oil:It is planted for Myrtaceae
Volatile oil of the dry flower of object cloves through distillation gained.Warm stomach, warm kidney.Cure mainly swollen stomach cold pain, hiccup, vomiting and diarrhoea, numbness pain, hernia
Bitterly, halitosis, toothache.3, the effect of peppermint oil:Peppermint oil is colourless or flaxen supernatant liquid.There are special refrigerant fragrance, taste
It is just pungent, rear cool.With the passing of time, color gradual change is deep for storage.It is commonly used for expelling mosquito, alleviates physical fatigue.4, the effect of xylitol:Xylose
Alcohol is the best sweetener of anti-caries.First:It is cannot to be produced cariogenic bacterium in oral cavity to ferment, and is using xylitol
Unique polyol, it can individually forbid the growth of streptococcus and its mutant, to mitigate the sense of saprodontia
Dye rate can inhibit the generation of streptococcus growth and acid.
The present invention adds nisin in toothpaste and substitutes chemical preservative, effectively oral cavity bacterium can be inhibited to grow
It is raw, and nisin has no toxic and side effect to human body, and is natural sandy gravel, to protecting human health, effectively
The mouth diseases such as anti-treating dental ulcer, gingivitis, saprodontia, halitosis.
Specific implementation mode
A kind of streptococcus lactis dentifrice, by nisin, calcium carbonate, glycerine, caryophyllus oil, peppermint oil, xylitol,
Sodium fluoride, surfactant, chlorophyll and pure water composition, the mass fraction that wherein each component uses are:Nisin
0.1 ~ 0.25 part, 10 parts of calcium carbonate, 5 ~ 10 parts of glycerine, 0.5 part of caryophyllus oil, 0.5 part of peppermint oil, 8 parts of xylitol, 2 parts of sodium fluoride,
5 parts of surfactant, 2 parts of chlorophyll, 5 ~ 10 parts of pure water.
Above-mentioned surfactant is anion surfactant.
The preparation method of above-mentioned streptococcus lactis dentifrice is that extracting lactic acid streptococcus is dissolved in pure water and stirs evenly shape
At nisin aqueous solution, then nisin aqueous solution will be formed and glycerine is uniformly mixed, then carbon is added thereto
Sour calcium and xylitol and surfactant are heated up to 70 DEG C ~ 80 DEG C and stir evenly, finally by caryophyllus oil, chlorophyll, peppermint oil and
Sodium fluoride be added thereto and go to de-airing mixer stir evenly, deaerate after pack.
In the Chinese medicine additive of the present invention:1, the effect of nisin:Most of gram-positive bacteriums are can inhibit,
And have strong inhibiting effect to the spore of bacillus, therefore it is widely used in food service industry as food preservative.Food
It is hydrolyzed into amino acid quickly under the effect of the physiological pH condition and alpha -chymotrypsin of human body after, human body intestinal canal will not be changed
Interior normal flora and the generation resistance problem that such as other antibiotic occur more will not occur intersecting anti-with other antibiotic
Property, it is a kind of efficient, nontoxic, safe, without side-effects antiseptics for natural food.2, the effect of caryophyllus oil:It is planted for Myrtaceae
Volatile oil of the dry flower of object cloves through distillation gained.Warm stomach, warm kidney.Cure mainly swollen stomach cold pain, hiccup, vomiting and diarrhoea, numbness pain, hernia
Bitterly, halitosis, toothache.3, the effect of peppermint oil:Peppermint oil is colourless or flaxen supernatant liquid.There are special refrigerant fragrance, taste
It is just pungent, rear cool.With the passing of time, color gradual change is deep for storage.It is commonly used for expelling mosquito, alleviates physical fatigue.4, the effect of xylitol:Xylose
Alcohol is the best sweetener of anti-caries.First:It is cannot to be produced cariogenic bacterium in oral cavity to ferment, and is using xylitol
Unique polyol, it can individually forbid the growth of streptococcus and its mutant, to mitigate the sense of saprodontia
Dye rate can inhibit the generation of streptococcus growth and acid.
Claims (3)
1. a kind of streptococcus lactis dentifrice, it is characterized in that by nisin, calcium carbonate, glycerine, caryophyllus oil, peppermint oil,
Xylitol, sodium fluoride, surfactant, chlorophyll and pure water composition, the mass fraction that wherein each component uses are:Lactic acid chain
0.1 ~ 0.25 part of coccus element, 10 parts of calcium carbonate, 5 ~ 10 parts of glycerine, 0.5 part of caryophyllus oil, 0.5 part of peppermint oil, 8 parts of xylitol, fluorination
2 parts of sodium, 5 parts of surfactant, 2 parts of chlorophyll, 5 ~ 10 parts of pure water.
2. streptococcus lactis dentifrice according to claim 1, it is characterized in that surfactant is anion surface active
Agent.
3. the preparation method of streptococcus lactis dentifrice as claimed in claim 1 or 2, which is extracting lactic acid streptococcus, is dissolved to pure water
In stir evenly to form nisin aqueous solution, then nisin aqueous solution will be formed and glycerine is uniformly mixed, then
Calcium carbonate and xylitol and surfactant are added thereto, is heated up to 70 DEG C ~ 80 DEG C and stirs evenly, finally by caryophyllus oil, leaf
Green element, peppermint oil and sodium fluoride be added thereto and go to de-airing mixer stir evenly, deaerate after pack.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810891834.4A CN108685716A (en) | 2018-08-07 | 2018-08-07 | Streptococcus lactis dentifrice and preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810891834.4A CN108685716A (en) | 2018-08-07 | 2018-08-07 | Streptococcus lactis dentifrice and preparation method |
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| Publication Number | Publication Date |
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| CN108685716A true CN108685716A (en) | 2018-10-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201810891834.4A Pending CN108685716A (en) | 2018-08-07 | 2018-08-07 | Streptococcus lactis dentifrice and preparation method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109908000A (en) * | 2019-03-15 | 2019-06-21 | 朗力生物医药(武汉)有限公司 | A kind of saprodontia orientation is dispelled rotten agent and preparation method thereof |
| CN110507813A (en) * | 2019-10-12 | 2019-11-29 | 德州学院 | Cure mainly the traditional Chinese medicine reagent and its preparation method of canker sore |
| US11304888B2 (en) | 2019-04-29 | 2022-04-19 | Sunstar Americas, Inc. | Oral care composition |
-
2018
- 2018-08-07 CN CN201810891834.4A patent/CN108685716A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109908000A (en) * | 2019-03-15 | 2019-06-21 | 朗力生物医药(武汉)有限公司 | A kind of saprodontia orientation is dispelled rotten agent and preparation method thereof |
| US11304888B2 (en) | 2019-04-29 | 2022-04-19 | Sunstar Americas, Inc. | Oral care composition |
| CN110507813A (en) * | 2019-10-12 | 2019-11-29 | 德州学院 | Cure mainly the traditional Chinese medicine reagent and its preparation method of canker sore |
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Application publication date: 20181023 |
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